{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:32:23Z","timestamp":1790620343054,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.fitote.2019.104394","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:21:25Z","timestamp":1572002485000},"page":"104394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Geraniol targets KV1.3 ion channel and exhibits anti-inflammatory activity in vitro and in vivo"],"prefix":"10.1016","volume":"139","author":[{"given":"Chen-Jun","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-An","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2019.104394_bb0005","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1517\/14728222.2016.1112792","article-title":"The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies","volume":"20","author":"P\u00e9rez-Verdaguer","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.fitote.2019.104394_bb0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tips.2004.03.010","article-title":"K channels as targets for specific immunomodulation","volume":"25","author":"Chandy","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.fitote.2019.104394_bb0015","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI16921","article-title":"The voltage-gated Kv1.3 K channel in effector memory T cells as new target for MS","volume":"111","author":"Wulff","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.fitote.2019.104394_bb0020","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.immuni.2008.07.015","article-title":"Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block","volume":"29","author":"Matheu","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.fitote.2019.104394_bb0025","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1073\/pnas.0501770102","article-title":"The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain","volume":"102","author":"Rus","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fitote.2019.104394_bb0030","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","article-title":"Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases","volume":"103","author":"Beeton","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fitote.2019.104394_bb0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2014.07.003","article-title":"Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis \u2013 xenograft model","volume":"55","author":"Kundu-Raychaudhuri","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.fitote.2019.104394_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/436572","article-title":"Roles of lymphocyte Kv1.3-channels in the pathogenesis of renal diseases and novel therapeutic implications of targeting the channels","volume":"2015","author":"Kazama","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.fitote.2019.104394_bb0045","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.crohns.2014.04.003","article-title":"Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis","volume":"8","author":"Hansen","year":"2014","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.fitote.2019.104394_bb0050","doi-asserted-by":"crossref","first-page":"12623","DOI":"10.1074\/jbc.M113.517037","article-title":"Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma","volume":"289","author":"Koshy","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fitote.2019.104394_bb0055","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.2174\/092986710792065072","article-title":"Use of Kv1.3 blockers for inflammatory skin conditions","volume":"17","author":"Nguyen","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.fitote.2019.104394_bb0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2340\/00015555-1931","article-title":"New drugs and treatment targets in psoriasis","volume":"95","author":"Kofoed","year":"2015","journal-title":"Acta Dermato Venereol."},{"key":"10.1016\/j.fitote.2019.104394_bb0065","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1021\/acs.orglett.6b00787","article-title":"Three minor Diterpenoids with three carbon skeletons from Euphorbia peplus","volume":"18","author":"Wan","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.fitote.2019.104394_bb0070","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3109\/13880209.2012.690430","article-title":"Plants and plant products with potential antipsoriatic activity \u2013 a review","volume":"50","author":"Kaur","year":"2012","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.fitote.2019.104394_bb0075","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2174\/1389557514666141127145820","article-title":"An overview of the pharmacological properties and potential applications of natural monoterpenes","volume":"14","author":"Koziol","year":"2014","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.fitote.2019.104394_bb0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jtcme.2015.09.005","article-title":"Rosa damascena as holy ancient herb with novel applications","volume":"6","author":"Mahboubi","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.fitote.2019.104394_bb0085","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jep.2011.07.021","article-title":"Lemongrass and citral effect on cytokines production by murine macrophages","volume":"137","author":"Bachiega","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2019.104394_bb0090","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.colsurfb.2018.08.001","article-title":"Linalool bioactive properties and potential applicability in drug delivery systems","volume":"171","author":"Pereira","year":"2018","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.fitote.2019.104394_bb0095","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pharmthera.2015.05.006","article-title":"Effects of monoterpenes on ion channels of excitable cells","volume":"152","author":"Oz","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fitote.2019.104394_bb0100","article-title":"Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.fitote.2019.104394_bb0105","doi-asserted-by":"crossref","first-page":"22211","DOI":"10.1073\/pnas.0910123106","article-title":"A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library","volume":"106","author":"Takacs","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.fitote.2019.104394_bb0110","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1096\/fj.201800087R","article-title":"Pore-forming toxin-like protein complex expressed by frog promotes tissue repair[J]","volume":"33","author":"Gao","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.fitote.2019.104394_bb0115","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 Axis","volume":"182","author":"Fits","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.fitote.2019.104394_bb0120","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.anai.2016.03.029","article-title":"Effect of treatment with geraniol on ovalbumin-induced allergic asthma in mice","volume":"116","author":"Xue","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.fitote.2019.104394_bb0125","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.intimp.2017.04.022","article-title":"Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-\u03baB pathway","volume":"48","author":"Chen","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fitote.2019.104394_bb0130","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1084\/jem.20130291","article-title":"Epidermal IL-15R\u03b1 acts as an endogenous antagonist of psoriasiform inflammation in mouse and man","volume":"210","author":"Bouchaud","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fitote.2019.104394_bb0135","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1073\/pnas.86.24.10171","article-title":"Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes","volume":"86","author":"Price","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fitote.2019.104394_bb0140","doi-asserted-by":"crossref","first-page":"10094","DOI":"10.1073\/pnas.89.21.10094","article-title":"Selective blockers of voltage-gated K channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin","volume":"89","author":"Leonard","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fitote.2019.104394_bb0145","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and therapy of psoriasis","volume":"445","author":"Lowes","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.fitote.2019.104394_bb0150","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.phrs.2017.11.012","article-title":"Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-\u03b1\/IFN-\u03b3-induced inflammatory response in keratinocytes and T cell-derived IL-17","volume":"129","author":"Lin","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fitote.2019.104394_bb0155","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1055\/s-0030-1249947","article-title":"Inhibitory effects of citronellol and geraniol on nitric oxide and prostaglandin e2 production in macrophages","volume":"76","author":"Su","year":"2010","journal-title":"Planta Medica"},{"key":"10.1016\/j.fitote.2019.104394_bb0160","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejphar.2016.02.036","article-title":"Nerol alleviates pathologic markers in the oxazolone-induced colitis model","volume":"776","author":"Gonz\u00e1lez-Ram\u00edrez","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fitote.2019.104394_bb0165","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.intimp.2015.09.005","article-title":"Linalool inhibits cigarette smoke-induced lung inflammation by inhibiting NF-\u03baB activation","volume":"29","author":"Ma","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fitote.2019.104394_bb0170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cellimm.2012.09.002","article-title":"D-limonene modulates T lymphocyte activity and viability","volume":"279","author":"Lappas","year":"2012","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.fitote.2019.104394_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00018","article-title":"Geraniol pharmacokinetics, bioavailability and its multiple effects on the liver antioxidant and xenobiotic-metabolizing enzymes","volume":"9","author":"Pavan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fitote.2019.104394_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00038","article-title":"Dietary geraniol by oral or enema administration strongly reduces dysbiosis and systemic inflammation in dextran sulfate sodium-treated mice","volume":"7","author":"Fazio","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fitote.2019.104394_bb0185","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.drudis.2007.09.001","article-title":"Status of terpenes as skin penetration enhancers","volume":"12","author":"Aqil","year":"2007","journal-title":"Drug Discov. Today"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19311530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19311530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:21:54Z","timestamp":1759796514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X19311530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":37,"alternative-id":["S0367326X19311530"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2019.104394","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Geraniol targets KV1.3 ion channel and exhibits anti-inflammatory activity in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2019.104394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104394"}}