{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:43:05Z","timestamp":1790199785892,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.fitote.2020.104631","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T21:44:02Z","timestamp":1589838242000},"page":"104631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Identification of a natural compound, sesamin, as a novel TRPM8 antagonist with inhibitory effects on prostate adenocarcinoma"],"prefix":"10.1016","volume":"145","author":[{"given":"Yutong","family":"Sui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2020.104631_bb0005","first-page":"1431","article-title":"Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines","volume":"40","author":"Okamoto","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.fitote.2020.104631_bb0010","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00432-015-2112-1","article-title":"TRPM8: a potential target for cancer treatment","volume":"142","author":"Liu","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.fitote.2020.104631_bb0015","first-page":"87","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.fitote.2020.104631_bb0020","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"NEOPLASIA"},{"key":"10.1016\/j.fitote.2020.104631_bb0025","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.fitote.2020.104631_bb0030","doi-asserted-by":"crossref","first-page":"F803","DOI":"10.1152\/ajprenal.90269.2008","article-title":"AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome","volume":"295","author":"Lashinger","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.fitote.2020.104631_bb0035","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1523\/JNEUROSCI.0890-04.2004","article-title":"TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH","volume":"24","author":"Andersson","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.fitote.2020.104631_bb0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pharmthera.2016.03.001","article-title":"Phytomedicine polypharmacology: cancer therapy through modulating the tumor microenvironment and oxylipin dynamics","volume":"162","author":"Apaya","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fitote.2020.104631_bb0045","first-page":"5773","article-title":"Natural products that target cancer stem cells","volume":"35","author":"Moselhy","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fitote.2020.104631_bb0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jcb.22114","article-title":"Down-regulating cold shock protein genes impairs cancer cell survival and enhances chemosensitivity","volume":"107","author":"Zeng","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fitote.2020.104631_bb0055","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1007\/s00018-016-2253-7","article-title":"Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold","volume":"73","author":"Zhu","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fitote.2020.104631_bb0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2490-13-17","article-title":"Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer","volume":"13","author":"Boman","year":"2013","journal-title":"BMC Urol."},{"key":"10.1016\/j.fitote.2020.104631_bb0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1479-5876-8-78","article-title":"Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer","volume":"8","author":"Ehlen","year":"2010","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.fitote.2020.104631_bb0070","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/prca.201100020","article-title":"High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer","volume":"5","author":"Hjelm","year":"2011","journal-title":"Proteom. Clin. Appl."},{"key":"10.1016\/j.fitote.2020.104631_bb0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1479-5876-9-114","article-title":"Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: an analysis of 215 cases from the Malmo Diet and Cancer Study","volume":"9","author":"Jonsson","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.fitote.2020.104631_bb0080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1746-1596-6-91","article-title":"High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression","volume":"6","author":"Jonsson","year":"2011","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.fitote.2020.104631_bb0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2050-7771-2-11","article-title":"High expression of RNA-binding motif protein 3 in esophageal and gastric adenocarcinoma correlates with intestinal metaplasia-associated tumours and independently predicts a reduced risk of recurrence and death","volume":"2","author":"Jonsson","year":"2014","journal-title":"Biomark Res."},{"key":"10.1016\/j.fitote.2020.104631_bb0090","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1158\/0008-5472.CAN-12-1343","article-title":"Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing","volume":"73","author":"Zeng","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.fitote.2020.104631_bb0095","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1128\/MCB.01386-08","article-title":"Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation","volume":"29","author":"Artero-Castro","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.fitote.2020.104631_bb0100","first-page":"43","article-title":"A new generation of proto-oncogenes: cold-inducible RNA binding proteins","volume":"1805","author":"Lleonart","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fitote.2020.104631_bb0105","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/mc.22597","article-title":"The mechanism of CIRP in inhibition of keratinocytes growth arrest and apoptosis following low dose UVB radiation","volume":"56","author":"Liao","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.fitote.2020.104631_bb0110","first-page":"1782","article-title":"Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo","volume":"118","author":"Fang","year":"2012","journal-title":"Am. Cancer Soc."},{"key":"10.1016\/j.fitote.2020.104631_bb0115","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/1878-0261.12116","article-title":"Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway","volume":"11","author":"Chen","year":"2017","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.fitote.2020.104631_bb0120","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.canlet.2014.08.029","article-title":"Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo","volume":"354","author":"Nakamura","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fitote.2020.104631_bb0125","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1074\/mcp.M112.017384","article-title":"Secretomic analysis identifies alpha-1 antitrypsin (A1AT) as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells","volume":"11","author":"Chang","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.fitote.2020.104631_bb0130","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13045-017-0441-z","article-title":"Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis","volume":"10","author":"Wang","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.fitote.2020.104631_bb0135","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1158\/0008-5472.CAN-11-1919","article-title":"Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts","volume":"72","author":"Moschetta","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.fitote.2020.104631_bb0140","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1158\/2159-8290.CD-16-0231","article-title":"MENA promotes tumor-intrinsic metastasis through ECM remodeling and haptotaxis","volume":"6","author":"Santiago-Medina","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.fitote.2020.104631_bb0145","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.canlet.2015.12.027","article-title":"Matrix control of pancreatic cancer: new insights into fibronectin signaling","volume":"381","author":"Topalovski","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fitote.2020.104631_bb0150","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1083\/jcb.201704053","article-title":"Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin","volume":"216","author":"Erdogan","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.fitote.2020.104631_bb0155","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1083\/jcb.201702033","article-title":"Cancer-associated fibroblasts lead tumor invasion through integrin-beta3-dependent fibronectin assembly","volume":"216","author":"Attieh","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.fitote.2020.104631_bb0160","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.jid.2018.04.029","article-title":"TGFbeta, fibronectin and integrin alpha5beta1 promote invasion in basal cell carcinoma","volume":"138","author":"Kuonen","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.fitote.2020.104631_bb0165","first-page":"273","article-title":"A cool channel in cold transduction","volume":"26","author":"Latorre","year":"2011","journal-title":"Physiology (Bethesda)"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X20302136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X20302136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:22:31Z","timestamp":1759796551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X20302136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":33,"alternative-id":["S0367326X20302136"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2020.104631","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a natural compound, sesamin, as a novel TRPM8 antagonist with inhibitory effects on prostate adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2020.104631","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104631"}}