{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:47:16Z","timestamp":1762271236492,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fungal Genetics and Biology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.fgb.2008.03.005","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T09:31:56Z","timestamp":1207128716000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing"],"prefix":"10.1016","volume":"45","author":[{"given":"Carlos","family":"Garc\u00eda-Estrada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Vaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Fierro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaas","family":"Sjollema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marten","family":"Veenhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Francisco","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fgb.2008.03.005_bib1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev.mi.46.100192.002333","article-title":"Penicillin and cephalosporin biosynthetic genes: structure, regulation, and evolution","volume":"46","author":"Aharonowitz","year":"1992","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.fgb.2008.03.005_bib2","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1128\/AAC.31.11.1675","article-title":"Purification to homogeneity and characterization of the acyl-CoA: 6-APA acyltransferase of Penicillium chrysogenum","volume":"31","author":"\u00c1lvarez","year":"1987","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fgb.2008.03.005_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0378-1119(89)90115-7","article-title":"Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic-acid-acyltransferase gene of Penicillium chrysogenum","volume":"83","author":"Barredo","year":"1989","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2008.03.005_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1574-6968.1983.tb00103.x","article-title":"The penicillin acylase from Escherichia coli ATCC11105 consists of two dissimilar subunits","volume":"20","author":"B\u00f6ck","year":"1983","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.fgb.2008.03.005_bib5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/378416a0","article-title":"A protein catalytic framework with an N-terminal nucleophile is capable of self-activation","volume":"378","author":"Brannigan","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.fgb.2008.03.005_bib6","first-page":"494","article-title":"High frequency transformation of Penicillium chrysogenum","volume":"5","author":"Cantoral","year":"1987","journal-title":"Biotechnology"},{"key":"10.1016\/j.fgb.2008.03.005_bib7","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s004380051048","article-title":"Intrachromosomal recombination between direct repeats in Penicillium chrysogenum: gene conversion and deletion events","volume":"261","author":"Casqueiro","year":"1999","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.fgb.2008.03.005_bib8","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1128\/jb.174.19.6270-6276.1992","article-title":"Effects of site-directed mutations on processing and activities of penicillin G acylase from Escherichia coli ATCC11105","volume":"174","author":"Choi","year":"1992","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.fgb.2008.03.005_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00435290","article-title":"Isolation and characterization of pyrG mutants of Penicillium chrysogenum by resistance to 5\u2032-fluorotic acid","volume":"12","author":"D\u00edez","year":"1987","journal-title":"Curr. Genet."},{"key":"10.1016\/j.fgb.2008.03.005_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/373264a0","article-title":"Penicillin acylase has a single-amino-acid catalytic centre","volume":"373","author":"Duggleby","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.fgb.2008.03.005_bib11","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1046\/j.1432-1033.2003.03561.x","article-title":"The isopenicillin N acyltransferases of Aspergillus nidulans and Penicillium chrysogenum differ in their ability to maintain the 40-kDa alphabeta heterodimer in an undissociated form","volume":"270","author":"Fern\u00e1ndez","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.fgb.2008.03.005_bib12","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1073\/pnas.92.13.6200","article-title":"The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences","volume":"92","author":"Fierro","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.fgb.2008.03.005_bib13","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.fgb.2006.03.001","article-title":"Transcriptional and bioinformatic analysis of the 56.8kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum","volume":"43","author":"Fierro","year":"2006","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.fgb.2008.03.005_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00253-007-0999-4","article-title":"In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum","volume":"76","author":"Garc\u00eda-Estrada","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.fgb.2008.03.005_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1006\/jmbi.2000.4105","article-title":"Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active-site cleft","volume":"302","author":"Hewitt","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.fgb.2008.03.005_bib16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1749-6632.1987.tb45692.x","article-title":"Penicillin amidase from E. coli","volume":"501","author":"Kasche","year":"1987","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.fgb.2008.03.005_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0167-4838(99)00155-7","article-title":"Intramolecular autoproteolysis initiates the maturation of penicillin amidase from Escherichia coli","volume":"1433","author":"Kasche","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fgb.2008.03.005_bib18","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/AEM.68.3.1211-1219.2002","article-title":"Production of penicillin by fungi growing on food products: identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum","volume":"68","author":"Laich","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fgb.2008.03.005_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/BJ20051599","article-title":"Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N acyltransferase","volume":"395","author":"Lamas-Maceiras","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.fgb.2008.03.005_bib20","doi-asserted-by":"crossref","first-page":"12646","DOI":"10.1016\/S0021-9258(18)98948-9","article-title":"\u03b4-(l-\u03b1-Aminoadipyl)-l-cysteinyl-d-valine synthetase from Aspergillus nidulans","volume":"266","author":"MacCabe","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fgb.2008.03.005_bib21","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1128\/jb.178.8.2211-2215.1996","article-title":"Specific inhibition of mature fungal serine proteinases and metalloproteinases by their propeptides","volume":"178","author":"Markaryan","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.fgb.2008.03.005_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.mi.43.100189.001133","article-title":"Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites","volume":"43","author":"Mart\u00edn","year":"1989","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.fgb.2008.03.005_bib23","series-title":"Molecular Industrial Mycology","first-page":"149","article-title":"Molecular genetics of penicillin and cephalosporin antibiotic biosynthesis","author":"Mart\u00edn","year":"1990"},{"key":"10.1016\/j.fgb.2008.03.005_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/jmbi.2001.5043","article-title":"Crystal structures of penicillin acylase enzyme\u2013substrate complexes: structural insights into the catalytic mechanism","volume":"313","author":"McVey","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.fgb.2008.03.005_bib25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/BF00259395","article-title":"Cloning, characterization of the acyl-CoA: 6 amino penicillanic acid acyltransferase gene of Aspergillus nidulans and linkage to the isopenicillin N synthase gene","volume":"221","author":"Montenegro","year":"1990","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.fgb.2008.03.005_bib26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/j.1460-2075.1991.tb07971.x","article-title":"Localization of the pathway of the penicillin biosynthesis in Penicillium chrysogenum","volume":"10","author":"M\u00fcller","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.fgb.2008.03.005_bib27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0304-4165(92)90118-E","article-title":"Involvement of microbodies in penicillin biosynthesis","volume":"1116","author":"M\u00fcller","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fgb.2008.03.005_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-4165(95)00106-L","article-title":"Enrichment of Penicillium chrysogenum microbodies by isopycnic centrifugation in nycodenz as visualized with immuno-electron microscopy","volume":"1245","author":"M\u00fcller","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fgb.2008.03.005_bib29","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1128\/JB.186.19.6457-6464.2004","article-title":"Hetero- and autoprocessing of the extracellular metalloprotease (Mpr) in Bacillus subtilis","volume":"186","author":"Park","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.fgb.2008.03.005_bib30","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/382468a0","article-title":"Autocatalytic processing of the 20S proteasome","volume":"382","author":"Seem\u00fcller","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.fgb.2008.03.005_bib31","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1128\/jb.172.10.5908-5914.1990","article-title":"Molecular characterization of the acyl-coenzyme A: isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in E. coli","volume":"172","author":"Tobin","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.fgb.2008.03.005_bib32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0378-1119(93)90196-A","article-title":"The requirement for subunit interaction in the production of Penicillium chrysogenum acyl-coenzyme A: isopenicillin N acyltransferase in Escherichia coli","volume":"132","author":"Tobin","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2008.03.005_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0378-1119(95)00369-H","article-title":"Amino acid substitutions in the cleavage site of acyl-coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum: effect on proenzyme cleavage and activity","volume":"162","author":"Tobin","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2008.03.005_bib34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0968-0004(91)90014-M","article-title":"The role of penicillin amidases in nature and in industry","volume":"16","author":"Valle","year":"1991","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fgb.2008.03.005_bib35","series-title":"Genetics and Molecular Biology of Industrial Microorganisms","first-page":"262","article-title":"Cloning of penicillin biosynthetic genes","author":"Veenstra","year":"1989"},{"key":"10.1016\/j.fgb.2008.03.005_bib36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1083\/jcb.127.3.737","article-title":"The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals","volume":"127","author":"Waterham","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.fgb.2008.03.005_bib37","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0014-5793(90)80224-7","article-title":"Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans","volume":"262","author":"Whiteman","year":"1990","journal-title":"FEBS Lett."}],"container-title":["Fungal Genetics and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184508000418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184508000418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:40:07Z","timestamp":1761068407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1087184508000418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S1087184508000418"],"URL":"https:\/\/doi.org\/10.1016\/j.fgb.2008.03.005","relation":{},"ISSN":["1087-1845"],"issn-type":[{"type":"print","value":"1087-1845"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing","name":"articletitle","label":"Article Title"},{"value":"Fungal Genetics and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fgb.2008.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}