{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:53:07Z","timestamp":1785037987597,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"High-end Engineering and Technical Personnel Training Plan of Chongqing"},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education","doi-asserted-by":"crossref","award":["20130182110023"],"award-info":[{"award-number":["20130182110023"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"name":"County-University Cooperation Innovation Funds of Southwest University","award":["Sz201501"],"award-info":[{"award-number":["Sz201501"]}]},{"name":"County-University Cooperation Innovation Funds of Southwest University","award":["HZ201601"],"award-info":[{"award-number":["HZ201601"]}]},{"name":"Major Program of Chongqing Educational Commission","award":["KJZH14203"],"award-info":[{"award-number":["KJZH14203"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.fitote.2016.09.019","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T16:26:36Z","timestamp":1475857596000},"page":"111-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4\u03b1\/FTF-mediated CYP7A1 activation"],"prefix":"10.1016","volume":"115","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangni","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuming","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2016.09.019_bb0005","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jacc.2008.03.054","article-title":"Childhood levels of serum apolipoproteins B and A-I predict carotid intima-media thickness and brachial endothelial function in adulthood: the cardiovascular risk in young Finns study","volume":"52","author":"Juonala","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.fitote.2016.09.019_bb0010","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/MOL.0000000000000051","article-title":"Hyperlipidemia and cardiovascular disease: inflammation, dyslipidemia, and atherosclerosis","volume":"25","author":"Tietge","year":"2014","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.fitote.2016.09.019_bb0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jacl.2010.12.001","article-title":"Comparative prognostic utility of conventional and novel lipid parameters for cardiovascular disease risk prediction: do novel lipid parameters offer an advantage?","volume":"5","author":"Manickam","year":"2011","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.fitote.2016.09.019_bb0020","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/01.hco.0000231412.15049.fb","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines","volume":"21","author":"Cheng","year":"2006","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.fitote.2016.09.019_bb0025","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/j.1445-5994.2011.02622.x","article-title":"Relationships between HMG-CoA reductase inhibitors (statin) use and strength, balance and falls in older people","volume":"42","author":"Haerer","year":"2012","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.fitote.2016.09.019_bb0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1476-511X-9-135","article-title":"Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells","volume":"9","author":"Notarnicola","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.fitote.2016.09.019_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12011-011-9300-x","article-title":"Excess iodine and high-fat diet combination modulates lipid profile, thyroid hormone, and hepatic LDLr expression values in mice","volume":"147","author":"Han","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fitote.2016.09.019_bb0040","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/ATVBAHA.108.179564","article-title":"The LDL receptor","volume":"29","author":"Goldstein","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.fitote.2016.09.019_bb0045","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1016\/S0021-9258(19)39010-6","article-title":"Human apolipoprotein A-IV binds to apolipoprotein A-I\/A-II receptor sites and promotes cholesterol efflux from adipose cells","volume":"265","author":"Steinmetz","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fitote.2016.09.019_bb0050","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1172\/JCI0215387","article-title":"Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype","volume":"110","author":"Pullinger","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fitote.2016.09.019_bb0055","doi-asserted-by":"crossref","first-page":"d176","DOI":"10.2741\/A273","article-title":"Regulation of bile acid synthesis","volume":"3","author":"Chiang","year":"1998","journal-title":"Front. Biosci."},{"key":"10.1016\/j.fitote.2016.09.019_bb0060","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jhep.2003.11.006","article-title":"Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms","volume":"40","author":"Chiang","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.fitote.2016.09.019_bb0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.fitote.2016.09.019_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/11584380-000000000-00000","article-title":"Clinical implications of pharmacogenetic variation on the effects of statins","volume":"34","author":"Maggo","year":"2011","journal-title":"Drug Saf."},{"key":"10.1016\/j.fitote.2016.09.019_bb0075","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bmcl.2006.12.085","article-title":"Antiviral activity of berberine and related compounds against human cytomegalovirus","volume":"17","author":"Hayashi","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.fitote.2016.09.019_bb0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.fitote.2011.09.014","article-title":"Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells","volume":"83","author":"Chen","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fitote.2016.09.019_bb0085","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.fitote.2016.09.019_bb0090","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11745-014-3983-7","article-title":"The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters","volume":"50","author":"He","year":"2015","journal-title":"Lipids"},{"key":"10.1016\/j.fitote.2016.09.019_bb0095","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/ptr.5295","article-title":"Hypolipidemic Effect and Mechanism of Palmatine from Coptis chinensis in Hamsters Fed High-Fat diet","volume":"29","author":"Ning","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fitote.2016.09.019_bb0100","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.phymed.2014.05.002","article-title":"The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis","volume":"21","author":"Wu","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fitote.2016.09.019_bb0105","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.toxlet.2012.10.015","article-title":"Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity","volume":"215","author":"Bao","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fitote.2016.09.019_bb0110","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jep.2012.10.062","article-title":"Safety evaluation of main alkaloids from Rhizoma Coptidis","volume":"145","author":"Yi","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2016.09.019_bb0115","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.fitote.2016.09.019_bb0120","first-page":"344","article-title":"Effect of additives on absorption of Coptis chinensis total alkaloids and pharmacokinetics in mice","volume":"34","author":"Li","year":"2009","journal-title":"China journal of Chinese Materia Medica"},{"key":"10.1016\/j.fitote.2016.09.019_bb0125","doi-asserted-by":"crossref","first-page":"12012","DOI":"10.1016\/S0021-9258(19)38501-1","article-title":"Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA","volume":"265","author":"Li","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fitote.2016.09.019_bb0130","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.fitote.2016.09.019_bb0135","first-page":"90","article-title":"Mortality from coronary heart disease and acute myocardial infarction\u2014United States, 1998","volume":"50","author":"Centers for Disease C, Prevention","year":"2001","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.fitote.2016.09.019_bb0140","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0140-6736(13)62076-0","article-title":"Overweight, obesity, and outcomes: fat mass and beyond","volume":"383","author":"Van Gaal","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.fitote.2016.09.019_bb0145","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0021-9150(01)00585-8","article-title":"Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients","volume":"160","author":"Inoue","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fitote.2016.09.019_bb0150","first-page":"1696","article-title":"Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways","volume":"2016","author":"He","year":"1862","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fitote.2016.09.019_bb0155","first-page":"1560","article-title":"Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding","volume":"2013","author":"Wu","year":"1832","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fitote.2016.09.019_bb0160","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0378-1119(00)00518-7","article-title":"Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha)","volume":"262","author":"Chiang","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.fitote.2016.09.019_bb0165","doi-asserted-by":"crossref","first-page":"41690","DOI":"10.1074\/jbc.M105117200","article-title":"Transcriptional regulation of the human sterol 12 alpha-hydroxylase gene (CYP8B1) - roles of hepatocyte nuclear factor 4 alpha in mediating bile acid repression","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fitote.2016.09.019_bb0170","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-1119(03)00631-0","article-title":"Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha)","volume":"313","author":"Chen","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.fitote.2016.09.019_bb0175","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.3390\/molecules18066883","article-title":"Arylsulfonylamino-benzanilides as inhibitors of the apical sodium-dependent bile salt transporter (SLC10A2)","volume":"18","author":"Liu","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.fitote.2016.09.019_bb0180","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1476-511X-11-56","article-title":"Dietary resveratrol increases the expression of hepatic 7alpha-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL\/6J mice","volume":"11","author":"Chen","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.fitote.2016.09.019_bb0185","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/hep.24107","article-title":"Overexpression of cholesterol 7 alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis","volume":"53","author":"Li","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.fitote.2016.09.019_bb0190","doi-asserted-by":"crossref","first-page":"21206","DOI":"10.1074\/jbc.M401523200","article-title":"The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element","volume":"279","author":"Pare","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fitote.2016.09.019_bb0195","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.fitote.2016.09.019_bb0200","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1093\/nar\/29.19.4035","article-title":"Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism","volume":"29","author":"del Castillo-Olivares","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fitote.2016.09.019_bb0205","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tips.2007.03.002","article-title":"FXR: a promising target for the metabolic syndrome?","volume":"28","author":"Cariou","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.fitote.2016.09.019_bb0210","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"Sinal","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.fitote.2016.09.019_bb0215","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1128\/MCB.21.4.1393-1403.2001","article-title":"Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis","volume":"21","author":"Hayhurst","year":"2001","journal-title":"Mol. Cell. Biol."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X16304932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X16304932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T22:52:05Z","timestamp":1657407125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X16304932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":43,"alternative-id":["S0367326X16304932"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2016.09.019","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4\u03b1\/FTF-mediated CYP7A1 activation","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2016.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}