{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:10:22Z","timestamp":1778325022900,"version":"3.51.4"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Malaysia Ministry of Higher Education","doi-asserted-by":"publisher","award":["GP-IPS\/2016\/9482000"],"award-info":[{"award-number":["GP-IPS\/2016\/9482000"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.fitote.2025.106925","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:20:40Z","timestamp":1759764040000},"page":"106925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acmella uliginosa (Sw.) Cass hampers complete Freund's adjuvant-induced arthritis in rats by inhibiting the VEGF axis"],"prefix":"10.1016","volume":"187","author":[{"given":"Baizura Mohd","family":"Borhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Aimi Faqiehah","family":"Wan Mohd Fadzil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Blin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roslida Abd","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5114\/reum.2016.60216","article-title":"Social implications of rheumatic diseases","volume":"54","author":"K\u0142ak","year":"2016","journal-title":"Reumatologia"},{"key":"10.1016\/j.fitote.2025.106925_bb0010","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1098\/rstb.2015.0522","article-title":"The temporal basis of angiogenesis","volume":"372","author":"Bentley","year":"2017","journal-title":"Philos. Trans. Roy. Soc. B Biol. Sci."},{"issue":"10","key":"10.1016\/j.fitote.2025.106925_bb0015","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/rheumatology\/keq188","article-title":"Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis","volume":"49","author":"Walsh","year":"2010","journal-title":"Rheumatology"},{"key":"10.1016\/j.fitote.2025.106925_bb0020","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jbspin.2010.06.004","article-title":"Blood vessels, a potential therapeutic target in rheumatoid arthritis?","volume":"78","author":"Semerano","year":"2011","journal-title":"Jt. Bone Spine"},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10456-011-9208-2","article-title":"Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience","volume":"14","author":"Thairu","year":"2011","journal-title":"Angiogenesis"},{"issue":"8","key":"10.1016\/j.fitote.2025.106925_bb0030","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.4049\/jimmunol.152.8.4149","article-title":"Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis","volume":"152","author":"Koch","year":"1994","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.fitote.2025.106925_bb0035","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ncprheum0559","article-title":"Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis","volume":"3","author":"Lainer-Carr","year":"2007","journal-title":"Nat. Clin. Pract. Rheumatol."},{"issue":"6","key":"10.1016\/j.fitote.2025.106925_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179065","article-title":"Proteome profiling in IL-1\u03b2 and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis","volume":"12","author":"Mohr","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.fitote.2025.106925_bb0045","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.semarthrit.2020.08.002","article-title":"Medicare expenditures for conventional and biologic disease modifying agents commonly used for treatment of rheumatoid arthritis","volume":"50","author":"Dalal","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0050","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/BOR.0000000000000496","article-title":"Recent advances in the treatment of rheumatoid arthritis","volume":"30","author":"Mahajan","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.fitote.2025.106925_bb0055","series-title":"Bioprospecting of Tropical Medicinal Plants","article-title":"Herbal drugs: safety, cost-effectiveness, regulation, current trends, and future directions","author":"Ahmed","year":"2023"},{"key":"10.1016\/j.fitote.2025.106925_bb0060","series-title":"Plant and Human Health","article-title":"Medicinal plants in the treatment of arthritis","volume":"vol. 3","author":"Saleem","year":"2019"},{"key":"10.1016\/j.fitote.2025.106925_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/25027614","article-title":"The systematics of Acmella (Asteraceae \u2013 Heliantheae)","volume":"8","author":"Jansen","year":"1985","journal-title":"Syst. Bot. Monogr."},{"key":"10.1016\/j.fitote.2025.106925_bb0070","first-page":"73","article-title":"Notes on Acmella (Asteraceae: Helianthae) in Taiwan","volume":"49","author":"Chung","year":"2008","journal-title":"Bot. Stud."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0075","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jep.2010.09.030","article-title":"Antinociceptive activity of methanolic extract of Acmella uliginosa (Sw.) Cass","volume":"133","author":"Ong","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106925_bb0080","first-page":"61","article-title":"Anti-inflammatory activity of Acmella uliginosa (sw.) cass. flower methanolic extract on membrane stabilization and protein denaturation: an in vitro evaluation","volume":"11","author":"Modak","year":"2017","journal-title":"NBU J. Anim. Sci."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0085","first-page":"44","article-title":"Phytochemical composition, antioxidant, and anti-inflammatory activities of essential oil of Acmella uliginosa (Sw.) Cass. grown in North India Terai region of Uttarakhand","volume":"1","author":"Gairola","year":"2021","journal-title":"Trends Phytochem. Res."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0090","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5455\/jice.20160521010145","article-title":"Assessment of anti-inflammatory and anti-arthritic properties of Acmella uliginosa (Sw.) Cass. based on experiments in arthritic rat models and qualitative gas chromatography-mass spectrometry analyses","volume":"5","author":"Paul","year":"2016","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106925_bb0095","series-title":"Anti-arthritic potential of Acmella uliginosa flowers and leaves in Sprague-Dawley rats induced with complete Freund\u2019s adjuvant","author":"Borhan","year":"2013"},{"key":"10.1016\/j.fitote.2025.106925_bb0100","author":"Graveson"},{"key":"10.1016\/j.fitote.2025.106925_bb0105","series-title":"PROTA4U Web Database","author":"PROTA","year":"2014"},{"key":"10.1016\/j.fitote.2025.106925_bb0110","series-title":"A dictionary of the economic products of the Malay Peninsula","volume":"vol. II","author":"Burkill","year":"1966"},{"key":"10.1016\/j.fitote.2025.106925_bb0115","series-title":"Thai Medicinal Plants Recommended for Primary Health Care System","author":"Farnsworth","year":"1992"},{"key":"10.1016\/j.fitote.2025.106925_bb0120","series-title":"Tradition Medicinal Plants","author":"Bunyapraphatsara","year":"1999"},{"key":"10.1016\/j.fitote.2025.106925_bb0125","series-title":"Medicinal Plants of East and South-East Asia","author":"Perry","year":"1980"},{"key":"10.1016\/j.fitote.2025.106925_bb0130","author":"National Parks, Singapore"},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0135","first-page":"128","article-title":"Spilanthol: Occurrence, extraction, chemistry and biological activities","volume":"26","author":"Barbosa","year":"2015","journal-title":"Rev. Bras"},{"issue":"4","key":"10.1016\/j.fitote.2025.106925_bb0140","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.anres.2015.11.002","article-title":"Chemical composition of essential oil and hexane extract and antioxidant activity of various extracts of Acmella uliginosa (Sw.) Cass flowers from Indonesia","volume":"50","author":"Maimulyanti","year":"2016","journal-title":"Agri. Nat. Resour."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0145","doi-asserted-by":"crossref","first-page":"162","DOI":"10.22146\/ijc.21160","article-title":"Chemical composition, phytochemical screening and antioxidant activity of Acmella uliginosa (Sw.) Cass Leaves","volume":"16","author":"Maimulyanti","year":"2016","journal-title":"Indon. J. Chem."},{"key":"10.1016\/j.fitote.2025.106925_bb0150","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12906-016-1014-3","article-title":"Antimicrobial, antioxidant, toxicity and phytochemical assessment of extracts from Acmella uliginosa, a leafy-vegetable consumed in B\u00e9nin, West Africa","volume":"16","author":"Lagnika","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.fitote.2025.106925_bb0155","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902022e20353","article-title":"Composition, antioxidant and anti-inflammatory activities of hexane and methanol extracts of Acmella uliginosa from Terai region of Uttarakhand","volume":"58","author":"Gairola","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"issue":"64","key":"10.1016\/j.fitote.2025.106925_bb0160","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4103\/pm.pm_71_19","article-title":"Evaluation of the effectiveness of Acmella uliginosa (Sw.) Cass. flower methanolic extract in pain amelioration and memory impairment in the experimental rat models: search for an alternative remedy over opioid painkillers","volume":"15","author":"Paul","year":"2019","journal-title":"Pharmacogn. Mag."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0165","first-page":"1129","article-title":"A Review on: Medicinal properties and therapeutic uses of an Acmella uliginosa (pipulka) plant","volume":"12","author":"Dukre","year":"2022","journal-title":"World J. Pharm. Res."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0170","first-page":"2292","article-title":"Evaluation of antimicrobial activity of selected indigenous medicinal plants","volume":"9","author":"Kumar","year":"2020","journal-title":"J. Pharmacogn. Phytochem."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.32539\/bsm.v1i1.5","article-title":"Antifungi effect of keghenyat leaves fraction (Acmella uliginosa) in vitro study","volume":"1","author":"Hijir","year":"2017","journal-title":"BioscMed"},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0180","doi-asserted-by":"crossref","first-page":"640","DOI":"10.52711\/0974-360X.2023.00109","article-title":"Anticancer activity of Acmella uliginosa against WiDr colon cancer cell line and T47D breast cancer cell line","volume":"16","author":"Kholifah","year":"2023","journal-title":"Res. J. Pharm. Tech."},{"key":"10.1016\/j.fitote.2025.106925_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.materresbull.2021.111726","article-title":"Facile preparation of CuO-Gd2Ti2O7 using Acmella uliginosa leaf extract for photocatalytic degradation of malachite green","volume":"150","author":"Halomoan","year":"2022","journal-title":"Mater. Res. Bull."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0190","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jpba.2010.02.010","article-title":"LC-MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol","volume":"53","author":"Boonen","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"157","key":"10.1016\/j.fitote.2025.106925_bb0195","article-title":"Analytical and preparative chromatographic approaches for extraction of spilanthol from Acmella oleracea flowers","volume":"2020","author":"Balieiro","year":"2020","journal-title":"Microchem. J."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0200","doi-asserted-by":"crossref","DOI":"10.1177\/15593258221103846","article-title":"Effect of diclofenac and andrographolide combination on carrageenan-induced paw edema and hyperalgesia in rats","volume":"20","author":"Tandoh","year":"2022","journal-title":"Dose-Response"},{"key":"10.1016\/j.fitote.2025.106925_bb0205","series-title":"Current Protocols in Immunology","first-page":"15.5.1","article-title":"Collagen-induced arthritis","author":"Rosloniec","year":"2010"},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0210","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1080\/21691401.2019.1649269","article-title":"Evaluation of antiarthritic activity of nimbolide against Freund\u2019s adjuvant induced arthritis in rats","volume":"47","author":"Cui","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.fitote.2025.106925_bb0215","first-page":"1","article-title":"Evaluation of the anti-inflammatory activity of methanol extract of Barleria cristata leaves by in vivo and in vitro methods","volume":"7","author":"Gambhire","year":"2009","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106925_bb0220","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.fitote.2025.106925_bb0225","series-title":"Discovery Studio Visualizer","author":"Biovia","year":"2024"},{"issue":"6","key":"10.1016\/j.fitote.2025.106925_bb0230","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0161-4630(81)90122-1","article-title":"Effects of indomethacin on hematopoiesis in mice","volume":"6","author":"Razin","year":"1981","journal-title":"Prostaglandins Med."},{"issue":"10","key":"10.1016\/j.fitote.2025.106925_bb0235","first-page":"1","article-title":"Can serum lactate dehydrogenase be used as a disease severity biochemical marker in rheumatoid arthritis?","volume":"17","author":"Patel","year":"2018","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"10.1016\/j.fitote.2025.106925_bb0240","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5346483","article-title":"Clinical and diagnostic significance of lactate dehydrogenase and its isoenzymes in animals","volume":"2020","author":"Klein","year":"2020","journal-title":"Vet. Med. Int."},{"issue":"5","key":"10.1016\/j.fitote.2025.106925_bb0245","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac337","article-title":"ToxCSM: Comprehensive prediction of small molecule toxicity profiles","volume":"23","author":"De S\u00e1","year":"2022","journal-title":"Brief. Bioinform."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0250","first-page":"114","article-title":"Rodent models of rheumatoid arthritis","volume":"55","author":"Brand","year":"2005","journal-title":"Comp. Med."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0255","first-page":"16","article-title":"Effect of Nigella sativa oil in a rat model of adjuvant-induced arthritis","volume":"11","author":"Nasuti","year":"2019","journal-title":"Proceedings"},{"issue":"6","key":"10.1016\/j.fitote.2025.106925_bb0260","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/1529-0131(200006)43:6<1266::AID-ANR9>3.0.CO;2-P","article-title":"Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis","volume":"43","author":"Szekanecz","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0265","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s43094-021-00361-w","article-title":"Amelioration of complete Freund\u2019s adjuvant-induced arthritis by Calotropis procera latex in rats","volume":"7","author":"Patel","year":"2021","journal-title":"Futur. J. Pharm. Sci."},{"key":"10.1016\/j.fitote.2025.106925_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01341","article-title":"In vivo and in vitro approach to anti-arthritic and anti-inflammatory effect of crocetin by alteration of nuclear factor-E2-related factor 2\/hem oxygenase (HO)-1 and NF-\u03baB expression","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.fitote.2025.106925_bb0275","doi-asserted-by":"crossref","first-page":"551","DOI":"10.5650\/jos.ess21413","article-title":"Specneuzhenide ameliorate complete freund adjuvant induced arthritis in rats: involvement of NF-\u03baB and HO-1\/Nrf-2 pathway","volume":"71","author":"Zeng","year":"2022","journal-title":"J. Oleo Sci."},{"issue":"11","key":"10.1016\/j.fitote.2025.106925_bb0280","article-title":"Inflammation and skeletal muscle wasting during cachexia","volume":"19","author":"Webster","year":"2020","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0285","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1590\/S0100-879X2007000100015","article-title":"Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats","volume":"40","author":"Azoubel","year":"2007","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.fitote.2025.106925_bb0290","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phymed.2018.10.028","article-title":"Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review","volume":"57","author":"Carvalho","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fitote.2025.106925_bb0295","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1460-9568.2004.03514.x","article-title":"Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS","volume":"20","author":"Raghavendra","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0300","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.thorsurg.2018.12.001","article-title":"The role of the thymus in the immune response","volume":"29","author":"Thapa","year":"2019","journal-title":"Thorac. Surg. Clin."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0305","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.bbadis.2018.12.019","article-title":"Fatty acids uptake and oxidation are increased in the liver of rats with adjuvant-induced arthritis","volume":"1865","author":"Wendt","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"8","key":"10.1016\/j.fitote.2025.106925_bb0310","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0192-0561(93)90011-M","article-title":"Kidney dysfunction in the arthritic rat","volume":"15","author":"Dijoseph","year":"1993","journal-title":"Int. J. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0315","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40780-023-00312-y","article-title":"Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone","volume":"9","author":"Deguchi","year":"2023","journal-title":"J. Pharm. Health Care Sci."},{"key":"10.1016\/j.fitote.2025.106925_bb0320","first-page":"226","article-title":"Protective effect of curcumin on experimentally induced arthritic rats: detailed histopathological study of the joints and white blood cell count","volume":"11","author":"Kamarudin","year":"2012","journal-title":"EXCLI J."},{"key":"10.1016\/j.fitote.2025.106925_bb0325","series-title":"Biochemistry, Lactate Dehydrogenase","author":"Farhana","year":"2022"},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0330","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.bjp.0704497","article-title":"Disparate effects of non-steroidal anti-inflammatory drugs on apoptosis in guinea-pig gastric mucous cells: inhibition of basal apoptosis by diclofenac","volume":"135","author":"Ashton","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106925_bb0335","series-title":"The Laboratory Rat","author":"Sharp","year":"2012"},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0340","article-title":"Alkaline phosphatase is an independent risk factor for periprosthetic fractures in total joint arthroplasty","volume":"7","author":"Lung","year":"2023","journal-title":"J. Am. Acad. Orthop. Surg. Glob. Res. Rev."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0345","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cld.562","article-title":"Standard liver tests","volume":"8","author":"Kasarala","year":"2016","journal-title":"Clin. Liver Dis."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0350","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.fshw.2017.12.002","article-title":"Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed","volume":"7","author":"Hasan","year":"2018","journal-title":"Food Sci. Human Wellness"},{"key":"10.1016\/j.fitote.2025.106925_bb0355","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15532","article-title":"Protective effect of fustin against adjuvant-induced arthritis through the restoration of proinflammatory response and oxidative stress","volume":"11","author":"Alshehri","year":"2023","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0360","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejr.2021.11.004","article-title":"Significance of vascular endothelial growth factor (VEGFA)-1154 G\/A gene polymorphism (rs1570360) in rheumatoid arthritis patients","volume":"44","author":"Bakry","year":"2022","journal-title":"Egypt. Rheumatol."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0365","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/ar292","article-title":"Angiogenesis in the pathogenesis of inflammatory joint and lung diseases","volume":"3","author":"Walsh","year":"2001","journal-title":"Arthritis Res."},{"issue":"9","key":"10.1016\/j.fitote.2025.106925_bb0370","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/1529-0131(200009)43:9<2056::AID-ANR17>3.0.CO;2-2","article-title":"Suppression of arthritis and protection from bone destruction by treatment with TNP-470\/AGM-1470 in a transgenic mouse model of rheumatoid arthritis","volume":"43","author":"de Bandt","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0375","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5487\/TR.2013.29.3.195","article-title":"Anti-inflammatory effect of Isaria sinclairii Glycosaminoglycan in an adjuvant-treated arthritis rat model","volume":"29","author":"Ahn","year":"2013","journal-title":"Toxicol. Res."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0380","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0014-4800(03)00019-4","article-title":"The role of COX-2 in angiogenesis and rheumatoid arthritis","volume":"74","author":"Woods","year":"2003","journal-title":"Exp. Mol. Pathol."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0385","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.intimp.2012.12.005","article-title":"Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-\u03baB and MAPK inactivation in RAW 264.7 cells","volume":"15","author":"Park","year":"2013","journal-title":"Int. Immunopharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.fitote.2025.106925_bb0390","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1186\/ar44","article-title":"The role of COX-2 in rheumatoid arthritis synovial tissues","volume":"1","author":"Crofford","year":"2000","journal-title":"Arthritis Res."},{"key":"10.1016\/j.fitote.2025.106925_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.579266","article-title":"Non-transcriptional and translational function of canonical NF-\u03baB signaling in activating ERK1\/2 in IL-1\u03b2-induced COX-2 expression in synovial fibroblasts","volume":"11","author":"Nakano","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0400","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar2717","article-title":"Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids","volume":"11","author":"Gheorghe","year":"2009","journal-title":"Arth. Res. Ther."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0405","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1006\/bbrc.1999.1732","article-title":"5-Lipoxygenase upregulation by dexamethasone in human mast cells","volume":"265","author":"Colamorea","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5655","key":"10.1016\/j.fitote.2025.106925_bb0410","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1090985","article-title":"Regulation of bone mass in mice by the lipoxygenase gene Alox15","volume":"303","author":"Klein","year":"2004","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.fitote.2025.106925_bb0415","first-page":"2542","article-title":"LOX inhibitor HOEC interfered arachidonic acid metabolic flux in collagen-induced arthritis rats","volume":"10","author":"Yang","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.fitote.2025.106925_bb0420","first-page":"9","article-title":"Neuroinflammation in neurodegenerative disorders: The roles of microglia and astrocytes","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.fitote.2025.106925_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101359","article-title":"5-Lipoxygenase as an emerging target against age-related brain disorders","volume":"69","author":"Yan","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.fitote.2025.106925_bb0430","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/129873","article-title":"Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention","volume":"2008","author":"Yoo","year":"2008","journal-title":"Mediat. Inflamm."},{"issue":"10","key":"10.1016\/j.fitote.2025.106925_bb0435","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.3390\/ijms22105387","article-title":"Vascular endothelial growth factor biology and its potential as a therapeutic target in rheumatic diseases","volume":"22","author":"Le","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2025.106925_bb0440","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.taap.2018.07.014","article-title":"Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis","volume":"356","author":"Abdel-Maged","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106925_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114702","article-title":"Efficacy and safety of Ramucirumab and methotrexate co-therapy in rheumatoid arthritis experimental model: Involvement of angiogenic and immunomodulatory signaling","volume":"380","author":"Abdel-Maged","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.fitote.2025.106925_bb0450","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0006-291X(02)02707-9","article-title":"Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells","volume":"299","author":"Li","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.fitote.2025.106925_bb0455","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1096\/fj.01-0390rev","article-title":"Cyclooxygenase-independent actions of cyclooxygenase inhibitors","volume":"15","author":"Tegeder","year":"2001","journal-title":"FASEB J."},{"issue":"35","key":"10.1016\/j.fitote.2025.106925_bb0460","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.3748\/wjg.v18.i35.4866","article-title":"Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats","volume":"18","author":"Esquivias","year":"2012","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0465","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.bbrc.2016.08.078","article-title":"Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells","volume":"478","author":"Kim","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.fitote.2025.106925_bb0470","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1038\/sj.bjc.6603813","article-title":"Mechanisms of adverse effects of anti-VEGF therapy for cancer","volume":"96","author":"Kamba","year":"2007","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.fitote.2025.106925_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.103050","article-title":"The 5-lipoxygenase\/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis","volume":"299","author":"Nakashima","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fitote.2025.106925_bb0480","first-page":"1957","article-title":"In vitro anti-inflammatory and anti-arthritic activity in methanolic extract of Cocculus hirsutus (L.) Diels. In Vivo and In vitro","volume":"5","author":"Arya","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0485","doi-asserted-by":"crossref","first-page":"160","DOI":"10.7897\/2230-8407.04332","article-title":"In vitro anti arthritic activity of ethanolic extract of Callicarpa macrophylla flower","volume":"4","author":"Gupta","year":"2013","journal-title":"Int. Res. J. Pharm."},{"issue":"1","key":"10.1016\/j.fitote.2025.106925_bb0490","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1080\/13880209.2017.1280513","article-title":"Appraisal of anti-arthritic and nephroprotective potential of Cuscuta reflexa","volume":"55","author":"Niazi","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.fitote.2025.106925_bb0495","first-page":"211","article-title":"In vitro anti-inflammatory and anti-arthritic activities of leaves of Physalis angulata L","volume":"1","author":"Kishore","year":"2011","journal-title":"Int. J. Pharm. Ind. Res."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0500","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF02976483","article-title":"Inhibition of heat-induced denaturation of albumin by nonsteroidal anti-inflammatory drugs (NSAIDs): pharmacological implications","volume":"24","author":"Saso","year":"2001","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.fitote.2025.106925_bb0505","article-title":"Medical implications of the relationships among protein denaturation, necrosis and inflammation: an intriguing story","author":"Silvestrini","year":"2022","journal-title":"IntechOpen"},{"issue":"3","key":"10.1016\/j.fitote.2025.106925_bb0510","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1046\/j.1523-1755.1998.00804.x","article-title":"Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease","volume":"53","author":"Zoja","year":"1998","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.fitote.2025.106925_bb0515","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10585-012-9473-5","article-title":"Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models","volume":"29","author":"Zollo","year":"2012","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.fitote.2025.106925_bb0520","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2019.03.019","article-title":"Ribes orientale: A novel therapeutic approach targeting rheumatoid arthritis with reference to pro-inflammatory cytokines, inflammatory enzymes and anti-inflammatory cytokines","volume":"237","author":"Uttra","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.fitote.2025.106925_bb0525","first-page":"367","article-title":"Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark","volume":"7","author":"Foyet","year":"2014","journal-title":"Pharm. Res."},{"issue":"7","key":"10.1016\/j.fitote.2025.106925_bb0530","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1021\/jf073057e","article-title":"Anti-inflammatory effect of spilanthol from Spilanthes acmella on murine macrophage by down-regulating LPS-induced inflammatory mediators","volume":"56","author":"Wu","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fitote.2025.106925_bb0535","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.supflu.2018.07.028","article-title":"Isolation of spilanthol from Acmella oleracea based on Green Chemistry and evaluation of its in vitro anti-inflammatory activity","volume":"140","author":"Freitas Blanco","year":"2018","journal-title":"J. Supercrit. Fluids"},{"issue":"17","key":"10.1016\/j.fitote.2025.106925_bb0540","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.3390\/ijms20174308","article-title":"Spilanthol inhibits inflammatory transcription factors and iNOS expression in macrophages and exerts anti-inflammatory effects in dermatitis and pancreatitis","volume":"20","author":"Bakondi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2025.106925_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113610","article-title":"Chymase inhibition: A key factor in the anti-inflammatory activity of ethanolic extracts and spilanthol isolated from Acmella oleracea","volume":"270","author":"Stein","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.fitote.2025.106925_bb0550","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1055\/s-2006-962097","article-title":"In vitro inhibition of arachidonate metabolism by some alkamides and prenylated phenols","volume":"55","author":"Wagner","year":"1989","journal-title":"Planta Med."},{"key":"10.1016\/j.fitote.2025.106925_bb0555","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.supflu.2011.09.020","article-title":"Spilanthol from Spilanthes acmella flowers, leaves and stems obtained by selective supercritical carbon dioxide extraction","volume":"61","author":"Dias","year":"2011","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.fitote.2025.106925_bb0560","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1007\/s10753-018-0837-0","article-title":"Spilanthol inhibits COX-2 and ICAM-1 expression via suppression of NF-\u03baB and MAPK signaling in Interleukin-1\u03b2-stimulated human lung epithelial cells","volume":"41","author":"Huang","year":"2018","journal-title":"Inflammation"},{"issue":"18","key":"10.1016\/j.fitote.2025.106925_bb0565","first-page":"2987","article-title":"Spilanthol inhibits TNF \u03b1 induced ICAM 1 expression and pro-inflammatory responses by inducing heme oxygenase 1 expression and suppressing pJNK in HaCaT keratinocytes","volume":"2018","author":"Huang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.fitote.2025.106925_bb0570","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/ijms20102490","article-title":"Topical spilanthol inhibits MAPK signaling and ameliorates allergic inflammation in DNCB-induced atopic dermatitis in mice","volume":"20","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fitote.2025.106925_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2021.114027","article-title":"Spilanthol-rich essential oil obtained by microwave-assisted extraction from Acmella oleracea (L.) RK Jansen and its nanoemulsion: Insecticidal, cytotoxic and anti-inflammatory activities","volume":"172","author":"Spinozzi","year":"2021","journal-title":"Ind. Crop. Prod."},{"issue":"4","key":"10.1016\/j.fitote.2025.106925_bb0580","doi-asserted-by":"crossref","first-page":"264","DOI":"10.14715\/cmb\/2020.66.4.31","article-title":"Phytol anti-inflammatory activity: pre-clinical assessment and possible mechanism of action elucidation","volume":"6","author":"Islam","year":"2020","journal-title":"Cell. Mol. Biol."},{"issue":"9","key":"10.1016\/j.fitote.2025.106925_bb0585","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030348","article-title":"A new arthritis therapy with oxidative burst inducers","volume":"3","author":"Hultqvist","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.fitote.2025.106925_bb0590","doi-asserted-by":"crossref","DOI":"10.1111\/fcp.12049","article-title":"Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production andoxidative stress","volume":"28","author":"Silva","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106925_bb0595","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.18639\/RABM.2018.04.643518","article-title":"Phytol reduces oxidative stress and cyclooxygenase-2 expression in kidney of diabetic wistar rats","volume":"4","author":"Israel","year":"2018","journal-title":"Recent Adv. Biol. Med."},{"key":"10.1016\/j.fitote.2025.106925_bb0600","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.fct.2018.08.032","article-title":"Phytol: A review of biomedical activities","volume":"121","author":"Islam","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.fitote.2025.106925_bb0605","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/acs.jnatprod.9b01116","article-title":"Phytol, a chlorophyll component, produces antihyperalgesic, anti-inflammatory, and antiarthritic effects: possible NF\u03baB pathway involvement and reduced levels of the proinflammatory cytokines TNF-\u03b1 and IL-6","volume":"83","author":"Carvalho","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"15","key":"10.1016\/j.fitote.2025.106925_bb0610","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.3390\/foods11152366","article-title":"Acyclic diterpene phytol from hemp seed oil (Cannabis sativa L.) exerts anti-inflammatory activity on primary human monocytes-macrophages","volume":"11","author":"Claro-Cala","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.fitote.2025.106925_bb0615","first-page":"426","article-title":"Ethanopharmacological anti-inflammatory study of phytol in ethanol extract of Woodfordia floribunda Salisb","volume":"11","author":"Pankaj","year":"2022","journal-title":"Ann. Phytomed."},{"key":"10.1016\/j.fitote.2025.106925_bb0620","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s13205-024-03924-9","article-title":"Phytol from Scoparia dulcis prevents NF-\u03baB-mediated inflammatory responses during macrophage polarization","volume":"14","author":"Duraisamy","year":"2024","journal-title":"3 Biotech"},{"issue":"4","key":"10.1016\/j.fitote.2025.106925_bb0625","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1039\/C7FO01817G","article-title":"Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) \u03b1 in mice fed high-fat diet","volume":"9","author":"Zhang","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.fitote.2025.106925_bb0630","first-page":"881","article-title":"Effect of phytol following single\u2013dose oral and intravenous administration in healthy rats","volume":"881","author":"Saranya","year":"2022","journal-title":"Pharma Innov. J."},{"key":"10.1016\/j.fitote.2025.106925_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.bse.2023.104775","article-title":"Jansen essential oils: Chemical composition, antioxidant, and cytotoxic activities","volume":"112","author":"Jer\u00f4nimo","year":"2024","journal-title":"Biochem. Syst. Ecol."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0640","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jep.2013.11.004","article-title":"Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach","volume":"151","author":"Napagoda","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0645","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jep.2013.11.052","article-title":"Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1","volume":"151","author":"Napagoda","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fitote.2025.106925_bb0650","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.biopha.2018.06.035","article-title":"Phytol shows anti-angiogenic activity and induces apoptosis in A549 cells by depolarizing the mitochondrial membrane potential","volume":"105","author":"Sakthivel","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fitote.2025.106925_bb0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.fufo.2021.100022","article-title":"N-alkylamides of Spilanthes (syn: Acmella): Structure, purification, characterization, biological activities and applications \u2013 a review","volume":"3","author":"Sharma","year":"2021","journal-title":"Future Foods"},{"issue":"2","key":"10.1016\/j.fitote.2025.106925_bb0660","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/molecules27020523","article-title":"The bioavailability and biological activities of phytosterols as modulators of cholesterol metabolism","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.fitote.2025.106925_bb0665","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3390\/antibiotics13121171","article-title":"Analysis of the antibiotic-potentiating activity, absorption, distribution, metabolism, and excretion (ADME) and the molecular docking properties of phytol against multi-drug-resistant (MDR) strains","volume":"13","author":"Almeida-Bezerra","year":"2024","journal-title":"Antibiotics (Basel)"}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25005519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25005519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:00:02Z","timestamp":1778324402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X25005519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":133,"alternative-id":["S0367326X25005519"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106925","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acmella uliginosa (Sw.) Cass hampers complete Freund's adjuvant-induced arthritis in rats by inhibiting the VEGF axis","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106925"}}