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Sci."},{"issue":"1","key":"10.1016\/j.fitote.2025.106965_bb0485","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12906-025-04964-1","article-title":"Insights into the antiviral mechanisms of \u03b2-caryophyllene: inhibiting viral spread and its synergy with acyclovir","volume":"25","author":"Yasaghi","year":"2025","journal-title":"BMC Complement. Med. Ther."},{"issue":"24","key":"10.1016\/j.fitote.2025.106965_bb0490","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.3390\/app9245420","article-title":"\u03b2-Caryophyllene: a sesquiterpene with countless biological properties","volume":"9","author":"Francomano","year":"2019","journal-title":"Appl. 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Appl."},{"issue":"6","key":"10.1016\/j.fitote.2025.106965_bb0615","first-page":"1129","article-title":"Studies on the antioxidant section and its antioxidant activity in Fanhuncao Granule","volume":"35","author":"Jia","year":"2019","journal-title":"J. Changchun Univ. Chin. Med."},{"issue":"4","key":"10.1016\/j.fitote.2025.106965_bb0620","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/biof.1507","article-title":"Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway","volume":"45","author":"Yao","year":"2019","journal-title":"Biofactors"},{"issue":"5","key":"10.1016\/j.fitote.2025.106965_bb0625","doi-asserted-by":"crossref","first-page":"H1862","DOI":"10.1152\/ajpheart.00651.2005","article-title":"Activation of Nrf2\/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression","volume":"290","author":"Chen","year":"2006","journal-title":"Am. 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Sci."},{"key":"10.1016\/j.fitote.2025.106965_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144211","article-title":"Comprehensive review of pyrrolizidine alkaloids in bee products: occurrence, extraction, and analytical methods","volume":"483","author":"Brugnerotto","year":"2025","journal-title":"Food Chem."},{"issue":"9","key":"10.1016\/j.fitote.2025.106965_bb0640","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/toxins14090633","article-title":"Combined hepatotoxicity and toxicity mechanism of intermedine and lycopsamine","volume":"14","author":"Wang","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.fitote.2025.106965_bb0645","first-page":"94","article-title":"Mechanistic studies of hepatotoxicities induced by retrorsine and monocrotaline","author":"Yang","year":"2018","journal-title":"Shenyang Pharm. 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Sci."},{"issue":"1","key":"10.1016\/j.fitote.2025.106965_bb0720","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/s41467-017-01803-x","article-title":"The microbiota protects against respiratory infection via GM-CSF signaling","volume":"8","author":"Brown","year":"2017","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.fitote.2025.106965_bb0725","first-page":"2550","article-title":"Impact of the microbiota on the respiratory system","volume":"35","author":"Yuan","year":"2022","journal-title":"J. Med. Theory Pract."},{"key":"10.1016\/j.fitote.2025.106965_bb0730","first-page":"1","article-title":"Research progress on the mechanism of gut microbiota in COPD based on the lung gut axis","author":"Yang","year":"2025","journal-title":"J. Pract. Tradit. Chin. Intern. 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