{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:27:00Z","timestamp":1762302420132,"version":"build-2065373602"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019597","name":"Advanced Instrumentation Research Facility","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017896","name":"Jawaharlal Nehru University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.fitote.2025.106540","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:48:31Z","timestamp":1744372111000},"page":"106540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Phytochemicals from Musa acuminata Colla peel exhibit cathepsin B inhibition and anti-inflammatory activity"],"prefix":"10.1016","volume":"183","author":[{"given":"Sabita","family":"Rangra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Agnihotri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagarika","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3792-9062","authenticated-orcid":false,"given":"Kamal Krishan","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fitote.2025.106540_bb0005","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.berh.2019.03.011","article-title":"Malignancy and rheumatoid arthritis: epidemiology, risk factors and management","volume":"32","author":"De Cock","year":"2018","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.fitote.2025.106540_bb0010","first-page":"1","article-title":"Natural medicines of targeted rheumatoid arthritis and its action mechanism","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fitote.2025.106540_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res."},{"key":"10.1016\/j.fitote.2025.106540_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9010074","article-title":"Quantitative predictive modelling approaches to understanding rheumatoid arthritis: a brief review","volume":"9","author":"Macfarlane","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.fitote.2025.106540_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28020887","article-title":"Major phytochemicals: recent advances in health benefits and extraction method","volume":"28","author":"Kumar","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.fitote.2025.106540_bb0030","series-title":"Bioact. Food as Diet. Interv. Arthritis Relat. Inflamm. Dis","first-page":"233","article-title":"Chapter 13 - Zingiber officinale: Antiinflammatory actions and potential usage for arthritic conditions","author":"Karunakaran","year":"2019"},{"key":"10.1016\/j.fitote.2025.106540_bb0035","first-page":"41","article-title":"Antiarthritic effect of aqueous and ethanolic leaf extracts of Pistia stratiotes in adjuvant-induced arthritis in Sprague-Dawley rats","volume":"4","author":"Kyei","year":"2012","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106540_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2019.152876","article-title":"Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats","volume":"58","author":"Yu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fitote.2025.106540_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-017-1623-5","article-title":"Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund\u2019s adjuvant-induced arthritis in rats","volume":"17","author":"Mbiantcha","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.fitote.2025.106540_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2021.629607","article-title":"Anti-inflammatory and anti-arthritic potential of standardized extract of Clerodendrum serratum (L.) Moon","volume":"12","author":"Tiwari","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106540_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/159089","article-title":"Zingiber officinale\u00a0: a potential plant against rheumatoid arthritis","volume":"2014","author":"Al-Nahain","year":"2014","journal-title":"Arthritis"},{"key":"10.1016\/j.fitote.2025.106540_bb0060","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1021\/jf021150r","article-title":"Potential therapeutic applications of some antinutritional plant secondary metabolites","volume":"51","author":"Singh","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fitote.2025.106540_bb0065","first-page":"18","article-title":"Antibacterial and phytochemical analysis of banana fruit peel","volume":"4","author":"Ehiowemwenguan","year":"2014","journal-title":"IOSR J. Pharm."},{"key":"10.1016\/j.fitote.2025.106540_bb0070","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40816-021-00291-3","article-title":"Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review","volume":"7","author":"Santiago","year":"2021","journal-title":"Clin. Phytoscience"},{"key":"10.1016\/j.fitote.2025.106540_bb0075","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.intimp.2017.12.011","article-title":"Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway","volume":"55","author":"Pan","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fitote.2025.106540_bb0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biopha.2017.03.026","article-title":"Therapeutic effect of quercetin in collagen-induced arthritis","volume":"90","author":"Haleagrahara","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fitote.2025.106540_bb0085","first-page":"1","article-title":"Anti-arthritic effect of chebulanin on collagen-induced arthritis in mice","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fitote.2025.106540_bb0090","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/bbrc.2001.4787","article-title":"Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis","volume":"283","author":"Hashimoto","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fitote.2025.106540_bb0095","doi-asserted-by":"crossref","first-page":"10985","DOI":"10.1080\/07391102.2023.2203234","article-title":"A cystatin C similar protein from Musa acuminata that inhibits cathepsin B involved in rheumatoid arthritis using in silico approach and in vitro cathepsin B inhibition by protein extract","volume":"41","author":"Rangra","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.fitote.2025.106540_bb0100","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jep.2016.12.009","article-title":"Traditional uses, phytochemistry and pharmacology of wild banana (Musa acuminata Colla): a review","volume":"196","author":"Mathew","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106540_bb0105","doi-asserted-by":"crossref","first-page":"036","DOI":"10.30574\/wjbphs.2021.7.1.0073","article-title":"Banana (Musa acuminata): Most popular and common Indian plant with multiple pharmacological potentials","volume":"7","author":"Yadav","year":"2021","journal-title":"World J. Biol. Pharm. Heal. Sci."},{"key":"10.1016\/j.fitote.2025.106540_bb0110","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1007\/s13197-012-0861-2","article-title":"Banana by-products: an under-utilized renewable food biomass with great potential","volume":"51","author":"Padam","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.fitote.2025.106540_bb0115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jep.2018.12.048","article-title":"Wild banana [Ensete superbum (Roxb.) Cheesman.]: Ethnomedicinal, phytochemical and pharmacological overview","volume":"233","author":"Sethiya","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106540_bb0120","doi-asserted-by":"crossref","first-page":"156","DOI":"10.31254\/phyto.2021.10302","article-title":"Evaluation of pharmacognostic, nutraceutic and phytotherapeutic constituents of unripe Musa sapientum hydromethanolic extracts","volume":"10","author":"Ilochi","year":"2021","journal-title":"J. Phytopharm."},{"key":"10.1016\/j.fitote.2025.106540_bb0125","first-page":"1","article-title":"Gas chromatography mass spectrometry investigation and minerals, proximate components and their relationship on hydromethanolic extract of unripe Musa sapientum peel and pulp","volume":"3","author":"Ogadinma","year":"2021","journal-title":"Int. J. Biomed. Investig."},{"key":"10.1016\/j.fitote.2025.106540_bb0130","first-page":"1","article-title":"ClassyFire: automated chemical classification with a comprehensive, computable taxonomy","volume":"8","author":"Djoumbou Feunang","year":"2016","journal-title":"J. Chemother."},{"key":"10.1016\/j.fitote.2025.106540_bb0135","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1111\/j.1742-4658.2010.07824.x","article-title":"Stefin a displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft","volume":"277","author":"Renko","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.fitote.2025.106540_bb0140","doi-asserted-by":"crossref","unstructured":"S. Kim, J. Chen, T. Cheng, A. Gindulyte, J. He, S. He, Q. Li, B.A. Shoemaker, P.A. Thiessen, B. Yu, L. Zaslavsky, J. Zhang, E.E. Bolton, PubChem 2023 update, Nucleic Acids Res. 51 (2022) D1373\u2013D1380. doi:https:\/\/doi.org\/10.1093\/nar\/gkac956.","DOI":"10.1093\/nar\/gkac956"},{"key":"10.1016\/j.fitote.2025.106540_bb0145","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.fitote.2025.106540_bb0150","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.fitote.2025.106540_bb0155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1097-0282(1999)51:1<99::AID-BIP11>3.0.CO;2-R","article-title":"Structural basis of inhibition of cysteine proteases by E-64 and its derivatives","volume":"51","author":"Matsumoto","year":"1999","journal-title":"Biopolym. - Pept. Sci. Sect."},{"key":"10.1016\/j.fitote.2025.106540_bb0160","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/bioinformatics\/bty707","article-title":"AdmetSAR 2.0: web-service for prediction and optimization of chemical ADMET properties","volume":"35","author":"Yang","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fitote.2025.106540_bb0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0076-6879(81)80043-2","article-title":"Cathepsin B, cathepsin H, and cathepsin L","volume":"80","author":"Barrett","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fitote.2025.106540_bb0170","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1007\/s00044-013-0872-1","article-title":"Curcumin as inhibitor of mammalian cathepsin B, cathepsin H, acid phosphatase and alkaline phosphatase: a correlation with pharmacological activities","volume":"23","author":"Ravish","year":"2014","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.fitote.2025.106540_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13040512","article-title":"Purification and characterization of a novel thermostable papain inhibitor from Moringa oleifera with antimicrobial and anticoagulant properties","volume":"13","author":"Cotabarren","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.fitote.2025.106540_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20211392","article-title":"Anti-inflammatory activity of nicotine isolated from Brassica oleracea in rheumatoid arthritis","volume":"42","author":"Rakhecha","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.fitote.2025.106540_bb0185","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/art.1780370802","article-title":"Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?","volume":"37","author":"Vincenti","year":"1994","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.fitote.2025.106540_bb0190","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/ard.34.3.225","article-title":"Proteinase inhibitors in rheumatoid arthritis","volume":"34","author":"Brackertz","year":"1975","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.fitote.2025.106540_bb0195","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3390\/antiox12030604","article-title":"Phytochemicals and biological activities of walnut septum: a systematic review","volume":"12","author":"Mate\u0219","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.fitote.2025.106540_bb0200","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1440-6047.2000.00167.x","article-title":"Recommended dietary intake levels for phytochemicals: feasible or fanciful?","volume":"9","author":"Dreosti","year":"2000","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.fitote.2025.106540_bb0205","series-title":"Secondary Metabolites of Plants, in: Med. Orchid","first-page":"59","author":"Teoh","year":"2016"},{"key":"10.1016\/j.fitote.2025.106540_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052690","article-title":"Plant secondary metabolites as defense tools against herbivores for sustainable crop protection","volume":"23","author":"Divekar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2025.106540_bb0215","first-page":"1","article-title":"Phytochemicals of nutraceutical importance: do they defend against diseases?","author":"Sharma","year":"2014","journal-title":"Phytochem. Nutraceutical Importance."},{"key":"10.1016\/j.fitote.2025.106540_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-017-0888-1","article-title":"Phytochemicals as potential antidotes for targeting NF-\u03baB in rheumatoid arthritis","volume":"7","author":"Aravilli","year":"2017","journal-title":"3 Biotech"},{"key":"10.1016\/j.fitote.2025.106540_bb0225","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1021\/acs.jnatprod.6b00554","article-title":"Effects of koumine on adjuvant- and collagen-induced arthritis in rats","volume":"79","author":"Yang","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fitote.2025.106540_bb0230","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1021\/acs.jafc.9b00185","article-title":"Liquiritin from Glycyrrhiza uralensis attenuating rheumatoid arthritis via reducing inflammation, suppressing angiogenesis, and inhibiting MAPK signaling pathway","volume":"67","author":"Zhai","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fitote.2025.106540_bb0235","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/87559129.2020.1725890","article-title":"A comprehensive review on nutritional value, medicinal uses, and processing of banana","volume":"38","author":"Ranjha","year":"2022","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.fitote.2025.106540_bb0240","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/iwj.12371","article-title":"Wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana) in Wistar albino rats","volume":"13","author":"Amutha","year":"2016","journal-title":"Int. Wound J."},{"key":"10.1016\/j.fitote.2025.106540_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/agriculture13020451","article-title":"Anti-inflammatory and T-cell immunomodulatory effects of banana peel extracts and selected bioactive components in LPS-challenged in vitro and in vivo models","volume":"13","author":"Hong","year":"2023","journal-title":"Agriculture"},{"key":"10.1016\/j.fitote.2025.106540_bb0250","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s13105-011-0091-5","article-title":"Beneficial effects of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats","volume":"67","author":"Bhaskar","year":"2011","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.fitote.2025.106540_bb0255","first-page":"1","article-title":"Anti-inflammatory properties of extracts from Chimonanthus nitens Oliv. leaf","volume":"12","author":"Sun","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.fitote.2025.106540_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-019-2765-4","article-title":"Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma","volume":"19","author":"Eftekhar","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.fitote.2025.106540_bb0265","article-title":"Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower","volume":"15","author":"Liu","year":"2022","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.fitote.2025.106540_bb0270","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s13668-025-00629-0","article-title":"Antidiabetic potential of bananas (Musa spp.): a systematic review of bioactive compounds and antihyperglycemic activities","volume":"14","author":"Kwok","year":"2025","journal-title":"Curr. Nutr. Rep."},{"key":"10.1016\/j.fitote.2025.106540_bb0275","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.sajb.2019.12.019","article-title":"Evaluation of the antioxidant and anti-arthritic potential of Zingiber officinale Rosc. By in vitro and in silico analysis","volume":"130","author":"Murugesan","year":"2020","journal-title":"South African J. Bot."},{"key":"10.1016\/j.fitote.2025.106540_bb0280","first-page":"1","article-title":"Aggarwal, identification of thrombin inhibiting antithrombin-III like protein from Punica granatum using in silico approach and in vitro validation of thrombin inhibition activity in crude protein","volume":"0","author":"Sawetaji","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.fitote.2025.106540_bb0285","first-page":"1","article-title":"Inhibition of human cathepsins B and L by caffeic acid and its derivatives","volume":"11","author":"Ul\u010dakar","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.fitote.2025.106540_bb0290","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1080\/14786419.2014.1002404","article-title":"Evaluation of flavonols and derivatives as human cathepsin B inhibitor","volume":"29","author":"Ramalho","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.fitote.2025.106540_bb0295","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-444-63749-9.00006-2","article-title":"Natural products as cathepsin inhibitors","volume":"50","author":"Vidal-Albalat","year":"2016","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.fitote.2025.106540_bb0300","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.21577\/1984-6835.20200100","article-title":"Isolated compounds and semi-synthetic derivatives from Miconia ferruginata as inhibitors of cathepsins K and B and their cytotoxic evaluation","volume":"12","author":"Cunha","year":"2020","journal-title":"Rev. Virtual Quim."},{"key":"10.1016\/j.fitote.2025.106540_bb0305","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jpha.2021.07.002","article-title":"Phytochemicals targeting NF-\u03baB signaling: potential anti-cancer interventions","volume":"12","author":"Chauhan","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.fitote.2025.106540_bb0310","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-\u03baB p65 and strategies for therapeutic manipulation","volume":"11","author":"Giridharan","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.fitote.2025.106540_bb0315","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/fcp.12049","article-title":"Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress","volume":"28","author":"Silva","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106540_bb0320","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/acs.jnatprod.9b01116","article-title":"Phytol, a chlorophyll component, produces antihyperalgesic, anti-inflammatory, and antiarthritic effects: possible NF\u03baB pathway involvement and reduced levels of the proinflammatory cytokines TNF-\u03b1 and IL-6","volume":"83","author":"Carvalho","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fitote.2025.106540_bb0325","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12272-017-0905-2","article-title":"Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway","volume":"40","author":"Dong","year":"2017","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.fitote.2025.106540_bb0330","first-page":"1840","article-title":"Cycloartenol exerts anti-proliferative effects on glioma U87 cells via induction of cell cycle arrest and p38 MAPK-mediated apoptosis","volume":"23","author":"Niu","year":"2018","journal-title":"J. BUON"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25001650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25001650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:22:44Z","timestamp":1762302164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X25001650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":66,"alternative-id":["S0367326X25001650"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106540","relation":{},"ISSN":["0367-326X"],"issn-type":[{"type":"print","value":"0367-326X"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytochemicals from Musa acuminata Colla peel exhibit cathepsin B inhibition and anti-inflammatory activity","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106540"}}