{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:58:47Z","timestamp":1773273527002,"version":"3.50.1"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006250","name":"Southwest University","doi-asserted-by":"publisher","award":["SZ201703"],"award-info":[{"award-number":["SZ201703"]}],"id":[{"id":"10.13039\/501100006250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006250","name":"Southwest University","doi-asserted-by":"publisher","award":["HZ201601"],"award-info":[{"award-number":["HZ201601"]}],"id":[{"id":"10.13039\/501100006250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["XDJK2017D160"],"award-info":[{"award-number":["XDJK2017D160"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.fitote.2019.03.003","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T10:49:02Z","timestamp":1551523742000},"page":"210-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine"],"prefix":"10.1016","volume":"134","author":[{"given":"Hang","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuegang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0005","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5603\/IMH.2016.0039","article-title":"Knowledge, attitudes, and related practices of Filipino seafarers regarding cardiovascular diseases","volume":"67","author":"Jr","year":"2016","journal-title":"Int Marit Health."},{"key":"10.1016\/j.fitote.2019.03.003_bb0010","first-page":"1","article-title":"Communication-based influence components model","author":"Cugelman","year":"2009","journal-title":"New York Acm."},{"issue":"11","key":"10.1016\/j.fitote.2019.03.003_bb0015","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.3390\/molecules22111867","article-title":"Study of absorption characteristics of the total saponins from Radix Ilicis Pubescentis in an in situ single-pass intestinal perfusion (SPIP) rat model by using ultra performance liquid chromatography (UPLC)","volume":"22","author":"Kuang","year":"2017","journal-title":"Molecules."},{"issue":"9","key":"10.1016\/j.fitote.2019.03.003_bb0020","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1021\/acs.molpharmaceut.7b00505","article-title":"Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in treating rheumatoid arthritis","volume":"14","author":"Wang","year":"2017","journal-title":"Mol. Pharm."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0025","doi-asserted-by":"crossref","first-page":"254","DOI":"10.6061\/clinics\/2017(04)10","article-title":"Theoretical basis, application, reliability, and sample size estimates of a Meridian energy analysis device for traditional Chinese medicine research","volume":"72","author":"Tsai","year":"2017","journal-title":"Clinics."},{"key":"10.1016\/j.fitote.2019.03.003_bb0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.trac.2017.09.008","article-title":"Techniques for biological fingerprinting of traditional Chinese medicine","volume":"97","author":"Tao","year":"2017","journal-title":"TrAC Trends Anal. Chem."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0035","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/bcp.12598","article-title":"An overview on adverse drug reactions to traditional Chinese medicines","volume":"80","author":"Chan","year":"2015","journal-title":"Brit. J. Clin. Pharmaco."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0040","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jep.2012.01.058","article-title":"Pharmacovigilance practice and risk control of traditional Chinese medicine drugs in China: current status and future perspective","volume":"140","author":"Zhang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/rcm.7990","article-title":"Metabolic profile of Rhizoma coptidis in human plasma determined using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry","volume":"32","author":"Zhang","year":"2018","journal-title":"Rapid. Commun. Mass Sp."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0050","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/chromsci\/bmx009","article-title":"Determination of alkaloid contents in various tissues of Coptis chinensis franch. By reversed phase-high performance liquid chromatography and ultraviolet spectrophotometry","volume":"55","author":"Yang","year":"2017","journal-title":"J. Chromatogr. Sci."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fitote.2013.10.010","article-title":"Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis","volume":"92","author":"Yang","year":"2014","journal-title":"Fitoterapia."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0060","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1463-1326.2010.01336.x","article-title":"Diabetes is an inflammatory disease: evidence from traditional Chinese medicines","volume":"13","author":"Xie","year":"2015","journal-title":"Diabetes. Obes. Metab."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0065","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ddr.21302","article-title":"Antihyperglycemia and Antihyperlipidemia effect of protoberberine alkaloids from Rhizoma Coptidis in HepG2 cell and diabetic KK-ay mice","volume":"77","author":"Ma","year":"2016","journal-title":"Drug Dev. Res."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jep.2009.08.009","article-title":"Berberine and Coptidis Rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations","volume":"126","author":"Tang","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0075","first-page":"798093","article-title":"The Antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological research","volume":"2014","author":"Hui","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0080","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s11418-018-1209-7","article-title":"Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production","volume":"72","author":"Oshima","year":"2018","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.fitote.2019.03.003_bb0085","first-page":"1","article-title":"Effect of Rhizoma coptidis (Huang Lian) on treating diabetes mellitus","volume":"2015","author":"Pang","year":"2015","journal-title":"Evid-Based Compl. Alt."},{"key":"10.1016\/j.fitote.2019.03.003_bb0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.biopha.2018.01.007","article-title":"Effects of Berberine chloride on the liver of streptozotocin-induced diabetes in albino Wistar rats","volume":"99","author":"Chandirasegaran","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0095","doi-asserted-by":"crossref","first-page":"11015","DOI":"10.1038\/s41598-017-10296-z","article-title":"Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls","volume":"7","author":"Henquin","year":"2017","journal-title":"Sci. Rep.UK."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0100","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/03009734.2016.1156789","article-title":"Glucagon secretion from pancreatic \u03b1-cells","volume":"121","author":"Linford","year":"2016","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.fitote.2019.03.003_bb0105","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.mce.2017.09.002","article-title":"Impaired insulin signaling upon loss of ovarian function is associated with a reduction of tristetraprolin and an increased stabilization of chemokine in adipose tissue","volume":"461","author":"Choi","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"issue":"9","key":"10.1016\/j.fitote.2019.03.003_bb0110","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.molmet.2016.05.016","article-title":"Gut microbiota and immune crosstalk in metabolic disease","volume":"5","author":"Burcelin","year":"2016","journal-title":"Mol. Metab."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0115","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/jcb.26261","article-title":"A shared comparison of diabetes mellitus and neurodegenerative disorders","volume":"119","author":"Morsi","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/dmrr.2644","article-title":"Anti-diabetic and neuroprotective effects of pancreatic islet transplantation in the central nervous system","volume":"32","author":"Lazard","year":"2016","journal-title":"Diabetes\/Metab. Res. Rev."},{"issue":"10","key":"10.1016\/j.fitote.2019.03.003_bb0125","first-page":"607","article-title":"Molecular mechanisms of insulin resistance","volume":"79","author":"Pillay","year":"1991","journal-title":"S. Afr. Med. J. = Suid-Afrikaanse tydskrif vir geneeskunde"},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0130","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"CELL."},{"issue":"10","key":"10.1016\/j.fitote.2019.03.003_bb0135","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1507\/endocrj.K10E-043","article-title":"Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR\u03b1 and PPAR\u03b1 transcriptional programs","volume":"57","author":"Liu","year":"2010","journal-title":"Endocr. J."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.metabol.2008.08.013","article-title":"Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression","volume":"58","author":"Kong","year":"2009","journal-title":"Metab. Clin. Exp."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0145","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ejphar.2011.07.036","article-title":"Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver","volume":"668","author":"Xing","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0150","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2337\/diabetes.54.3.657","article-title":"The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes","volume":"54","author":"Ozawa","year":"2005","journal-title":"Diabetes."},{"issue":"12","key":"10.1016\/j.fitote.2019.03.003_bb0155","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1074\/jbc.275.12.9047","article-title":"The c-Jun NH2 -terminal kinase promotes insulin resistance during association with insulin receptor Substrate-1 and phosphorylation of Ser307","volume":"275","author":"Aguirre","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0160","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/aps.2010.30","article-title":"Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells","volume":"31","author":"Wang","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"S3","key":"10.1016\/j.fitote.2019.03.003_bb0165","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/sj.ijo.0802502","article-title":"Inflammatory pathways and insulin action","volume":"27","author":"Hotamisligil","year":"2003","journal-title":"Int. J. Obes."},{"issue":"386","key":"10.1016\/j.fitote.2019.03.003_bb0170","doi-asserted-by":"crossref","first-page":"a73","DOI":"10.1126\/scisignal.aaa4374","article-title":"Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2","volume":"8","author":"Vila-Bedmar","year":"2015","journal-title":"Sci. Signal."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0175","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10753-010-9276-2","article-title":"Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes","volume":"34","author":"Lou","year":"2011","journal-title":"Inflammation."},{"key":"10.1016\/j.fitote.2019.03.003_bb0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.fitote.2015.06.005","article-title":"Coptisine attenuates obesity-related inflammation through LPS\/TLR-4-mediated signaling pathway in Syrian golden hamsters","volume":"105","author":"Zou","year":"2015","journal-title":"Fitoterapia."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0185","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.3892\/mmr.2016.5634","article-title":"Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model","volume":"14","author":"Yang","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0190","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/db07-1552","article-title":"Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action","volume":"57","author":"Turner","year":"2008","journal-title":"Diabetes."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/B:REMD.0000021433.63915.bb","article-title":"AMP-activated protein kinase: a master switch in glucose and lipid metabolism","volume":"5","author":"Hardie","year":"2004","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"8","key":"10.1016\/j.fitote.2019.03.003_bb0200","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.metabol.2013.02.007","article-title":"Berberine improves insulin resistance in cardiomyocytes via activation of 5\u2032-adenosine monophosphate-activated protein kinase","volume":"62","author":"Chang","year":"2013","journal-title":"Metab-clin. Exp."},{"issue":"8","key":"10.1016\/j.fitote.2019.03.003_bb0205","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","article-title":"Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states","volume":"55","author":"Lee","year":"2006","journal-title":"Diabetes."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0210","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbadis.2011.10.008","article-title":"Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis","volume":"1822","author":"Gomes","year":"2012","journal-title":"BBA \u2013 Mol. Basis Dis."},{"issue":"1\u20132","key":"10.1016\/j.fitote.2019.03.003_bb0215","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mce.2009.12.027","article-title":"Berberine modulates insulin signaling transduction in insulin-resistant cells","volume":"317","author":"Liu","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"issue":"12","key":"10.1016\/j.fitote.2019.03.003_bb0220","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.metabol.2009.06.009","article-title":"Berberine improves free-fatty-acid\u2013induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator\u2013activated receptor \u03b3 and fatty acid transferase expressions","volume":"58","author":"Chen","year":"2009","journal-title":"Metabolism."},{"issue":"3\u20134","key":"10.1016\/j.fitote.2019.03.003_bb0225","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.phymed.2012.11.006","article-title":"Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes","volume":"20","author":"Sangeetha","year":"2013","journal-title":"Phytomedicine."},{"issue":"12","key":"10.1016\/j.fitote.2019.03.003_bb0230","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.febslet.2011.04.051","article-title":"Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes","volume":"585","author":"Li","year":"2011","journal-title":"FEBS Lett."},{"issue":"11","key":"10.1016\/j.fitote.2019.03.003_bb0235","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1074\/jbc.M207198200","article-title":"Structure-function studies of the adipocyte-secreted hormone Acrp30\/adiponectin","volume":"278","author":"Pajvani","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fitote.2019.03.003_bb0240","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.biopha.2017.03.003","article-title":"Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: a new mechanism linking berberine to insulin resistance improvement","volume":"89","author":"Zhou","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fitote.2019.03.003_bb0245","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.lfs.2016.09.025","article-title":"Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance","volume":"166","author":"Ye","year":"2016","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0250","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1248\/bpb.34.644","article-title":"Berberine-improved visceral white adipose tissue insulin resistance associated with altered sterol regulatory element-binding proteins, liver x receptors, and peroxisome proliferator-activated receptors transcriptional programs in diabetic hamsters","volume":"34","author":"Li","year":"2011","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0255","first-page":"519371","article-title":"Berberine improves glucose homeostasis in streptozotocin-induced diabetic rats in association with multiple factors of insulin resistance","volume":"2011","author":"Chen","year":"2014","journal-title":"Isrn. Endocrinol."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0260","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jep.2015.05.020","article-title":"Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies","volume":"171","author":"Choi","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0265","first-page":"336","article-title":"Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid","volume":"8","author":"Ali","year":"2013","journal-title":"Bangl. J. Pharmacol."},{"key":"10.1016\/j.fitote.2019.03.003_bb0270","doi-asserted-by":"crossref","first-page":"2039897","DOI":"10.1155\/2016\/2039897","article-title":"In vivo interrelationship between insulin resistance and interferon gamma production: protective and therapeutic effect of Berberine","volume":"2016","author":"Mahmoud","year":"2016","journal-title":"Evid-Based Compl. Alt."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0275","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.metabol.2009.07.029","article-title":"Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression","volume":"59","author":"Zhang","year":"2010","journal-title":"Metab-clin. Exp."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0280","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2337\/diabetes.51.1.66","article-title":"Cell death and mass in Syngeneically transplanted islets exposed to short- and long-term hyperglycemia","volume":"51","author":"Biarnes","year":"2002","journal-title":"Diabetes."},{"issue":"14","key":"10.1016\/j.fitote.2019.03.003_bb0285","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1021\/jf201627w","article-title":"Berberine, an Isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice","volume":"59","author":"Chueh","year":"2011","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0290","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.coph.2010.08.010","article-title":"HNF4\u03b1 \u2014 role in drug metabolism and potential drug target?","volume":"10","author":"Hwang-Verslues","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"issue":"39","key":"10.1016\/j.fitote.2019.03.003_bb0295","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.3748\/wjg.14.6004","article-title":"Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity","volume":"14","author":"Wang","year":"2008","journal-title":"World J. Gastroenterol."},{"issue":"1\u20133","key":"10.1016\/j.fitote.2019.03.003_bb0300","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejphar.2008.12.056","article-title":"Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate\/high-fat diet-induced diabetic rats","volume":"606","author":"Zhou","year":"2009","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0305","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.3892\/mmr.2017.7467","article-title":"Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin-5f cells","volume":"16","author":"Jiang","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"13","key":"10.1016\/j.fitote.2019.03.003_bb0310","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1111\/bph.12666","article-title":"Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets","volume":"171","author":"Liu","year":"2014","journal-title":"Brit. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.fitote.2019.03.003_bb0315","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.phymed.2011.05.006","article-title":"Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia","volume":"18","author":"Patel","year":"2011","journal-title":"Phytomedicine."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0320","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI30076","article-title":"The role of gut hormones in glucose homeostasis","volume":"117","author":"Drucker","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0325","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1124\/pr.108.000604","article-title":"The role of incretins in glucose homeostasis and diabetes treatment","volume":"60","author":"Kim","year":"2008","journal-title":"Pharmacol. Rev."},{"issue":"7","key":"10.1016\/j.fitote.2019.03.003_bb0330","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.bcp.2009.11.017","article-title":"Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies","volume":"79","author":"Yu","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0335","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1677\/JOE-08-0419","article-title":"Berberine promotes glucagon-like peptide-1 (7\u201336) amide secretion in streptozotocin-induced diabetic rats","volume":"200","author":"Lu","year":"2009","journal-title":"J. Endocrinol."},{"issue":"42","key":"10.1016\/j.fitote.2019.03.003_bb0340","first-page":"42","article-title":"Berberine attenuates intestinal mucosal barrier dysfunction in type 2 diabetic rats","volume":"8","author":"Gong","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0345","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/JOE-13-0184","article-title":"Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats","volume":"218","author":"Shan","year":"2013","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0350","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/1472-6882-14-188","article-title":"Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine","volume":"14","author":"Zhang","year":"2014","journal-title":"BMC Complem. Altern. M."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0355","first-page":"384","article-title":"Berberine attenuates intestinal disaccharidases in streptozotocin-induced diabetic rats","volume":"63","author":"Liu","year":"2008","journal-title":"Pharmazie."},{"issue":"5883","key":"10.1016\/j.fitote.2019.03.003_bb0360","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.1155725","article-title":"Evolution of mammals and their gut microbes","volume":"320","author":"Ley","year":"2008","journal-title":"Science."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0365","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.diabet.2014.02.004","article-title":"Glucose metabolism: focus on gut microbiota, the endocannabinoid system and beyond","volume":"40","author":"Cani","year":"2014","journal-title":"Diabetes Metab."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0370","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like Peptide-1 secretion via the G-protein\u2013coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035240","article-title":"Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.fitote.2019.03.003_bb0380","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice","volume":"58","author":"Gao","year":"2009","journal-title":"DIABETES."},{"issue":"8","key":"10.1016\/j.fitote.2019.03.003_bb0385","article-title":"Structural changes of gut microbiota during Berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.fitote.2019.03.003_bb0390","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.metabol.2017.02.003","article-title":"Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism","volume":"70","author":"Wang","year":"2017","journal-title":"Metabolism."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0395","first-page":"197","article-title":"Modulation of gut microbiota by Berberine improves steatohepatitis in high-fat diet-fed BALB\/C mice","volume":"19","author":"Cao","year":"2016","journal-title":"Arch. Iran Med."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0400","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12906-016-1367-7","article-title":"Dose-response effect of berberine on bile acid profile and gut microbiota in mice","volume":"16","author":"Guo","year":"2016","journal-title":"BMC Complem. Altern. M."},{"issue":"08","key":"10.1016\/j.fitote.2019.03.003_bb0405","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1055\/s-0043-125066","article-title":"Berberine modulates gut microbiota and reduces insulin resistance via the TLR4 signaling pathway","volume":"126","author":"Liu","year":"2018","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0410","first-page":"9365","article-title":"Berberine ameliorates type 2 diabetes via modulation of Bifidobacterium species, tumor necrosis factor-\u03b1, and lipopolysaccharide","volume":"9","author":"Chen","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0415","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000449507","article-title":"Modulation of microbiota-gut-brain Axis by Berberine resulting in improved metabolic status in high-fat diet-fed rats","volume":"9","author":"Sun","year":"2017","journal-title":"Obes. Facts"},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0420","doi-asserted-by":"crossref","first-page":"12155","DOI":"10.1038\/srep12155","article-title":"Transforming berberine into its intestine-absorbable form by the gut microbiota","volume":"5","author":"Feng","year":"2015","journal-title":"Sci. Rep-UK."},{"issue":"6865","key":"10.1016\/j.fitote.2019.03.003_bb0425","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0430","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiol. Rev."},{"issue":"3_suppl_1","key":"10.1016\/j.fitote.2019.03.003_bb0435","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1681\/ASN.2004110970","article-title":"Pathogenetic mechanisms of diabetic nephropathy","volume":"16","author":"Schena","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"Suppl. 2","key":"10.1016\/j.fitote.2019.03.003_bb0440","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2337\/diab.32.2.S64","article-title":"The stages of diabetic renal disease : with emphasis on the stage of incipient diabetic nephrophaty","volume":"32","author":"Mogensen","year":"1983","journal-title":"Diabetes."},{"issue":"12","key":"10.1016\/j.fitote.2019.03.003_bb0445","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0450","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.2013.81","article-title":"Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-\u03b21 signaling","volume":"84","author":"Ueno","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.fitote.2019.03.003_bb0455","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ejphar.2015.07.040","article-title":"Renoprotective effects of berberine through regulation of the MMPs\/TIMPs system in streptozocin-induced diabetic nephropathy in rats","volume":"764","author":"Ni","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.fitote.2019.03.003_bb0460","first-page":"L1006","article-title":"Matrix metalloproteinase-9 activates TGF-\u03b2 and stimulates fibroblast contraction of collagen gels","volume":"306","author":"Kobayashi","year":"2014","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0465","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease","volume":"75","author":"Raffetto","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0470","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2337\/diab.37.6.688","article-title":"Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?","volume":"37","author":"Greene","year":"1988","journal-title":"Diabetes."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0475","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.abb.2008.04.022","article-title":"Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose","volume":"475","author":"Liu","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"issue":"12","key":"10.1016\/j.fitote.2019.03.003_bb0480","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1210\/me.2011-0095","article-title":"Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells","volume":"25","author":"Lan","year":"2011","journal-title":"Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.fitote.2019.03.003_bb0485","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043874","article-title":"Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models","volume":"7","author":"Huang","year":"2012","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0490","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.abb.2010.07.012","article-title":"Berberine ameliorates renal injury in diabetic C57BL\/6 mice: involvement of suppression of SphK\u2013S1P signaling pathway","volume":"502","author":"Lan","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.fitote.2019.03.003_bb0495","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.yexcr.2016.06.005","article-title":"Berberine attenuates high glucose-induced fibrosis by activating the G protein-coupled bile acid receptor TGR5 and repressing the S1P2\/MAPK signaling pathway in glomerular mesangial cells","volume":"346","author":"Yang","year":"2016","journal-title":"Exp. Cell Res."},{"issue":"1\u20133","key":"10.1016\/j.fitote.2019.03.003_bb0500","first-page":"165","article-title":"Berberine suppresses high glucose-induced TGF-\u03b21 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1\/AP-1 pathway","volume":"697","author":"Tian","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"19","key":"10.1016\/j.fitote.2019.03.003_bb0505","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1073\/pnas.91.19.8807","article-title":"Receptor for advanced glycation end products (AGEs) has a central role in Vessel Wall interactions and gene activation in response to circulating AGE proteins","volume":"91","author":"Schmidt","year":"1994","journal-title":"P. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.fitote.2019.03.003_bb0510","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2017.01.009","article-title":"Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy","volume":"443","author":"Qiu","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0515","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/hep.26965","article-title":"Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis","volume":"59","author":"Afford","year":"2014","journal-title":"Hepatology."},{"issue":"41","key":"10.1016\/j.fitote.2019.03.003_bb0520","doi-asserted-by":"crossref","first-page":"14710","DOI":"10.1073\/pnas.1408556111","article-title":"ICAM-1 as a molecular target for triple negative breast cancer","volume":"111","author":"Guo","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0525","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1046\/j.1365-2559.1996.d01-471.x","article-title":"Expression of adhesion molecules and extracellular matrix proteins in glioblastomas: relation to angiogenesis and spread","volume":"28","author":"Vitolo","year":"2010","journal-title":"Histopathology."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0530","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/1753-0407.12349","article-title":"Renoprotective effects of berberine and its potential effect on the expression of \u03b2-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic nephropathy rats","volume":"8","author":"Tang","year":"2016","journal-title":"J Diabetes."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0535","first-page":"1073","article-title":"Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation","volume":"443","author":"Molteni","year":"2018","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0540","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1478-811X-11-37","article-title":"The C-terminus region of \u03b2-arrestin1 modulates VE-cadherin expression and endothelial cell permeability","volume":"11","author":"Hebda","year":"2013","journal-title":"Cell. Commun. Signal."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0545","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s10157-013-0781-0","article-title":"Role of the endothelial-to-mesenchymal transition in renal fibrosis of;chronic kidney disease","volume":"17","author":"Xu","year":"2013","journal-title":"Clin. Exp. Nephrol."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0550","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ki.2010.172","article-title":"Expression of notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function","volume":"78","author":"Murea","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.fitote.2019.03.003_bb0555","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2147\/DDDT.S124971","article-title":"Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the notch\/snail pathway in diabetic nephropathy model KKAy mice","volume":"11","author":"Yang","year":"2017","journal-title":"Drug. Des. Dev. Ther."},{"issue":"13278","key":"10.1016\/j.fitote.2019.03.003_bb0560","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3390\/ijms17081327","article-title":"Protective effects of Berberine on renal injury in Streptozotocin (STZ)-induced diabetic mice","volume":"17","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0565","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/1440-1681.12402","article-title":"Renoprotective effect of berberine on type 2 diabetic nephropathy in rats","volume":"42","author":"Sun","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0570","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3923\/ijp.2017.247.256","article-title":"Renoprotective effect of Berberine on Streptozotocin-inducedDiabetic nephropathy rats","volume":"13","author":"Wu","year":"2017","journal-title":"Int. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.fitote.2019.03.003_bb0575","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejphar.2010.04.033","article-title":"Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury","volume":"638","author":"Liu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0580","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/FJC.0b013e3182a3718f","article-title":"Rho kinases in cardiovascular physiology and pathophysiology","volume":"62","author":"Shi","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"12","key":"10.1016\/j.fitote.2019.03.003_bb0585","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0962-8924(01)02153-5","article-title":"Rho family proteins: coordinating cell responses","volume":"11","author":"Ridley","year":"2001","journal-title":"Trends Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.fitote.2019.03.003_bb0590","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mce.2013.07.019","article-title":"Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA\/ROCK signaling","volume":"381","author":"Xie","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"issue":"9","key":"10.1016\/j.fitote.2019.03.003_bb0595","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ki.2011.263","article-title":"Cyclooxygenase-2 in the kidney: good, BAD, or both?","volume":"80","author":"Russ Price","year":"2011","journal-title":"Kidney Int."},{"issue":"21","key":"10.1016\/j.fitote.2019.03.003_bb0600","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1111\/bph.12815","article-title":"Multiple roles of the PGE2-EP receptor signal in vascular permeability","volume":"171","author":"Omori","year":"2015","journal-title":"Brit. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0605","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/bph.12560","article-title":"Vascular targets for cannabinoids: animal and human studies","volume":"171","author":"Stanley","year":"2014","journal-title":"Brit. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.fitote.2019.03.003_bb0610","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/jcmm.12837","article-title":"Renoprotective effect of berberinevia regulating the PGE2 -EP1-G\u03b1q-Ca2+ signalling pathway in glomerular mesangial cells of diabetic rats","volume":"20","author":"Ni","year":"2016","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.fitote.2019.03.003_bb0615","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1007\/s11033-014-3196-4","article-title":"Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy","volume":"41","author":"Tang","year":"2014","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.fitote.2019.03.003_bb0620","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s11033-012-2321-5","article-title":"Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats","volume":"40","author":"Wang","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0625","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1007\/s11033-012-2468-0","article-title":"Berberine ameliorates renal injury by regulating G proteins-AC- cAMP;signaling in diabetic rats with nephropathy","volume":"40","author":"Tang","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"8\u20139","key":"10.1016\/j.fitote.2019.03.003_bb0630","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.phymed.2012.03.003","article-title":"Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin","volume":"19","author":"Wu","year":"2012","journal-title":"Phytomedicine."},{"issue":"11","key":"10.1016\/j.fitote.2019.03.003_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113398","article-title":"Berberine improves kidney function in diabetic mice via AMPK activation","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.fitote.2019.03.003_bb0640","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s10495-016-1234-5","article-title":"Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase\/Akt-dependent mechanism","volume":"21","author":"Zhang","year":"2016","journal-title":"Apoptosis."},{"issue":"20 Suppl","key":"10.1016\/j.fitote.2019.03.003_bb0645","first-page":"S635","article-title":"The metabolic syndrome, type 2 diabetes, and cardiovascular disease: understanding the role of insulin resistance","volume":"8","author":"Kendall","year":"2002","journal-title":"Am. J. Manag. Care"},{"issue":"4","key":"10.1016\/j.fitote.2019.03.003_bb0650","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tips.2005.02.007","article-title":"The efficiency of multi-target drugs: the network approach might help drug design","volume":"26","author":"Csermely","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.fitote.2019.03.003_bb0655","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.bbadis.2016.06.006","article-title":"Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways","volume":"1862","author":"He","year":"2016","journal-title":"Biochim. Biophys. Acta"}],"updated-by":[{"DOI":"10.1016\/j.fitote.2019.104451","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000}}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19301042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19301042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T10:41:05Z","timestamp":1565174465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X19301042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":131,"alternative-id":["S0367326X19301042"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2019.03.003","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.fitote.2019.104451","asserted-by":"object"}]},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2019.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}