{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:51:14Z","timestamp":1777870274770,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["ZDY-2017-97"],"award-info":[{"award-number":["ZDY-2017-97"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.fitote.2019.104299","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T02:01:00Z","timestamp":1565316060000},"page":"104299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["8-methoxysmyrindiol from Gerbera piloselloides (L.) Cass. and its vasodilation effects on isolated rat mesenteric arteries"],"prefix":"10.1016","volume":"138","author":[{"given":"Fa","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huicong","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2019.104299_bb0005","first-page":"137","article-title":"A revision of Gerbera L. ex Cass. (s. lat.) and its distribution in China","volume":"24","author":"Wu","year":"2002","journal-title":"Acta Bot. Yunnanica"},{"key":"10.1016\/j.fitote.2019.104299_bb0010","first-page":"426","article-title":"The antitussive and de-sputum essential substance from the root of Gerbera piloselloides and its analytical compositions","volume":"28","author":"Tang","year":"2003","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"key":"10.1016\/j.fitote.2019.104299_bb0015","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1107\/S010827010301864X","article-title":"Dibothrioclinin I and II, epimers from Gerbera piloselloides (L.) Cass","volume":"59","author":"Wang","year":"2003","journal-title":"Acta Crystallogr. C"},{"key":"10.1016\/j.fitote.2019.104299_bb0020","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1248\/cpb.52.1362","article-title":"Two novel dicoumaro-p-menthanes from Gerbera piloselloides (L.) CASS","volume":"52","author":"Xiao","year":"2004","journal-title":"Chem. Pharm. Bull. (Tokyo)."},{"key":"10.1016\/j.fitote.2019.104299_bb0025","first-page":"109","article-title":"Studies on chemical constituents from Gerbera piloselloides","volume":"34","author":"Xiao","year":"2003","journal-title":"Tradit. Herb. Drugs"},{"key":"10.1016\/j.fitote.2019.104299_bb0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1248\/yakushi1947.110.6_374","article-title":"Pharmacognostical studies on the folk medicine in Sichuan Prov. in China. II. On tu-er-feng derived from Gerbera plants","volume":"110","author":"Ye","year":"1990","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.fitote.2019.104299_bb0035","first-page":"744","article-title":"Studies on antibacterial constituents from Gerbera anandria (L.)SchBip. IV","volume":"10","author":"Gu","year":"1989","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.fitote.2019.104299_bb0040","first-page":"51","article-title":"The progress of chemical and pharmacological studies on Gerbera L. ex Cass","volume":"14","author":"Xiao","year":"2002","journal-title":"Nat. Prod. Res. Dev."},{"key":"10.1016\/j.fitote.2019.104299_bb0045","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1080\/14786419.2014.924000","article-title":"Antioxidants from Gerbera piloselloides: an ethnomedicinal plant from southwestern China","volume":"28","author":"Wang","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.fitote.2019.104299_bb0050","first-page":"944","article-title":"Analysis of volatile oil from Gerbera piloselloides by GC-MS","volume":"36","author":"Luo","year":"2013","journal-title":"Zhong Yao Cai."},{"key":"10.1016\/j.fitote.2019.104299_bb0055","first-page":"1037","article-title":"Small artery structure and function in hypertension","volume":"14","author":"Heagerty","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.fitote.2019.104299_bb0060","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1001\/jama.2017.15519","article-title":"Excessive weight gain, obesity, and cancer: opportunities for clinical intervention","volume":"318","author":"Massetti","year":"2017","journal-title":"JAMA."},{"key":"10.1016\/j.fitote.2019.104299_bb0065","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0165-1838(00)00113-2","article-title":"Role of gap junctions in acetylcholine-induced vasodilation of proximal and distal arteries of the rat mesentery","volume":"81","author":"Hill","year":"2000","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.fitote.2019.104299_bb0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/13880209.2018.1446031","article-title":"Vascular mechanisms underlying the hypotensive effect of Rumexacetosa","volume":"56","author":"Hafiz","year":"2018","journal-title":"Pharm. Biol."},{"issue":"5","key":"10.1016\/j.fitote.2019.104299_bb0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1034\/j.1600-0781.2002.02770.x","article-title":"Photochemotherapy of vascular cells with 8-methoxypsoralen and visible light: differential effects on endothelial and smooth muscle cells","author":"Lee","year":"2002","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.fitote.2019.104299_bb0080","first-page":"2126","article-title":"Ultraviolet light and 8-methoxypsoralen inhibit expression of endothelial adhesion molecules","volume":"11","author":"Laing","year":"1995","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.fitote.2019.104299_bb0085","first-page":"289","article-title":"Phototoxic effects of 8-methoxypsoralen on rabbit corneal endothelium","volume":"1-2","author":"Menon","year":"1989","journal-title":"Lens Eye Toxic Res."},{"key":"10.1016\/j.fitote.2019.104299_bb0090","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/hr.2008.33","article-title":"An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein","volume":"32","author":"Kamata","year":"2009","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.fitote.2019.104299_bb0095","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.pharep.2018.02.017","article-title":"KMUP-1 protects against streptozotocin-induced mesenteric artery dysfunction via activation of ATP-sensitive potassium channels","volume":"70","author":"Lee","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.fitote.2019.104299_bb0100","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejphar.2018.05.006","article-title":"SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries","volume":"831","author":"Rayan","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fitote.2019.104299_bb0105","first-page":"R821","article-title":"The roles of KCa, KATP, and KV channels in regulating cutaneous vasodilation and sweating during exercise in the heat","volume":"312","author":"Louie","year":"2017","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.fitote.2019.104299_bb0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/jre.12083","article-title":"Periodontitis increases vascular cyclooxygenase-2: potential effect on vascular tone","volume":"49","author":"Mendes","year":"2014","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.fitote.2019.104299_bb0115","first-page":"614","article-title":"Study on composition of two polysaccharides Gbp and Gcp from root of Gerbera piloselloides","volume":"35","author":"She","year":"2004","journal-title":"Tradit. Herb. Drugs"},{"key":"10.1016\/j.fitote.2019.104299_bb0120","first-page":"594","article-title":"Studies on the chemical constituents from the roots and rhizomes of Gerbera piloselloides","volume":"27","author":"Xiao","year":"2002","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"key":"10.1016\/j.fitote.2019.104299_bb0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jep.2017.06.010","article-title":"8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells","volume":"207","author":"Bartnik","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2019.104299_bb0130","first-page":"174","article-title":"Clinical pharmacology of oral psoralen drugs","volume":"1","author":"Brickl","year":"1984","journal-title":"Photodermatol."},{"key":"10.1016\/j.fitote.2019.104299_bb0135","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0014-827X(00)00076-8","article-title":"PUVA (psoralen+ UVA) photochemotherapy: processes triggered in the cells","volume":"55","author":"Zarebska","year":"2000","journal-title":"Farmaco."},{"key":"10.1016\/j.fitote.2019.104299_bb0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tox.2017.05.011","article-title":"8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity","volume":"386","author":"Zhao","year":"2017","journal-title":"Toxicology."},{"key":"10.1016\/j.fitote.2019.104299_bb0145","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.4103\/ijo.IJO_413_17","article-title":"Methoxsalen-induced macular toxicity","volume":"65","author":"Aditya","year":"2017","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.fitote.2019.104299_bb0150","first-page":"4278","article-title":"8-MOP on blood-brain barrier via the Nrf-2\/HO-1 pathway in mice model of cerebral infarction","volume":"22","author":"Liu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.fitote.2019.104299_bb0155","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.phrs.2016.01.025","article-title":"The anti-metastatic effect of 8-MOP on hepatocellular carcinoma is potentiated by the down-regulation of bHLH transcription factor DEC1","volume":"105","author":"Xiong","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fitote.2019.104299_bb0160","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.3390\/molecules19044046","article-title":"Chemical composition and biological activities of Gerbera anandria","volume":"19","author":"He","year":"2014","journal-title":"Molecules."},{"key":"10.1016\/j.fitote.2019.104299_bb0165","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.msec.2018.06.049","article-title":"Formulation characterization and in vitro drug release of hydrogel-thickened nanoemulsions for topical delivery of 8-methoxypsoralen","volume":"92","author":"Barradas","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.fitote.2019.104299_bb0170","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/15569527.2014.961070","article-title":"Intravitreal administration of known phototoxicants in the rabbit fails to produce phototoxicity: implications for phototoxicity testing of intravitreally administered small molecule therapeutics","volume":"34","author":"Thackaberry","year":"2015","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.fitote.2019.104299_bb0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vph.2015.01.002","article-title":"Cilostazol induces vasodilation through the activation of Ca(2+)-activated K(+) channels in aortic smooth muscle","volume":"70","author":"Li","year":"2015","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.fitote.2019.104299_bb0180","first-page":"L226","article-title":"Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells","volume":"287","author":"Platoshyn","year":"2004","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.fitote.2019.104299_bb0185","doi-asserted-by":"crossref","first-page":"C1363","DOI":"10.1152\/ajpcell.1993.265.5.C1363","article-title":"Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries","volume":"265","author":"Quayle","year":"1993","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.fitote.2019.104299_bb0190","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1152\/physrev.2001.81.4.1415","article-title":"Ion channels and their functional role in vascular endothelium","volume":"81","author":"Nilius","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.fitote.2019.104299_bb0195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3565(25)10649-6","article-title":"Barium inhibits the endothelium-dependent component of flow but not acetylcholine-induced relaxation in isolated rabbit cerebral arteries","volume":"274","author":"Wellman","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19313589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19313589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:47:12Z","timestamp":1777564032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X19313589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":39,"alternative-id":["S0367326X19313589"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2019.104299","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"8-methoxysmyrindiol from Gerbera piloselloides (L.) Cass. and its vasodilation effects on isolated rat mesenteric arteries","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2019.104299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104299"}}