{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:34:35Z","timestamp":1791038075122,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81403003"],"award-info":[{"award-number":["81403003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81602850"],"award-info":[{"award-number":["81602850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81672961"],"award-info":[{"award-number":["81672961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC0903100"],"award-info":[{"award-number":["2016YFC0903100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC0903102"],"award-info":[{"award-number":["2016YFC0903102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Projects of Shenyang Science & Technology Plan","award":["F13-221-9-17"],"award-info":[{"award-number":["F13-221-9-17"]}]},{"name":"Individualized Diagnosis and Treatment of Colorectal Cancer","award":["LNCCC-B05-2015"],"award-info":[{"award-number":["LNCCC-B05-2015"]}]},{"name":"Foundation of Committee on Science and Technology of Tianjin","award":["15JCYBJC54700"],"award-info":[{"award-number":["15JCYBJC54700"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M590210"],"award-info":[{"award-number":["2016M590210"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Health Bureau Science Foundation Key Project","award":["16KG154"],"award-info":[{"award-number":["16KG154"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.fitote.2017.03.010","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T03:03:34Z","timestamp":1490324614000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis"],"prefix":"10.1016","volume":"119","author":[{"given":"Jin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Feng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ze","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Tu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Zhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.fitote.2017.03.010_bb0005","first-page":"1779","article-title":"Herbal supplements and hepatotoxicity: a short review","volume":"10","author":"Haslan","year":"2015","journal-title":"Nat. Prod. Commun."},{"issue":"5","key":"10.1016\/j.fitote.2017.03.010_bb0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02353475","article-title":"Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans","volume":"24","author":"Wilkinson","year":"1996","journal-title":"J. Pharmacokinet. Biopharm."},{"issue":"4","key":"10.1016\/j.fitote.2017.03.010_bb0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/86882","article-title":"Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression","volume":"27","author":"Kuehl","year":"2001","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.fitote.2017.03.010_bb0020","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1248\/jhs.56.239","article-title":"Comparison of the contributions of cytochromes P450 3A4 and 3A5 in drug oxidation rates and substrate inhibition","volume":"56","author":"Niwa","year":"2010","journal-title":"J. Health Sci."},{"issue":"5","key":"10.1016\/j.fitote.2017.03.010_bb0025","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1124\/dmd.105.008680","article-title":"Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro","volume":"34","author":"Dai","year":"2006","journal-title":"Drug Metab. Dispos."},{"issue":"8","key":"10.1016\/j.fitote.2017.03.010_bb0030","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1124\/dmd.106.009902","article-title":"Selective metabolism of vincristine in vitro by CYP3A5","volume":"34","author":"Dennison","year":"2006","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.fitote.2017.03.010_bb0035","first-page":"313","article-title":"Simultaneous determination of eight lignans in Schisandra chinensis (Turcz.) Baill.from different habitats by HPLC","volume":"34","author":"Hu","year":"2012","journal-title":"Chin. Tradit. Pat. Medieine"},{"issue":"8","key":"10.1016\/j.fitote.2017.03.010_bb0040","first-page":"1715","article-title":"Anti-AIDS AgentsmXXVI","volume":"5","author":"Chen","year":"1997","journal-title":"Structure-Activity Correlations of Gomisin-G-Related Anti-HIV Lignans From Kadsura interior and of Related Synthetic Analogues, Bioorganic & Medicinal Chemistry"},{"issue":"3","key":"10.1016\/j.fitote.2017.03.010_bb0045","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1476-5381.1994.tb17084.x","article-title":"Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils","volume":"113","author":"Wang","year":"1994","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.fitote.2017.03.010_bb0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1124\/dmd.113.053884","article-title":"Deoxyschizandrin, a naturally occurring Lignan, is a specific probe substrate of human cytochrome P450 3A","volume":"42","author":"Wu","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.fitote.2017.03.010_bb0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/00498250903366052","article-title":"CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes","volume":"40","author":"Cao","year":"2010","journal-title":"Xenobiotica; the fate of foreign compounds in biological systems"},{"issue":"12","key":"10.1016\/j.fitote.2017.03.010_bb0060","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1124\/dmd.104.000646","article-title":"Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract","volume":"32","author":"Iwata","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"9","key":"10.1016\/j.fitote.2017.03.010_bb0065","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1124\/dmd.31.9.1108","article-title":"Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine","volume":"31","author":"Galetin","year":"2003","journal-title":"Drug Metab. Dispos."},{"issue":"12","key":"10.1016\/j.fitote.2017.03.010_bb0070","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1124\/dmd.30.12.1311","article-title":"Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions","volume":"30","author":"Yuan","year":"2002","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.fitote.2017.03.010_bb0075","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1208\/s12248-015-9827-4","article-title":"Gomisin a is a novel isoform-specific probe for the selective sensing of human cytochrome P450 3A4 in liver Microsomes and living cells","volume":"18","author":"Wu","year":"2016","journal-title":"AAPS J."},{"issue":"11","key":"10.1016\/j.fitote.2017.03.010_bb0080","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1124\/dmd.110.034736","article-title":"Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution","volume":"38","author":"Kirby","year":"2010","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.fitote.2017.03.010_bb0085","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2125.2009.03383.x","article-title":"Effects of Schisandra sphenanthera extract on the pharmacokinetics of midazolam in healthy volunteers","volume":"67","author":"Xin","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.fitote.2017.03.010_bb0090","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/01.CIR.56.4.605","article-title":"Prediction of the normal blood volume. Relation of blood volume to body habitus","volume":"56","author":"Feldschuh","year":"1977","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.fitote.2017.03.010_bb0095","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1124\/dmd.106.013607","article-title":"Characterization of benidipine and its enantiomers' metabolism by human liver cytochrome P450 enzymes","volume":"35","author":"Yoon","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"7","key":"10.1016\/j.fitote.2017.03.010_bb0100","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1124\/dmd.31.7.938","article-title":"In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5","volume":"31","author":"Patki","year":"2003","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.fitote.2017.03.010_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1872312807666131229121228","article-title":"Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation","volume":"8","author":"Niwa","year":"2014","journal-title":"Drug Metab. Lett."},{"issue":"Pt 2","key":"10.1016\/j.fitote.2017.03.010_bb0110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/bj3550373","article-title":"Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6","volume":"355","author":"Hayhurst","year":"2001","journal-title":"Biochem. J."},{"issue":"49","key":"10.1016\/j.fitote.2017.03.010_bb0115","doi-asserted-by":"crossref","first-page":"14571","DOI":"10.1021\/ja0265409","article-title":"Roles of the proximal hydrogen bonding network in cytochrome P450cam-catalyzed oxygenation","volume":"124","author":"Yoshioka","year":"2002","journal-title":"J. Am. Chem. Soc."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X16309182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X16309182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T18:47:02Z","timestamp":1589741222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X16309182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":23,"alternative-id":["S0367326X16309182"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2017.03.010","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2017.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}