{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:31:17Z","timestamp":1791297077212,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI074677"],"award-info":[{"award-number":["AI074677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fungal Genetics and Biology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.fgb.2014.09.004","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T05:09:31Z","timestamp":1411448971000},"page":"55-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":120,"special_numbering":"C","title":["Virulence mechanisms and Cryptococcus neoformans pathogenesis"],"prefix":"10.1016","volume":"78","author":[{"given":"J. Andrew","family":"Alspaugh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fgb.2014.09.004_b0005","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/EC.00399-06","article-title":"Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans","volume":"6","author":"Baker","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.09.004_b0010","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1128\/EC.4.11.1902-1912.2005","article-title":"A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans","volume":"4","author":"Banks","year":"2005","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.09.004_b0015","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/EC.2.4.655-663.2003","article-title":"A yeast under cover: the capsule of Cryptococcus neoformans","volume":"2","author":"Bose","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.09.004_b0020","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1172\/JCI112000","article-title":"Virulence of Cryptococcus neoformans: regulation of capsule synthesis by carbon dioxide","volume":"76","author":"Granger","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fgb.2014.09.004_b0025","doi-asserted-by":"crossref","first-page":"e1002411","DOI":"10.1371\/journal.ppat.1002411","article-title":"Toward an integrated model of capsule regulation in Cryptococcus neoformans","volume":"7","author":"Haynes","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fgb.2014.09.004_b0030","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1128\/IAI.01037-12","article-title":"Cryptococcus neoformans requires the ESCRT protein Vps23 for iron acquisition from heme, for capsule formation, and for virulence","volume":"81","author":"Hu","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.09.004_b0035","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1462-5822.2008.01128.x","article-title":"Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells","volume":"10","author":"Jong","year":"2008","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.fgb.2014.09.004_b0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0966-842X(00)88957-X","article-title":"Virulence factors of Cryptococcus neoformans","volume":"3","author":"Kozel","year":"1995","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.fgb.2014.09.004_b0045","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2958.2007.05666.x","article-title":"TUP1 disruption in Cryptococcus neoformans uncovers a peptide-mediated density-dependent growth phenomenon that mimics quorum sensing","volume":"64","author":"Lee","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fgb.2014.09.004_b0050","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/CMR.00001-12","article-title":"The Cryptococcus neoformans capsule: a sword and a shield","volume":"25","author":"O\u2019Meara","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.fgb.2014.09.004_b0055","article-title":"Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses","volume":"4","author":"O\u2019Meara","year":"2013","journal-title":"MBiology"},{"key":"10.1016\/j.fgb.2014.09.004_b0060","doi-asserted-by":"crossref","first-page":"e1000953","DOI":"10.1371\/journal.ppat.1000953","article-title":"Cryptococcal cell morphology affects host cell interactions and pathogenicity","volume":"6","author":"Okagaki","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fgb.2014.09.004_b0065","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/IAI.01171-09","article-title":"Extracellular vesicles from Cryptococcus neoformans modulate macrophage functions","volume":"78","author":"Oliveira","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.09.004_b0070","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1046\/j.1365-2958.2003.03780.x","article-title":"Cell wall alpha-1,3-glucan is required to anchor the Cryptococcus neoformans capsule","volume":"50","author":"Reese","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fgb.2014.09.004_b0075","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1286-4579(99)80025-2","article-title":"Pathogenicity of Cryptococcus neoformans: virulence factors and immunological mechanisms","volume":"1","author":"Rodrigues","year":"1999","journal-title":"Microbes Infect."},{"key":"10.1016\/j.fgb.2014.09.004_b0080","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/EC.00370-07","article-title":"Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence","volume":"7","author":"Rodrigues","year":"2008","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.09.004_b0085","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1128\/IAI.72.4.2229-2239.2004","article-title":"Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model","volume":"72","author":"Santangelo","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.09.004_b0090","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1073\/pnas.261418798","article-title":"Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages","volume":"98","author":"Steenbergen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.fgb.2014.09.004_b0095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/infdis\/167.1.186","article-title":"Regulation of cryptococcal capsular polysaccharide by iron","volume":"167","author":"Vartivarian","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.fgb.2014.09.004_b0100","doi-asserted-by":"crossref","first-page":"e1000945","DOI":"10.1371\/journal.ppat.1000945","article-title":"Fungal cell gigantism during mammalian infection","volume":"6","author":"Zaragoza","year":"2010","journal-title":"PLoS Pathog."}],"container-title":["Fungal Genetics and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184514001613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184514001613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T09:21:48Z","timestamp":1538212908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1087184514001613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":20,"alternative-id":["S1087184514001613"],"URL":"https:\/\/doi.org\/10.1016\/j.fgb.2014.09.004","relation":{},"ISSN":["1087-1845"],"issn-type":[{"value":"1087-1845","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virulence mechanisms and Cryptococcus neoformans pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Fungal Genetics and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fgb.2014.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}