{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:59:05Z","timestamp":1791273545536,"version":"4.1.0"},"reference-count":175,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fungal Genetics and Biology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.fgb.2009.08.002","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T07:11:27Z","timestamp":1249974687000},"page":"94-106","source":"Crossref","is-referenced-by-count":266,"title":["Regulation of multidrug resistance in pathogenic fungi"],"prefix":"10.1016","volume":"47","author":[{"given":"Joachim","family":"Morschh\u00e4user","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fgb.2009.08.002_bib1","doi-asserted-by":"crossref","first-page":"19304","DOI":"10.1074\/jbc.272.31.19304","article-title":"AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily","volume":"272","author":"Alarco","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.fgb.2009.08.002_bib2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1128\/JB.181.3.700-708.1999","article-title":"The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans","volume":"181","author":"Alarco","year":"1999","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.fgb.2009.08.002_bib3","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1128\/AAC.40.12.2835","article-title":"Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance","volume":"40","author":"Albertson","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1128\/AAC.01223-07","article-title":"Increase of virulence and its phenotypic traits in drug-resistant strains of Candida albicans","volume":"52","author":"Angiolella","year":"2008","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib5","doi-asserted-by":"crossref","first-page":"7210","DOI":"10.1128\/jb.179.23.7210-7218.1997","article-title":"The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter","volume":"179","author":"Balan","year":"1997","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.fgb.2009.08.002_bib6","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1128\/AAC.44.6.1578-1584.2000","article-title":"Experimental induction of fluconazole resistance in Candida tropicalis ATCC 750","volume":"44","author":"Barchiesi","year":"2000","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib7","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1128\/AAC.48.5.1773-1777.2004","article-title":"Mechanism of increased fluconazole resistance in Candida glabrata during prophylaxis","volume":"48","author":"Bennett","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1128\/AAC.38.4.648","article-title":"Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene","volume":"38","author":"Ben-Yaacov","year":"1994","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/AAC.49.2.783-787.2005","article-title":"Rapid acquisition of stable azole resistance by Candida glabrata isolates obtained before the clinical introduction of fluconazole","volume":"49","author":"Borst","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1099\/0022-1317-49-11-977","article-title":"In-vivo selection of an azole-resistant petite mutant of Candida glabrata","volume":"49","author":"Bouchara","year":"2000","journal-title":"Journal of Medical Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib11","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/AAC.48.5.1788-1796.2004","article-title":"Mechanisms of azole resistance in petite mutants of Candida glabrata","volume":"48","author":"Brun","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jac\/dki200","article-title":"Biological consequences of petite mutations in Candida glabrata","volume":"56","author":"Brun","year":"2005","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2958.2005.04562.x","article-title":"Regulation of azole drug susceptibility by Candida albicans protein kinase CK2","volume":"56","author":"Bruno","year":"2005","journal-title":"Molecular Microbiology"},{"issue":"Pt 11","key":"10.1016\/j.fgb.2009.08.002_bib14","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1099\/00221287-146-11-2743","article-title":"A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole","volume":"146","author":"Calabrese","year":"2000","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib15","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1128\/AAC.48.12.4505-4512.2004","article-title":"CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1","volume":"48","author":"Chen","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.gene.2006.08.010","article-title":"The bZip transcription factor Cgap1p is involved in multidrug resistance and required for activation of multidrug transporter gene Cg FLR1 in Candida glabrata","volume":"386","author":"Chen","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2009.08.002_bib17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1128\/EC.00240-07","article-title":"CTA4 transcription factor mediates induction of nitrosative stress response in Candida albicans","volume":"7","author":"Chiranand","year":"2008","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/AAC.40.2.419","article-title":"Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance","volume":"40","author":"Clark","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib19","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1534\/genetics.105.054767","article-title":"A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans","volume":"172","author":"Coste","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.fgb.2009.08.002_bib20","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1128\/EC.00151-07","article-title":"Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates","volume":"6","author":"Coste","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib21","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/EC.3.6.1639-1652.2004","article-title":"TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2","volume":"3","author":"Coste","year":"2004","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib22","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1099\/mic.0.2007\/016063-0","article-title":"Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae","volume":"154","author":"Coste","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib23","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1128\/EC.00069-09","article-title":"Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system","volume":"8","author":"Coste","year":"2009","journal-title":"Eukaryot Cell."},{"key":"10.1016\/j.fgb.2009.08.002_bib24","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1128\/JB.182.6.1515-1522.2000","article-title":"Evolution of drug resistance in experimental populations of Candida albicans","volume":"182","author":"Cowen","year":"2000","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.fgb.2009.08.002_bib25","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1128\/AAC.48.11.4405-4413.2004","article-title":"In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance","volume":"48","author":"da Silva Ferreira","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib26","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1128\/AAC.45.6.1660-1670.2001","article-title":"Genomic profiling of the response of Candida albicans to itraconazole treatment using a DNA microarray","volume":"45","author":"De Backer","year":"2001","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib27","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1046\/j.1365-2958.2002.02814.x","article-title":"A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance","volume":"43","author":"de Micheli","year":"2002","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/fgbi.2000.1206","article-title":"Fungal transporters involved in efflux of natural toxic compounds and fungicides","volume":"30","author":"Del Sorbo","year":"2000","journal-title":"Fungal Genetics and Biology"},{"key":"10.1016\/j.fgb.2009.08.002_bib29","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1128\/AAC.48.6.2223-2227.2004","article-title":"Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans","volume":"48","author":"Dodgson","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/(SICI)1097-0061(19990130)15:2<111::AID-YEA350>3.0.CO;2-E","article-title":"Asymmetric distribution of phosphatidylethanolamine in C. albicans: possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily","volume":"15","author":"Dogra","year":"1999","journal-title":"Yeast"},{"key":"10.1016\/j.fgb.2009.08.002_bib31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00294-004-0499-3","article-title":"Shuttle vectors for Candida albicans: control of plasmid copy number and elevated expression of cloned genes","volume":"45","author":"Du","year":"2004","journal-title":"Current Genetics"},{"key":"10.1016\/j.fgb.2009.08.002_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2958.2008.06309.x","article-title":"Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains","volume":"69","author":"Dunkel","year":"2008","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib33","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1128\/EC.00103-08","article-title":"A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate","volume":"7","author":"Dunkel","year":"2008","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib34","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1128\/AAC.49.2.843-845.2005","article-title":"Effects of cetylpyridinium chloride resistance and treatment on fluconazole activity versus Candida albicans","volume":"49","author":"Edlind","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib35","doi-asserted-by":"crossref","first-page":"e1000268","DOI":"10.1371\/journal.ppat.1000268","article-title":"Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence","volume":"5","author":"Ferrari","year":"2009","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.fgb.2009.08.002_bib36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF00259685","article-title":"Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate","volume":"227","author":"Fling","year":"1991","journal-title":"Molecular and General Genetics"},{"key":"10.1016\/j.fgb.2009.08.002_bib37","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1128\/AAC.00880-08","article-title":"Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae","volume":"53","author":"Florent","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib38","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1128\/AAC.42.12.3065","article-title":"Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains","volume":"42","author":"Franz","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-1119(98)00412-0","article-title":"A fourth gene from the Candida albicans CDR family of ABC transporters","volume":"220","author":"Franz","year":"1998","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2009.08.002_bib40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1439-0507.1999.00498.x","article-title":"Molecular aspects of fluconazole resistance development in Candida albicans","volume":"42","author":"Franz","year":"1999","journal-title":"Mycoses"},{"key":"10.1016\/j.fgb.2009.08.002_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000088141","article-title":"Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans","volume":"9","author":"Gaur","year":"2005","journal-title":"Journal of Molecular Microbiology and Biotechnology"},{"key":"10.1016\/j.fgb.2009.08.002_bib42","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1186\/1471-2164-9-579","article-title":"MFS transportome of the human pathogenic yeast Candida albicans","volume":"9","author":"Gaur","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fgb.2009.08.002_bib43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1567-1356(03)00204-6","article-title":"Identification of a negative regulatory element which regulates basal transcription of a multidrug resistance gene CDR1 of Candida albicans","volume":"4","author":"Gaur","year":"2004","journal-title":"FEMS Yeast Research"},{"key":"10.1016\/j.fgb.2009.08.002_bib44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbrc.2005.04.113","article-title":"Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element","volume":"332","author":"Gaur","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.fgb.2009.08.002_bib45","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1128\/AAC.47.5.1543-1554.2003","article-title":"Functional similarities and differences between Candida albicans Cdr1p and Cdr2p transporters","volume":"47","author":"Gauthier","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib46","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/CMR.12.4.501","article-title":"Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance","volume":"12","author":"Ghannoum","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.fgb.2009.08.002_bib47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.diagmicrobio.2004.04.009","article-title":"Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil","volume":"50","author":"Goldman","year":"2004","journal-title":"Diagnostic Microbiology and Infectious Disease"},{"key":"10.1016\/j.fgb.2009.08.002_bib48","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1128\/AAC.39.2.422","article-title":"Multidrug resistance in Candida albicans: disruption of the BENr gene","volume":"39","author":"Goldway","year":"1995","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib49","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.bi.62.070193.002125","article-title":"Biochemistry of multidrug resistance mediated by the multidrug transporter","volume":"62","author":"Gottesman","year":"1993","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.fgb.2009.08.002_bib50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1128\/MMBR.66.4.671-701.2002","article-title":"Regulation of bacterial drug export systems","volume":"66","author":"Grkovic","year":"2002","journal-title":"Microbiology and Molecular Biology Reviews"},{"key":"10.1016\/j.fgb.2009.08.002_bib51","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1128\/EC.00254-07","article-title":"Multidrug resistance in fungi","volume":"6","author":"Gulshan","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib52","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s002940050385","article-title":"Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation","volume":"34","author":"Gupta","year":"1998","journal-title":"Current Genetics"},{"key":"10.1016\/j.fgb.2009.08.002_bib53","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1128\/AAC.49.7.2785-2792.2005","article-title":"Drug-induced regulation of the MDR1 promoter in Candida albicans","volume":"49","author":"Harry","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib54","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/AAC.43.8.1968","article-title":"Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents","volume":"43","author":"Henry","year":"1999","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib55","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/(SICI)1097-0061(19980430)14:6<517::AID-YEA250>3.0.CO;2-D","article-title":"Induced expression of the Candida albicans multidrug resistance gene CDR1 in response to fluconazole and other antifungals","volume":"14","author":"Hernaez","year":"1998","journal-title":"Yeast"},{"key":"10.1016\/j.fgb.2009.08.002_bib56","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1128\/AAC.48.4.1382-1383.2004","article-title":"Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis","volume":"48","author":"Hernandez","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib57","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1128\/AAC.50.4.1365-1371.2006","article-title":"Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans","volume":"50","author":"Hiller","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib57a","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1128\/AAC.00196-06","article-title":"Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate","volume":"50","author":"Hiller","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib58","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1128\/AAC.37.9.1962","article-title":"Fluconazole resistance in Candida glabrata","volume":"37","author":"Hitchcock","year":"1993","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib59","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1128\/AAC.48.11.4377-4386.2004","article-title":"Molecular mechanisms of primary resistance to flucytosine in Candida albicans","volume":"48","author":"Hope","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/yea.962","article-title":"Function of Candida glabrata ABC transporter gene, PDH1","volume":"20","author":"Izumikawa","year":"2003","journal-title":"Yeast"},{"key":"10.1016\/j.fgb.2009.08.002_bib61","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1128\/AAC.47.10.3195-3201.2003","article-title":"Cyclic AMP signaling pathway modulates susceptibility of Candida species and Saccharomyces cerevisiae to antifungal azoles and other sterol biosynthesis inhibitors","volume":"47","author":"Jain","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib62","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1128\/AAC.39.7.1526","article-title":"Cross-resistance to polyene and azole drugs in Cryptococcus neoformans","volume":"39","author":"Joseph-Horne","year":"1995","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib63","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1128\/AAC.48.8.3064-3079.2004","article-title":"Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters","volume":"48","author":"Karababa","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/yea.1067","article-title":"SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter","volume":"21","author":"Karnani","year":"2004","journal-title":"Yeast"},{"key":"10.1016\/j.fgb.2009.08.002_bib65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/mmy.39.1.109.116","article-title":"Identification and expression of multidrug resistance-related ABC transporter genes in Candida krusei","volume":"39","author":"Katiyar","year":"2001","journal-title":"Medical Mycology"},{"key":"10.1016\/j.fgb.2009.08.002_bib66","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1128\/AAC.48.5.1600-1613.2004","article-title":"Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast Candida glabrata: roles of calcium signaling and mitochondria","volume":"48","author":"Kaur","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1574-6968.1994.tb07140.x","article-title":"Resistance to amphotericin B associated with defective sterol \u039487 isomerase in a Cryptococcus neoformans strain from an AIDS patient","volume":"122","author":"Kelly","year":"1994","journal-title":"FEMS Microbiology Letters"},{"key":"10.1016\/j.fgb.2009.08.002_bib68","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0014-5793(96)01360-9","article-title":"Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol \u03945,6-desaturation","volume":"400","author":"Kelly","year":"1997","journal-title":"FEBS Letters"},{"key":"10.1016\/j.fgb.2009.08.002_bib69","first-page":"171","article-title":"Y132H substitution in Candida albicans sterol 14\u03b1-demethylase confers fluconazole resistance by preventing binding to haem","volume":"180","author":"Kelly","year":"1999","journal-title":"FEMS Microbiology Letters"},{"key":"10.1016\/j.fgb.2009.08.002_bib70","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/bbrc.1999.1136","article-title":"The G464S amino acid substitution in Candida albicans sterol 14\u03b1-demethylase causes fluconazole resistance in the clinic through reduced affinity","volume":"262","author":"Kelly","year":"1999","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.fgb.2009.08.002_bib71","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1128\/AAC.46.4.1046-1052.2002","article-title":"In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry","volume":"46","author":"Kohli","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib76a","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0163-7258(97)00094-6","article-title":"Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance","volume":"76","author":"Kolaczkowski","year":"1997","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.fgb.2009.08.002_bib72","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1574-6968.1998.tb12910.x","article-title":"Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones","volume":"160","author":"Krishnamurthy","year":"1998","journal-title":"FEMS Microbiology Letters"},{"key":"10.1016\/j.fgb.2009.08.002_bib73","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1574-6968.1997.tb10240.x","article-title":"Reduced intracellular accumulation of azole antifungal results in resistance in Candida albicans isolate NCPF 3363","volume":"147","author":"Lamb","year":"1997","journal-title":"FEMS Microbiology Letters"},{"key":"10.1016\/j.fgb.2009.08.002_bib74","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1128\/AAC.44.1.63-67.2000","article-title":"The R467K amino acid substitution in Candida albicans sterol 14\u03b1-demethylase causes drug resistance through reduced affinity","volume":"44","author":"Lamb","year":"2000","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib75","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1128\/EC.00091-07","article-title":"Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae","volume":"6","author":"Lamping","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib76","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/AAC.01095-08","article-title":"Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei","volume":"53","author":"Lamping","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib77","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1186\/1471-2164-9-578","article-title":"A toolbox for epitope-tagging and genome-wide location analysis in Candida albicans","volume":"9","author":"Lavoie","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fgb.2009.08.002_bib78","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jac\/dkh040","article-title":"Drug resistance genes and trailing growth in Candida albicans isolates","volume":"53","author":"Lee","year":"2004","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib79","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1128\/AAC.49.6.2226-2236.2005","article-title":"Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans","volume":"49","author":"Liu","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib80","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1128\/EC.00327-07","article-title":"Genome-wide expression and location analyses of the Candida albicans Tac1p regulon","volume":"6","author":"Liu","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib81","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1128\/AAC.42.11.2932","article-title":"Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis","volume":"42","author":"Lopez-Ribot","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib82","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1128\/AAC.43.7.1621","article-title":"Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients","volume":"43","author":"Lopez-Ribot","year":"1999","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib83","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1128\/AAC.44.9.2296-2303.2000","article-title":"Transcriptional analyses of antifungal drug resistance in Candida albicans","volume":"44","author":"Lyons","year":"2000","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib84","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/MMBR.00015-06","article-title":"A fungal family of transcriptional regulators: the zinc cluster proteins","volume":"70","author":"MacPherson","year":"2006","journal-title":"Microbiology and Molecular Biology Reviews"},{"key":"10.1016\/j.fgb.2009.08.002_bib85","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1128\/AAC.01106-07","article-title":"Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans","volume":"52","author":"Manoharlal","year":"2008","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib86","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1439-0507.1995.tb00032.x","article-title":"Origin of differences in susceptibility of Candida krusei to azole antifungal agents","volume":"38","author":"Marichal","year":"1995","journal-title":"Mycoses"},{"key":"10.1016\/j.fgb.2009.08.002_bib87","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1128\/AAC.41.10.2229","article-title":"Molecular biological characterization of an azole-resistant Candida glabrata isolate","volume":"41","author":"Marichal","year":"1997","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib88","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1128\/AAC.42.10.2584","article-title":"Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR","volume":"42","author":"Marr","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib89","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/AAC.45.1.52-59.2001","article-title":"Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans","volume":"45","author":"Marr","year":"2001","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib90","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/jac\/49.3.515","article-title":"Heterogeneous mechanisms of azole resistance in Candida albicans clinical isolates from an HIV-infected patient on continuous fluconazole therapy for oropharyngeal candidosis","volume":"49","author":"Martinez","year":"2002","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib91","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1128\/AAC.42.7.1695","article-title":"Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata","volume":"42","author":"Miyazaki","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib92","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1128\/AAC.46.9.2829-2841.2002","article-title":"The Candida dubliniensis CdCDR1 gene is not essential for fluconazole resistance","volume":"46","author":"Moran","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib93","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1128\/AAC.42.7.1819","article-title":"Identification and expression of multidrug transporters responsible for fluconazole resistance in Candida dubliniensis","volume":"42","author":"Moran","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib94","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2958.1999.01393.x","article-title":"Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination","volume":"32","author":"Morschh\u00e4user","year":"1999","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib95","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0925-4439(02)00087-X","article-title":"The genetic basis of fluconazole resistance development in Candida albicans","volume":"1587","author":"Morschh\u00e4user","year":"2002","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.fgb.2009.08.002_bib96","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1371\/journal.ppat.0030164","article-title":"The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans","volume":"3","author":"Morschh\u00e4user","year":"2007","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.fgb.2009.08.002_bib97","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1128\/AAC.49.2.767-769.2005","article-title":"Multiechinocandin and multiazole-resistant Candida parapsilosis isolates serially obtained during therapy for prosthetic valve endocarditis","volume":"49","author":"Moudgal","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib97a","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0079-6603(03)01008-0","article-title":"Transcriptional control of multidrug resistance in the yeast Saccharomyces","volume":"73","author":"Moye-Rowley","year":"2003","journal-title":"Progress in Nucleic Acid Research and Molecular Biology"},{"key":"10.1016\/j.fgb.2009.08.002_bib98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.03.019","article-title":"Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae","volume":"354","author":"Moye-Rowley","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2009.08.002_bib99","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1128\/AAC.48.5.1778-1787.2004","article-title":"Membrane sphingolipid\u2013ergosterol interactions are important determinants of multidrug resistance in Candida albicans","volume":"48","author":"Mukhopadhyay","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib100","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1128\/AAC.47.5.1719-1726.2003","article-title":"Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole","volume":"47","author":"Nascimento","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib101","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/AAC.50.4.1148-1155.2006","article-title":"Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility","volume":"50","author":"Niimi","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib102","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1570-0232(02)00668-2","article-title":"Identification of two proteins induced by exposure of the pathogenic fungus Candida glabrata to fluconazole","volume":"782","author":"Niimi","year":"2002","journal-title":"Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences"},{"key":"10.1016\/j.fgb.2009.08.002_bib103","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/jac\/dkh456","article-title":"Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance","volume":"54","author":"Niimi","year":"2004","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib104","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1128\/AAC.47.4.1275-1284.2003","article-title":"Flucytosine\u2013fluconazole cross-resistance in purine\u2013cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter","volume":"47","author":"Noel","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib105","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1128\/AAC.41.1.196","article-title":"Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia","volume":"41","author":"Nolte","year":"1997","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib106","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1128\/AAC.42.10.2645","article-title":"Mechanism of fluconazole resistance in Candida krusei","volume":"42","author":"Orozco","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib107","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1128\/AAC.00824-06","article-title":"Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance","volume":"51","author":"Papon","year":"2007","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib108","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1128\/AAC.39.8.1696","article-title":"Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata","volume":"39","author":"Parkinson","year":"1995","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib109","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1128\/AAC.45.10.2676-2684.2001","article-title":"Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients","volume":"45","author":"Perea","year":"2001","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib110","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1128\/AAC.46.6.1695-1703.2002","article-title":"Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis","volume":"46","author":"Perea","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib111","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.drup.2007.04.002","article-title":"Resistance to echinocandin-class antifungal drugs","volume":"10","author":"Perlin","year":"2007","journal-title":"Drug Resistance Updates"},{"key":"10.1016\/j.fgb.2009.08.002_bib112","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1128\/AAC.47.8.2424-2437.2003","article-title":"Molecular mechanisms of itraconazole resistance in Candida dubliniensis","volume":"47","author":"Pinjon","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib113","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1128\/AAC.49.4.1312-1318.2005","article-title":"Reduced azole susceptibility in genotype 3 Candida dubliniensis isolates associated with increased CdCDR1 and CdCDR2 expression","volume":"49","author":"Pinjon","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib114","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1073\/pnas.0809793106","article-title":"Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata","volume":"106","author":"Polakova","year":"2009","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.fgb.2009.08.002_bib115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1365-2958.2003.03281.x","article-title":"Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole","volume":"47","author":"Posteraro","year":"2003","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib116","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00352101","article-title":"Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals","volume":"27","author":"Prasad","year":"1995","journal-title":"Current Genetics"},{"key":"10.1016\/j.fgb.2009.08.002_bib117","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1128\/AAC.49.8.3442-3452.2005","article-title":"Functional analysis of Ca IPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans","volume":"49","author":"Prasad","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib118","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1574-6968.1999.tb08798.x","article-title":"CDR1, a multidrug resistance gene from Candida albicans, contains multiple regulatory domains in its promoter and the distal AP-1 element mediates its induction by miconazole","volume":"180","author":"Puri","year":"1999","journal-title":"FEMS Microbiology Letters"},{"key":"10.1016\/j.fgb.2009.08.002_bib119","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/JCM.41.2.619-622.2003","article-title":"Multiple patterns of resistance to fluconazole in Candida glabrata isolates from a patient with oropharyngeal candidiasis receiving head and neck radiation","volume":"41","author":"Redding","year":"2003","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib120","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1128\/EC.00243-06","article-title":"Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site","volume":"5","author":"Riggle","year":"2006","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib121","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1099\/mic.0.29277-0","article-title":"Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance","volume":"152","author":"Rognon","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib122","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1046\/j.1365-2958.2003.03358.x","article-title":"A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis","volume":"47","author":"Rottmann","year":"2003","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib123","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1099\/00221287-148-4-1061","article-title":"Homozygosity at the Candida albicans MTL locus associated with azole resistance","volume":"148","author":"Rustad","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib124","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/00362178485380091","article-title":"Azole resistance in Candida albicans","volume":"22","author":"Ryley","year":"1984","journal-title":"Sabouraudia"},{"key":"10.1016\/j.fgb.2009.08.002_bib125","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/j.1365-2958.2006.05196.x","article-title":"PDR16-mediated azole resistance in Candida albicans","volume":"60","author":"Saidane","year":"2006","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib126","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1128\/AAC.39.11.2378","article-title":"Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters","volume":"39","author":"Sanglard","year":"1995","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib127","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1128\/AAC.40.10.2300","article-title":"Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors","volume":"40","author":"Sanglard","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"Pt 2","key":"10.1016\/j.fgb.2009.08.002_bib128","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1099\/00221287-143-2-405","article-title":"Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene","volume":"143","author":"Sanglard","year":"1997","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib129","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/AAC.42.2.241","article-title":"Amino acid substitutions in the cytochrome P-450 lanosterol 14\u03b1-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents","volume":"42","author":"Sanglard","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib130","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1128\/AAC.43.11.2753","article-title":"The ATP binding cassette transporter gene Cg CDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents","volume":"43","author":"Sanglard","year":"1999","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib131","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/AAC.45.4.1174-1183.2001","article-title":"Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata","volume":"45","author":"Sanglard","year":"2001","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib132","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1128\/AAC.49.2.668-679.2005","article-title":"Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance","volume":"49","author":"Sanguinetti","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib133","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/IAI.74.2.1352-1359.2006","article-title":"Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans","volume":"74","author":"Sanguinetti","year":"2006","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.fgb.2009.08.002_bib134","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1128\/AAC.00740-08","article-title":"Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains","volume":"52","author":"Schubert","year":"2008","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib135","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2958.2003.03430.x","article-title":"The Candida albicans Cdr2p ATP-binding cassette (ABC) transporter confers resistance to caspofungin","volume":"48","author":"Schuetzer-Muehlbauer","year":"2003","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib136","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/EC.00074-09","article-title":"Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicans","volume":"8","author":"Sellam","year":"2009","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.fgb.2009.08.002_bib137","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1126\/science.1128242","article-title":"Aneuploidy and isochromosome formation in drug-resistant Candida albicans","volume":"313","author":"Selmecki","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.fgb.2009.08.002_bib138","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-2958.2008.06176.x","article-title":"An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1","volume":"68","author":"Selmecki","year":"2008","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib139","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/13693780701816557","article-title":"Characterization of caspofungin susceptibilities by broth and agar in Candida albicans clinical isolates with characterized mechanisms of azole resistance","volume":"46","author":"Silver","year":"2008","journal-title":"Medical Mycology"},{"key":"10.1016\/j.fgb.2009.08.002_bib140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1087-1845(02)00016-6","article-title":"Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate","volume":"36","author":"Slaven","year":"2002","journal-title":"Fungal Genetics and Biology"},{"key":"10.1016\/j.fgb.2009.08.002_bib141","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1128\/AAC.46.11.3532-3539.2002","article-title":"Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation","volume":"46","author":"Smith","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib142","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/yea.818","article-title":"ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators","volume":"19","author":"Smriti","year":"2002","journal-title":"Yeast"},{"key":"10.1016\/j.fgb.2009.08.002_bib143","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.7702654","article-title":"The emerging fungal threat","volume":"266","author":"Sternberg","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.fgb.2009.08.002_bib143a","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1128\/JB.181.1.231-240.1999","article-title":"Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae","volume":"181","author":"Talibi","year":"1999","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.fgb.2009.08.002_bib144","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nature06836","article-title":"A nuclear receptor-like pathway regulating multidrug resistance in fungi","volume":"452","author":"Thakur","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.fgb.2009.08.002_bib144a","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-1119(97)00421-6","article-title":"Cloning and characterization of CneMDR1: a Cryptococcus neoformans gene encoding a protein related to multidrug resistance proteins","volume":"201","author":"Thornewell","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2009.08.002_bib145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-1119(97)00281-3","article-title":"Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus","volume":"200","author":"Tobin","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2009.08.002_bib146","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2958.2008.06143.x","article-title":"The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata","volume":"68","author":"Torelli","year":"2008","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib147","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1128\/AAC.50.4.1384-1392.2006","article-title":"Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants","volume":"50","author":"Tsai","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib148","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1128\/AAC.00926-08","article-title":"Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance","volume":"53","author":"Tsao","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib149","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pbio.0060038","article-title":"The evolution of combinatorial gene regulation in fungi","volume":"6","author":"Tuch","year":"2008","journal-title":"PLoS Biology"},{"key":"10.1016\/j.fgb.2009.08.002_bib150","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1074\/jbc.274.4.1934","article-title":"PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs","volume":"274","author":"van den Hazel","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.fgb.2009.08.002_bib151","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1128\/AAC.01510-06","article-title":"Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth","volume":"51","author":"Vandeputte","year":"2007","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib152","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1574-6968.1995.tb07797.x","article-title":"Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug","volume":"131","author":"Venkateswarlu","year":"1995","journal-title":"FEMS Microbiology Letters"},{"key":"10.1016\/j.fgb.2009.08.002_bib153","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1128\/AAC.40.11.2443","article-title":"Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance","volume":"40","author":"Venkateswarlu","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib154","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1128\/AAC.48.10.3773-3781.2004","article-title":"Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor","volume":"48","author":"Vermitsky","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib155","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1365-2958.2006.05235.x","article-title":"Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies","volume":"61","author":"Vermitsky","year":"2006","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib156","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/jac\/dkm513","article-title":"Rifampicin induces MDR1 expression in Candida albicans","volume":"61","author":"Vogel","year":"2008","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib157","doi-asserted-by":"crossref","first-page":"46809","DOI":"10.1074\/jbc.M207817200","article-title":"Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties","volume":"277","author":"Wada","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.fgb.2009.08.002_bib158","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1439-0507.2006.01327.x","article-title":"Voriconazole and multidrug resistance in Candida albicans","volume":"50","author":"Wakiec","year":"2007","journal-title":"Mycoses"},{"key":"10.1016\/j.fgb.2009.08.002_bib159","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1128\/AAC.41.7.1482","article-title":"Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus","volume":"41","author":"White","year":"1997","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib160","doi-asserted-by":"crossref","first-page":"e1000200","DOI":"10.1371\/journal.ppat.1000200","article-title":"A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus","volume":"4","author":"Willger","year":"2008","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.fgb.2009.08.002_bib161","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/JB.182.2.400-404.2000","article-title":"Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor","volume":"182","author":"Wirsching","year":"2000","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.fgb.2009.08.002_bib162","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1046\/j.1365-2958.2000.01899.x","article-title":"Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates","volume":"36","author":"Wirsching","year":"2000","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib163","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1128\/AAC.45.12.3416-3421.2001","article-title":"MDR1-mediated drug resistance in Candida dubliniensis","volume":"45","author":"Wirsching","year":"2001","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib164","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1093\/emboj\/17.24.7416","article-title":"Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor","volume":"17","author":"Yan","year":"1998","journal-title":"EMBO Journal"},{"key":"10.1016\/j.fgb.2009.08.002_bib165","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/j.1745-7270.2008.00483.x","article-title":"DNA microarray analysis of fluconazole resistance in a laboratory Candida albicans strain","volume":"40","author":"Yan","year":"2008","journal-title":"Acta Biochimica et Biophysica Sinica (Shanghai)"},{"key":"10.1016\/j.fgb.2009.08.002_bib166","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/yea.770","article-title":"Functional isolation of the Candida albicans FCR3 gene encoding a bZip transcription factor homologous to Saccharomyces cerevisiae Yap3p","volume":"18","author":"Yang","year":"2001","journal-title":"Yeast"},{"key":"10.1016\/j.fgb.2009.08.002_bib167","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1128\/AAC.47.9.2717-2724.2003","article-title":"Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae","volume":"47","author":"Young","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.fgb.2009.08.002_bib168","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1365-2958.2000.01877.x","article-title":"Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p","volume":"36","author":"Zhang","year":"2000","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib169","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2958.2007.05931.x","article-title":"The zinc cluster transcription factor Tac1p regulates PDR16 expression in Candida albicans","volume":"66","author":"Znaidi","year":"2007","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.fgb.2009.08.002_bib170","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1128\/EC.00002-09","article-title":"Identification of the Candida albicans Cap1p regulon","volume":"8","author":"Znaidi","year":"2009","journal-title":"Eukaryotic Cell"}],"container-title":["Fungal Genetics and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184509001479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184509001479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T09:38:42Z","timestamp":1590053922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1087184509001479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":175,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S1087184509001479"],"URL":"https:\/\/doi.org\/10.1016\/j.fgb.2009.08.002","relation":{},"ISSN":["1087-1845"],"issn-type":[{"value":"1087-1845","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}