{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:27:26Z","timestamp":1784431646211,"version":"3.55.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["116S299"],"award-info":[{"award-number":["116S299"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.fitote.2023.105652","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T11:30:44Z","timestamp":1692185444000},"page":"105652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Cocktail of three isoquinoline alkaloids derived from Glaucium grandiflorum Boiss. &amp; A. Huet subsp. refractum (N\u00e1belek) Mory inhibits the production of LPS-induced ROS, pro-inflammatory cytokines, and mediators through the down-regulation of p38 MAPK in BV-2 cells"],"prefix":"10.1016","volume":"170","author":[{"given":"Serap","family":"Nigdelioglu Dolanbay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"\u015eirin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belma","family":"Aslim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2023.105652_bb0005","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.bbi.2020.11.004","article-title":"Therapeutic role of inflammasome inhibitors in neurodegenerative disorders","volume":"91","author":"Lahooti","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.fitote.2023.105652_bb0010","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1007\/s12035-015-9337-5","article-title":"Oxidative stress in neurodegenerative diseases","volume":"53","author":"Niedzielska","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.fitote.2023.105652_bb0015","article-title":"Blueberry treatment administered before and\/or after lipopolysaccharide stimulation attenuates inflammation and oxidative stress in rat microglial cells","volume":"1-11","author":"Cahoon","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.fitote.2023.105652_bb0020","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3233\/JAD-210198","article-title":"New approaches to profile the microbiome for treatment of neurodegenerative disease","volume":"82","author":"Elmaleh","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.fitote.2023.105652_bb0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.brainresbull.2021.10.010","article-title":"Electroacupuncture prevents LPS-induced neuroinflammation via upregulation of PICK-TLR4 complexes in the microglia of hippocampus","volume":"177","author":"Mo","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.fitote.2023.105652_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107712","article-title":"Safinamide prevents lipopolysaccharide (LPS)-induced inflammation in macrophages by suppressing TLR4\/NF-\u03baB signaling","volume":"96","author":"Qian","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fitote.2023.105652_bb0035","doi-asserted-by":"crossref","first-page":"13942","DOI":"10.1021\/acs.jafc.1c04190","article-title":"Rotenone-induced neurodegeneration is enabled by a p38-Parkin-ROS signaling feedback loop","volume":"69","author":"Chen","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fitote.2023.105652_bb0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molmed.2020.09.013","article-title":"Towards advanced iPSC-based drug development for neurodegenerative disease","volume":"27","author":"Pasteuning-Vuhman","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fitote.2023.105652_bb0045","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s10571-020-00936-w","article-title":"Ryanodine receptors: a potential treatment target in various neurodegenerative disease","volume":"41","author":"Sun","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.fitote.2023.105652_bb0050","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/molecules26030728","article-title":"Potential of naturally derived alkaloids as multi-targeted therapeutic agents for neurodegenerative diseases","volume":"26","author":"Kong","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.fitote.2023.105652_bb0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2174\/1871530320666200821124817","article-title":"Natural alkaloids and diabetes mellitus: a review","volume":"21","author":"Ajebli","year":"2021","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1016\/j.fitote.2023.105652_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113165","article-title":"Discovery of natural anti-inflammatory alkaloids: potential leads for the drug discovery for the treatment of inflammation","volume":"213","author":"Bai","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.fitote.2023.105652_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111690","article-title":"Neuroprotective effects of allocryptopine-rich alkaloid extracts against oxidative stress-induced neuronal damage","volume":"140","author":"Nigdelioglu Dolanbay","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fitote.2023.105652_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.685556","article-title":"Novel isoquinoline alkaloid Litcubanine A-a potential anti-inflammatory candidate","volume":"12","author":"Xia","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fitote.2023.105652_bb0075","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1021\/acs.jnatprod.0c01044","article-title":"In vivo profiling of a natural alkaloid, anatabine, in rodents: pharmacokinetics and anti-inflammatory efficacy","volume":"84","author":"Xia","year":"2021","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fitote.2023.105652_bb0080","first-page":"1437","article-title":"Anesthetic isoflurane attenuates activated microglial cytokine-induced VSC4. 1 motoneuronal apoptosis","volume":"8","author":"Yang","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"2","key":"10.1016\/j.fitote.2023.105652_bb0085","first-page":"255","article-title":"T\u00fcrkiye\u2019de yay\u0131l\u0131\u015f g\u00f6steren baz\u0131 Glaucium mill.(Papaveraceae) taksonlar\u0131n\u0131n habitat \u00f6zellikleri","volume":"3","author":"K\u0131l\u0131\u00e7","year":"2021","journal-title":"Turk. J. Life Sci."},{"issue":"5","key":"10.1016\/j.fitote.2023.105652_bb0090","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1049\/iet-nbt.2017.0265","article-title":"Green synthesis of silver nanoparticles using Glaucium corniculatum (L.) Curtis extract and evaluation of its antibacterial activity","volume":"12","author":"Allafchian","year":"2018","journal-title":"IET Nanobiotechnol."},{"issue":"6","key":"10.1016\/j.fitote.2023.105652_bb0095","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1021\/np50048a055","article-title":"Alkaloids of Glaucium grandiflorum","volume":"49","author":"El-Afifi","year":"1986","journal-title":"J. Nat. Prod."},{"issue":"73","key":"10.1016\/j.fitote.2023.105652_bb0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/pm.pm_348_20","article-title":"Chemical composition and neurotherapeutic potential of Glaucium corniculatum extracts","volume":"17","author":"Kocanci","year":"2021","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.fitote.2023.105652_bb0105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/0973-7847.120511","article-title":"Cholinesterase inhibitors from botanicals","volume":"7","author":"Ahmed","year":"2013","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.fitote.2023.105652_bb0110","first-page":"7","article-title":"The anti-AChE and anti-proliferative activities of Glaucium acutidentatum and Glaucium corniculatum alkaloid extracts","volume":"8","author":"Kocanci","year":"2017","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.fitote.2023.105652_bb0115","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0091-3057(02)00940-1","article-title":"A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba anticholinesterase and cognitive enhancing activities","volume":"73","author":"Das","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.fitote.2023.105652_bb0120","first-page":"58","article-title":"The relationship between neuroprotective activity and antigenotoxic and acetylcholinesterase inhibitory effects of Glaucium corniculatum extracts","author":"Kocanci","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.fitote.2023.105652_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/728983","article-title":"New acetylcholinesterase inhibitors for Alzheimer\u2019s disease","volume":"2012","author":"Mehta","year":"2012","journal-title":"Int. J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.fitote.2023.105652_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2003.11.016","article-title":"Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants","volume":"91","author":"Orhan","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2023.105652_bb0135","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1211\/0022357001774598","article-title":"In vitro inhibition of human erythrocyte acetylcholinesterase by Salvia lavandulaefolia essential oil and constituent terpenes","volume":"52","author":"Perry","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.fitote.2023.105652_bb0140","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1211\/0022357011777846","article-title":"In vitro activities of Salvia lavandulaefolia (Spanish Sage) relevant to treatment of Alzheimer\u2019s disease","volume":"53","author":"Perry","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"issue":"2","key":"10.1016\/j.fitote.2023.105652_bb0145","first-page":"57","article-title":"Evaluating antimicrobial effect of Glaucium on oral microflora","volume":"9","author":"Majd","year":"1996","journal-title":"Int. J. Dent. Med."},{"key":"10.1016\/j.fitote.2023.105652_bb0150","first-page":"1","article-title":"Histopathological evaluation of wound healing by extracts from Glaucium corniculatum (L.)","author":"Miroliaei","year":"2018","journal-title":"Curt. Cell. Mol. Biol."},{"key":"10.1016\/j.fitote.2023.105652_bb0155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biopha.2018.05.108","article-title":"Dangguishaoyao-San attenuates LPS-induced neuroinflammation via the TLRs\/NF-\u03baB signaling pathway","volume":"105","author":"Ding","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fitote.2023.105652_bb0160","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11373-005-9039-5","article-title":"Protective effect of 1, 2, 4-benzenetriol on LPS-induced NO production by BV2 microglial cells","volume":"13","author":"Hou","year":"2006","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.fitote.2023.105652_bb0165","author":"LabHeat"},{"key":"10.1016\/j.fitote.2023.105652_bb0170","author":"Heidolph Laborota"},{"key":"10.1016\/j.fitote.2023.105652_bb0175","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.indcrop.2016.09.016","article-title":"Isoquinoline alkaloid fractions of Fumaria officinalis: characterization and evaluation of their antioxidant and antibacterial activities","volume":"94","author":"Khamtache-Abderrahim","year":"2016","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.fitote.2023.105652_bb0180","first-page":"118","article-title":"GC-MS investigation and acetylcholinesterase inhibitory activity of Galanthus rizehensis","volume":"68","author":"Sarikaya","year":"2013","journal-title":"J. Biosci."},{"key":"10.1016\/j.fitote.2023.105652_bb0185","author":"Sanyo"},{"key":"10.1016\/j.fitote.2023.105652_bb0190","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/cells8020194","article-title":"Anti-inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK\/AP-1\/NF-\u03baB inhibition and Nrf2\/HO-1 activation","volume":"8","author":"Subedi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.fitote.2023.105652_bb0195","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"55\u201363","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.fitote.2023.105652_bb0200","author":"Biotek Instruments"},{"key":"10.1016\/j.fitote.2023.105652_bb0205","author":"VWR"},{"key":"10.1016\/j.fitote.2023.105652_bb0210","author":"BioAssay Systems"},{"key":"10.1016\/j.fitote.2023.105652_bb0215","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bcmd.2017.06.002","article-title":"Moderate exercise training decreases inflammation in transgenic sickle cell mice","volume":"69","author":"Charrin","year":"2018","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.fitote.2023.105652_bb0220","first-page":"2266","article-title":"Oxysophocarpine reduces oxygen-glucose deprivation-induced microglial activation and injury","volume":"9","author":"Lu","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.fitote.2023.105652_bb0225","author":"Agilent"},{"key":"10.1016\/j.fitote.2023.105652_bb0230","first-page":"628370","article-title":"Missense mutations in the MLKL \u2018brace\u2019region lead to lethal neonatal inflammation in mice and are present in high frequency in humans","author":"Hildebrand","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.fitote.2023.105652_bb0235","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-12-49","article-title":"Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia","volume":"12","author":"Huo","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.fitote.2023.105652_bb0240","author":"Zymo Research"},{"key":"10.1016\/j.fitote.2023.105652_bb0245","author":"Thermo Fisher Scientific"},{"key":"10.1016\/j.fitote.2023.105652_bb0250","author":"Solis Biodyne"},{"key":"10.1016\/j.fitote.2023.105652_bb0255","author":"Applied Biosystems"},{"key":"10.1016\/j.fitote.2023.105652_bb0260","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3389\/fmicb.2017.02017","article-title":"Resolving species level changes in a representative soil bacterial community using microfluidic quantitative PCR","volume":"8","author":"Kleyer","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fitote.2023.105652_bb0265","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.phymed.2016.10.007","article-title":"Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK\/STAT and Nrf2\/HO-1 signaling pathways","volume":"23","author":"Guo","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fitote.2023.105652_bb0270","first-page":"149","article-title":"IP-10, p53, and Foxp3 expression in hepatocytes of chronic hepatitis B patients with cirrhosis and hepatocellular carcinoma","volume":"6","author":"Shahera","year":"2016","journal-title":"Eur. J. Hepatogastroenterol."},{"key":"10.1016\/j.fitote.2023.105652_bb0275","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cimid.2011.01.005","article-title":"Cloning and phylogenetic analysis of Interleukin-6 (IL-6) and tumor necrosis factor-\u03b1 (TNF-\u03b1) from Indian dromedaries (Camelus dromedarius)","volume":"34","author":"Nagarajan","year":"2011","journal-title":"Comp. Immunol. Microbiol. Infect."},{"key":"10.1016\/j.fitote.2023.105652_bb0280","author":"Bio-Rad"},{"key":"10.1016\/j.fitote.2023.105652_bb0285","author":"Bio-Rad"},{"key":"10.1016\/j.fitote.2023.105652_bb0290","author":"Bio-Rad"},{"key":"10.1016\/j.fitote.2023.105652_bb0295","author":"Bio-Rad"},{"issue":"3","key":"10.1016\/j.fitote.2023.105652_bb0300","article-title":"Antibodies to the glycoprotein GP2 subunit cross-react between old and new world arenaviruses","volume":"3","author":"Amanat","year":"2018","journal-title":"Sphere"},{"key":"10.1016\/j.fitote.2023.105652_bb0305","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.molcel.2018.01.034","article-title":"NADH shuttling couples cytosolic reductive carboxylation of glutamine with glycolysis in cells with mitochondrial dysfunction","volume":"69","author":"Gaude","year":"2018","journal-title":"Mol. Cell"},{"issue":"12","key":"10.1016\/j.fitote.2023.105652_bb0310","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/md15120367","article-title":"Three new malyngamides from the marine cyanobacterium Moorea producens","volume":"15","author":"Sueyoshi","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fitote.2023.105652_bb0315","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1038\/s41598-017-07544-7","article-title":"Involvement of insulin signaling disturbances in bisphenol A-induced Alzheimer\u2019s disease-like neurotoxicity","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fitote.2023.105652_bb0320","article-title":"Quercetin protects against Okadaic acid-induced injury via MAPK and PI3K\/Akt\/GSK3\u03b2 signaling pathways in HT22 hippocampal neurons","volume":"11","author":"Jiang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.fitote.2023.105652_bb0325","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.fob.2015.09.006","article-title":"Functional distribution of synapsin I in human sperm","volume":"5","author":"Coleman","year":"2015","journal-title":"FEBS Open Bio."},{"key":"10.1016\/j.fitote.2023.105652_bb0330","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10571-014-0147-5","article-title":"Resveratrol protects PC12 cells from high glucose-induced neurotoxicity via PI3K\/Akt\/FoxO3a pathway","volume":"35","author":"Liu","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.fitote.2023.105652_bb0335","first-page":"1561","article-title":"Hydrogen peroxide controls Akt activity via ubiquitination\/degradation pathways","volume":"26","author":"Kim","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.fitote.2023.105652_bb0340","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13065-014-0048-1","article-title":"Evaluation of solvent effect on the extraction of phenolic compounds and antioxidant capacities from the berries: application of principal component analysis","volume":"8","author":"Boeing","year":"2014","journal-title":"Chem. Cent. J."},{"issue":"1\u20132","key":"10.1016\/j.fitote.2023.105652_bb0345","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.chroma.2004.05.003","article-title":"Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series","volume":"1041","author":"Wu","year":"2004","journal-title":"J. Chromatogr. A"},{"issue":"09\/10","key":"10.1016\/j.fitote.2023.105652_bb0350","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1055\/a-1803-3259","article-title":"Pressurized natural deep eutectic solvent extraction of galanthamine and related alkaloids from Narcissus pseudonarcissus","volume":"88","author":"Rachmaniah","year":"2022","journal-title":"Planta Med."},{"key":"10.1016\/j.fitote.2023.105652_bb0355","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bse.2014.07.007","article-title":"Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin","volume":"56","author":"Doncheva","year":"2014","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.fitote.2023.105652_bb0360","doi-asserted-by":"crossref","DOI":"10.1177\/24705470221076390","article-title":"The role of lipopolysaccharide-induced cell signalling in chronic inflammation","volume":"6","author":"Page","year":"2022","journal-title":"Chronic Stress"},{"issue":"2","key":"10.1016\/j.fitote.2023.105652_bb0365","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/BJ20061430","article-title":"Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages","volume":"402","author":"Emre","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.fitote.2023.105652_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/9944880","article-title":"Anti-inflammatory effects of empagliflozin and gemigliptin on LPS-stimulated macrophage via the IKK\/NF-\u03baB, MKK7\/JNK, and JAK2\/STAT1 signalling pathways","volume":"2021a","author":"Lee","year":"2021","journal-title":"J Immunol Res"},{"key":"10.1016\/j.fitote.2023.105652_bb0375","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1615\/JEnvironPatholToxicolOncol.2021038944","article-title":"Protective effect of isopulegol in alleviating neuroinflammation in lipopolysaccharide-induced BV-2 cells and in parkinson disease model induced with MPTP","volume":"40","author":"Kang","year":"2021","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.fitote.2023.105652_bb0380","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/pm.pm_393_20","article-title":"Oroxylum indicum Kurz (L.) seed extract exerts antioxidant and anti-inflammatory effects on lipopolysaccharide-stimulated BV2 microglial cells","volume":"17","author":"Mairuae","year":"2021","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.fitote.2023.105652_bb0385","article-title":"Natural isoquinoline alkaloids: pharmacological features and multi-target potential for complex diseases","volume":"106126","author":"Plazas","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fitote.2023.105652_bb0390","first-page":"1","article-title":"Oxyberberine prevented lipopolysaccharide-induced acute lung injury through inhibition of mitophagy","volume":"2021a","author":"Zhao","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.fitote.2023.105652_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/etm.2021.10402","article-title":"Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling","volume":"22","author":"Jin","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.fitote.2023.105652_bb0400","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s10753-020-01370-2","article-title":"Isoliquiritigenin reduces LPS-induced inflammation by preventing mitochondrial fission in BV-2 microglial cells","volume":"44","author":"Lee","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.fitote.2023.105652_bb0405","article-title":"Qualitative and quantitative analyses of aconite alkaloids in Aconiti kusnezoffii Radix, and NO inhibitory activity evaluation of the alkaloid extracts","volume":"42","author":"Li","year":"2021","journal-title":"Food Sci. Technol."},{"key":"10.1016\/j.fitote.2023.105652_bb0410","first-page":"111","article-title":"Curine ameliorates lipopolysaccharide-induced acute lung injury by downregulating the TLR4\/MD-2\/NF-\u03baB (p65) signaling pathway","volume":"32","author":"Paiva Ferreira","year":"2022","journal-title":"Rev. Bras"},{"key":"10.1016\/j.fitote.2023.105652_bb0415","doi-asserted-by":"crossref","first-page":"8519","DOI":"10.3390\/ijms22168519","article-title":"Inhibition of autotaxin and lysophosphatidic acid receptor 5 attenuates neuroinflammation in LPS-activated BV-2 microglia and a mouse endotoxemia model","volume":"22","author":"Joshi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2023.105652_bb0420","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.3390\/molecules26175351","article-title":"Anti-inflammatory effects of 6-methylcoumarin in LPS-stimulated RAW 264.7 macrophages via regulation of MAPK and NF-\u03baB signaling pathways","volume":"26","author":"Kang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.fitote.2023.105652_bb0425","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1179\/1476830512Y.0000000020","article-title":"Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells","volume":"15","author":"Chen","year":"2012","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.fitote.2023.105652_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/983401","article-title":"BHBA suppresses LPS-induced inflammation in BV-2 cells by inhibiting NF-\u03baB activation","volume":"2014","author":"Fu","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.fitote.2023.105652_bb0435","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/ijms17020190","article-title":"GLP-2 attenuates LPS-induced inflammation in BV-2 cells by inhibiting ERK1\/2, JNK1\/2 and NF-\u03baB signaling pathways","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2023.105652_bb0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-018-1308-0","article-title":"Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice","volume":"15","author":"Nam","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.fitote.2023.105652_bb0445","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/08923973.2019.1666406","article-title":"Resveratrol protects BV2 mouse microglial cells against LPS-induced inflammatory injury by altering the miR-146a-5p\/TRAF6\/NF-\u03baB axis","volume":"41","author":"Ge","year":"2019","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.fitote.2023.105652_bb0450","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3390\/app9102144","article-title":"Increased anti-inflammatory effects on LPS-induced microglia cells by Spirulina maxima extract from ultrasonic process","volume":"9","author":"Choi","year":"2019","journal-title":"Appl. Sci."},{"key":"10.1016\/j.fitote.2023.105652_bb0455","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4062\/biomolther.2009.17.1.70","article-title":"Inhibitory effects of Coptis japonica alkaloids on the LPS-induced activation of BV2 microglial cells","volume":"17","author":"Jeon","year":"2009","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.fitote.2023.105652_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153540","article-title":"Narciclasine inhibits LPS-induced neuroinflammation by modulating the Akt\/IKK\/NF-\u03baB and JNK signaling pathways","volume":"85","author":"Zhao","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fitote.2023.105652_bb0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/459723","article-title":"Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine","volume":"2013","author":"Olajide","year":"2013","journal-title":"J. Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.fitote.2023.105652_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102522","article-title":"Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-\u03baB and ERK signaling pathways in BV2 cells","volume":"9","author":"Dang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fitote.2023.105652_bb0475","doi-asserted-by":"crossref","first-page":"38397","DOI":"10.1039\/C9RA07266G","article-title":"Curcumin alleviates LPS-induced inflammation and oxidative stress in mouse microglial BV2 cells by targeting miR-137-3p\/NeuroD1","volume":"9","author":"Gao","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.fitote.2023.105652_bb0480","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7834381","article-title":"Royal jelly attenuates LPS-induced inflammation in BV-2 microglial cells through modulating NF-\u03baB and p38\/JNK signaling pathways","volume":"2018","author":"You","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.fitote.2023.105652_bb0485","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/sj.bjp.0707187","article-title":"YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-\u03baB in microglia","volume":"151","author":"Lu","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fitote.2023.105652_bb0490","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4062\/biomolther.2009.17.1.47","article-title":"Schizandra chinensis alkaloids inhibit lipopolysaccharide-induced inflammatory responses in BV2 microglial cells","volume":"17","author":"Min Sik","year":"2009","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.fitote.2023.105652_bb0495","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jphs.2015.04.005","article-title":"Anti-inflammatory effects of glaucocalyxin B in microglia cells","volume":"128","author":"Gan","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.fitote.2023.105652_bb0500","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1039\/C7RA01882G","article-title":"Inhibitory effects of three bisbenzylisoquinoline alkaloids on lipopolysaccharide-induced microglial activation","volume":"7","author":"Meng","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.fitote.2023.105652_bb0505","first-page":"165","article-title":"Anti-inflammatory effects of oxymatrine through inhibition of nuclear factor\u2013kappa b and mitogen-activated protein kinase activation in lipopolysaccharide-induced BV2 microglia cells","volume":"12","author":"Dong","year":"2013","journal-title":"Iran. J. Pharm. Res."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X23002277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X23002277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:30:15Z","timestamp":1759797015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X23002277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":101,"alternative-id":["S0367326X23002277"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2023.105652","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cocktail of three isoquinoline alkaloids derived from Glaucium grandiflorum Boiss. & A. Huet subsp. refractum (N\u00e1belek) Mory inhibits the production of LPS-induced ROS, pro-inflammatory cytokines, and mediators through the down-regulation of p38 MAPK in BV-2 cells","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2023.105652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105652"}}