{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:23:28Z","timestamp":1768721008156,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002385","name":"Ministry of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.fitote.2020.104765","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T12:39:40Z","timestamp":1603715980000},"page":"104765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Cytotoxic polyhydroxy sterols from the Egyptian Red Sea soft coral Sarcophyton acutum"],"prefix":"10.1016","volume":"147","author":[{"given":"Sabry A.H.","family":"Zidan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda A.","family":"Abdelhamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montaser","family":"Al-Hammady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa A.","family":"Fouad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Matsunami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.A.","family":"Orabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2020.104765_bb0005","series-title":"Handbook of Anticancer Drugs from Marine Origin","author":"Kim","year":"2015"},{"issue":"8","key":"10.1016\/j.fitote.2020.104765_bb0010","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.tetlet.2012.12.037","article-title":"Bioactive cembranoids from the Red Sea soft coral Sarcophyton glaucum","volume":"54","author":"El-Ezz","year":"2013","journal-title":"Tetrahedron Lett."},{"issue":"7","key":"10.1016\/j.fitote.2020.104765_bb0015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/md17070411","article-title":"New antiproliferative cembrane diterpenes from the Red Sea Sarcophyton species","volume":"17","author":"Hassan","year":"2019","journal-title":"Mar. Drugs"},{"issue":"6","key":"10.1016\/j.fitote.2020.104765_bb0020","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1021\/cr800503e","article-title":"Marine metabolites: the sterols of soft coral","volume":"109","author":"Sarma","year":"2009","journal-title":"Chem. Rev."},{"issue":"5","key":"10.1016\/j.fitote.2020.104765_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.fitote.2020.104765_bb0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10544-018-0355-8","article-title":"Microneedle-based delivery of amphotericin B for treatment of cutaneous leishmaniasis","volume":"21","author":"Nguyen","year":"2019","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.fitote.2020.104765_bb0035","first-page":"1","article-title":"Ellagitannins and simple phenolics from the halophytic plant Tamarix nilotica","author":"Orabi","year":"2020","journal-title":"Nat. Prod. Res."},{"issue":"10","key":"10.1016\/j.fitote.2020.104765_bb0040","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1021\/ol500792x","article-title":"Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral","volume":"16","author":"Von Salm","year":"2014","journal-title":"Org. Lett."},{"issue":"8","key":"10.1016\/j.fitote.2020.104765_bb0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3923\/ajbs.2011.575.590","article-title":"Prediction of medicinal properties of marine biota using computational bioinformatics techniques","volume":"4","author":"Gupta","year":"2011","journal-title":"Asian J. Biol. Sci."},{"issue":"21","key":"10.1016\/j.fitote.2020.104765_bb0050","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1080\/14786419.2013.814053","article-title":"New 18-oxygenated polyhydroxy steroid from a South China Sea soft coral Sarcophyton sp","volume":"27","author":"Sun","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.fitote.2020.104765_bb0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.phytol.2015.09.002","article-title":"New cis-ent-clerodanes from Linaria japonica","volume":"14","author":"Widyowati","year":"2015","journal-title":"Phytochem. Lett."},{"issue":"6","key":"10.1016\/j.fitote.2020.104765_bb0060","article-title":"A new macrolactone, racemolide along with seven known compounds with biological activities from mangrove plant, Lumnitzera racemosa","volume":"14","author":"Gomaa Darwish","year":"2019","journal-title":"Nat. Prod. Commun."},{"issue":"21","key":"10.1016\/j.fitote.2020.104765_bb0065","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1021\/jm1007769","article-title":"Sterols as anticancer agents: synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis","volume":"53","author":"Carvalho","year":"2010","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.fitote.2020.104765_bb0070","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0039-128X(99)00032-X","article-title":"Steroids from sponges: recent reports","volume":"64","author":"Aiello","year":"1999","journal-title":"Steroids"},{"issue":"7","key":"10.1016\/j.fitote.2020.104765_bb0075","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1248\/cpb.c18-00281","article-title":"Alkylated benzoquinones: Ardisiaquinones A\u2013H from the leaves of Ardisia quinquegona and their anti-Leishmania activity","volume":"66","author":"Asaumi","year":"2018","journal-title":"Chem. Pharm. Bull."},{"issue":"16","key":"10.1016\/j.fitote.2020.104765_bb0080","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1016\/S0040-4020(01)85020-1","article-title":"Studies towards the synthesis of polyoxygenated steroids. Reaction of 7, 9 (11)-diene steroids with RuO4","volume":"50","author":"Notaro","year":"1994","journal-title":"Tetrahedron"},{"issue":"13","key":"10.1016\/j.fitote.2020.104765_bb0085","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1016\/j.bmcl.2014.04.103","article-title":"NF-\u03baB inhibitory activity of polyoxygenated steroids from the Vietnamese soft coral Sarcophyton pauciplicatum","volume":"24","author":"Thao","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.fitote.2020.104765_bb0090","first-page":"144","article-title":"Isolation of 24-methylenecholesterol-3-O-L-fucopyranoside and 24-methylenecholest-7-ene-3,6,9,11-tetrol from a soft coral of the Andaman and Nicobar Islands","volume":"33","author":"Anjaneyulu","year":"1994","journal-title":"Indian J. Chem. Sect. B"},{"issue":"14","key":"10.1016\/j.fitote.2020.104765_bb0095","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.steroids.2013.10.004","article-title":"Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba","volume":"78","author":"Cheng","year":"2013","journal-title":"Steroids"},{"issue":"9","key":"10.1016\/j.fitote.2020.104765_bb0100","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1039\/c1ob05106g","article-title":"Hirsutosterols A\u2013G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta","volume":"9","author":"Chen","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.fitote.2020.104765_bb0105","series-title":"Lipid Biochemistry of Fungi and Other Organisms","first-page":"224","article-title":"Sterols, carotenoids, and polyprenols","author":"Weete","year":"1980"},{"key":"10.1016\/j.fitote.2020.104765_bb0110","series-title":"Molecular Asymmetry and Sterol Evolution","author":"Nes","year":"1994"},{"key":"10.1016\/j.fitote.2020.104765_bb0115","series-title":"Analysis of Sterols: by L. John Goad and Toshihiro Akihisa","author":"G\u00f6r\u00f6g","year":"1997"},{"issue":"1","key":"10.1016\/j.fitote.2020.104765_bb0120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1248\/cpb.27.38","article-title":"Carbon-13 nuclear magnetic resonance of 24-substituted steroids","volume":"27","author":"Koizumi","year":"1979","journal-title":"Chem. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.fitote.2020.104765_bb0125","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1248\/cpb.31.1848","article-title":"Marine sterols. XI. Polyhydroxysterols of the soft coral Sarcophyton glaucum: isolation and synthesis of 5\u03b1-cholestane-1\u03b2, 3\u03b2, 5, 6\u03b2-tetrol","volume":"31","author":"Kobayashi","year":"1983","journal-title":"Chem. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.fitote.2020.104765_bb0130","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12272-010-0402-3","article-title":"Chemical components from the Vietnamese soft coral Lobophytum sp","volume":"33","author":"Tung","year":"2010","journal-title":"Arch. Pharm. Res."},{"issue":"8","key":"10.1016\/j.fitote.2020.104765_bb0135","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1080\/14786419.2015.1079187","article-title":"A review of steroids from Sarcophyton species","volume":"30","author":"Zubair","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.fitote.2020.104765_bb0140","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.phytol.2020.02.006","article-title":"Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea","volume":"36","author":"Abdelkarem","year":"2020","journal-title":"Phytochemistry Letters"},{"issue":"3","key":"10.1016\/j.fitote.2020.104765_bb0145","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0039-128X(79)90080-1","article-title":"Marine sterols. IX. Occurrence 0f 24\u03be-methylcholestane-1\u03b2, 3\u03b2, 5\u03b1, 6\u03b2, 25-pentol 25-monoacetate in the soft coral, Sarcophyton glaucum","volume":"34","author":"Kobayashi","year":"1979","journal-title":"Steroids"},{"issue":"7","key":"10.1016\/j.fitote.2020.104765_bb0150","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1021\/np50085a009","article-title":"Polyhydroxysterols from the soft coral Sarcophyton subviride of Andaman and Nicobar coasts","volume":"55","author":"Raju","year":"1992","journal-title":"J. Nat. Prod."},{"issue":"9","key":"10.1016\/j.fitote.2020.104765_bb0155","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1021\/np960255j","article-title":"Sarcoaldesterols a and B, two new polyhydroxylated sterols from the soft coral Sarcophyton sp","volume":"59","author":"Umeyama","year":"1996","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fitote.2020.104765_bb0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.steroids.2018.11.015","article-title":"Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp","volume":"141","author":"Zhang","year":"2019","journal-title":"Steroids"},{"issue":"4","key":"10.1016\/j.fitote.2020.104765_bb0165","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jccs.199100068","article-title":"Isolation of a bioactive sterol from the soft coral Lobophytum mirabile","volume":"38","author":"Sheu","year":"1991","journal-title":"J. Chin. Chem. Soc."},{"issue":"6","key":"10.1016\/j.fitote.2020.104765_bb0170","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1248\/cpb.38.1724","article-title":"Marine sterols. XVI.: Polyhydroxysterols of the soft corals of the Andaman and Nicobar coasts. 1. Isolation of (24S)-24-Methylcholest-5-ene-3\u03b2, 25\u03b6, 26-triol and (24S)-24-Methylcholestane-3\u03b2, 5\u03b2, 6\u03b1, 25-tetrol","volume":"38","author":"Kobayashi","year":"1990","journal-title":"Chem. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.fitote.2020.104765_bb0175","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3762\/bjoc.13.50","article-title":"Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia)","volume":"13","author":"Bogdanov","year":"2017","journal-title":"Beilstein J. Org. Chem."},{"issue":"27","key":"10.1016\/j.fitote.2020.104765_bb0180","doi-asserted-by":"crossref","first-page":"9301","DOI":"10.1016\/S0040-4020(97)00584-X","article-title":"Rare aromadendrane diterpenoids from a new soft coral species of Sinularia genus of the Indian Ocean","volume":"53","author":"Anjaneyulu","year":"1997","journal-title":"Tetrahedron"},{"issue":"2","key":"10.1016\/j.fitote.2020.104765_bb0185","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1248\/cpb.28.473","article-title":"Studies on marine natural products. II. New polyhydroxylated sterols from the soft coral Lobophytum pauciflorum (Ehrenberg)","volume":"28","author":"Yamada","year":"1980","journal-title":"Chem. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.fitote.2020.104765_bb0190","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/10286020008039897","article-title":"Alcyonacean metabolites VII\u2013chemical constituents of Lobophytum denticulatum and Lobophytum strictum of the Indian Ocean","volume":"2","author":"Vanisree","year":"2000","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"7","key":"10.1016\/j.fitote.2020.104765_bb0195","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.bmcl.2011.01.072","article-title":"Cytotoxic and antioxidant activities of diterpenes and sterols from the Vietnamese soft coral Lobophytum compactum","volume":"21","author":"Van Minh","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"11","key":"10.1016\/j.fitote.2020.104765_bb0200","article-title":"A new 9, 11-secosterol from the Vietnamese sea soft coral, Sarcophyton mililatensis, increases the function of osteoblastic MC3T3-E1 cells","volume":"2","author":"Van Minh","year":"2007","journal-title":"Nat. Prod. Commun."},{"issue":"3","key":"10.1016\/j.fitote.2020.104765_bb0205","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3390\/md11030775","article-title":"Bioactive polyoxygenated steroids from the South China Sea soft coral, Sarcophyton sp","volume":"11","author":"Wang","year":"2013","journal-title":"Mar. Drugs"},{"issue":"12","key":"10.1016\/j.fitote.2020.104765_bb0210","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1080\/10286020.2017.1307192","article-title":"Cytotoxic steroid derivatives from the Vietnamese soft coral Sinularia brassica","volume":"19","author":"Tran","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"2","key":"10.1016\/j.fitote.2020.104765_bb0215","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"issue":"12","key":"10.1016\/j.fitote.2020.104765_bb0220","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1021\/np0002381","article-title":"Cytotoxic cembrenolides and steroids from the Formosan soft coral Sarcophyton crassocaule","volume":"63","author":"Duh","year":"2000","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.fitote.2020.104765_bb0225","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jccs.200400033","article-title":"Novel polyhydroxysteroids from the Formosan soft coral Sarcophyton glaucum","volume":"51","author":"Wang","year":"2004","journal-title":"J. Chin. Chem. Soc."},{"issue":"12","key":"10.1016\/j.fitote.2020.104765_bb0230","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.3390\/md11124788","article-title":"Polyhydroxylated steroids from the South China Sea soft coral Sarcophyton sp. and their cytotoxic and antiviral activities","volume":"11","author":"Gong","year":"2013","journal-title":"Mar. Drugs"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X20303476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X20303476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:26:00Z","timestamp":1759796760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X20303476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":46,"alternative-id":["S0367326X20303476"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2020.104765","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytotoxic polyhydroxy sterols from the Egyptian Red Sea soft coral Sarcophyton acutum","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2020.104765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104765"}}