{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:04:00Z","timestamp":1776139440634,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food Microbiology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.fm.2021.103961","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T08:38:01Z","timestamp":1638434281000},"page":"103961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Impact of serine and serine synthesis genes on H2S release in Saccharomyces cerevisiae during wine fermentation"],"prefix":"10.1016","volume":"103","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junling","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.fm.2021.103961_bib1","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1074\/jbc.M211692200","article-title":"Ser3p (Yer081wp) and Ser 33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae","volume":"278","author":"Albers","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"28","key":"10.1016\/j.fm.2021.103961_bib2","doi-asserted-by":"crossref","first-page":"7942","DOI":"10.1021\/acs.jafc.9b01844","article-title":"Saccharomyces cerevisiae and Torulaspora delbrueckii intra- and extra-cellular aromatic amino acids metabolism","volume":"67","author":"\u00c1lvarez-Fern\u00e1ndez","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.fm.2021.103961_bib3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jdermsci.2011.06.001","article-title":"l-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of l-serine biosynthesis","volume":"63","author":"Bachelor","year":"2011","journal-title":"J. Dermatol. Sci."},{"issue":"51","key":"10.1016\/j.fm.2021.103961_bib4","doi-asserted-by":"crossref","first-page":"13483","DOI":"10.1021\/acs.jafc.8b04690","article-title":"Liberation of hydrogen sulfide from dicysteinyl polysulfanes in model wine","volume":"66","author":"Bekker","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.fm.2021.103961_bib5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1021\/jf0487001","article-title":"Influence of the timing of nitrogen additions during synthetic grape must fermentations on fermentation kinetics and nitrogen consumption","volume":"53","author":"Beltran","year":"2005","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.fm.2021.103961_bib6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/fmic.1997.0125","article-title":"When is simple good enough: a comparison of the Gompertz, Baranyi, and three-phase linear models for fitting bacterial growth curves","volume":"14","author":"Buchanan","year":"1997","journal-title":"Food Microbiol."},{"issue":"3","key":"10.1016\/j.fm.2021.103961_bib7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1567-1364.2009.00489.x","article-title":"Isolation of sulfite reductase variants of a commercial wine yeast with significantly reduced hydrogen sulfide production","volume":"9","author":"Cordente","year":"2009","journal-title":"FEMS Yeast Res."},{"issue":"10","key":"10.1016\/j.fm.2021.103961_bib8","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1021\/acs.jafc.7b02427","article-title":"Elusive chemistry of hydrogen sulfide and mercaptans in wine","volume":"66","author":"Ferreira","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fm.2021.103961_bib9","series-title":"Yeast Protocol","first-page":"107","article-title":"Yeast transformation by the LiAc\/SS carrier DNA\/PEG method","author":"Gietz","year":"2006"},{"issue":"6","key":"10.1016\/j.fm.2021.103961_bib10","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1093\/nar\/30.6.e23","article-title":"A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast","volume":"30","author":"Gueldener","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fm.2021.103961_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s004380051199","article-title":"Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae","volume":"263","author":"Hansen","year":"2000","journal-title":"Mol. Gen. Genet."},{"issue":"16","key":"10.1016\/j.fm.2021.103961_bib12","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.1007\/s00253-014-5789-1","article-title":"MET2 affects production of hydrogen sulfide during wine fermentation","volume":"98","author":"Huang","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"8","key":"10.1016\/j.fm.2021.103961_bib13","doi-asserted-by":"crossref","first-page":"fow100","DOI":"10.1093\/femsyr\/fow100","article-title":"The yeast TUM1 affects production of hydrogen sulfide from cysteine treatment during fermentation","volume":"16","author":"Huang","year":"2016","journal-title":"FEMS Yeast Res."},{"issue":"6","key":"10.1016\/j.fm.2021.103961_bib14","doi-asserted-by":"crossref","first-page":"fox058","DOI":"10.1093\/femsyr\/fox058","article-title":"Hydrogen sulfide and its roles in Saccharomyces cerevisiae in a winemaking context","volume":"17","author":"Huang","year":"2017","journal-title":"FEMS Yeast Res."},{"issue":"1","key":"10.1016\/j.fm.2021.103961_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5344\/ajev.1995.46.1.75","article-title":"Amino acid and ammonium utilization by Saccharomyces cerevisiae wine yeasts from a chemically defined medium","volume":"46","author":"Jiranek","year":"1995","journal-title":"Am. J. Enol. Vitic."},{"issue":"2","key":"10.1016\/j.fm.2021.103961_bib16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1128\/aem.61.2.461-467.1995","article-title":"Regulation of hydrogen sulfide liberation in wine-producing Saccharomyces cerevisiae strains by assimilable nitrogen","volume":"61","author":"Jiranek","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"issue":"3","key":"10.1016\/j.fm.2021.103961_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5344\/ajev.2010.61.3.365","article-title":"Survey of hydrogen sulfide production in wine strains of Saccharomyces cerevisiae","volume":"61","author":"Kumar","year":"2010","journal-title":"Am. J. Enol. Vitic."},{"issue":"4","key":"10.1016\/j.fm.2021.103961_bib18","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.celrep.2014.04.045","article-title":"Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells","volume":"7","author":"Labuschagne","year":"2014","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.fm.2021.103961_bib19","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/1567-1364.12063","article-title":"Cellular responses to l-serine in Saccharomyces cerevisiae: roles of general amino acid control, compartmentalization, and aspartate synthesis","volume":"1","author":"Lee","year":"2013","journal-title":"FEMS Yeast Res."},{"issue":"3","key":"10.1016\/j.fm.2021.103961_bib20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.molcel.2015.09.024","article-title":"Serine and SAM responsive complex SESAME regulates histone modification crosstalk by sensing cellular metabolism","volume":"60","author":"Li","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.fm.2021.103961_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fm.2018.10.021","article-title":"Saccharomyces cerevisiae isolates with extreme hydrogen sulfide production showed different oxidative stress resistances responses during wine fermentation by RNA sequencing analysis","volume":"79","author":"Li","year":"2019","journal-title":"Food Microbiol."},{"issue":"23","key":"10.1016\/j.fm.2021.103961_bib22","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.1128\/AEM.01666-10","article-title":"Identification of MET10-932 and characterization as an allele reducing hydrogen sulfide formation in wine strains of Saccharomyces cerevisiae","volume":"76","author":"Linderholm","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"issue":"5","key":"10.1016\/j.fm.2021.103961_bib23","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1128\/AEM.01758-07","article-title":"Identification of genes affecting hydrogen sulfide formation in saccharomyces cerevisiae","volume":"74","author":"Linderholm","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"issue":"3","key":"10.1016\/j.fm.2021.103961_bib24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1534\/genetics.111.133306","article-title":"Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae","volume":"190","author":"Ljungdahl","year":"2012","journal-title":"Genetics"},{"issue":"4","key":"10.1016\/j.fm.2021.103961_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10295-009-0527-x","article-title":"The production of hydrogen sulphide and other aroma compounds by wine strains of Saccharomyces cerevisiae in synthetic media with different nitrogen concentrations","volume":"36","author":"Mendes-Ferreira","year":"2009","journal-title":"J. Ind. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.fm.2021.103961_bib26","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2672.2009.04457.x","article-title":"The timing of diammonium phosphate supplementation of wine must affects subsequent H2S release during fermentation","volume":"108","author":"Mendes-Ferreira","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.fm.2021.103961_bib27","doi-asserted-by":"crossref","first-page":"103484","DOI":"10.1016\/j.fm.2020.103484","article-title":"A time course metabolism comparison among Saccharomyces cerevisiae, S. uvarum and S. kudriavzevii species in wine fermentation","volume":"90","author":"Minebois","year":"2020","journal-title":"Food Microbiol."},{"issue":"15","key":"10.1016\/j.fm.2021.103961_bib28","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1091\/mbc.e12-03-0233","article-title":"Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway","volume":"23","author":"Petti","year":"2012","journal-title":"Mol. Biol. Cell"},{"issue":"8","key":"10.1016\/j.fm.2021.103961_bib29","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00018-016-2406-8","article-title":"H2S biosynthesis and catabolism: new insights from molecular studies","volume":"74","author":"Rose","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.fm.2021.103961_bib30","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"10","key":"10.1016\/j.fm.2021.103961_bib31","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1128\/AEM.66.10.4421-4426.2000","article-title":"MET17 and hydrogen sulfide formation in Saccharomyces cerevisiae","volume":"66","author":"Spiropoulos","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"issue":"5","key":"10.1016\/j.fm.2021.103961_bib32","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00253-006-0828-1","article-title":"Modulation of volatile sulfur compounds by wine yeast","volume":"74","author":"Swiegers","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.fm.2021.103961_bib33","first-page":"503","article-title":"Metabolism of sulfur amino acids in Saccharomyces cerevisiae","volume":"61","author":"Thomas","year":"1997","journal-title":"Microbiol. Mol. Boil.R: MMBR (Microbiol. Mol. Biol. Rev.)"},{"issue":"11","key":"10.1016\/j.fm.2021.103961_bib34","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1021\/jf8037693","article-title":"Effect of nitrogen supplementation and Saccharomyces species on hydrogen sulfide and other volatile sulfur compounds in shiraz fermentation and wine","volume":"57","author":"Ugliano","year":"2009","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.fm.2021.103961_bib35","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1042\/BJ20041162","article-title":"High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts","volume":"388","author":"Villas-B\u00d4As","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.fm.2021.103961_bib36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.fm.2017.10.006","article-title":"Hydrogen sulfide synthesis in native Saccharomyces cerevisiae strains during alcoholic fermentations","volume":"70","author":"Wang","year":"2018","journal-title":"Food Microbiol."},{"issue":"1","key":"10.1016\/j.fm.2021.103961_bib37","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/s41598-017-01435-7","article-title":"Simultaneous quantification of amino metabolites in multiple metabolic pathways using ultra-high performance liquid chromatography with tandem-mass spectrometry","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.fm.2021.103961_bib38","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nrc.2016.81","article-title":"Serine and one-carbon metabolism in cancer","volume":"16","author":"Yang","year":"2016","journal-title":"Nat. Rev. Cancer"}],"container-title":["Food Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740002021002276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740002021002276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:15:49Z","timestamp":1760037349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0740002021002276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":38,"alternative-id":["S0740002021002276"],"URL":"https:\/\/doi.org\/10.1016\/j.fm.2021.103961","relation":{},"ISSN":["0740-0020"],"issn-type":[{"value":"0740-0020","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of serine and serine synthesis genes on H2S release in Saccharomyces cerevisiae during wine fermentation","name":"articletitle","label":"Article Title"},{"value":"Food Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fm.2021.103961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103961"}}