{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:22:20Z","timestamp":1778613740234,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.fitote.2017.08.014","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T19:46:00Z","timestamp":1503776760000},"page":"67-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli"],"prefix":"10.1016","volume":"122","author":[{"given":"Gregorio","family":"Peron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Sut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pellizzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-9000","authenticated-orcid":false,"given":"Paola","family":"Brun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-8038","authenticated-orcid":false,"given":"Dario","family":"Voinovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Castagliuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-6953","authenticated-orcid":false,"given":"Stefano","family":"Dall'Acqua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2017.08.014_bb0005","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJM199810083391516","article-title":"Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries [6]","volume":"339","author":"Howell","year":"1998","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.fitote.2017.08.014_bb0010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0031-9422(99)00573-7","article-title":"The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro","volume":"54","author":"Foo","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fitote.2017.08.014_bb0015","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1021\/np000128u","article-title":"A-type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli","volume":"63","author":"Foo","year":"2000","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fitote.2017.08.014_bb0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/10408390209351915","article-title":"Cranberry proanthocyanidins and the maintenance of urinary tract health","volume":"42","author":"Howell","year":"2002","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fitote.2017.08.014_bb0025","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.phytochem.2005.05.022","article-title":"A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity","volume":"66","author":"Howell","year":"2005","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fitote.2017.08.014_bb0030","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1128\/AEM.05561-11","article-title":"Inhibition of Escherichia coli CFT073 fliC expression and motility by cranberry materials","volume":"77","author":"Hidalgo","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fitote.2017.08.014_bb0035","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3945\/an.113.004473","article-title":"Cranberries and their bioactive constituents in human health","volume":"4","author":"Blumberg","year":"2013","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.fitote.2017.08.014_bb0040","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.juro.2007.01.114","article-title":"Cranberry products inhibit adherence of P-Fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells","volume":"177","author":"Gupta","year":"2007","journal-title":"J. Urol."},{"key":"10.1016\/j.fitote.2017.08.014_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001321.pub5","article-title":"Cranberries for treating urinary tract infections","volume":"10","author":"Jepson","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.fitote.2017.08.014_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001321.pub5","article-title":"Cranberries for preventing urinary tract infections","volume":"10","author":"Jepson","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.fitote.2017.08.014_bb0055","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/10408398.2011.625574","article-title":"Cranberry and recurrent cystitis: more than marketing?","volume":"54","author":"Micali","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fitote.2017.08.014_bb0060","first-page":"2640","article-title":"Prevention of urinary tract infection with Oximacro\u00ae, a cranberry extract with a high content of a-type proanthocyanidins: a pre-clinical double-blind controlled study","volume":"13","author":"Occhipinti","year":"2016","journal-title":"Urol. J."},{"key":"10.1016\/j.fitote.2017.08.014_bb0065","first-page":"475","article-title":"Cranberry products in recurrent urinary tract infections: active or not? The need for standardisation","volume":"68","author":"Oosterlinck","year":"2012","journal-title":"Tijdschr. Geneeskd."},{"key":"10.1016\/j.fitote.2017.08.014_bb0070","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1447-0756.2009.01026.x","article-title":"Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits","volume":"35","author":"P\u00e9rez-L\u00f3pez","year":"2009","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.fitote.2017.08.014_bb0075","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1039\/C5FO01441G","article-title":"Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli","volume":"7","author":"Rodr\u00edguez-P\u00e9rez","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.fitote.2017.08.014_bb0080","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00204-014-1330-7","article-title":"Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update","volume":"88","author":"Rodriguez-Mateos","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fitote.2017.08.014_bb0085","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s11255-016-1342-8","article-title":"Effect of oral cranberry extract (standardized proanthocyanidin-A) in patients with recurrent UTI by pathogenic E. coli: a randomized placebo-controlled clinical research study","volume":"48","author":"Singh","year":"2016","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.fitote.2017.08.014_bb0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jff.2015.05.016","article-title":"Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli","volume":"17","author":"Sun","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fitote.2017.08.014_bb0095","article-title":"Biofilm formation and virulence of uropathogenic Escherichia coli in urine after consumption of cranberry-lingonberry juice","author":"Tapiainen","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.fitote.2017.08.014_bb0100","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jff.2015.08.009","article-title":"Phenolic acid content and antiadherence activity in the urine of patients treated with cranberry syrup (Vaccinium macrocarpon) vs. trimethoprim for recurrent urinary tract infection","volume":"18","author":"Uberos","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fitote.2017.08.014_bb0105","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.nutres.2013.05.018","article-title":"Current clinical status on the preventive effects of cranberry consumption against urinary tract infections","volume":"33","author":"Vasileiou","year":"2013","journal-title":"Nutr. Res."},{"key":"10.1016\/j.fitote.2017.08.014_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.5427","article-title":"Are high proanthocyanidins key to cranberry efficacy in the prevention of recurrent urinary tract infection?","author":"Vostalova","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fitote.2017.08.014_bb0115","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1001\/archinternmed.2011.306","article-title":"Cranberries vs antibiotics to prevent urinary tract infections: a randomized double-blind noninferiority trial in premenopausal women","volume":"171","author":"Beerepoot","year":"2011","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.fitote.2017.08.014_bb0120","doi-asserted-by":"crossref","first-page":"661","DOI":"10.6061\/clinics\/2012(06)18","article-title":"Cranberries and lower urinary tract infection prevention","volume":"67","author":"Hisano","year":"2012","journal-title":"Clinics"},{"key":"10.1016\/j.fitote.2017.08.014_bb0125","doi-asserted-by":"crossref","first-page":"194.e1","DOI":"10.1016\/j.ajog.2015.04.003","article-title":"Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial","volume":"213","author":"Foxman","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.fitote.2017.08.014_bb0130","first-page":"398","article-title":"Cranberry juice for urinary tract infection in children","volume":"58","author":"Goldman","year":"2012","journal-title":"Can. Fam. Physician"},{"key":"10.1016\/j.fitote.2017.08.014_bb0135","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.foodchem.2014.07.062","article-title":"Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults","volume":"168","author":"McKay","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0140","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"Del Rio","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.fitote.2017.08.014_bb0145","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1039\/c0fo00132e","article-title":"Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites","volume":"1","author":"Monagas","year":"2010","journal-title":"Food Funct."},{"key":"10.1016\/j.fitote.2017.08.014_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jff.2016.05.015","article-title":"Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli","volume":"25","author":"Polewski","year":"2016","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fitote.2017.08.014_bb0155","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1039\/C6FO00109B","article-title":"Atomic force microscopy-guided fractionation reveals the influence of cranberry phytochemicals on adhesion of Escherichia coli","volume":"7","author":"Gupta","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.fitote.2017.08.014_bb0160","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.foodchem.2011.03.062","article-title":"Characterisation of genuine and derived cranberry proanthocyanidins by LC-ESI-MS","volume":"128","author":"Tarascou","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0165","doi-asserted-by":"crossref","first-page":"C690","DOI":"10.1111\/j.1750-3841.2010.01799.x","article-title":"Extraction and normal-phase HPLC-fluorescence-electrospray MS characterization and quantification of procyanidins in cranberry extracts","volume":"75","author":"Wallace","year":"2010","journal-title":"J. Food Sci."},{"key":"10.1016\/j.fitote.2017.08.014_bb0170","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1021\/jf001211q","article-title":"Identification of procyanidins and anthocyanins in blueberries and cranberries (Vaccinium spp.) Using high-performance liquid chromatography\/mass spectrometry","volume":"49","author":"Prior","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0175","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/jsfa.3966","article-title":"Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders","volume":"90","author":"Prior","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.fitote.2017.08.014_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0929867323666160615104837","article-title":"Nutraceuticals, a new challenge for medicinal chemistry","volume":"23","author":"Sut","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0185","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jff.2015.01.018","article-title":"A 1H NMR-based approach to investigate metabolomic differences in the plasma and urine of young women after cranberry juice or apple juice consumption","volume":"14","author":"Liu","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fitote.2017.08.014_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201500236","article-title":"Profiling the metabolome changes caused by cranberry procyanidins in plasma of female rats using 1H NMR and UHPLC-Q-Orbitrap-HRMS global metabolomics approaches","author":"Liu","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fitote.2017.08.014_bb0195","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jnutbio.2016.05.007","article-title":"NMR-based metabolomics reveals urinary metabolome modifications in female Sprague-Dawley rats by cranberry procyanidins","volume":"34","author":"Liu","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0200","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.7b01856","article-title":"Anti-adhesive activity and metabolomics analysis of rat urine after cranberry (Vaccinium macrocarpon Aiton) administration","author":"Peron","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0205","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1021\/ac503775m","article-title":"Untargeted UPLC-MS profiling pipeline to expand tissue metabolome coverage: application to cardiovascular disease","volume":"87","author":"Vorkas","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0210","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jff.2016.12.035","article-title":"5-(3\u2032,4\u2032-Dihydroxyphenyl)-\u03b3-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells","volume":"29","author":"Mena","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fitote.2017.08.014_bb0215","series-title":"Database (Oxford). 2010","article-title":"Phenol-Explorer: an online comprehensive database on polyphenol contents in foods","author":"Neveu","year":"2010"},{"key":"10.1016\/j.fitote.2017.08.014_bb0220","doi-asserted-by":"crossref","first-page":"7263","DOI":"10.1021\/ac3017339","article-title":"Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake","volume":"84","author":"Van Der Hooft","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0225","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s00216-009-2676-1","article-title":"Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats","volume":"394","author":"Urpi-Sarda","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.fitote.2017.08.014_bb0230","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.abb.2016.01.014","article-title":"Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols","volume":"599","author":"Feliciano","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fitote.2017.08.014_bb0235","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00240-011-0398-2","article-title":"Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin","volume":"40","author":"Gupta","year":"2012","journal-title":"Urol. Res."},{"key":"10.1016\/j.fitote.2017.08.014_bb0240","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.fitote.2011.04.007","article-title":"Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-\u03b2-D-glucuronide in Polygonum perfoliatum L","volume":"82","author":"Fan","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fitote.2017.08.014_bb0245","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jmgm.2015.07.005","article-title":"Docking studies of flavonoid compounds as inhibitors of \u03b2-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli","volume":"61","author":"Sabbagh","year":"2015","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.fitote.2017.08.014_bb0250","doi-asserted-by":"crossref","first-page":"12119","DOI":"10.3390\/ijms160612119","article-title":"Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures","volume":"16","author":"De Llano","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2017.08.014_bb0255","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.bcp.2007.11.002","article-title":"Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity","volume":"75","author":"Loke","year":"2008","journal-title":"Biochem. Pharmacol."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X1730878X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X1730878X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T04:30:47Z","timestamp":1535430647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X1730878X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":51,"alternative-id":["S0367326X1730878X"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2017.08.014","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2017.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}