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There is evidence from both human and animal models suggesting beneficial effects of these steroids for obesity, diabetes mellitus, hypertension, and osteoporosis, conditions associated with the post\u2010menopausal period. Accordingly, we hypothesized that DHEA supplementation in ovariectomized (OVX) female rats fed a high\u2010fat diet would maintain glucose\u2010induced insulin secretion (GSIS) and pancreatic islet function. OVX resulted in a 30% enlargement of the pancreatic islets area compared to the control rats, which was accompanied by a 50% reduction in the phosphorylation of AKT protein in the pancreatic islets. However, a short\u2010term high\u2010fat diet induced insulin resistance, accompanied by impaired GSIS in isolated pancreatic islets. These effects were reversed by DHEA treatment, with improved insulin sensitivity to levels similar to the control group, and with increased serine phosphorylation of the AKT protein. These data confirm the protective effect of DHEA on the endocrine pancreas in a situation of diet\u2010induced overweight and low estrogen concentrations, a phenotype similar to that of the post\u2010menopausal period.<\/jats:p>","DOI":"10.1016\/j.fob.2014.01.005","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T17:43:59Z","timestamp":1390067039000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["DHEA supplementation in ovariectomized rats reduces impaired glucose\u2010stimulated insulin secretion induced by a high\u2010fat diet"],"prefix":"10.1002","volume":"4","author":[{"given":"Katherine","family":"Veras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Natali","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Tadeu","family":"Nachbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Sim\u00f5es","family":"de Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo","family":"Camporez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c2ngelo Rafael","family":"Carpinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia H.","family":"Goedecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Roberta","family":"de Oliveira Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199809080-00006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262902"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.04.056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610787104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs1020151"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1107"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0900059"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1653"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602956103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.242"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2741\/3686"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2012.01.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1055"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0246"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01647.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215276"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80546-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.01.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb17376.x"},{"key":"e_1_2_7_21_1","first-page":"95","article-title":"Extragonadal synthesis of sex steroids: intracrinology","volume":"64","author":"Labrie F.","year":"2003","journal-title":"Ann. 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