{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:50:12Z","timestamp":1792792212130,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.fitote.2015.11.018","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T12:19:28Z","timestamp":1448453968000},"page":"196-205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Chemical modification of arglabin and biological activity of its new derivatives"],"prefix":"10.1016","volume":"110","author":[{"given":"S.M.","family":"Adekenov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2015.11.018_bb0005","series-title":"Terpenoids of Essential Oils of Plants. Distribution, Chemical Modification and Biological Activity","author":"Atazhanova","year":"2008"},{"key":"10.1016\/j.fitote.2015.11.018_bb0010","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF00575063","volume":"18","author":"Adekenov","year":"1982","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.fitote.2015.11.018_bb0015","series-title":"Problems Rational Application of Medicinal and Technical Plants of Kazakhstan","first-page":"230","author":"Mukhametzhanov","year":"1986"},{"key":"10.1016\/j.fitote.2015.11.018_bb0020","series-title":"Dr. Chem. Sciences, Institute of bioorganic Chemistry Named by M.M. Shemyakin RAS, Moskow","author":"Adekenov","year":"1992"},{"issue":"2","key":"10.1016\/j.fitote.2015.11.018_bb0025","first-page":"142","volume":"LXVI","author":"Adekenov","year":"1995","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fitote.2015.11.018_bb0030","unstructured":"USA Patent 6,242,617,B1, 5.06.01.; Deutschen Patent 697 2504.9\u201308, 23.10.03.; Europ\u0435an Patent 0946565, 15.10.03.; Patent of China ZL 200680055852.4, 26.12.12. Adekenov S.M. Method and device for production of lyophilized hydrochloride-1\u03b2,10\u03b2-epoxy-13-dimethylaminoguai-3(4)-en-6,12-olide; The Eurasian patent 015557, 30.08.11. Adekenov S.M. Method of obtaining 1(10)\u03b2-epoxy-13-dimethylamino-5,7\u03b1,6,11\u03b2(\u041d)\u2013guai-3(4)-en-6,12-olide hydrochloride lyophilized, antitumor drug \u00abArglabin\u00bb."},{"issue":"11","key":"10.1016\/j.fitote.2015.11.018_bb0035","first-page":"2","volume":"2","author":"Adekenov","year":"2012","journal-title":"Russian biotherapeutic journal"},{"key":"10.1016\/j.fitote.2015.11.018_bb0040","series-title":"The Clinical Aspects of Using Antitumor Preparation \u201cArglabin\u201d","first-page":"68-7","author":"- Shaikenov","year":"2002"},{"key":"10.1016\/j.fitote.2015.11.018_bb0045","first-page":"173","volume":"8","author":"Shaikenov","year":"2001","journal-title":"Oncolog. Rep."},{"key":"10.1016\/j.fitote.2015.11.018_bb0050","unstructured":"Innovative patent RK 16656, 27.09.05. Jalmakhanbetova R.I., Atazhanova G.A., Adekenov S.M., Kuliyasov A.T. 1,10\u03b2-epoxy-5,7\u03b1,6\u03b2(\u041d)-guai-3,4-en-6,12-olide, possessing high anti-inflammatory activity."},{"key":"10.1016\/j.fitote.2015.11.018_bb0060","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ardp.201100065","volume":"345","author":"Csuk","year":"2012","journal-title":"Arch. Pharm. Chem. Life Sci."},{"issue":"52","key":"10.1016\/j.fitote.2015.11.018_bb0065","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1023\/A:1023943830932","author":"Jalmakhanbetova","year":"2003","journal-title":"Russ. Chem. Bull., Int. Ed."},{"key":"10.1016\/j.fitote.2015.11.018_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00629826","volume":"27","author":"Adekenov","year":"1991","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.fitote.2015.11.018_bb0075","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0040-4020(79)80099-X","volume":"35","author":"Salazar","year":"1979","journal-title":"Tetrahedron"},{"key":"10.1016\/j.fitote.2015.11.018_bb0080","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s10600-007-0188-9","volume":"43","author":"Jalmakhanbetova","year":"2007","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.fitote.2015.11.018_bb0085","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s10600-005-0204-x","volume":"41","author":"Jalmakhanbetova","year":"2005","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.fitote.2015.11.018_bb0090","unstructured":"Innovative patent RK 11729, 24.04.02. Jalmakhanbetova R.I., Adekenov S.M., Kuliyasov A.T. Methyliodide 13-dimethylamino-1,10\u03b2-epoxy-5,7\u03b1,6\u03b2(\u041d)-guai-3,4-en-6,12-olide, possessing high cytotoxicity."},{"key":"10.1016\/j.fitote.2015.11.018_bb0100","unstructured":"Innovative patent RK 17751, 15.07.06. Jalmakhanbetova R.I., Atazhanova G.A., Adekenov S.M. Methyliodide 1,10\u03b2-epoxy-13-dimethylamino-5,7\u03b1,6\u03b2(\u041d)-guai-3,4-en-6,12-olide, possessing high antifungal activity."},{"key":"10.1016\/j.fitote.2015.11.018_bb0110","unstructured":"Innovative patent RK 17754, 15.07.06. Jalmakhanbetova R.I., Atazhanova G.A., Adekenov S.M. 1,10\u03b2-epoxy-3,4-dibromo-11,13\u03b2- dibromocyclopropyl-5\u03b1,7\u03b1,6\u03b2(\u041d)-guai-6,12-olide, possessing high antifungal activity."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X15301258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X15301258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T08:51:44Z","timestamp":1537174304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X15301258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":19,"alternative-id":["S0367326X15301258"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2015.11.018","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical modification of arglabin and biological activity of its new derivatives","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2015.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}