{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:16:06Z","timestamp":1788189366712,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31502079"],"award-info":[{"award-number":["31502079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360902"],"award-info":[{"award-number":["32360902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2021GXNSFAA196058"],"award-info":[{"award-number":["2021GXNSFAA196058"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food Microbiology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.fm.2026.105254","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:43:25Z","timestamp":1785167005000},"page":"105254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Antibacterial efficacy of recombinant phage lysin JD007-LY01 against Staphylococcus aureus in food matrices"],"prefix":"10.1016","volume":"141","author":[{"given":"Yonghua","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fm.2026.105254_bib1","article-title":"ZAM-CS, a novel chimeric endolysin with enhanced stability and rapid action against methicillin-resistant Staphylococcus aureus","volume":"25","author":"Ahmadbeigi","year":"2025","journal-title":"BMC Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3184\/003685016X14627913637705","article-title":"Bacteriophage endolysins and their applications","volume":"99","author":"Ajuebor","year":"2016","journal-title":"Sci. Prog. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1574-6968.2009.01541.x","article-title":"LysK CHAP endopeptidase domain is required for lysis of live staphylococcal cells","volume":"294","author":"Becker","year":"2009","journal-title":"FEMS Microbiol. Lett. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib4","article-title":"Expression and characterization of novel chimeric endolysin CHAPk-SH3bk against biofilm-forming methicillin-resistant Staphylococcus aureus","volume":"254","author":"Behera","year":"2024","journal-title":"Int. J. Biol. Macromol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41522-025-00728-4","article-title":"Activity of GS-linked chimeric endolysin CHAPk-SH3bk against methicillin-resistant Staphylococcus aureus biofilms: an in-vitro, ex-vivo and in-vivo study","volume":"11","author":"Behera","year":"2025","journal-title":"NPJ Biofilms Microbiom. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/mmi.14134","article-title":"Catalytic diversity and cell wall binding repeats in the phage\u2010encoded endolysins","volume":"110","author":"Broendum","year":"2018","journal-title":"Mol. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib7","article-title":"Effective removal of staphylococcal biofilms on various food contact surfaces by Staphylococcus aureus phage endolysin LysCSA13","volume":"84","author":"Cha","year":"2019","journal-title":"Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fm.2017.07.004","article-title":"Characterization of a novel endolysin LysSA11 and its utility as a potent biocontrol agent against Staphylococcus aureus on food and utensils","volume":"68","author":"Chang","year":"2017","journal-title":"Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib9","article-title":"Phage\u2010derived proteins: advancing food safety through biocontrol and detection of foodborne pathogens","volume":"24","author":"Choi","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib10","article-title":"Prevalence and characterization of Staphylococcus aureus isolated from pasteurized milk in China","volume":"10","author":"Dai","year":"2019","journal-title":"Front. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib11","article-title":"Antibacterial effect of the endolysin LysMD10 combined with citric acid against Salmonella and its application for eggshells decontamination","volume":"182","author":"Ding","year":"2026","journal-title":"Food Control [J]"},{"key":"10.1016\/j.fm.2026.105254_bib12","article-title":"Linker-improved chimeric endolysin selectively kills Staphylococcus aureus in vitro, on reconstituted human epidermis, and in a murine model of skin infection","volume":"66","author":"Eichenseher","year":"2022","journal-title":"Antimicrob. Agents Chemother. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib13","article-title":"Effective removal of staphylococcal biofilms by the endolysin LysH5","volume":"9","author":"Guti\u00e9rrez","year":"2014","journal-title":"PloS One [J]"},{"key":"10.1016\/j.fm.2026.105254_bib14","article-title":"Recombinant endolysins as potential therapeutics against antibiotic-resistant Staphylococcus aureus: current status of research and novel delivery strategies","volume":"31","author":"Haddad Kashani","year":"2018","journal-title":"Clin. Microbiol. Rev. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib15","article-title":"Evaluation of the prevalence of Staphylococcus aureus in chicken fillets and its bio-control using different seaweed extracts","volume":"12","author":"Hamad","year":"2022","journal-title":"Foods [J]"},{"key":"10.1016\/j.fm.2026.105254_bib16","article-title":"Domain interactions in a chimeric dual-domain lysin lead to broad bactericidal activity","volume":"437","author":"Hu","year":"2025","journal-title":"J. Mol. Biol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib17","article-title":"Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria","volume":"13","author":"Igbinosa","year":"2023","journal-title":"Front. Cell Infect. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/827965","article-title":"Staphylococcus aureusand staphylococcal food-borne disease: an ongoing challenge in public health","volume":"2014","author":"Kadariya","year":"2014","journal-title":"BioMed. Res. Int. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib19","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1007\/s10068-025-01849-4","article-title":"Endolysin-based biocontrol strategies against Listeria monocytogenes in food: a comprehensive review","volume":"34","author":"Kim","year":"2025","journal-title":"Food Sci. Biotechnol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib20","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1365-2958.2009.06595.x","article-title":"The CHAP domain of Cse functions as an endopeptidase that acts at mature septa to promote Streptococcus thermophilus cell separation","volume":"71","author":"Layec","year":"2009","journal-title":"Mol. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib21","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1021\/acsinfecdis.0c00812","article-title":"Development of advanced chimeric endolysin to control multidrug-resistant Staphylococcus aureus through domain shuffling","volume":"7","author":"Lee","year":"2021","journal-title":"ACS Infect. Dis. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib22","article-title":"The food application of a novel Staphylococcus aureus bacteriophage vB_SA_STAP152 and its endolysin LysP152 with high enzymatic activity under cold temperature","volume":"128","author":"Li","year":"2025","journal-title":"Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.mib.2005.06.002","article-title":"Bacteriophage endolysins \u2014 current state of research and applications","volume":"8","author":"Loessner","year":"2005","journal-title":"Curr. Opin. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib24","article-title":"Phage endolysin LysP108 showed promising antibacterial potential against methicillin-resistant Staphylococcus aureus","volume":"11","author":"Lu","year":"2021","journal-title":"Front. Cell. Infect. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib25","article-title":"High lytic activity of endolysin LysDCp1 from phage DCp1 against Clostridium perfringens and biofilms","volume":"50","author":"Ma","year":"2025","journal-title":"Vet. Res. Commun. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib26","article-title":"Gut virome derived bacteriophage endolysin Lys572 can effectively control Streptococcus suis in refrigerated and thawed pork","volume":"452","author":"Ning","year":"2026","journal-title":"Int. J. Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib27","article-title":"Characterization and antibacterial activity of highly thermo- and pH-stable endolysin LysCPQ7 and its application as a biocontrol agent against Clostridium perfringens in milk and cheese","volume":"156","author":"Noor Mohammadi","year":"2024","journal-title":"Food Control [J]"},{"key":"10.1016\/j.fm.2026.105254_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/10408398.2025.2528165","article-title":"Staphylococcus aureus in food safety: antimicrobial resistance, detection technologies, and future perspectives","volume":"66","author":"Nunes Nascimento","year":"2026","journal-title":"Crit. Rev. Food Sci. Nutr. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41579-025-01226-2","article-title":"Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment","volume":"24","author":"Parsons","year":"2025","journal-title":"Nat. Rev. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib30","article-title":"Advances in the application and use of bacteriophages and endolysins to inhibit Staphylococcus aureus contamination in foods","volume":"182","author":"Santos","year":"2026","journal-title":"Food Control [J]"},{"key":"10.1016\/j.fm.2026.105254_bib31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/AEM.01616-06","article-title":"Lytic activity of recombinant bacteriophage \u03c611 and \u03c612 endolysins on whole cells and biofilms of Staphylococcus aureus","volume":"73","author":"Sass","year":"2007","journal-title":"Appl. Environ. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib32","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/jac\/dku552","article-title":"Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection","volume":"70","author":"Schmelcher","year":"2015","journal-title":"J. Antimicrob. Chemother. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib33","article-title":"Development of a novel chimeric endolysin, Lys109 with enhanced lytic activity against Staphylococcus aureus","volume":"11","author":"Son","year":"2021","journal-title":"Front. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib34","article-title":"Bacteriophages and endolysins used in the biocontrol of Staphylococcus aureus","volume":"13","author":"Soto Lopez","year":"2025","journal-title":"Microorganisms [J]"},{"key":"10.1016\/j.fm.2026.105254_bib35","article-title":"Application of endolysin LysPEF1-1 with cinnamon bark against planktonic and mixed-species biofilm cells of Listeria monocytogenes and Enterococcus faecalis on various food and food contact surfaces","volume":"183","author":"Wang","year":"2026","journal-title":"Food Control [J]"},{"key":"10.1016\/j.fm.2026.105254_bib36","article-title":"Effective treatment of a broad-host-range lytic phage SapYZU15 in eliminating Staphylococcus aureus from subcutaneous infection","volume":"276","author":"Wen","year":"2023","journal-title":"Microbiol. Res. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib37","article-title":"Characterization of a phage endolysin LysLFP01 and its antibacterial activity","volume":"432","author":"Wen","year":"2025","journal-title":"Int. J. Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib38","article-title":"Endolysins against Streptococci as an antibiotic alternative","volume":"13","author":"Wong","year":"2022","journal-title":"Front. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib39","article-title":"Staphylococcus aureus isolated from retail meat and meat products in China: incidence, antibiotic resistance and genetic diversity","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib40","article-title":"A novel enterococcus phage endolysin Lys22 with a wide host range against mixed biofilm of Enterococcus faecalis, Staphylococcus aureus, and Acinetobacter baumannii","volume":"14","author":"Yang","year":"2025","journal-title":"Pathogens [J]"},{"key":"10.1016\/j.fm.2026.105254_bib41","article-title":"Application of a novel phage vB_Sa_2868B2 and its endolysin LytN with broad antibacterial spectrum against multidrug-resistant Staphylococcus aureus on food matrices, and metal surfaces","volume":"448","author":"Zhang","year":"2026","journal-title":"Int. J. Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib42","article-title":"Prevalence, antibiotic resistance, and enterotoxin genes of Staphylococcus aureus isolated from milk and dairy products worldwide: a systematic review and meta-analysis","volume":"162","author":"Zhang","year":"2022","journal-title":"Food Res. Int. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib43","article-title":"Characterization of the Clostridium perfringens phage endolysin cpp-lys and its application on lettuce","volume":"405","author":"Zhao","year":"2023","journal-title":"Int. J. Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib44","article-title":"Prophage transduction promotes the transmission of phage resistance interfering with adsorption among Chinese foodborne Staphylococcus aureus","volume":"440","author":"Zhou","year":"2025","journal-title":"Int. J. Food Microbiol. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib45","article-title":"Effect and mechanism of prophage lysogeny on antimicrobial resistance and virulence of Staphylococcus aureus from retail meat","volume":"231","author":"Zhou","year":"2026","journal-title":"Food Res. Int. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib46","article-title":"Temperate bacteriophage SapYZUs7 alters Staphylococcus aureus fitness balance by regulating expression of phage resistance, virulence and antimicrobial resistance gene","volume":"292","author":"Zhou","year":"2025","journal-title":"Microbiol. Res. [J]"},{"key":"10.1016\/j.fm.2026.105254_bib47","article-title":"WGS analysis of two Staphylococcus aureus bacteriophages from sewage in China provides insights into the genetic feature of highly efficient lytic phages","volume":"271","author":"Zhou","year":"2023","journal-title":"Microbiol. Res. [J]"}],"container-title":["Food Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740002026002182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740002026002182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:24:33Z","timestamp":1788186273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0740002026002182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":47,"alternative-id":["S0740002026002182"],"URL":"https:\/\/doi.org\/10.1016\/j.fm.2026.105254","relation":{},"ISSN":["0740-0020"],"issn-type":[{"value":"0740-0020","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibacterial efficacy of recombinant phage lysin JD007-LY01 against Staphylococcus aureus in food matrices","name":"articletitle","label":"Article Title"},{"value":"Food Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fm.2026.105254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105254"}}