{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:12:03Z","timestamp":1783606323341,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH427"],"award-info":[{"award-number":["ZR2023QH427"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023ZD25"],"award-info":[{"award-number":["ZR2023ZD25"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016694","name":"Science and Technology Development Plan of Shandong Province","doi-asserted-by":"publisher","award":["Q-2023107"],"award-info":[{"award-number":["Q-2023107"]}],"id":[{"id":"10.13039\/100016694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tstp20230633"],"award-info":[{"award-number":["tstp20230633"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202408246"],"award-info":[{"award-number":["tsqn202408246"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751899"],"award-info":[{"award-number":["2024M751899"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["202228048"],"award-info":[{"award-number":["202228048"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fitoterapia"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.fitote.2025.106935","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:15:25Z","timestamp":1760541325000},"page":"106935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Shenmai injection attenuates sepsis-associated acute lung injury by remodeling gut microbiota and restoring steroid hormone biosynthesis"],"prefix":"10.1016","volume":"187","author":[{"given":"Mingxuan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-wu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.fitote.2025.106935_bb0005","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1056\/NEJMclde1815472","article-title":"Sepsis guidelines","volume":"380","author":"Chen","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.fitote.2025.106935_bb0010","doi-asserted-by":"crossref","first-page":"1800786","DOI":"10.1183\/13993003.00786-2018","article-title":"Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury","volume":"53","author":"Park","year":"2019","journal-title":"Eur. Respir."},{"key":"10.1016\/j.fitote.2025.106935_bb0015","doi-asserted-by":"crossref","first-page":"1289194","DOI":"10.3389\/fmed.2023.1289194","article-title":"Acute lung injury caused by sepsis: how does it happen?","volume":"10","author":"Sun","year":"2023","journal-title":"Front. Med."},{"issue":"10","key":"10.1016\/j.fitote.2025.106935_bb0020","doi-asserted-by":"crossref","first-page":"16113","DOI":"10.1038\/nmicrobiol.2016.113","article-title":"Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome","volume":"1","author":"Dickson","year":"2016","journal-title":"Nat. Microbiol."},{"issue":"1","key":"10.1016\/j.fitote.2025.106935_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13054-024-04966-4","article-title":"Exploring the lung-gut direction of the gut-lung axis in patients with ARDS","volume":"28","author":"Ziaka","year":"2024","journal-title":"Crit. Care"},{"issue":"6","key":"10.1016\/j.fitote.2025.106935_bb0030","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1007\/s13346-023-01494-6","article-title":"Cell-derived biomimetic nanoparticles for the targeted therapy of ALI\/ARDS","volume":"14","author":"Gao","year":"2024","journal-title":"Drug Deliv. Transl. Re."},{"issue":"3","key":"10.1016\/j.fitote.2025.106935_bb0035","article-title":"Overcoming challenges of clinical cell therapies for Parkinson's disease with photobiomodulation","volume":"2","author":"Chamkouri","year":"2024","journal-title":"IMed"},{"key":"10.1016\/j.fitote.2025.106935_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscia.2025.100070","article-title":"Antimicrobial potentials and challenges of paracetamol: a comprehensive reassessment based on database reports","volume":"3","author":"Islam","year":"2025","journal-title":"Pharm. Sci. Adv."},{"issue":"5","key":"10.1016\/j.fitote.2025.106935_bb0045","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.joim.2023.08.004","article-title":"Xuebijing injection, a Chinese patent medicine, against severe pneumonia: current research progress and future perspectives","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.fitote.2025.106935_bb0050","article-title":"An overview of systematic reviews of shenmai injection for healthcare, evidence-based complementary and alternative medicine","volume":"2014","author":"Lu","year":"2014","journal-title":"eCAM"},{"issue":"4","key":"10.1016\/j.fitote.2025.106935_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.imr.2021.100778","article-title":"Chinese herbal injections for coronavirus disease 2019 (COVID-19): a narrative review","volume":"10","author":"Zhu","year":"2021","journal-title":"Integr. Med. Res."},{"issue":"05","key":"10.1016\/j.fitote.2025.106935_bb0060","article-title":"Effect of Shenmai injection intervention on new organ damages in sepsis, China","volume":"21","author":"Yang","year":"2024","journal-title":"Med. Herald"},{"key":"10.1016\/j.fitote.2025.106935_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153597","article-title":"Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity","volume":"88","author":"Wu","year":"2021","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.fitote.2025.106935_bb0070","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0254-6272(10)60055-6","article-title":"Study on modified shengmai yin injection for prevention and treatment of brain impairment in endotoxin shock rats","volume":"30","author":"Zhang","year":"2010","journal-title":"J. Tradit. Chin. Med."},{"issue":"1\u20133","key":"10.1016\/j.fitote.2025.106935_bb0075","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejphar.2012.04.032","article-title":"Ginsenoside Rb\u2081 inhibits the carotid neointimal hyperplasia induced by balloon injury in rats via suppressing the phenotype modulation of vascular smooth muscle cells","volume":"685","author":"Zhang","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106935_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106805","article-title":"Ginsenoside Rg1 prevent and treat inflammatory diseases: a review","volume":"87","author":"Gao","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.fitote.2025.106935_bb0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbrc.2017.06.007","article-title":"Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPAR\u03b1 in HUVECs","volume":"490","author":"Huang","year":"2017","journal-title":"Biochem. Biophy. Res. Co."},{"key":"10.1016\/j.fitote.2025.106935_bb0090","article-title":"Modeling inflammation in zebrafish for the development of anti-inflammatory drugs","volume":"8","author":"Xie","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.fitote.2025.106935_bb0095","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s12276-021-00571-5","article-title":"Zebrafish as an animal model for biomedical research","volume":"53","author":"Choi","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.fitote.2025.106935_bb0100","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1021\/acsami.4c17885","article-title":"Therapeutic potential of carbon dots derived from phytochemicals as nanozymes exhibiting superoxide dismutase activity for anemia","volume":"17","author":"Lu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.fitote.2025.106935_bb0105","article-title":"Fine-tuning of cholesterol homeostasis controls erythroid differentiation","volume":"9","author":"Lu","year":"2022","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.fitote.2025.106935_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.781874","article-title":"Pulmonary interstitial matrix and lung fluid balance from normal to the acutely injured lung","volume":"12","author":"Beretta","year":"2021","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.fitote.2025.106935_bb0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF02836471","article-title":"Change of TH1\/TH2 cytokine equilibrium in rats with severe sepsis and therapeutic effect of recombinant interleukin-12 and Shenmai injection","volume":"11","author":"Yu","year":"2005","journal-title":"Chin. J. Integr. Med."},{"issue":"1","key":"10.1016\/j.fitote.2025.106935_bb0120","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12906-024-04737-2","article-title":"Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism","volume":"25","author":"Li","year":"2025","journal-title":"BMC Complement. Med. Ther."},{"issue":"2","key":"10.1016\/j.fitote.2025.106935_bb0125","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Nogales","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.fitote.2025.106935_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1159094","article-title":"Exploring the mechanism of JiGuCao capsule formula on treating hepatitis B virus infection via network pharmacology analysis and in vivo\/vitro experiment verification","volume":"14","author":"Cao","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fitote.2025.106935_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105549","article-title":"Exploring the possible molecular targeting mechanism of Saussurea involucrata in the treatment of COVID-19 based on bioinformatics and network pharmacology","volume":"146","author":"Zhang","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.fitote.2025.106935_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1151144","article-title":"The calcium-sensing receptor modulates the prostaglandin E(2) pathway in intestinal inflammation","volume":"14","author":"Gushchina","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.fitote.2025.106935_bb0145","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3390\/biom11121873","article-title":"Essential fatty acids and their metabolites in the pathobiology of inflammation and its resolution","volume":"11","author":"Das","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.fitote.2025.106935_bb0150","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1134\/S1607672924701126","article-title":"The role of Hydroxyeicosatetraenoic acids in the regulation of inflammation in bronchial asthma","volume":"519","author":"Kytikova","year":"2024","journal-title":"Dokl. Biochem. Biophys."},{"issue":"10","key":"10.1016\/j.fitote.2025.106935_bb0155","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1021\/acsinfecdis.4c00529","article-title":"Mycobacterium tuberculosis suppresses inflammatory responses in host through its cholesterol metabolites","volume":"10","author":"Wu","year":"2024","journal-title":"ACS Infect. Dis."},{"issue":"4","key":"10.1016\/j.fitote.2025.106935_bb0160","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/andr.13544","article-title":"Inflammatory markers and androstenedione modify the effect of serum testosterone on obesity among men: findings from a Chinese population","volume":"12","author":"Huan","year":"2024","journal-title":"Andrology"},{"key":"10.1016\/j.fitote.2025.106935_bb0165","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1038\/ncomms8979","article-title":"Oestrogen sulfotransferase ablation sensitizes mice to sepsis","volume":"6","author":"Chai","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.fitote.2025.106935_bb0170","first-page":"57","article-title":"New generation estrogen receptor-targeted agents in breast cancer: present situation and future prospectives","volume":"3","author":"Min","year":"2024","journal-title":"Acta Mater. Med."},{"key":"10.1016\/j.fitote.2025.106935_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106450","article-title":"Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3\u03b2-hydroxysteroid dehydrogenases for therapeutic purposes","volume":"238","author":"Ren","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"5","key":"10.1016\/j.fitote.2025.106935_bb0180","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s13238-020-00814-7","article-title":"The role of the gut microbiome and its metabolites in metabolic diseases","volume":"12","author":"Wu","year":"2021","journal-title":"Protein Cell"},{"issue":"2","key":"10.1016\/j.fitote.2025.106935_bb0185","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cell.2024.11.020","article-title":"A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity","volume":"188","author":"Burrows","year":"2025","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.fitote.2025.106935_bb0190","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/microorganisms8111715","article-title":"The influence of probiotics on the firmicutes\/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.fitote.2025.106935_bb0195","article-title":"Severe pneumonia caused by Chlamydia abortus complicated by hemophagocytic syndrome: a case report","volume":"12","author":"Xu","year":"2025","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.fitote.2025.106935_bb0200","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/pathogens11010093","article-title":"Effect of female sex hormones on the immune response against Chlamydia abortus and on protection conferred by an inactivated experimental vaccine in a mouse model","volume":"11","author":"Del Rio","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.fitote.2025.106935_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1330094","article-title":"Microbiota modulates the steroid response to acute immune stress in male mice","volume":"15","author":"Vagnerov\u00e1","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fitote.2025.106935_bb0210","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13054-023-04310-2","article-title":"Rationale for sequential extracorporeal therapy (SET) in sepsis","volume":"27","author":"Ronco","year":"2023","journal-title":"Crit. Care"},{"issue":"10","key":"10.1016\/j.fitote.2025.106935_bb0215","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00134-023-07194-6","article-title":"Sex and gender differences in intensive care medicine","volume":"49","author":"Merdji","year":"2023","journal-title":"Intensive Care Med."},{"issue":"3","key":"10.1016\/j.fitote.2025.106935_bb0220","first-page":"320","article-title":"Statistical evaluation of absolute change versus responder analysis in clinical trials","volume":"1","author":"Wang","year":"2022","journal-title":"Acta Mater. Med."}],"container-title":["Fitoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25005611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0367326X25005611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:07:11Z","timestamp":1778324831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0367326X25005611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S0367326X25005611"],"URL":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106935","relation":{},"ISSN":["0367-326X"],"issn-type":[{"value":"0367-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shenmai injection attenuates sepsis-associated acute lung injury by remodeling gut microbiota and restoring steroid hormone biosynthesis","name":"articletitle","label":"Article Title"},{"value":"Fitoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fitote.2025.106935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106935"}}