{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:15:27Z","timestamp":1791357327296,"version":"4.3.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470182"],"award-info":[{"award-number":["31470182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270113"],"award-info":[{"award-number":["31270113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fungal Genetics and Biology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.fgb.2019.103240","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T17:45:24Z","timestamp":1560015924000},"page":"103240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["The PP2A regulatory subunits, Cdc55 and Rts1, play distinct roles in Candida albicans\u2019 growth, morphogenesis, and virulence"],"prefix":"10.1016","volume":"131","author":[{"given":"Qi","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fgb.2019.103240_b0005","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/mmy\/myv098","article-title":"Regulatory roles of phosphorylation in model and pathogenic fungi","volume":"54","author":"Albataineh","year":"2016","journal-title":"Med. Mycol."},{"key":"10.1016\/j.fgb.2019.103240_b0010","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nrg948","article-title":"Candida albicans: a molecular revolution built on lessons from budding yeast","volume":"3","author":"Berman","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.fgb.2019.103240_b0015","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1083\/jcb.201103076","article-title":"Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis","volume":"193","author":"Bizzari","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.fgb.2019.103240_b0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature05351","article-title":"Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme","volume":"445","author":"Cho","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.fgb.2019.103240_b0025","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.bi.58.070189.002321","article-title":"The structure and regulation of protein phosphatases","volume":"58","author":"Cohen","year":"1989","journal-title":"Annu Rev Biochem."},{"key":"10.1016\/j.fgb.2019.103240_b0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mib.2016.08.006","article-title":"Cell biology of Candida albicans-host interactions","volume":"34","author":"Da","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.fgb.2019.103240_b0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1534-5807(03)00061-3","article-title":"Phosphorylation-dependent regulation of septin dynamics during the cell cycle","volume":"4","author":"Dobbelaere","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.fgb.2019.103240_b0040","first-page":"4974","article-title":"Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis","volume":"127","author":"Eshleman","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.fgb.2019.103240_b0045","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/genetics\/134.3.717","article-title":"Isogenic strain construction and gene mapping in Candida albicans","volume":"134","author":"Fonzi","year":"1993","journal-title":"Genetics"},{"key":"10.1016\/j.fgb.2019.103240_b0050","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/bj3530417","article-title":"Protein phosphatase 2A: a highly regulated family of serine\/threonine phosphatases implicated in cell growth and signalling","volume":"353","author":"Janssens","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.fgb.2019.103240_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2012.02.015","article-title":"PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates","volume":"499","author":"Kurimchak","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2019.103240_b0060","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mib.2017.12.008","article-title":"Microscopy of fungal biofilms","volume":"43","author":"Lagree","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.fgb.2019.103240_b0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/mmi.13376","article-title":"Tpd3-Pph21 phosphatase plays a direct role in Sep7 dephosphorylation in Candida albicans","volume":"101","author":"Liu","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fgb.2019.103240_b0070","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"Lo","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.fgb.2019.103240_b0075","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tim.2014.09.001","article-title":"Candida albicans hyphal initiation and elongation","volume":"22","author":"Lu","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.fgb.2019.103240_b0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida albicans pathogenicity mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"key":"10.1016\/j.fgb.2019.103240_b0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fgb.2018.12.010","article-title":"Phosphatidate phosphatase Pah1 has a role in the hyphal growth and virulence of Candida albicans","volume":"124","author":"Mu","year":"2019","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.fgb.2019.103240_b0090","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1101\/gad.240291.114","article-title":"Tension-dependent removal of pericentromeric shugoshin is an indicator of sister chromosome biorientation","volume":"28","author":"Nerusheva","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.fgb.2019.103240_b0095","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1016\/S1470-2045(12)70558-2","article-title":"Protein phosphatase 2A: a target for anticancer therapy","volume":"14","author":"Perrotti","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.fgb.2019.103240_b0100","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1021\/bi0008478","article-title":"Effects of regulatory subunits on the kinetics of protein phosphatase 2A","volume":"39","author":"Price","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.fgb.2019.103240_b0105","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.gene.2004.06.021","article-title":"The SAT1 flipper, an optimized tool for gene disruption in Candida albicans","volume":"341","author":"Reuss","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.fgb.2019.103240_b0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2013.02.036","article-title":"Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer","volume":"335","author":"Seshacharyulu","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fgb.2019.103240_b0115","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/mpp.12023","article-title":"Protein phosphatase 2A regulatory subunits perform distinct functional roles in the maize pathogen Fusarium verticillioides","volume":"14","author":"Shin","year":"2013","journal-title":"Mol. Plant. Pathol."},{"key":"10.1016\/j.fgb.2019.103240_b0120","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2007.06.011","article-title":"Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development","volume":"13","author":"Sinha","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.fgb.2019.103240_b0125","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/pathogens4030606","article-title":"Interleukin 17-mediated host defense against Candida albicans","volume":"4","author":"Sparber","year":"2015","journal-title":"Pathogens"},{"key":"10.1016\/j.fgb.2019.103240_b0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tim.2004.05.008","article-title":"The distinct morphogenic states of Candida albicans","volume":"12","author":"Sudbery","year":"2004","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.fgb.2019.103240_b0135","doi-asserted-by":"crossref","first-page":"e1003995","DOI":"10.1371\/journal.ppat.1003995","article-title":"Modulation of phagosomal pH by Candida albicans promotes hyphal morphogenesis and requires Stp2p, a regulator of amino acid transport","volume":"10","author":"Vylkova","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fgb.2019.103240_b0140","doi-asserted-by":"crossref","first-page":"e1000040","DOI":"10.1371\/journal.ppat.1000040","article-title":"Stimulation of chitin synthesis rescues Candida albicans from echinocandins","volume":"4","author":"Walker","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fgb.2019.103240_b0145","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1074\/jbc.M008694200","article-title":"Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p","volume":"276","author":"Wei","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fgb.2019.103240_b0150","first-page":"61","article-title":"Tolerance to caspofungin in Candida albicans is associated with at least three distinctive mechanisms that govern expression of FKS genes and cell wall remodeling","author":"Yang","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fgb.2019.103240_b0155","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1083\/jcb.201309119","article-title":"PP2A Rts1 is a master regulator of pathways that control cell size","volume":"204","author":"Zapata","year":"2014","journal-title":"J. Cell Biol."}],"container-title":["Fungal Genetics and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184519300775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087184519300775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:34:49Z","timestamp":1778798089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1087184519300775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":31,"alternative-id":["S1087184519300775"],"URL":"https:\/\/doi.org\/10.1016\/j.fgb.2019.103240","relation":{},"ISSN":["1087-1845"],"issn-type":[{"value":"1087-1845","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PP2A regulatory subunits, Cdc55 and Rts1, play distinct roles in Candida albicans\u2019 growth, morphogenesis, and virulence","name":"articletitle","label":"Article Title"},{"value":"Fungal Genetics and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fgb.2019.103240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103240"}}