{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:13:02Z","timestamp":1789661582224,"version":"4.0.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.fitote.2020.104480","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T11:36:03Z","timestamp":1578569763000},"page":"104480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Pharmacokinetics, tissue distribution and excretion study of Oroxylin A, Oroxylin A 7-O-glucuronide and Oroxylin A sodium sulfonate in rats after administration of Oroxylin A"],"prefix":"10.1016","volume":"142","author":[{"given":"Guanghui","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanru","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueying","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.fitote.2020.104480_bb0005","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/ptr.5694","article-title":"Overview of Oroxylin A: a promising flavonoid compound","volume":"30","author":"Lu","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fitote.2020.104480_bb0010","doi-asserted-by":"crossref","first-page":"9241769","DOI":"10.1155\/2019\/9241769","article-title":"Oroxylin a suppresses the cell proliferation, migration, and EMT via NF-kappaB signaling pathway in human breast cancer cells","volume":"2019","author":"Sun","year":"2019","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.fitote.2020.104480_bb0015","doi-asserted-by":"crossref","first-page":"e2865","DOI":"10.1038\/cddis.2017.261","article-title":"Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1alpha-modulated fatty acid metabolism","volume":"8","author":"Ni","year":"2017","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.fitote.2020.104480_bb0020","doi-asserted-by":"crossref","first-page":"e2944","DOI":"10.1038\/cddis.2017.335","article-title":"Oroxylin A activates PKM1\/HNF4 alpha to induce hepatoma differentiation and block cancer progression","volume":"8","author":"Wei","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fitote.2020.104480_bb0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainresbull.2014.09.001","article-title":"Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice","volume":"108","author":"Kim","year":"2014","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.fitote.2020.104480_bb0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4062\/biomolther.2012.20.1.027","article-title":"Oroxylin A induces BDNF expression on cortical neurons through adenosine A2A receptor stimulation: a possible role in neuroprotection","volume":"20","author":"Jeon","year":"2012","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.fitote.2020.104480_bb0035","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.intimp.2016.09.006","article-title":"Therapeutic potential of Oroxylin A in rheumatoid arthritis","volume":"40","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fitote.2020.104480_bb0040","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.biopha.2017.10.140","article-title":"Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs","volume":"97","author":"Jin","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.fitote.2020.104480_bb0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1139\/bcb-2014-0030","article-title":"Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2\/ARE activation","volume":"92","author":"Ye","year":"2014","journal-title":"Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.fitote.2020.104480_bb0050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3892\/etm.2016.3320","article-title":"Anti-inflammatory effects of oroxylin A on RAW 264.7 mouse macrophages induced with polyinosinic-polycytidylic acid","volume":"12","author":"Lee","year":"2016","journal-title":"Exp Ther Med"},{"issue":"5","key":"10.1016\/j.fitote.2020.104480_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155784","article-title":"Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice","volume":"11","author":"Kwon","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.fitote.2020.104480_bb0060","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4062\/biomolther.2015.200","article-title":"Inhibitory effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71","volume":"24","author":"Choi","year":"2016","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.fitote.2020.104480_bb0065","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.phymed.2017.10.003","article-title":"Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice","volume":"38","author":"Sun","year":"2018","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.fitote.2020.104480_bb0070","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.fitote.2010.01.018","article-title":"Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers","volume":"81","author":"Marques","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fitote.2020.104480_bb0075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jchromb.2015.11.049","article-title":"Oral pharmacokinetics of baicalin, wogonoside, oroxylin a 7-O-beta-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat","volume":"1026","author":"Cai","year":"2016","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.fitote.2020.104480_bb0080","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jpba.2018.03.019","article-title":"Determination of oroxylin A and oroxylin A 7-O-d-glucuronide in HepG2 cell lysate and subcellular fractions with SPE-UPLC-MS\/MS: cellular pharmacokinetic study to indicate anti-cancer mechanisms","volume":"154","author":"Zhang","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1\u20132","key":"10.1016\/j.fitote.2020.104480_bb0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10337-011-2020-8","article-title":"Simultaneous quantification of oroxylin A and its metabolite Oroxylin A-7-O-Glucuronide: application to a pharmacokinetic study in rat","volume":"74","author":"Liu","year":"2011","journal-title":"Chromatographia"},{"key":"10.1016\/j.fitote.2020.104480_bb0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpba.2014.03.033","article-title":"Development of a SPE-LC\/MS\/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies","volume":"97","author":"Fong","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.fitote.2020.104480_bb0095","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jpba.2010.10.005","article-title":"Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product","volume":"54","author":"Li","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.fitote.2020.104480_bb0100","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jchromb.2006.07.021","article-title":"Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma","volume":"844","author":"Kim","year":"2006","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.fitote.2020.104480_bb0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jpba.2012.03.051","article-title":"Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry","volume":"70","author":"Tong","year":"2012","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19323743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X19323743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:21:55Z","timestamp":1759796515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X19323743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":21,"alternative-id":["S0367326X19323743"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2020.104480","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics, tissue distribution and excretion study of Oroxylin A, Oroxylin A 7-O-glucuronide and Oroxylin A sodium sulfonate in rats after administration of Oroxylin A","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2020.104480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104480"}}