{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:21:18Z","timestamp":1782166878781,"version":"3.54.5"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI059681"],"award-info":[{"award-number":["R01 AI059681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fungal Genetics and Biology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.fgb.2014.10.004","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T17:52:21Z","timestamp":1413222741000},"page":"59-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Aging as an emergent factor that contributes to phenotypic variation in Cryptococcus neoformans"],"prefix":"10.1016","volume":"78","author":[{"given":"Tejas","family":"Bouklas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina C.","family":"Fries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fgb.2014.10.004_b0005","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1216166","article-title":"Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility","volume":"335","author":"Aldridge","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.fgb.2014.10.004_b0010","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/QAD.0b013e32832605fe","article-title":"Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures","volume":"23","author":"Bicanic","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.fgb.2014.10.004_b0015","doi-asserted-by":"crossref","first-page":"833","DOI":"10.18388\/abp.2006_3313","article-title":"Hypothesis: cell volume limits cell divisions","volume":"53","author":"Bilinski","year":"2006","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.fgb.2014.10.004_b0020","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.mib.2013.03.011","article-title":"Cryptococcus neoformans constitutes an ideal model organism to unravel the contribution of cellular aging to the virulence of chronic infections","volume":"16","author":"Bouklas","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0025","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00455-13","article-title":"Old Cryptococcus neoformans cells contribute to virulence in chronic cryptococcosis","volume":"4","author":"Bouklas","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.fgb.2014.10.004_b0030","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0002-9440(10)62265-1","article-title":"Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier","volume":"166","author":"Charlier","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fgb.2014.10.004_b0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans","volume":"77","author":"Charlier","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0040","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1128\/IAI.00628-09","article-title":"Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus neoformans","volume":"77","author":"Cheng","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0045","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1128\/IAI.63.5.1899-1905.1995","article-title":"Variation in the structure of glucuronoxylomannan in isolates from patients with recurrent cryptococcal meningitis","volume":"63","author":"Cherniak","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0050","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1128\/IAI.05789-11","article-title":"Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans","volume":"79","author":"Cordero","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0055","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4161\/cc.10.1.14457","article-title":"Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast","volume":"10","author":"Delaney","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.fgb.2014.10.004_b0060","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1371\/journal.pmed.0040021","article-title":"Determinants of disease presentation and outcome during cryptococcosis: the CryptoA\/D study","volume":"4","author":"Dromer","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.fgb.2014.10.004_b0065","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1099\/00221287-147-8-2355","article-title":"Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection","volume":"147","author":"Feldmesser","year":"2001","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2014.10.004_b0070","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1086\/314521","article-title":"Serial isolates of Cryptococcus neoformans from patients with AIDS differ in virulence for mice","volume":"178","author":"Fries","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.fgb.2014.10.004_b0075","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1128\/IAI.67.11.6076-6083.1999","article-title":"Phenotypic switching in Cryptococcus neoformans results in changes in cellular morphology and glucuronoxylomannan structure","volume":"67","author":"Fries","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0080","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1172\/JCI13407","article-title":"Phenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection","volume":"108","author":"Fries","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fgb.2014.10.004_b0085","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1128\/IAI.73.3.1779-1787.2005","article-title":"Phenotypic switching of Cryptococcus neoformans can produce variants that elicit increased intracranial pressure in a rat model of cryptococcal meningoencephalitis","volume":"73","author":"Fries","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0090","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1474-9726.2008.00424.x","article-title":"Candida albicans, a distinctive fungal model for cellular aging study","volume":"7","author":"Fu","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0095","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1128\/IAI.72.6.3359-3365.2004","article-title":"Cryptococcus neoformans capsule structure evolution in vitro and during murine infection","volume":"72","author":"Garcia-Hermoso","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0100","doi-asserted-by":"crossref","first-page":"14967","DOI":"10.1073\/pnas.95.25.14967","article-title":"Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents","volume":"95","author":"Goldman","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.fgb.2014.10.004_b0105","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1128\/IAI.00529-08","article-title":"Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response","volume":"76","author":"Guerrero","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0110","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1128\/IAI.01049-09","article-title":"Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation","volume":"78","author":"Guerrero","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0115","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2217\/fmb.10.44","article-title":"Variability of phenotypic traits in Cryptococcus varieties and species and the resulting implications for pathogenesis","volume":"5","author":"Gupta","year":"2010","journal-title":"Future Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0120","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1186\/1471-2164-12-526","article-title":"Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients","volume":"12","author":"Hu","year":"2011","journal-title":"BMC Genom."},{"key":"10.1016\/j.fgb.2014.10.004_b0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11046-008-9137-9","article-title":"Phenotypic switching of Cryptococcus neoformans and Cryptococcus gattii","volume":"166","author":"Jain","year":"2008","journal-title":"Mycopathologia"},{"key":"10.1016\/j.fgb.2014.10.004_b0130","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1128\/JCM.43.11.5733-5742.2005","article-title":"Molecular epidemiology of clinical Cryptococcus neoformans strains from India","volume":"43","author":"Jain","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0135","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1567-1364.2006.00039.x","article-title":"Phenotypic switching and its implications for the pathogenesis of Cryptococcus neoformans","volume":"6","author":"Jain","year":"2006","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.fgb.2014.10.004_b0140","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1128\/IAI.74.2.896-903.2006","article-title":"Phenotypic switching in a Cryptococcus neoformans variety gattii strain is associated with changes in virulence and promotes dissemination to the central nervous system","volume":"74","author":"Jain","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0145","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1128\/EC.00017-09","article-title":"Isolation and characterization of senescent Cryptococcus neoformans and implications for phenotypic switching and pathogenesis in chronic cryptococcosis","volume":"8","author":"Jain","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/IAI.01079-08","article-title":"Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans","volume":"77","author":"Jain","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0155","doi-asserted-by":"crossref","first-page":"e44582","DOI":"10.1371\/journal.pone.0044582","article-title":"Cell division site placement and asymmetric growth in mycobacteria","volume":"7","author":"Joyce","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.fgb.2014.10.004_b0160","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature08981","article-title":"Lessons on longevity from budding yeast","volume":"464","author":"Kaeberlein","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.fgb.2014.10.004_b0165","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0168-9525(96)80018-7","article-title":"Genetic analysis of aging in Saccharomyces cerevisiae","volume":"12","author":"Kennedy","year":"1996","journal-title":"Trends Genet."},{"key":"10.1016\/j.fgb.2014.10.004_b0170","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1083\/jcb.127.6.1985","article-title":"Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span","volume":"127","author":"Kennedy","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.fgb.2014.10.004_b0175","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S1369-5266(00)00118-7","article-title":"Plant cell-size control: growing by ploidy?","volume":"3","author":"Kondorosi","year":"2000","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.fgb.2014.10.004_b0180","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1099\/00221287-148-9-2661","article-title":"Phenotypic switching and filamentation in Candida glabrata","volume":"148","author":"Lachke","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2014.10.004_b0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1534\/g3.111.001255","article-title":"Genetic diversity and genomic plasticity of Cryptococcus neoformans AD hybrid strains","volume":"2","author":"Li","year":"2012","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.fgb.2014.10.004_b0190","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/EC.00162-07","article-title":"Capsule structural heterogeneity and antigenic variation in Cryptococcus neoformans","volume":"6","author":"McFadden","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0195","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1126\/science.1087706","article-title":"An age-induced switch to a hyper-recombinational state","volume":"301","author":"McMurray","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.fgb.2014.10.004_b0200","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1099\/mic.0.26333-0","article-title":"Budding of melanized Cryptococcus neoformans in the presence or absence of L-dopa","volume":"149","author":"Nosanchuk","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2014.10.004_b0205","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/EC.00121-12","article-title":"Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections","volume":"11","author":"Okagaki","year":"2012","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0210","doi-asserted-by":"crossref","first-page":"e1000953","DOI":"10.1371\/journal.ppat.1000953","article-title":"Cryptococcal cell morphology affects host cell interactions and pathogenicity","volume":"6","author":"Okagaki","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fgb.2014.10.004_b0215","doi-asserted-by":"crossref","first-page":"e1003764","DOI":"10.1371\/journal.ppat.1003764","article-title":"Balancing stability and flexibility within the genome of the pathogen Cryptococcus neoformans","volume":"9","author":"Ormerod","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fgb.2014.10.004_b0220","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1534\/g3.113.005660","article-title":"Comparative genomics of serial isolates of Cryptococcus neoformans reveals gene associated with carbon utilization and virulence","volume":"3","author":"Ormerod","year":"2013","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.fgb.2014.10.004_b0225","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1462-5822.2003.00297.x","article-title":"Phenotypic switching of Cryptococcus neoformans can influence the outcome of the human immune response","volume":"5","author":"Pietrella","year":"2003","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0230","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1099\/00222615-19-2-203","article-title":"Colony variants of Neisseria meningitidis strain 2996 (B:2b:P1.2): influence of class-5 outer membrane proteins and lipopolysaccharides","volume":"19","author":"Poolman","year":"1985","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0235","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1099\/mic.0.25940-0","article-title":"Chitin scar breaks in aged Saccharomyces cerevisiae","volume":"149","author":"Powell","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.fgb.2014.10.004_b0240","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrmicro1384","article-title":"Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections","volume":"4","author":"Proctor","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0245","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1128\/JB.38.4.461-477.1939","article-title":"Colony and antigenic variation in Klebsiella pneumoniae types A, B and C","volume":"38","author":"Randall","year":"1939","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.fgb.2014.10.004_b0250","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1365-2958.2006.05551.x","article-title":"Loss of cell wall alpha(1\u20133) glucan affects Cryptococcus neoformans from ultrastructure to virulence","volume":"63","author":"Reese","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0255","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1128\/IAI.66.10.5027-5030.1998","article-title":"Organ-dependent variation of capsule thickness in Cryptococcus neoformans during experimental murine infection","volume":"66","author":"Rivera","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0260","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/infdis\/jit435","article-title":"Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis","volume":"209","author":"Robertson","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.fgb.2014.10.004_b0265","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1128\/EC.00318-06","article-title":"Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport","volume":"6","author":"Rodrigues","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0270","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1128\/EC.00307-07","article-title":"Binding of the wheat germ lectin to Cryptococcus neoformans suggests an association of chitinlike structures with yeast budding and capsular glucuronoxylomannan","volume":"7","author":"Rodrigues","year":"2008","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0275","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1474-9726.2006.00225.x","article-title":"Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2","volume":"5","author":"Roux","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0280","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1749-6632.2010.05198.x","article-title":"A screen for genes involved in respiration control and longevity in Schizosaccharomyces pombe","volume":"1197","author":"Roux","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fgb.2014.10.004_b0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gerona\/glp152","article-title":"Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes","volume":"65","author":"Roux","year":"2010","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.fgb.2014.10.004_b0290","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1172\/JCI72950","article-title":"Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis","volume":"124","author":"Sabiiti","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fgb.2014.10.004_b0295","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI41963","article-title":"Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain","volume":"120","author":"Shi","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fgb.2014.10.004_b0300","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/mmi.12169","article-title":"Asymmetric growth and division in Mycobacterium spp.: compensatory mechanisms for non-medial septa","volume":"88","author":"Singh","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0305","doi-asserted-by":"crossref","first-page":"e1000848","DOI":"10.1371\/journal.ppat.1000848","article-title":"Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes","volume":"6","author":"Sionov","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fgb.2014.10.004_b0310","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.3901258","article-title":"High-frequency switching of colony morphology in Candida albicans","volume":"230","author":"Slutsky","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.fgb.2014.10.004_b0315","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mad.2006.11.017","article-title":"Genome-wide identification of conserved longevity genes in yeast and worms","volume":"128","author":"Smith","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.fgb.2014.10.004_b0320","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/EC.4.8.1434-1445.2005","article-title":"Phenotypic switching in Candida glabrata accompanied by changes in expression of genes with deduced functions in copper detoxification and stress","volume":"4","author":"Srikantha","year":"2005","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.fgb.2014.10.004_b0325","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.mib.2012.10.011","article-title":"Polarity and cell fate asymmetry in Caulobacter crescentus","volume":"15","author":"Tsokos","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0330","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/infdis\/167.1.186","article-title":"Regulation of cryptococcal capsular polysaccharide by iron","volume":"167","author":"Vartivarian","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.fgb.2014.10.004_b0335","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1128\/AAC.46.12.3802-3808.2002","article-title":"Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans","volume":"46","author":"Woyke","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fgb.2014.10.004_b0340","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4161\/cc.10.1.14455","article-title":"Cell size and growth rate are major determinants of replicative lifespan","volume":"10","author":"Yang","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.fgb.2014.10.004_b0345","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.mib.2013.03.006","article-title":"Titan cells in Cryptococcus neoformans: cells with a giant impact","volume":"16","author":"Zaragoza","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0350","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1128\/IAI.71.11.6155-6164.2003","article-title":"Induction of capsule growth in Cryptococcus neoformans by mammalian serum and CO2","volume":"71","author":"Zaragoza","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fgb.2014.10.004_b0355","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/eji.200323848","article-title":"The efficacy of complement-mediated phagocytosis of Cryptococcus neoformans is dependent on the location of C3 in the polysaccharide capsule and involves both direct and indirect C3-mediated interactions","volume":"33","author":"Zaragoza","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fgb.2014.10.004_b0360","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1111\/j.1462-5822.2008.01186.x","article-title":"Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival","volume":"10","author":"Zaragoza","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.fgb.2014.10.004_b0365","doi-asserted-by":"crossref","first-page":"e1000945","DOI":"10.1371\/journal.ppat.1000945","article-title":"Fungal cell gigantism during mammalian infection","volume":"6","author":"Zaragoza","year":"2010","journal-title":"PLoS Pathog."}],"container-title":["Fungal Genetics and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108718451400187X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108718451400187X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T22:15:19Z","timestamp":1650406519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108718451400187X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":73,"alternative-id":["S108718451400187X"],"URL":"https:\/\/doi.org\/10.1016\/j.fgb.2014.10.004","relation":{},"ISSN":["1087-1845"],"issn-type":[{"value":"1087-1845","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging as an emergent factor that contributes to phenotypic variation in Cryptococcus neoformans","name":"articletitle","label":"Article Title"},{"value":"Fungal Genetics and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fgb.2014.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}