{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:58:53Z","timestamp":1791370733044,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T00:00:00Z","timestamp":1440979200000},"content-version":"vor","delay-in-days":242,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Commonwealth Universal Research Enhancement (CURE)"},{"name":"Department of Health"},{"DOI":"10.13039\/100001447","name":"Rita Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to target<jats:italic>Mecp2. MECP2<\/jats:italic> mutations cause Rett syndrome and these patients report decreased pain perception. We confirmed MeCP2 upregulation in DRG following nerve injury and repression of MeCP2 by miRNAs<jats:italic>in vitro<\/jats:italic>. MeCP2 regulates brain\u2010derived neurotrophic factor (BDNF) and downregulation of MeCP2 by microRNAs decreased<jats:italic>Bdnf in vitro<\/jats:italic>. MeCP2 T158A mice exhibited reduced mechanical sensitivity and<jats:italic>Mecp2<\/jats:italic>\u2010null and MeCP2 T158A mice have decreased<jats:italic>Bdnf<\/jats:italic> in DRG. MeCP2\u2010mediated regulation of<jats:italic>Bdnf<\/jats:italic> in the DRG could contribute to altered pain sensitivity.<\/jats:p>","DOI":"10.1016\/j.fob.2015.08.010","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T17:16:32Z","timestamp":1441041392000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity"],"prefix":"10.1002","volume":"5","author":[{"given":"Melissa T.","family":"Manners","sequence":"first","affiliation":[{"name":"Pharmacology &amp; Physiology, Drexel University College of Medicine, Philadelphia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Tian","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Physiology, Drexel University College of Medicine, Philadelphia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seena K.","family":"Ajit","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Physiology, Drexel University College of Medicine, Philadelphia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.09.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.07.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017670"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25126"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.207456.112"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.11.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.033407"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0360575"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153252"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0169-11.2011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154121"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33314"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1262"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/415825"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.03.024"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.04.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00353-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-126"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.01.005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.053"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.010261"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2997"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn062"},{"key":"e_1_2_8_28_1","article-title":"Female Mecp2+\/\u2212 mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies","author":"Samaco R.C.","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"e_1_2_8_29_1","first-page":"1","article-title":"Effect of histone deacetylase inhibitor JNJ-26481585 in pain","author":"Capasso K.","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00276-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.017"},{"key":"e_1_2_8_32_1","unstructured":"2001 CRC Press J.G. Bennett Animal Models of Pain. In Methods in Pain Research"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2011.10.012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm416"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds406"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.05.014"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.08.040"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1306-07.2007"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-14"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4194-13.2014"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908151"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005595107"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-143"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543770902721261"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1810-06.2006"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02576-9"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.112929"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00884.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12522"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.fob.2015.08.010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.fob.2015.08.010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.fob.2015.08.010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.fob.2015.08.010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.fob.2015.08.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T11:58:45Z","timestamp":1692532725000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.fob.2015.08.010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1016\/j.fob.2015.08.010"],"URL":"https:\/\/doi.org\/10.1016\/j.fob.2015.08.010","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2015-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}