{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T22:28:01Z","timestamp":1794436081931,"version":"4.9.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstert.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.fertnstert.2026.06.001","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:41:21Z","timestamp":1780616481000},"page":"210-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Understanding and addressing oocyte maturation failure and failed or abnormal fertilization during oocyte-to-zygote transition"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-9205","authenticated-orcid":false,"given":"Giovanni","family":"Coticchio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Taggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rienzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fertnstert.2026.06.001_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/humupd\/dmv011","article-title":"Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization","volume":"21","author":"Coticchio","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/19396368.2026.2618253","article-title":"Fertilization and oocyte activation: overview, updates, and novel hypotheses from a molecular perspective","volume":"72","author":"Nisio","year":"2026","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib3","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1093\/humrep\/deac177","article-title":"Human 1PN and 3PN zygotes recapitulate all morphokinetic events of normal fertilization but reveal novel developmental errors","volume":"37","author":"Ezoe","year":"2022","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib4","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/humrep\/deae157","article-title":"An expert opinion on rescuing atypically pronucleated human zygotes by molecular genetic fertilization checks in IVF","volume":"39","author":"Capalbo","year":"2024","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10815-025-03722-z","article-title":"Rates and risk factors of oocyte immaturity: toward personalized selection for rescue in vitro maturation","volume":"43","author":"Taggi","year":"2026","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1472-6483(10)60168-X","article-title":"Effect of different gonadotrophin priming on IVM of oocytes from women with normal ovaries: a prospective randomized study","volume":"19","author":"Fadini","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib7","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s10815-021-02219-9","article-title":"The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility","volume":"38","author":"Zheng","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/humrep\/deaf099","article-title":"Rescue in vitro maturation of germinal vesicle oocytes after ovarian stimulation: the importance of the culture media","volume":"40","author":"Soler","year":"2025","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib9","article-title":"Advances in human oocyte in vitro maturation: current status and future perspectives: a narrative review","volume":"6","author":"Liu","year":"2025","journal-title":"Reprod Fertil"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib10","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.3390\/cells10092292","article-title":"The function of cumulus cells in oocyte growth and maturation and in subsequent ovulation and fertilization","volume":"10","author":"Turathum","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1387\/ijdb.120140ec","article-title":"Metabolism throughout follicle and oocyte development in mammals","volume":"56","author":"Collado-Fernandez","year":"2012","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humupd\/dmad023","article-title":"A fresh start for IVM: capacitating the oocyte for development using pre-IVM","volume":"30","author":"Gilchrist","year":"2023","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib13","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s10815-024-03211-9","article-title":"Assessing the developmental competence of oocytes matured following rescue in vitro maturation: a systematic review and meta-analysis","volume":"41","author":"Bartolacci","year":"2024","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib14","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/humrep\/dead129","article-title":"How to identify patients who would benefit from delayed-matured oocytes insemination: a sibling oocyte and ploidy outcome study","volume":"38","author":"Elkhatib","year":"2023","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib15","article-title":"Alpha Scientists in Reproductive Medicine. The Vienna consensus: report of an expert meeting on the development of art laboratory performance indicators","volume":"2017","year":"2017","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00441-015-2243-3","article-title":"The challenges involved in elucidating the molecular basis of sperm\u2013egg recognition in mammals and approaches to overcome them","volume":"363","author":"Wright","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/humupd\/dmv040","article-title":"Oocyte activation deficiency: a role for an oocyte contribution?","volume":"22","author":"Yeste","year":"2016","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/bs.ctdb.2024.12.002","article-title":"The characteristics of the Ca2+ signals that activate mammalian eggs at fertilization","volume":"162","author":"Swann","year":"2024","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fcell.2020.00028","article-title":"Essential role of sperm-specific PLC-zeta in egg activation and male factor infertility: an update","volume":"8","author":"Saleh","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib20","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3390\/ijms25021344","article-title":"Phospholipase C zeta in human spermatozoa: a systematic review on current development and clinical application","volume":"25","author":"Parrella","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/humupd\/dmad007","article-title":"Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation","volume":"29","author":"Campos","year":"2023","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib22","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1071\/RD12369","article-title":"The value of second polar body detection 4 hours after insemination and early rescue ICSI in preventing complete fertilisation failure in patients with borderline semen","volume":"26","author":"Jin","year":"2013","journal-title":"Reprod, Fertil Dev"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoad046","article-title":"Cumulative live birth rate and neonatal outcomes after early rescue ICSI: a propensity score matching analysis","volume":"2023","author":"Jiang","year":"2023","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib24","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/humrep\/dead097","article-title":"Day after rescue ICSI: eliminating total fertilization failure after conventional IVF with high live birth rates following cryopreserved blastocyst transfer","volume":"38","author":"Batha","year":"2023","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12958-021-00784-3","article-title":"Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis","volume":"19","author":"Paffoni","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/humrep\/dex344","article-title":"Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability","volume":"33","author":"Coticchio","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/jmedgenet-2019-106379","article-title":"Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest","volume":"57","author":"Wang","year":"2020","journal-title":"J M\u00e9d Genet"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/humrep\/deaf097.107","article-title":"The Istanbul consensus update: a revised ESHRE\/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment","volume":"40","author":"Coticchio","year":"2025","journal-title":"Hum Reprod"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib29","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1007\/s10815-024-03278-4","article-title":"Incidence of haploidy and triploidy in trophectoderm biopsies of blastocysts derived from normally and abnormally fertilized oocytes","volume":"41","author":"Girardi","year":"2024","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2025.105080","article-title":"To discard or not to discard 1PNs? A systematic review and meta-analysis on 291,474 embryos","volume":"52","author":"Lee","year":"2026","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.fertnstert.2021.08.036","article-title":"Developmental trajectory of monopronucleated zygotes after in vitro fertilization when they include both male and female genomes","volume":"117","author":"Wei","year":"2022","journal-title":"Fertil Steril"},{"key":"10.1016\/j.fertnstert.2026.06.001_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10815-018-1137-1","article-title":"Correlation between the pronucleus size and the potential for human single pronucleus zygotes to develop into blastocysts","volume":"35","author":"Araki","year":"2018","journal-title":"J Assist Reprod Genet"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028226004772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028226004772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:58:13Z","timestamp":1794434293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028226004772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0015028226004772"],"URL":"https:\/\/doi.org\/10.1016\/j.fertnstert.2026.06.001","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding and addressing oocyte maturation failure and failed or abnormal fertilization during oocyte-to-zygote transition","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fertnstert.2026.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92026 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine","name":"copyright","label":"Copyright"}]}}