{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:51:10Z","timestamp":1772956270951,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302491"],"award-info":[{"award-number":["82302491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925017"],"award-info":[{"award-number":["81925017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341098"],"award-info":[{"award-number":["82341098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130052"],"award-info":[{"award-number":["82130052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["ZD2021CY001"],"award-info":[{"award-number":["ZD2021CY001"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0707700"],"award-info":[{"award-number":["2020YFA0707700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0707701"],"award-info":[{"award-number":["2020YFA0707701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0707703"],"award-info":[{"award-number":["2020YFA0707703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fundamental Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.fmre.2025.07.007","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:52:44Z","timestamp":1752713564000},"page":"535-547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disruption of the nucleocapsid-RNA condensation by punicalagin is a broad-spectrum antiviral approach"],"prefix":"10.1016","volume":"6","author":[{"given":"Shao-Zhen","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu-Bing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beilei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Bo","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Jun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Shuo","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunkai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fmre.2025.07.007_bib0001","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-021-00592-1","article-title":"Progress of the COVID-19 vaccine effort: Viruses, vaccines and variants versus efficacy, effectiveness and escape","volume":"21","author":"Tregoning","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"2020","key":"10.1016\/j.fmre.2025.07.007_bib0002","first-page":"727","article-title":"A novel coronavirus from patients with pneumonia in China","volume":"382","author":"Zhu","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.fmre.2025.07.007_bib0003","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41573-023-00672-y","article-title":"Therapeutic strategies for COVID-19: Progress and lessons learned","volume":"22","author":"Li","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.fmre.2025.07.007_bib0004","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41577-022-00703-6","article-title":"SARS-CoV-2 infection and COVID-19 vaccination in pregnancy","volume":"22","author":"Male","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0005","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cell.2022.12.018","article-title":"Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants","volume":"186","author":"Wang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.fmre.2025.07.007_bib0006","first-page":"162","article-title":"SARS-CoV-2 variant biology: Immune escape, transmission and fitness","volume":"21","author":"Carabelli","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0007","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0008","first-page":"126","article-title":"The menstrual cycle after withdrawal of oral contraceptives with particular reference to return of ovulation","volume":"7","author":"Jordan","year":"1975","journal-title":"Mater. Med. Pol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0009","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00061-19","article-title":"Global organization and proposed megataxonomy of the virus world","volume":"84","author":"Koonin","year":"2020","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.fmre.2025.07.007_bib0010","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.chom.2022.06.008","article-title":"The logic of virus evolution","volume":"30","author":"Koonin","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.fmre.2025.07.007_bib0011","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/v12080835","article-title":"Nucleocapsid structure of negative strand RNA virus","volume":"12","author":"Luo","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.fmre.2025.07.007_bib0012","doi-asserted-by":"crossref","first-page":"eadg6473","DOI":"10.1126\/sciadv.adg6473","article-title":"A conserved oligomerization domain in the disordered linker of coronavirus nucleocapsid proteins","volume":"9","author":"Zhao","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.fmre.2025.07.007_bib0013","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41467-021-22297-8","article-title":"GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein","volume":"12","author":"Zhao","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fmre.2025.07.007_bib0014","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-020-0264-6","article-title":"RNA contributions to the form and function of biomolecular condensates","volume":"22","author":"Roden","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0015","doi-asserted-by":"crossref","first-page":"eaaf4382","DOI":"10.1126\/science.aaf4382","article-title":"Liquid phase condensation in cell physiology and disease","volume":"357","author":"Shin","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.fmre.2025.07.007_bib0016","doi-asserted-by":"crossref","first-page":"eaaz7095","DOI":"10.1126\/sciadv.aaz7095","article-title":"Measles virus nucleo- and phosphoproteins form liquid-like phase-separated compartments that promote nucleocapsid assembly","volume":"6","author":"Guseva","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.fmre.2025.07.007_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.084","article-title":"Pan-retroviral nucleocapsid-mediated phase separation regulates genomic RNA positioning and trafficking","volume":"31","author":"Monette","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.fmre.2025.07.007_bib0018","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41586-021-03703-z","article-title":"A condensate-hardening drug blocks RSV replication in vivo","volume":"595","author":"Risso-Ballester","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.fmre.2025.07.007_bib0019","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-023-05887-y","article-title":"A viral biomolecular condensate coordinates assembly of progeny particles","volume":"616","author":"Charman","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.fmre.2025.07.007_bib0020","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-022-04802-1","article-title":"Inflammasome activation in infected macrophages drives COVID-19 pathology","volume":"606","author":"Sefik","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.fmre.2025.07.007_bib0021","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1126\/science.abj7965","article-title":"Mechanisms of viral inflammation and disease in humans","volume":"374","author":"Casanova","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.fmre.2025.07.007_bib0022","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/infdis\/jiab065","article-title":"Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19","volume":"223","author":"Janssen","year":"2021","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.fmre.2025.07.007_bib0023","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/s12967-020-02646-9","article-title":"The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome","volume":"18","author":"Blot","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.fmre.2025.07.007_bib0024","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3390\/nu13072150","article-title":"Physiological and immune functions of punicalagin","volume":"13","author":"Venusova","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.fmre.2025.07.007_bib0025","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3390\/nu12051516","article-title":"Punicalagin protects diabetic nephropathy by inhibiting pyroptosis based on TXNIP\/NLRP3 pathway","volume":"12","author":"An","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.fmre.2025.07.007_bib0026","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41590-018-0262-4","article-title":"G3BP1 promotes DNA binding and activation of cGAS","volume":"20","author":"Liu","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009439","article-title":"A novel cell culture system modeling the SARS-CoV-2 life cycle","volume":"17","author":"Ju","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fmre.2025.07.007_bib0028","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41467-021-21213-4","article-title":"A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fmre.2025.07.007_bib0029","article-title":"Anti-Japanese-encephalitis-viral effects of kaempferol and daidzin and their RNA-binding characteristics","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fmre.2025.07.007_bib0030","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105938","article-title":"Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design","volume":"39","author":"Peng","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.fmre.2025.07.007_bib0031","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11373-005-9035-9","article-title":"Modular organization of SARS coronavirus nucleocapsid protein","volume":"13","author":"Chang","year":"2006","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.fmre.2025.07.007_bib0032","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41586-022-05514-2","article-title":"Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir","volume":"613","author":"Iketani","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.fmre.2025.07.007_bib0033","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-64384-y","article-title":"Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants","volume":"14","author":"Maass","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fmre.2025.07.007_bib0034","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41591-020-1051-9","article-title":"An inflammatory cytokine signature predicts COVID-19 severity and survival","volume":"26","author":"Del Valle","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.fmre.2025.07.007_bib0035","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41422-020-0391-9","article-title":"Dysregulated adaptive immune response contributes to severe COVID-19","volume":"30","author":"Yu","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.fmre.2025.07.007_bib0036","doi-asserted-by":"crossref","first-page":"29368","DOI":"10.1039\/C8RA05640D","article-title":"High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice","volume":"8","author":"Shan","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.fmre.2025.07.007_bib0037","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11262-017-1438-y","article-title":"Dynamic gene expression analysis in a H1N1 influenza virus mouse pneumonia model","volume":"53","author":"Bao","year":"2017","journal-title":"Virus Genes"},{"key":"10.1016\/j.fmre.2025.07.007_bib0038","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/s41586-022-04690-5","article-title":"Defining the risk of SARS-CoV-2 variants on immune protection","volume":"605","author":"DeGrace","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.fmre.2025.07.007_bib0039","doi-asserted-by":"crossref","DOI":"10.1128\/mmbr.00082-23","article-title":"Negative and ambisense RNA virus ribonucleocapsids: More than protective armor","volume":"87","author":"Sabsay","year":"2023","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.fmre.2025.07.007_bib0040","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1093\/molbev\/mss179","article-title":"Evolution of viral proteins originated de novo by overprinting","volume":"29","author":"Sabath","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0041","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2141.1971.tb03415.x","article-title":"Reptilase-R\u2013a new reagent in blood coagulation","volume":"21","author":"Funk","year":"1971","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0042","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3390\/pathogens11091039","article-title":"Determinants of virus variation, evolution, and host adaptation","volume":"11","author":"LaTourrette","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.fmre.2025.07.007_bib0043","doi-asserted-by":"crossref","DOI":"10.1080\/21645515.2024.2324549","article-title":"COVID-19 vaccines: Immune correlates and clinical outcomes","volume":"20","author":"Mahrokhian","year":"2024","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.fmre.2025.07.007_bib0044","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106478","article-title":"SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs","volume":"39","author":"Perdikari","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.fmre.2025.07.007_bib0045","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.cell.2020.09.018","article-title":"Molecular architecture of the SARS-CoV-2 virus","volume":"183","author":"Yao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.fmre.2025.07.007_bib0046","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1093\/nar\/gkae256","article-title":"Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid","volume":"52","author":"Zhao","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fmre.2025.07.007_bib0047","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1038\/s41467-021-21953-3","article-title":"The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA","volume":"12","author":"Cubuk","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fmre.2025.07.007_bib0048","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.coviro.2018.08.011","article-title":"Genome packaging of the Bunyavirales","volume":"33","author":"Wichgers Schreur","year":"2018","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0049","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/j.1460-2075.1996.tb00553.x","article-title":"Nucleocapsid-independent assembly of coronavirus-like particles by co-expression of viral envelope protein genes","volume":"15","author":"Vennema","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.fmre.2025.07.007_bib0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.virol.2006.07.046","article-title":"Coronavirus nucleocapsid protein is an RNA chaperone","volume":"357","author":"Zuniga","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.fmre.2025.07.007_bib0051","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41590-021-01091-0","article-title":"Innate immunity: The first line of defense against SARS-CoV-2","volume":"23","author":"Diamond","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0052","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nri3665","article-title":"Innate immunity to influenza virus infection","volume":"14","author":"Iwasaki","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fmre.2025.07.007_bib0053","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.fmre.2025.07.007_bib0054","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: Consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.fmre.2025.07.007_bib0055","first-page":"5","article-title":"Quantitation of red-cell-bound IgG in normal and pathologic states by an enzyme immunoassay (EIA) technique","volume":"47","author":"Hirano","year":"1985","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.fmre.2025.07.007_bib0056","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1186\/s12964-024-01847-9","article-title":"Punicalagin as a novel selective aryl hydrocarbon receptor (AhR) modulator upregulates AhR expression through the PDK1\/p90RSK\/AP-1 pathway to promote the anti-inflammatory response and bactericidal activity of macrophages","volume":"22","author":"Dai","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.fmre.2025.07.007_bib0057","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.12303","article-title":"Punicalagin, a pomegranate compound, induces apoptosis and autophagy in acute leukemia","volume":"9","author":"Subkorn","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.fmre.2025.07.007_bib0058","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s44318-024-00120-6","article-title":"Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1","volume":"43","author":"Zhan","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.fmre.2025.07.007_bib0059","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2015.07.047","article-title":"A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation","volume":"162","author":"Patel","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.fmre.2025.07.007_bib0060","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-022-05682-1","article-title":"Aberrant phase separation and nucleolar dysfunction in rare genetic diseases","volume":"614","author":"Mensah","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.fmre.2025.07.007_bib0061","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.cell.2020.09.002","article-title":"Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation","volume":"183","author":"Zhu","year":"2020","journal-title":"Cell"}],"container-title":["Fundamental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266732582500336X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266732582500336X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:59:39Z","timestamp":1772920779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266732582500336X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S266732582500336X"],"URL":"https:\/\/doi.org\/10.1016\/j.fmre.2025.07.007","relation":{},"ISSN":["2667-3258"],"issn-type":[{"value":"2667-3258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of the nucleocapsid-RNA condensation by punicalagin is a broad-spectrum antiviral approach","name":"articletitle","label":"Article Title"},{"value":"Fundamental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fmre.2025.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}