{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:29:27Z","timestamp":1790033367157,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Project for Realization of Regenerative Medicine","award":["08008010"],"award-info":[{"award-number":["08008010"]}]},{"name":"KAKENHI","award":["23590465"],"award-info":[{"award-number":["23590465"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology (MEXT)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Common marmoset (CM) is widely recognized as a useful non\u2010human primate for disease modeling and preclinical studies. Thus, embryonic stem cells (ESCs) derived from CM have potential as an appropriate cell source to test human regenerative medicine using human ESCs. CM ESCs have been established by us and other groups, and can be cultured\n                    <jats:italic>in vitro<\/jats:italic>\n                    . However, the growth factors and downstream pathways for self\u2010renewal of CM ESCs are largely unknown. In this study, we found that basic fibroblast growth factor (bFGF) rather than leukemia inhibitory factor (LIF) promoted CM ESC self\u2010renewal via the activation of phosphatidylinositol\u20103\u2010kinase (PI3K)\u2010protein kinase B (AKT) pathway on mouse embryonic fibroblast (MEF) feeders. Moreover, bFGF and transforming growth factor \u03b2 (TGF\u03b2) signaling pathways cooperatively maintained the undifferentiated state of CM ESCs under feeder\u2010free condition. Our findings may improve the culture techniques of CM ESCs and facilitate their use as a preclinical experimental resource for human regenerative medicine.\n                  <\/jats:p>","DOI":"10.1016\/j.fob.2014.02.007","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T23:08:11Z","timestamp":1392937691000},"page":"213-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of essential pathways for self\u2010renewal in common marmoset embryonic stem 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