{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:35:31Z","timestamp":1791261331137,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Center for Product Safety","award":["SCB-11068"],"award-info":[{"award-number":["SCB-11068"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food Microbiology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.fm.2019.103303","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T02:30:37Z","timestamp":1565922637000},"page":"103303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Inhibition of Escherichia coli O157:H7 and Salmonella enterica virulence factors by benzyl isothiocyanate"],"prefix":"10.1016","volume":"86","author":[{"given":"Jitendra","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Bai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Bauchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mowery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fm.2019.103303_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.foodchem.2009.05.009","article-title":"Glucosinolates, volatile constituents and biological activities of Erysimum corinthium Boiss. (Brassicaceae)","volume":"118","author":"Al-Gendy","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.fm.2019.103303_bib2","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1111\/j.1365-2672.2009.04180.x","article-title":"The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract","volume":"106","author":"Aires","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib3","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.4315\/0362-028X.JFP-16-104","article-title":"Efficacy of plant-derived antimicrobials in controlling enterohemorrhagic Escherichia coli virulence in vitro","volume":"79","author":"Baskaran","year":"2016","journal-title":"J. Food Prot."},{"key":"10.1016\/j.fm.2019.103303_bib4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/diseases4020022","article-title":"The role of glucosinolate hydrolysis products from Brassica vegetable consumption in inducing antioxidant activity and reducing cancer incidence","volume":"4","author":"Becker","year":"2016","journal-title":"Diseases"},{"key":"10.1016\/j.fm.2019.103303_bib5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3389\/fmicb.2017.00911","article-title":"Effect of dietary minerals on virulence attributes of Vibrio cholerae","volume":"8","author":"Bhattaram","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib6","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1128\/AEM.00340-07","article-title":"Carvacrol induces heat shock protein 60 and inhibits synthesis of flagellin in Escherichia coli O157: H7","volume":"73","author":"Burt","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrmicro1818","article-title":"The biology and future prospects of antivirulence therapies","volume":"6","author":"Cegelski","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib8","author":"Centers for Disease Control and Prevention (CDC)"},{"key":"10.1016\/j.fm.2019.103303_bib9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jep.2005.08.036","article-title":"Anti-diarrheal effect of Galla Chinensis on the Escherichia coli heat-labile enterotoxin and gangloside interaction","volume":"103","author":"Chen","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fm.2019.103303_bib10","first-page":"73","article-title":"Antimicrobial properties of isothiocyanates if food preservation","volume":"49","author":"Delaquis","year":"1995","journal-title":"Food Technol."},{"key":"10.1016\/j.fm.2019.103303_bib11","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cbpa.2008.06.022","article-title":"Antivirulence as a new antibacterial approach for chemotherapy","volume":"12","author":"Escaich","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.fm.2019.103303_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/10408398209527361","article-title":"Glucosinolates and their breakdown products in food and food plants","volume":"18","author":"Fenwick","year":"1983","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fm.2019.103303_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2958.2002.02899.x","article-title":"The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells","volume":"44","author":"Gir\u00f3n","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1741-7015-10-12","article-title":"Treatment of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic uremic syndrome (HUS)","volume":"10","author":"Goldwater","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.fm.2019.103303_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1039\/b204039p","article-title":"A critical review of the bioavailability of glucosinolates and related compounds","volume":"21","author":"Holst","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.fm.2019.103303_bib16","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1116739","article-title":"Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization","volume":"310","author":"Hung","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.fm.2019.103303_bib17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.vetmic.2011.12.021","article-title":"Sub-lethal levels of carvacrol reduce Salmonella Typhimurium motility and invasion of porcine epithelial cells","volume":"157","author":"Inamuco","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1750-3841.2010.01725.x","article-title":"Evaluation of antibacterial activity of 3\u2010butenyl, 4\u2010pentenyl, 2\u2010phenylethyl, and benzyl isothiocyanate in Brassica vegetables","volume":"75","author":"Jang","year":"2010","journal-title":"J. Food Sci."},{"key":"10.1016\/j.fm.2019.103303_bib19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/fpd.2009.0527","article-title":"Effect of subinhibitory concentrations of plant-derived molecules in increasing the sensitivity of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 to antibiotics","volume":"7","author":"Johny","year":"2010","journal-title":"Foodb. Pathog. Dis."},{"key":"10.1016\/j.fm.2019.103303_bib20","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1078\/1438-4221-00173","article-title":"The role of motility as a virulence factor in bacteria","volume":"291","author":"Josenhans","year":"2002","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib21","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00018-007-6484-5","article-title":"Molecular basis for chemoprevention by sulforaphane: a comprehensive review","volume":"64","author":"Juge","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fm.2019.103303_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1534735403261831","article-title":"Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium","volume":"3","author":"Keck","year":"2004","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.fm.2019.103303_bib23","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1021\/jf00059a013","article-title":"Antibacterial activity of some essential oil components against five foodborne pathogens","volume":"43","author":"Kim","year":"1995","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fm.2019.103303_bib24","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1128\/AEM.07643-11","article-title":"Reduction of Salmonella enterica serovar Enteritidis colonization in 20-day-old broiler chickens by the plant-derived compounds trans-cinnamaldehyde and eugenol","volume":"78","author":"Kollanoor-Johny","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.coph.2003.04.001","article-title":"Targeting virulence for antimicrobial chemotherapy","volume":"3","author":"Lee","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.fm.2019.103303_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.postharvbio.2007.06.003","article-title":"Control of brown rot on stone fruit by synthetic and glucosinolate-derived isothiocyanates","volume":"47","author":"Mari","year":"2008","journal-title":"Postharvest Biol. Technol."},{"key":"10.1016\/j.fm.2019.103303_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1586\/14787210.2.1.61","article-title":"Can virulence factors be viable antibacterial targets?","volume":"2","author":"Marra","year":"2004","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.fm.2019.103303_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00131-11","article-title":"The sociomicrobiology of antivirulence drug resistance: a proof of concept","volume":"2","author":"Mellbye","year":"2011","journal-title":"mBio"},{"key":"10.1016\/j.fm.2019.103303_bib29","series-title":"Escherichia coli O157:H7 and Other Shiga Toxin\u2013Producing E. coli Strains","first-page":"287","article-title":"Pathophysiology of hemolytic-uremic syndrome","author":"Monnens","year":"1998"},{"key":"10.1016\/j.fm.2019.103303_bib30","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1046\/j.1365-2958.1998.00890.x","article-title":"Functional and genetic analysis of regulatory regions of coliphage H-19B: location of Shigalike toxin and lysis genes suggest a role for phage functions in toxin release","volume":"28","author":"Neely","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fm.2019.103303_bib31","first-page":"65","article-title":"Shiga toxin: biochemistry, genetics, mode of action and role in pathogenesis","volume":"180","author":"O'Brien","year":"1992","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.fm.2019.103303_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3013","article-title":"Anti-virulence strategies to combat bacteria-mediated disease","volume":"9","author":"Rasko","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.fm.2019.103303_bib33","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1073\/pnas.0611643104","article-title":"Virstatin inhibits dimerization of the transcriptional activator ToxT","volume":"104","author":"Shakhnovich","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fm.2019.103303_bib34","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1128\/IAI.00927-10","article-title":"Activation of motility by sensing short-chain fatty acids via two steps in a flagellar gene regulatory cascade in enterohemorrhagic Escherichia coli","volume":"79","author":"Tobe","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fm.2019.103303_bib35","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1128\/JB.00852-06","article-title":"Uncovering a large set of genes that affect surface motility in Salmonella enterica serovar Typhimurium","volume":"188","author":"Wang","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.fm.2019.103303_bib36","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/pmj.78.918.216","article-title":"Mechanisms of bacterial pathogenicity","volume":"78","author":"Wilson","year":"2002","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.fm.2019.103303_bib37","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.3382\/ps\/pev207","article-title":"Controlling Aspergillus flavus and Aspergillus parasiticus growth and aflatoxin production in poultry feed using carvacrol and trans-cinnamaldehyde","volume":"94","author":"Yin","year":"2015","journal-title":"Poult. Sci."}],"container-title":["Food Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740002019303727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740002019303727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T22:26:46Z","timestamp":1572992806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0740002019303727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":37,"alternative-id":["S0740002019303727"],"URL":"https:\/\/doi.org\/10.1016\/j.fm.2019.103303","relation":{},"ISSN":["0740-0020"],"issn-type":[{"value":"0740-0020","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of Escherichia coli O157:H7 and Salmonella enterica virulence factors by benzyl isothiocyanate","name":"articletitle","label":"Article Title"},{"value":"Food Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fm.2019.103303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103303"}}