{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T00:10:41Z","timestamp":1794615041711,"version":"4.9.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774023"],"award-info":[{"award-number":["81774023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104540"],"award-info":[{"award-number":["82104540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ22H280015"],"award-info":[{"award-number":["LQ22H280015"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.fitote.2025.106529","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T10:01:58Z","timestamp":1744106518000},"page":"106529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Yinqiao antipruritic formula attenuates atopic dermatitis-like skin lesions through modulating the cytokine-cytokine receptor interaction pathway"],"prefix":"10.1016","volume":"183","author":[{"given":"Hua-qi","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-da","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai-bing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-die","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian-dong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2025.106529_bb0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jaci.2024.04.009","article-title":"Biologic and small-molecule therapy for treating moderate to severe atopic dermatitis: mechanistic considerations","volume":"154","author":"Rothenberg-Lausell","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fitote.2025.106529_bb0010","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.jaci.2024.02.015","article-title":"Atopic dermatitis phenotype affects expression of atopic diseases despite similar mononuclear cell cytokine response","volume":"153","author":"Taki","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fitote.2025.106529_bb0015","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jaci.2022.10.023","article-title":"Novel insights into atopic dermatitis","volume":"151","author":"Schuler","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fitote.2025.106529_bb0020","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jaip.2023.02.005","article-title":"Targeting skin barrier function in atopic dermatitis","volume":"11","author":"van den Bogaard","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.fitote.2025.106529_bb0025","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaci.2022.07.021","article-title":"Endotypes of atopic dermatitis and food allergy","volume":"151","author":"Hui-Beckman","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fitote.2025.106529_bb0030","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1080\/13880209.2023.2244004","article-title":"Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1\/miR-124-3p axis","volume":"61","author":"Zhao","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.fitote.2025.106529_bb0035","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaci.2022.11.009","article-title":"IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin","volume":"151","author":"Hashimoto","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fitote.2025.106529_bb0040","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1111\/all.15432","article-title":"Dupilumab significantly improves skin barrier function in patients with moderate-to-severe atopic dermatitis","volume":"77","author":"Berdyshev","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.fitote.2025.106529_bb0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaad.2021.07.078","article-title":"Itch: pathogenesis and treatment","volume":"86","author":"Sutaria","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.fitote.2025.106529_bb0050","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/all.14318","article-title":"Type 2 immunity in the skin and lungs","volume":"75","author":"Akdis","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.fitote.2025.106529_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11195633","article-title":"The IL-4\/\u221213 Axis and its blocking in the treatment of atopic dermatitis","volume":"11","author":"Pappa","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.fitote.2025.106529_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.927304","article-title":"Efficacy and safety of Chinese herbal medicine for atopic dermatitis: evidence from eight high-quality randomized placebo-controlled trials","volume":"13","author":"Cai","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106529_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116194","article-title":"Therapeutic effects and mechanisms of Ku-Gan formula on atopic dermatitis: a pilot clinical study and modular pharmacology analysis with animal validation","volume":"307","author":"Ma","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106529_bb0070","article-title":"Rosa davurica Pall. improves DNCB-induced atopic dermatitis in mice and regulated TNF-Alpa\/IFN-gamma-induced skin inflammatory responses in HaCaT cells","volume":"91","author":"Hwang","year":"2021","journal-title":"Phytomed. Int. J. Phytoth. Phytopharmacol."},{"key":"10.1016\/j.fitote.2025.106529_bb0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/derm.2024.0058","article-title":"The role of OX40-OX40L Axis in the pathogenesis of atopic dermatitis","volume":"36","author":"Schettini","year":"2025","journal-title":"Dermatitis"},{"key":"10.1016\/j.fitote.2025.106529_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115160","article-title":"Artemisia annua water extract attenuates DNCB-induced atopic dermatitis by restraining Th2 cell mediated inflammatory responses in BALB\/c mice","volume":"291","author":"Han","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106529_bb0085","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.fitote.2025.106529_bb0090","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/1871530321666210208221158","article-title":"Bioactive compounds of Polygonatum sibiricum - therapeutic effect and biological activity","volume":"22","author":"Zhao","year":"2022","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1016\/j.fitote.2025.106529_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115594","article-title":"Licorice: resources, applications in ancient and modern times","volume":"298","author":"Ding","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106529_bb0100","article-title":"Potential antioxidant and anti-inflammatory effects of Lonicera japonica and Citri Reticulatae Pericarpium polyphenolic extract (LCPE)","volume":"12","author":"Jeong","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.fitote.2025.106529_bb0105","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1016\/j.psj.2020.05.011","article-title":"Forsythia suspensa extract enhances performance via the improvement of nutrient digestibility, antioxidant status, anti-inflammatory function, and gut morphology in broilers","volume":"99","author":"Long","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.fitote.2025.106529_bb0110","article-title":"Comparison of the chemical components, efficacy and mechanisms of action of Chrysanthemum morifolium flower and its wild relative Chrysanthemum indicum flower against liver-fire hyperactivity syndrome of hypertension via integrative analyses","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2025.106529_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154318","article-title":"Terminalia chebula Retz. extract ameliorates the symptoms of atopic dermatitis by regulating anti-inflammatory factors in vivo and suppressing STAT1\/3 and NF-\u0138B signaling in vitro","volume":"104","author":"Kim","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fitote.2025.106529_bb0120","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41577-022-00735-y","article-title":"Role of thymic stromal lymphopoietin in allergy and beyond","volume":"23","author":"Ebina-Shibuya","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fitote.2025.106529_bb0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jid.2022.07.021","article-title":"Immunization with a pneumococcal pep27 mutant strain alleviates atopic dermatitis through the upregulation of regulatory T-cell activity and epithelial barrier function and suppressing TSLP expression","volume":"143","author":"Kim","year":"2023","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.fitote.2025.106529_bb0130","article-title":"Inhibitory effect of Centella asiatica extract on DNCB-induced atopic dermatitis in HaCaT cells and BALB\/c mice","volume":"12","author":"Lee","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.fitote.2025.106529_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073521","article-title":"Therapeutic potential of combining IL-6 and TNF blockade in a mouse model of allergic asthma","volume":"23","author":"Namakanova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2025.106529_bb0140","doi-asserted-by":"crossref","first-page":"275","DOI":"10.5483\/BMBRep.2022.55.6.144","article-title":"Anti-atopic dermatitis effects of Parasenecio auriculatus via simultaneous inhibition of multiple inflammatory pathways","volume":"55","author":"Kwon","year":"2022","journal-title":"BMB Rep."},{"key":"10.1016\/j.fitote.2025.106529_bb0145","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s13555-022-00737-7","article-title":"Current and emerging strategies to inhibit type 2 inflammation in atopic dermatitis","volume":"12","author":"Haddad","year":"2022","journal-title":"Dermatol. Ther. (Heidelb.)"},{"key":"10.1016\/j.fitote.2025.106529_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1068260","article-title":"JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fitote.2025.106529_bb0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/imcb.12491","article-title":"CD44 v5 domain inhibition represses the polarization of Th2 cells by interfering with the IL-4\/IL-4R signaling pathway","volume":"100","author":"Yang","year":"2022","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.fitote.2025.106529_bb0160","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/all.13954","article-title":"Interleukin-13: targeting an underestimated cytokine in atopic dermatitis","volume":"75","author":"Bieber","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.fitote.2025.106529_bb0165","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/imr.13230","article-title":"Engineering the IL-4\/IL-13 axis for targeted immune modulation","volume":"320","author":"Bernstein","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fitote.2025.106529_bb0170","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.alit.2023.01.002","article-title":"ILC2s in skin disorders","volume":"72","author":"Imai","year":"2023","journal-title":"Allergol. Int."},{"key":"10.1016\/j.fitote.2025.106529_bb0175","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00403-024-03262-z","article-title":"Exploring novel drug targets for atopic dermatitis through plasma proteome with genome","volume":"316","author":"Wu","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.fitote.2025.106529_bb0180","doi-asserted-by":"crossref","first-page":"23054","DOI":"10.1038\/s41598-024-73244-8","article-title":"Identification of novel hub genes and immune infiltration in atopic dermatitis using integrated bioinformatics analysis","volume":"14","author":"Zhou","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25001546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25001546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:23:08Z","timestamp":1762302188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X25001546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":36,"alternative-id":["S0367326X25001546"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106529","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yinqiao antipruritic formula attenuates atopic dermatitis-like skin lesions through modulating the cytokine-cytokine receptor interaction pathway","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106529"}}