{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T11:53:13Z","timestamp":1768132393539,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21102084"],"award-info":[{"award-number":["21102084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21272136"],"award-info":[{"award-number":["21272136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31070313"],"award-info":[{"award-number":["31070313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific and Technological Research Project of Hubei Provincial Department of Education","award":["Q20111210"],"award-info":[{"award-number":["Q20111210"]}]},{"name":"Science Foundation of China Three Gorges University","award":["KJ2010B001"],"award-info":[{"award-number":["KJ2010B001"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.fitote.2013.05.021","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T06:21:14Z","timestamp":1370240474000},"page":"210-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["The H+\/K+-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells"],"prefix":"10.1016","volume":"89","author":[{"given":"Qiaoyin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingruo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Qiao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2013.05.021_bb0005","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1007\/s10620-005-3013-y","article-title":"The effect of intragastric ammonia production on titratable gastric acid output in Helicobacter pylori-infected patients with chronic gastritis","volume":"50","author":"Cylwik","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.fitote.2013.05.021_bb0010","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1053\/j.gastro.2008.05.021","article-title":"Control of gastric acid secretion in health and disease","volume":"134","author":"Schubert","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fitote.2013.05.021_bb0015","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00018-007-7249-x","article-title":"Molecular mechanisms in therapy of acid-related diseases","volume":"65","author":"Shin","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.fitote.2013.05.021_bb0020","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00424-008-0495-4","article-title":"The gastric HK-ATPase: structure, function, and inhibition","volume":"457","author":"Shin","year":"2009","journal-title":"Eur J Physiol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0025","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbabio.2009.02.015","article-title":"Ion transport and energy transduction of P-type ATPases: implications from electrostatic calculations","volume":"1787","author":"Weidem\u00fcller","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.fitote.2013.05.021_bb0030","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1021\/jm100040c","article-title":"Tetrahydrochromenoimidazoles as potassium-competitive acid blockers (P-CABs): structure\u2013activity relationship of their antisecretory properties and their affinity toward the hERG channel","volume":"53","author":"Palmer","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.fitote.2013.05.021_bb0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3164\/jcbn.2008012","article-title":"Proton pump inhibitors and gastritis","volume":"42","author":"Suzuki","year":"2008","journal-title":"Clin Biochem Nutr"},{"key":"10.1016\/j.fitote.2013.05.021_bb0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0079-6468(08)00203-8","article-title":"H+\/K+-ATPase inhibitors in the treatment of acid-related disorders","volume":"47","author":"Bamford","year":"2009","journal-title":"Prog Med Chem"},{"key":"10.1016\/j.fitote.2013.05.021_bb0045","first-page":"1","article-title":"The gastric H+\u2013K+-ATPase","volume":"55","author":"Vagin","year":"2002","journal-title":"Mech Con Pro TABn"},{"key":"10.1016\/j.fitote.2013.05.021_bb0050","first-page":"105","article-title":"Pharmacology and adverse reactions of Prilosec intestines dissolving capsule","volume":"10","author":"Li","year":"2009","journal-title":"Chin Foreign Med Treat"},{"key":"10.1016\/j.fitote.2013.05.021_bb0055","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ajg.2012.451","article-title":"Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis","volume":"108","author":"Leontiadis","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0060","first-page":"664","article-title":"Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India","volume":"136","author":"Saxena","year":"2012","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.fitote.2013.05.021_bb0065","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/gut.40.2.247","article-title":"Relation between gastric cancer and previous peptic ulcer disease","volume":"40","author":"Molloy","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.fitote.2013.05.021_bb0070","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF01307545","article-title":"Endoscopy, gastric ulcer, and gastric cancer: follow-up endoscopy for all gastric ulcers","volume":"38","author":"Pruitt","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.fitote.2013.05.021_bb0075","first-page":"19","article-title":"Perforative gastroduodenal ulcers","volume":"12","author":"Rybachkov","year":"2012","journal-title":"Khirurgiia (Mosk)"},{"key":"10.1016\/j.fitote.2013.05.021_bb0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/0377-4929.77343","article-title":"Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with Helicobacter pylori","volume":"54","author":"Haghazali","year":"2011","journal-title":"Indian J Pathol Microbiol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0085","first-page":"856","article-title":"Advances in research on natural triterpenoids with bioactivities","volume":"28","author":"Meng","year":"2008","journal-title":"Guihaia"},{"key":"10.1016\/j.fitote.2013.05.021_bb0090","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bmc.2006.09.064","article-title":"Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus","volume":"15","author":"Nakata","year":"2007","journal-title":"Bioorg Med"},{"key":"10.1016\/j.fitote.2013.05.021_bb0095","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0031-9422(95)00762-8","article-title":"Antimicrobial steroids from the fungus Fomitopsis pinicola","volume":"41","author":"Keller","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fitote.2013.05.021_bb0100","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0031-9422(00)95099-4","article-title":"Triterpenes of Poria cocos","volume":"32","author":"Tai","year":"1993","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fitote.2013.05.021_bb0105","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1021\/np990367l","article-title":"New lanostanoids of Ganoderma tsugae","volume":"60","author":"Su","year":"2000","journal-title":"J Nat Prod"},{"key":"10.1016\/j.fitote.2013.05.021_bb0110","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.phytol.2012.04.010","article-title":"Four new lanostane-type triterpenoids from Inonotus obliquus","volume":"5","author":"Handa","year":"2012","journal-title":"Phytochem Eur"},{"key":"10.1016\/j.fitote.2013.05.021_bb0115","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00210-011-0711-1","article-title":"Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+\/K+-ATPase inhibition","volume":"385","author":"Singh","year":"2012","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jep.2005.10.014","article-title":"Inhibition of gastric H+\/K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants","volume":"105","author":"Reyes-Chilpa","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2006.09.046","article-title":"Inhibition of the gastric H+\/K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews","volume":"111","author":"Schultz","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00011-006-6127-6","article-title":"The inhibitory effects of H+\/K+-ATPase inhibitors on human neutrophils in vitro: restoration by a K+ ionophore","volume":"56","author":"Martins de Oliveira","year":"2007","journal-title":"Inflamm Res"},{"key":"10.1016\/j.fitote.2013.05.021_bb0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.archger.2006.10.014","article-title":"Decreased hydrogen\u2013potassium-activated ATPase(H+\/K+-ATPase) expression and gastric acid secretory capacity in aged mice","volume":"45","author":"Kanai","year":"2007","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.fitote.2013.05.021_bb0140","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.bcp.2005.11.030","article-title":"Characterization of the inhibitory activity of tenatoprazole on the gastric H+\/K+-ATPase in vitro and in vivo","volume":"71","author":"Shin","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0145","first-page":"150","article-title":"Effect of Chaihu Shugan Powder of behavior and stomach histological on acute gastric ulcer model rats","volume":"36","author":"Lu","year":"2012","journal-title":"J Sh Un TCM"},{"key":"10.1016\/j.fitote.2013.05.021_bb0150","first-page":"1204","article-title":"Effect of Cynomorium songaricum polysaccharide on acute gastric ulcer in model rats","volume":"15","author":"Yang","year":"2011","journal-title":"Anhui Med. Pharma. J."},{"key":"10.1016\/j.fitote.2013.05.021_bb0155","first-page":"235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Anhui Med. Pharma. J."},{"key":"10.1016\/j.fitote.2013.05.021_bb0160","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature07939","article-title":"Crystal structure of the sodium\u2013potassium pump at 2.4\u00c5 resolution","volume":"459","author":"Shinoda","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.fitote.2013.05.021_bb0165","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.fitote.2013.05.021_bb0170","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J Mol Biol"},{"key":"10.1016\/j.fitote.2013.05.021_bb0175","author":"Schr\u00f6dinger"},{"key":"10.1016\/j.fitote.2013.05.021_bb0180","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J Appl Crystallogr"},{"key":"10.1016\/j.fitote.2013.05.021_bb0185","series-title":"The PyMOL molecular graphics system","author":"DeLano","year":"2004"},{"key":"10.1016\/j.fitote.2013.05.021_bb0190","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1349-7006.2007.00642.x","article-title":"Retraction: blockage of intracellular proton extrusion with proton pump inhibitor induces apoptosis in gastric cancer","volume":"99","author":"Yeo","year":"2008","journal-title":"Cancer Sci"},{"key":"10.1016\/j.fitote.2013.05.021_bb0195","doi-asserted-by":"crossref","first-page":"10627","DOI":"10.1158\/0008-5472.CAN-07-1805","article-title":"Targeting vacuolar H+\/K+-ATPase as a new strategy against cancer","volume":"67","author":"Fais","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.fitote.2013.05.021_bb0200","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1479-5876-8-57","article-title":"Commentary. Proton dynamics in cancer","volume":"8","author":"Huber","year":"2010","journal-title":"J Transl Med"},{"key":"10.1016\/j.fitote.2013.05.021_bb0205","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00383-008-2229-2","article-title":"The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma","volume":"24","author":"Morimura","year":"2008","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.fitote.2013.05.021_bb0210","doi-asserted-by":"crossref","first-page":"8687","DOI":"10.1158\/1078-0432.CCR-04-1065","article-title":"Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells","volume":"10","author":"Yeo","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.fitote.2013.05.021_bb0215","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2796.2010.02225.x","article-title":"Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanism","volume":"267","author":"Fais","year":"2010","journal-title":"J Intern Med"},{"key":"10.1016\/j.fitote.2013.05.021_bb0220","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2174\/157018010791526340","article-title":"Triterpenes from Gloeophyllum odoratum as potential leads towards potent thrombin inhibitors","volume":"7","author":"Cateni","year":"2010","journal-title":"Lett Drug Des"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X1300141X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X1300141X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T15:48:50Z","timestamp":1715442530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X1300141X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":44,"alternative-id":["S0367326X1300141X"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2013.05.021","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The H+\/K+-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2013.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}