{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:32:06Z","timestamp":1793035926895,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"publisher","award":["UMO-2015\/19\/D\/NZ3\/00273"],"award-info":[{"award-number":["UMO-2015\/19\/D\/NZ3\/00273"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"publisher","award":["UMO-2015\/17\/B\/NZ3\/01040"],"award-info":[{"award-number":["UMO-2015\/17\/B\/NZ3\/01040"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.fitote.2019.02.020","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T02:55:26Z","timestamp":1551236126000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Therapeutic potential of monoterpene \u03b1-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro"],"prefix":"10.1016","volume":"134","author":[{"given":"Maciej","family":"Pude\u0142ek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Catapano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Kochanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Mrowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Janik-Olchawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Czy\u017c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Ryszawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2019.02.020_bb0005","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fitote.2019.02.020_bb0010","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/neuonc\/not239","article-title":"Sustained elevation of snail promotes glial-mesenchymal transition after irradiation in malignant glioma","volume":"16","author":"Mahabir","year":"2014","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.fitote.2019.02.020_bb0015","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1093\/carcin\/bgu033","article-title":"Functional links between Snail-1 and Cx43 account for the recruitment of Cx43-positive cells into the invasive front of prostate cancer","volume":"35","author":"Ryszawy","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fitote.2019.02.020_bb0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000086183","article-title":"Mechanisms of drug resistance in cancer chemotherapy","volume":"1","author":"Luqmani","year":"2005","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.fitote.2019.02.020_bb0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2001-1326-2-3","article-title":"Mechanisms of chemoresistance in cancer stem cells","volume":"2","author":"Abdullah","year":"2013","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.fitote.2019.02.020_bb0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12935-015-0221-1","article-title":"Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp","volume":"15","author":"Alfarouk","year":"2015","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.fitote.2019.02.020_bb0035","series-title":"Molecular Biology of the Cell","author":"Alberts","year":"2002"},{"key":"10.1016\/j.fitote.2019.02.020_bb0040","first-page":"464","article-title":"Cancer cells acquire resistance to anticancer drugs: an update","volume":"35","author":"Lu","year":"2012","journal-title":"Biom. J."},{"key":"10.1016\/j.fitote.2019.02.020_bb0045","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/j.talanta.2011.08.034","article-title":"Analysis of anticancer drugs: a review","volume":"85","author":"Nussbaumer","year":"2011","journal-title":"Talanta."},{"key":"10.1016\/j.fitote.2019.02.020_bb0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.semcancer.2012.03.002","article-title":"Cancer stem cells and metastasis","volume":"22","author":"Sampieri","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0055","doi-asserted-by":"crossref","first-page":"8169","DOI":"10.3390\/ijms15058169","article-title":"Cancer stem cells: biological functions and therapeutically targeting","volume":"15","author":"Ciurea","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2019.02.020_bb0060","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ijc.20620","article-title":"Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro","volume":"114","author":"Czyz","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.fitote.2019.02.020_bb0065","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cbi.2013.08.003","article-title":"Triterpene saponosides from Lysimachia ciliata differentially attenuate invasive potential of prostate cancer cells","volume":"206","author":"Koczurkiewicz","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fitote.2019.02.020_bb0070","doi-asserted-by":"crossref","first-page":"953451","DOI":"10.1155\/2014\/953451","article-title":"Antitumor activity of monoterpenes found in essential oils","volume":"2014","author":"Sobral","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.fitote.2019.02.020_bb0075","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3390\/molecules21080931","article-title":"Capsaicin: from plants to a cancer-suppressing agent","volume":"21","author":"Chapa-Oliver","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.fitote.2019.02.020_bb0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/JEP.S70568","article-title":"New insights into therapeutic activity and anticancer properties of curcumin","volume":"9","author":"Panda","year":"2017","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0085","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.surneu.2007.07.040","article-title":"Preliminary results from a phase I\/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas","volume":"70","author":"da Fonseca","year":"2008","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0090","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1111\/j.1742-4658.2010.07629.x","article-title":"Effects of thymoquinone on isolated and cellular proteasomes","volume":"277","author":"Cecarini","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.fitote.2019.02.020_bb0095","doi-asserted-by":"crossref","first-page":"e12124","DOI":"10.1371\/journal.pone.0012124","article-title":"Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells","volume":"5","author":"Gurung","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.fitote.2019.02.020_bb0100","series-title":"American Materia Medica, Therapeutics and Pharmacognosy","author":"Ellingwood","year":"1919"},{"key":"10.1016\/j.fitote.2019.02.020_bb0105","series-title":"King's American Dispensatory","author":"Felter","year":"1898"},{"key":"10.1016\/j.fitote.2019.02.020_bb0110","series-title":"Herbal Medicine, Healing & Cancer: A Comprehensive Program for Prevention and Treatment","author":"Yance","year":"1999"},{"key":"10.1016\/j.fitote.2019.02.020_bb0115","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1746-4269-10-16","article-title":"Ethnomedicine use in the war affected region of Northwest Pakistan","volume":"10","author":"Adnan","year":"2014","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.fitote.2019.02.020_bb0120","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1073\/pnas.070042397","article-title":"Alph\u03b1-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification","volume":"97","author":"H\u00f6ld","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fitote.2019.02.020_bb0125","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1746-4269-5-5","article-title":"Arginine, scurvy and Cartier's \u201ctree of life\u201d","volume":"5","author":"Durzan","year":"2009","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.fitote.2019.02.020_bb0130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ecam\/neh065","article-title":"Thuja occidentalis (Arbor vitae): a review of its pharmaceutical, pharmacological and clinical properties","volume":"2","author":"Naser","year":"2005","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.fitote.2019.02.020_bb0135","author":"Scientific Committee on Food"},{"key":"10.1016\/j.fitote.2019.02.020_bb0140","author":"Amberg-M\u00fcller"},{"key":"10.1016\/j.fitote.2019.02.020_bb0145","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.yrtph.2010.08.012","article-title":"Risk assessment of thujone in foods and medicines containing sage and wormwood - evidence for a need of regulatory changes?","volume":"58","author":"Lachenmeier","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0150","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.yrtph.2012.11.002","article-title":"Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment","volume":"65","author":"Pelkonen","year":"2013","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0155","doi-asserted-by":"crossref","first-page":"e1700102","DOI":"10.1002\/cbdv.201700102","article-title":"Salvia officinalis L. essential oils from Spain: determination of composition, antioxidant capacity, antienzymatic, and antimicrobial bioactivities","volume":"14","author":"Cutillas","year":"2017","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.fitote.2019.02.020_bb0160","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.micpath.2018.02.026","article-title":"Essential oils from Origanum vulgare and Salvia officinalis exhibit antibacterial and anti-biofilm activities against Streptococcus pyogenes","volume":"117","author":"Wijesundara","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fitote.2019.02.020_bb0165","series-title":"Committee of Experts on Flavouring Substances. Natural Sources of Flavourings- Report No","year":"2008"},{"key":"10.1016\/j.fitote.2019.02.020_bb0170","first-page":"1","article-title":"Toxicology and carcinogenesis studies of alpha, bet\u03b1-thujone (CAS no. 76231-76-0) in F344\/N rats and B6C3F1 mice (gavage studies)","volume":"570","author":"National Toxicology Program","year":"2011","journal-title":"Natl. Toxicol. Program Tech. Rep. Ser."},{"key":"10.1016\/j.fitote.2019.02.020_bb0175","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3109\/15563658108990357","article-title":"Toxicity of some essential plant oils. Clinical and experimental study","volume":"18","author":"Millet","year":"1981","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0180","unstructured":"EMEA- The European Agency for the Evaluation of Medicinal Products, 1999. Committee for veterinary Medicinal Products- Thuja occidentalis. https:\/\/www.ema.europa.eu\/documents\/mrl-report\/thuja-occidentalis-summary-report-committee-veterinary-medicinal-products_en.pdf."},{"key":"10.1016\/j.fitote.2019.02.020_bb0185","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/253365a0","article-title":"Marijuana, absinthe and the central nervous system","volume":"253","author":"del Castillo","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.fitote.2019.02.020_bb0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.32725\/jab.2003.036","article-title":"Pharmacology and toxicology of absinthe","volume":"1","author":"Pato\u010dka","year":"2003","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.fitote.2019.02.020_bb0195","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jep.2015.03.029","article-title":"Thuja occidentalis L. and its active compound, \u03b1-thujone: promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis","volume":"168","author":"K\u00fcpeli Akkol","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11060-016-2076-2","article-title":"Pro-apoptotic and anti-angiogenic properties of the \u03b1 \/\u03b2-thujone fraction from Thuja occidentalis on glioblastoma cells","volume":"128","author":"Torres","year":"2016","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.intimp.2015.11.027","article-title":"Enhancement of CD3AK cell proliferation and killing ability by \u03b1-Thujone","volume":"30","author":"Zhou","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0210","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1139\/y11-067","article-title":"Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL\/6 mice","volume":"89","author":"Siveen","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0215","doi-asserted-by":"crossref","DOI":"10.1093\/ecam\/neq042","article-title":"Thujone-rich fraction of Thuja occidentalis demonstrates major anti-cancer potentials: evidences from in vitro studies on A375 cells","volume":"2011","author":"Biswas","year":"2011","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.fitote.2019.02.020_bb0220","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3892\/or.2013.2323","volume":"29","author":"Musialik","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.fitote.2019.02.020_bb0225","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1042\/BC20070024","article-title":"Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells","volume":"99","author":"Sroka","year":"2007","journal-title":"Biol. Cell."},{"key":"10.1016\/j.fitote.2019.02.020_bb0230","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/ptr.3168","article-title":"In vitro and ex vivo antiangiogenic activity of Salvia officinalis","volume":"24","author":"Keshavarz","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fitote.2019.02.020_bb0235","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1021\/np200863q","article-title":"Modulation of GABAergic synaptic currents and current responses by \u03b1-thujone and dihydroumbellulone","volume":"75","author":"Szczot","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fitote.2019.02.020_bb0240","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fimmu.2016.00156","article-title":"Role of redox status in development of glioblastoma","volume":"7","author":"Salazar-Ramiro","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0245","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1258\/ebm.2010.009369","article-title":"Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species","volume":"235","author":"Koka","year":"2010","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.fitote.2019.02.020_bb0250","article-title":"Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular uptake and activationof ROS-mediated DNA damage","volume":"8","author":"Su","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fitote.2019.02.020_bb0255","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/0748233713484660","article-title":"Potential anticancer activity of carvone in N2a neuroblastoma cell line","volume":"31","author":"Ayd\u0131n","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.fitote.2019.02.020_bb0260","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cbi.2009.02.012","article-title":"Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels","volume":"180","author":"Usta","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fitote.2019.02.020_bb0265","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000264627","article-title":"Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24","volume":"77","author":"Li","year":"2009","journal-title":"Oncology"},{"key":"10.1016\/j.fitote.2019.02.020_bb0270","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2174\/1570159X14666160121115641","article-title":"Mitochondrial dysfunction in gliomas: pharmacotherapeutic potential of natural compounds","volume":"14","author":"Guntuku","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0275","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/bi051840z","article-title":"Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes","volume":"45","author":"Jiang","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.fitote.2019.02.020_bb0280","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fitote.2019.02.020_bb0285","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/00498254.2010.528066","article-title":"Metabolism of alph\u03b1-thujone in human hepatic preparations in vitro","volume":"41","author":"Abass","year":"2011","journal-title":"Xenobiotica."},{"key":"10.1016\/j.fitote.2019.02.020_bb0290","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/bs.apha.2015.03.003","article-title":"Involvement of cytochrome P450 in reactive oxygen species formation and cancer","volume":"74","author":"Hrycay","year":"2015","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.fitote.2019.02.020_bb0295","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1089\/ars.2008.2270","article-title":"Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment","volume":"11","author":"Azad","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.fitote.2019.02.020_bb0300","first-page":"145","article-title":"Reactive oxygen species in regulation of cell migration. The role of thioredoxin reductase","volume":"55","author":"Sroka","year":"2009","journal-title":"Postepy Biochem."},{"key":"10.1016\/j.fitote.2019.02.020_bb0305","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signaling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fitote.2019.02.020_bb0310","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.3171\/2014.12.FOCUS14758","article-title":"Therapeutic strategies to improve drug delivery across the blood-brain barrier","volume":"38","author":"Azad","year":"2015","journal-title":"Neurosurg. Focus."},{"key":"10.1016\/j.fitote.2019.02.020_bb0315","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.2147\/IJN.S117210","article-title":"Getting into the brain: liposome-based strategies for effective drug delivery across the blood-brain barrier","volume":"18","author":"Vieira","year":"2016","journal-title":"Int. J. Nanomedicine"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19301121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19301121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:21:11Z","timestamp":1759796471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X19301121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":63,"alternative-id":["S0367326X19301121"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2019.02.020","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of monoterpene \u03b1-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2019.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}