{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:53:54Z","timestamp":1793130834303,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2012R1A6A1028677"],"award-info":[{"award-number":["2012R1A6A1028677"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.fitote.2013.12.003","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T20:36:25Z","timestamp":1386880585000},"page":"260-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C\/EBP\u03b1 and PPAR\u03b3"],"prefix":"10.1016","volume":"92","author":[{"given":"Hyun Ah","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Young","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ju","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Yousof","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Sue","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2013.12.003_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1155\/2008\/609039","article-title":"Obesity: a review of pathogenesis and management strategies","volume":"22","author":"Kaila","year":"2008","journal-title":"Can J Gastroenterol"},{"key":"10.1016\/j.fitote.2013.12.003_bb0010","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.lfs.2008.03.003","article-title":"Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin","volume":"82","author":"Yang","year":"2008","journal-title":"Life Sci"},{"key":"10.1016\/j.fitote.2013.12.003_bb0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0026-0495(81)90174-8","article-title":"Exaggerated replication in culture of adipocyte precursors from massively obese persons","volume":"30","author":"Roncari","year":"1981","journal-title":"Metabolism"},{"key":"10.1016\/j.fitote.2013.12.003_bb0020","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1101\/gad.14.11.1293","article-title":"Transcriptional regulation of adipogenesis","volume":"14","author":"Rosen","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.fitote.2013.12.003_bb0025","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0065-3233(01)56006-4","article-title":"Peroxisome proliferator-activated receptor (PPAR) \u03b3 agonists for diabetes","volume":"56","author":"Moller","year":"2001","journal-title":"Adv Protein Chem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0030","doi-asserted-by":"crossref","first-page":"26458","DOI":"10.1074\/jbc.M004160200","article-title":"Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins","volume":"275","author":"Luong","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0035","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.fct.2009.06.010","article-title":"Anti-obesity effect of sulfated glucosamine by AMPK signal pathway in 3T3-L1 adipocytes","volume":"47","author":"Kong","year":"2009","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.fitote.2013.12.003_bb0040","series-title":"WHO Factsheet 311: obesity and over-weight","author":"WHO-World Health Organization","year":"2012"},{"key":"10.1016\/j.fitote.2013.12.003_bb0045","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.foodchem.2006.09.042","article-title":"Varieties of antioxidant and antibacterial properties of Ecklonia stolonifera and Ecklonia kurome products harvested and processed in the Noto peninsula, Japan","volume":"103","author":"Kuda","year":"2007","journal-title":"Food Chem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0050","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1248\/cpb.51.1012","article-title":"A new phlorotannin from the brown alga Ecklonia stolonifera","volume":"51","author":"Kang","year":"2003","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.fitote.2013.12.003_bb0055","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/BF02980106","article-title":"Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation","volume":"27","author":"Kang","year":"2004","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.fitote.2013.12.003_bb0060","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1016\/j.fct.2012.06.028","article-title":"Antimicrobial effect of phlorotannins from marine brown algae","volume":"50","author":"Eom","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.fitote.2013.12.003_bb0065","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.tiv.2011.09.012","article-title":"Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-\u03baB, Akt, and p38 MAPK","volume":"25","author":"Kim","year":"2011","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.fitote.2013.12.003_bb0070","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1007\/BF02977904","article-title":"Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells","volume":"28","author":"Kim","year":"2005","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.fitote.2013.12.003_bb0075","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1444-2906.2006.01288.x","article-title":"Angiotensin-converting enzyme I inhibitory activity of phlorotannins from Ecklonia stolonifera","volume":"72","author":"Jung","year":"2006","journal-title":"Fish Sci"},{"key":"10.1016\/j.fitote.2013.12.003_bb0080","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1444-2906.2007.01511.x","article-title":"Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera","volume":"74","author":"Yoon","year":"2008","journal-title":"Fish Sci"},{"key":"10.1016\/j.fitote.2013.12.003_bb0085","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1016\/j.bmc.2009.04.050","article-title":"Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on Fc(epsilon)RI expression","volume":"17","author":"Shim","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0090","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1007\/s12272-001-2152-8","article-title":"Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats","volume":"31","author":"Yoon","year":"2008","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.fitote.2013.12.003_bb0095","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1271\/bbb.110137","article-title":"Protein tyrosine phosphatase 1B and \u03b1-glucosidase inhibitory phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis","volume":"75","author":"Moon","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0100","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1248\/bpb.29.1735","article-title":"The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts","volume":"29","author":"Joe","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.fitote.2013.12.003_bb0105","first-page":"64","article-title":"Preventive effect of Ecklonia stolonifera on the frequency of benzo(a)pyrene-induced chromosomal aberration","volume":"1","author":"Lee","year":"1996","journal-title":"J Food Sci Nutr"},{"key":"10.1016\/j.fitote.2013.12.003_bb0110","first-page":"105","volume":"4","author":"Lee","year":"1998","journal-title":"Nat Prod Sci"},{"key":"10.1016\/j.fitote.2013.12.003_bb0115","first-page":"104","article-title":"Inhibitory effects of Ecklonia stolonifera on gene mutation on mouse lymphoma tk locus in L5178Y-3.7.2C cell and bone marrow micronuclei formation in ddY mice","volume":"20","author":"Han","year":"2000","journal-title":"Environ Mutagen Carcinog"},{"key":"10.1016\/j.fitote.2013.12.003_bb0120","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/BF02975886","article-title":"Tyrosinase inhibitors isolated from edible brown alga Ecklonia stolonifera","volume":"27","author":"Kang","year":"2004","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.fitote.2013.12.003_bb0125","article-title":"Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes","author":"Jung","year":"2013","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.fitote.2013.12.003_bb0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cbi.2010.04.003","article-title":"Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes","volume":"86","author":"Kim","year":"2010","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.fitote.2013.12.003_bb0135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10126-009-9224-z","article-title":"1-(3\u2032,5\u2032-dihydroxyphenoxy)-7-(2\u2033,4\u2033,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblast","volume":"12","author":"Kong","year":"2010","journal-title":"Mar Biotechnol"},{"key":"10.1016\/j.fitote.2013.12.003_bb0140","doi-asserted-by":"crossref","first-page":"3122S","DOI":"10.1093\/jn\/130.12.3122S","article-title":"Adipocyte differentiation and gene expression","volume":"130","author":"Ntambi","year":"2000","journal-title":"J Nutr"},{"key":"10.1016\/j.fitote.2013.12.003_bb0145","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1016\/j.lfs.2004.06.012","article-title":"Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells","volume":"17","author":"Jeon","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.fitote.2013.12.003_bb0150","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF00027655","article-title":"Chinese seaweeds in herbal medicine","volume":"116\/117","author":"Tseng","year":"1984","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.fitote.2013.12.003_bb0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1023\/B:JAPH.0000047783.36600.ef","article-title":"Medicinal and pharmaceutical uses of seaweed natural products: a review","volume":"16","author":"Smit","year":"2004","journal-title":"J Appl Phycol"},{"key":"10.1016\/j.fitote.2013.12.003_bb0160","first-page":"498","article-title":"Nutritional value of seaweeds","volume":"2","author":"Burtin","year":"2003","journal-title":"Electron J Environ Agric Food Chem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0165","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1349-7006.2001.tb01119.x","article-title":"Seaweed prevents breast cancer?","volume":"92","author":"Funahashi","year":"2001","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.fitote.2013.12.003_bb0170","first-page":"35","article-title":"Japan Collaborative Cohort Study for Evaluation of Cancer Nutrition and disease in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)","volume":"8","author":"Iso","year":"2007","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.fitote.2013.12.003_bb0175","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10811-012-9931-0","article-title":"The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle","volume":"25","author":"Teas","year":"2013","journal-title":"J Appl Phycol"},{"key":"10.1016\/j.fitote.2013.12.003_bb0180","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.tiv.2009.05.013","article-title":"Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation","volume":"23","author":"Heo","year":"2009","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.fitote.2013.12.003_bb0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4162\/nrp.2011.5.2.93","article-title":"Effect of phlorotannins isolated from Ecklonia cava on angiotensin I-converting enzyme (ACE) inhibitory activity","volume":"5","author":"Wijesinghe","year":"2011","journal-title":"Nutr Res Pract"},{"key":"10.1016\/j.fitote.2013.12.003_bb0190","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1271\/bbb.60417","article-title":"Isolation of a new anti-allergic phlorotannin, phlorofucofuroeckol-B, from an edible brown alga, Eisenia arborea","volume":"70","author":"Sugiura","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0195","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11418-012-0709-0","article-title":"Dieckol, isolated from Ecklonia stolonifera, induces apoptosis in human hepatocellular carcinoma Hep3B cells","volume":"67","author":"Yoon","year":"2013","journal-title":"J Nat Med"},{"key":"10.1016\/j.fitote.2013.12.003_bb0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/md11010165","article-title":"Isolation and structural determination of two novel phlorotannins from the brown alga Ecklonia kurome Okamura, and their radical scavenging activities","volume":"11","author":"Yotsu-Yamashita","year":"2013","journal-title":"Mar Drugs"},{"key":"10.1016\/j.fitote.2013.12.003_bb0205","first-page":"9752","article-title":"Deodorizing effects of phlorotannins from edible brown alga Eisenia bicyclis on methyl mercaptan","volume":"5","author":"Kim","year":"2012","journal-title":"J Agric Sci"},{"key":"10.1016\/j.fitote.2013.12.003_bb0210","doi-asserted-by":"crossref","first-page":"8541","DOI":"10.1021\/jf401454m","article-title":"Evaluation of inhibitory effect of phlorotannins from Ecklonia cava on triglyceride accumulation in adipocyte","volume":"61","author":"Kim","year":"2013","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.fitote.2013.12.003_bb0215","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cmet.2006.07.001","article-title":"Transcriptional control of adipocyte formation","volume":"4","author":"Farmer","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.fitote.2013.12.003_bb0220","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBP induces adipogenesis through PPAR\u03b3: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X13003122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X13003122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:19:15Z","timestamp":1759796355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X13003122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":44,"alternative-id":["S0367326X13003122"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2013.12.003","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C\/EBP\u03b1 and PPAR\u03b3","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2013.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}