{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:55:49Z","timestamp":1788209749766,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LTGN24C200006"],"award-info":[{"award-number":["LTGN24C200006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008867","name":"Department of Education of Zhejiang Province","doi-asserted-by":"publisher","award":["Y202558506"],"award-info":[{"award-number":["Y202558506"]}],"id":[{"id":"10.13039\/501100008867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food Chemistry: X"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.fochx.2025.103294","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:19:56Z","timestamp":1763659196000},"page":"103294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Novel multitarget ACE inhibitory peptides from grass carp swim bladder: Identification and potential antihypertensive mechanism"],"prefix":"10.1016","volume":"32","author":[{"given":"Ye","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fochx.2025.103294_bb0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.fochx.2025.103294_bb0010","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tifs.2022.11.024","article-title":"Purification and fractionation of bioactive peptides through membrane filtration: A critical and application review","volume":"131","author":"Alavi","year":"2023","journal-title":"Trends in Food Science & Technology"},{"key":"10.1016\/j.fochx.2025.103294_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112786","article-title":"Stability and bioactivity of peptides in food matrices based on processing conditions","volume":"168","author":"Ashaolu","year":"2023","journal-title":"Food Research International"},{"key":"10.1016\/j.fochx.2025.103294_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115689","article-title":"Machine learning discovery of novel antihypertensive peptides from highland barley protein inhibiting angiotensin I-converting enzyme (ACE)","volume":"202","author":"Bao","year":"2025","journal-title":"Food Research International"},{"key":"10.1016\/j.fochx.2025.103294_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2020.110502","article-title":"Proteolysis of tilapia skin collagen: Identification and release behavior of ACE-inhibitory peptides","volume":"139","author":"Chen","year":"2021","journal-title":"LWT"},{"key":"10.1016\/j.fochx.2025.103294_bb0030","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1021\/acs.jafc.1c02117","article-title":"Antihypertensive potential of plant foods: Research progress and prospect of plant-derived angiotensin-converting enzymeinhibition compounds","volume":"69","author":"Chen","year":"2021","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/md20090550","article-title":"Physicochemical, structural and antioxidant properties of collagens from the swim bladder of four fish species","volume":"20","author":"Dong","year":"2022","journal-title":"Marine Drugs"},{"key":"10.1016\/j.fochx.2025.103294_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137074","article-title":"A novel angiotensin-converting enzyme (ACE) inhibitory peptide from tilapia skin: Preparation, identification and its potential antihypertensive mechanism","volume":"430","author":"Dong","year":"2024","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137921","article-title":"ACE inhibitory peptides from enzymatic hydrolysate of fermented black sesame seed: Random forest-based optimization, screening, and molecular docking analysis","volume":"437","author":"Du","year":"2024","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.136085","article-title":"Identification and molecular interactions of novel ACE inhibitory peptides from rapeseed protein","volume":"422","author":"Duan","year":"2023","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0055","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"Journal of Chemical Information and Modeling"},{"key":"10.1016\/j.fochx.2025.103294_bb0060","article-title":"New perspectives in the renin-angiotensin-aldosterone system (RAAS) II: Albumin suppresses angiotensin converting enzyme (ACE) activity in human","volume":"9","author":"Fagyas","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fochx.2025.103294_bb0065","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1021\/acs.jafc.1c07161","article-title":"Chicken muscle-derived ACE2 upregulating peptide VVHPKESF inhibits angiotensin II-stimulated inflammation in vascular smooth muscle cells via the ACE2\/Ang (1\u20137)\/MasR axis","volume":"70","author":"Fan","year":"2022","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0070","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1080\/10408398.2018.1436038","article-title":"Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges","volume":"59","author":"Fu","year":"2019","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"10.1016\/j.fochx.2025.103294_bb0075","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.foodres.2016.08.037","article-title":"Angiotensin I\u2013converting enzyme\u2013inhibitory peptides from bovine collagen: Insights into inhibitory mechanism and transepithelial transport","volume":"89","author":"Fu","year":"2016","journal-title":"Food Research International"},{"key":"10.1016\/j.fochx.2025.103294_bb0080","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/acs.jafc.0c04232","article-title":"Identification and antihypertension study of novel angiotensin I-converting enzyme inhibitory peptides from the skirt of Chlamys farreri fermented with Bacillus natto","volume":"69","author":"Gao","year":"2021","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.112414","article-title":"Purification, identification and in silico studies of antioxidant, antidiabetogenic and antibacterial peptides obtained from sorghum spent grain hydrolysate","volume":"153","author":"Garz\u00f3n","year":"2022","journal-title":"LWT- Food Science and Technology"},{"key":"10.1016\/j.fochx.2025.103294_bb0090","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.3390\/molecules30132812","article-title":"Crucian carp-derived ACE-inhibitory peptides with in vivo antihypertensive activity: Insights into bioactivity, mechanism, and safety","volume":"30","author":"Han","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.fochx.2025.103294_bb0095","first-page":"651","article-title":"Akt1 and Akt2: Differentiating the aktion","volume":"26","author":"Heron-Milhavet","year":"2011","journal-title":"Histology and Histopathology"},{"key":"10.1016\/j.fochx.2025.103294_bb0100","series-title":"Angiotensin-I-converting enzyme (ACE)-inhibitory peptides from the collagens of monkfish (Lophius litulon) swim bladders: isolation, characterization, molecular docking analysis and activity evaluation","first-page":"21","author":"Hu","year":"2023"},{"key":"10.1016\/j.fochx.2025.103294_bb0105","series-title":"Extraction and antioxidative, antihypertensive, and antidiabetic properties of gelatin hydrolysates from lethrinid fish scales","volume":"2025","author":"Jena","year":"2025"},{"key":"10.1016\/j.fochx.2025.103294_bb0110","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1039\/D0FO01240H","article-title":"ACE inhibitory peptides derived from de-fatted lemon basil seeds: Optimization, purification, identification, structure\u2013activity relationship and molecular docking analysis","volume":"11","author":"Kheeree","year":"2020","journal-title":"Food & Function"},{"key":"10.1016\/j.fochx.2025.103294_bb0115","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cca.2021.10.029","article-title":"Angiotensin converting enzyme (ACE)","volume":"524","author":"Khurana","year":"2022","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.fochx.2025.103294_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/srep12512","article-title":"An in silico platform for predicting, screening and designing of antihypertensive peptides","volume":"5","author":"Kumar","year":"2015","journal-title":"Scientific Reports"},{"key":"10.1016\/j.fochx.2025.103294_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105672","article-title":"In vitro simulated gastrointestinal digestion stability and in vivo antihypertensive effect of the peptide KYPHVF and its network pharmacology","volume":"107","author":"Li","year":"2023","journal-title":"Journal of Functional Foods"},{"key":"10.1016\/j.fochx.2025.103294_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2024.116308","article-title":"ACE inhibitory activity and gastrointestinal digestion stability of umami peptides IIVFGRQLL from yeast extract","volume":"203","author":"Liang","year":"2024","journal-title":"LWT"},{"key":"10.1016\/j.fochx.2025.103294_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139297","article-title":"Identification and molecular mechanisms of novel antioxidant peptides from fermented broad bean paste: A combined in silico and in vitro study","volume":"450","author":"Lin","year":"2024","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0140","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1021\/acs.jafc.8b00313","article-title":"Quantitative structure\u2013activity relationship modeling coupled with molecular docking analysis in screening of angiotensin i-converting enzyme inhibitory peptides from qula casein hydrolysates obtained by two-enzyme combination hydrolysis","volume":"66","author":"Lin","year":"2018","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.145073","article-title":"Identification of novel ACE inhibitory peptides from Nannochloropsis oculata through peptidomics, in silico screening and molecular docking","volume":"490","author":"Lin","year":"2025","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0150","doi-asserted-by":"crossref","first-page":"H232","DOI":"10.1152\/ajpheart.00457.2005","article-title":"Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction","volume":"290","author":"Lindsey","year":"2006","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.fochx.2025.103294_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.111911","article-title":"Identification and action mechanism of low-molecular-weight peptides derived from Atlantic salmon (Salmo salar L.) skin inhibiting angiotensin I\u2013converting enzyme","volume":"150","author":"Liu","year":"2021","journal-title":"LWT- Food Science and Technology"},{"key":"10.1016\/j.fochx.2025.103294_bb0160","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/bioinformatics\/bty1047","article-title":"mAHTPred: A sequence-based meta-predictor for improving the prediction of anti-hypertensive peptides using effective feature representation","volume":"35","author":"Manavalan","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fochx.2025.103294_bb0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.compbiolchem.2018.10.001","article-title":"The potential peptides against angiotensin-I converting enzyme through a virtual tripeptide-constructing library","volume":"77","author":"Panyayai","year":"2018","journal-title":"Computational Biology and Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0170","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.amjcard.2023.07.036","article-title":"Differential impact of degree of hypertension on subclinical coronary atherosclerosis in asymptomatic subjects with and without diabetes mellitus","volume":"203","author":"Park","year":"2023","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.fochx.2025.103294_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.141087","article-title":"The possible inhibition mechanism of low salt dry-curing on volatile flavor deterioration in refrigerated grass carp (Ctenopharyngodon idella) blocks: Metabolomics and microorganisms","volume":"463","author":"Peng","year":"2025","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0180","doi-asserted-by":"crossref","DOI":"10.1051\/e3sconf\/202560202005","article-title":"In silico, molecular docking and in vitro angiotensin-converting enzyme-inhibitory activity of PGYALQR peptide derived from fish waste hydrolysate","volume":"602","author":"Phakeenuya","year":"2025","journal-title":"E3S Web Conf."},{"key":"10.1016\/j.fochx.2025.103294_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123414","article-title":"Highly biologically active and pH-sensitive collagen hydrolysate-chitosan film loaded with red cabbage extracts realizing dynamic visualization and preservation of shrimp freshness","volume":"233","author":"Ren","year":"2023","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.fochx.2025.103294_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.135046","article-title":"Bioactive food-derived peptides for functional nutrition: Effect of fortification, processing and storage on peptide stability and bioactivity within food matrices","volume":"406","author":"Rivero-Pino","year":"2023","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0195","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1080\/87559129.2025.2450052","article-title":"Techno-functional and bioactivity properties of collagen hydrolysate and peptide: A review","volume":"41","author":"Tawalbeh","year":"2025","journal-title":"Food Reviews International"},{"key":"10.1016\/j.fochx.2025.103294_bb0200","article-title":"Identification and in silico screening of novel angiotensin-converting enzyme inhibitory peptides from pacific saury: Interaction mechanism, network pharmacology, stability, Caco-2 monolayer transport","volume":"61","author":"Wang","year":"2024","journal-title":"Food Bioscience"},{"key":"10.1016\/j.fochx.2025.103294_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135469","article-title":"Angiotensin converting enzyme (ACE) inhibitory peptide from the tuna (Thunnus thynnus) muscle: Screening, interaction mechanism and stability","volume":"279","author":"Wang","year":"2024","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.fochx.2025.103294_bb0210","article-title":"Identification, structural characterization, and molecular dynamic simulation of ACE inhibitory peptides in whey hydrolysates from Chinese Rushan cheese by-product","volume":"21","author":"Wei","year":"2024","journal-title":"Food Chemistry: X"},{"key":"10.1016\/j.fochx.2025.103294_bb0215","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/s10126-022-10152-w","article-title":"First report of screening of novel angiotensin-I converting enzyme inhibitory peptides derived from the red alga Acrochaetium sp","volume":"24","author":"Windarto","year":"2022","journal-title":"Marine Biotechnology"},{"key":"10.1016\/j.fochx.2025.103294_bb0220","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1021\/acs.jafc.3c08795","article-title":"Novel multitarget ACE inhibitory peptides from bovine colostrum immunoglobulin G: Cellular transport, efficacy in regulating endothelial dysfunction, and network pharmacology studies","volume":"72","author":"Wu","year":"2024","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2025.106460","article-title":"Novel angiotensin-I-converting enzyme (ACE) inhibitory peptides from Porphyra haitanensis: Screening, digestion stability, and mechanistic insights","volume":"68","author":"Ye","year":"2025","journal-title":"Food Bioscience"},{"key":"10.1016\/j.fochx.2025.103294_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133551","article-title":"Identification of peptides in Qingke baijiu and evaluation of its angiotensin converting enzyme (ACE) inhibitory activity and stability","volume":"395","author":"Yin","year":"2022","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.112340","article-title":"Digestion, absorption, and transport properties of soy-fermented douchi hypoglycemic peptides VY and SFLLR under simulated gastrointestinal digestion and Caco-2 cell monolayers","volume":"164","author":"Yu","year":"2023","journal-title":"Food Research International"},{"key":"10.1016\/j.fochx.2025.103294_bb0240","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1111\/ijfs.14578","article-title":"Identification of novel angiotensin I-converting enzyme inhibitory peptide from collagen hydrolysates and its molecular inhibitory mechanism","volume":"55","author":"Yu","year":"2020","journal-title":"International Journal of Food Science & Technology"},{"key":"10.1016\/j.fochx.2025.103294_bb0245","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.foodchem.2013.05.058","article-title":"Effect of pretreatment on enzymatic hydrolysis of bovine collagen and formation of ACE-inhibitory peptides","volume":"141","author":"Zhang","year":"2013","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2025.103294_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmars.2022.977234","article-title":"Isolation, identification, molecular docking analysis, and cytoprotection of seven novel angiotensin I-converting enzyme inhibitory peptides from miiuy croaker byproducts-swim bladders","volume":"9","author":"Zhu","year":"2022","journal-title":"Frontiers in Marine Science"}],"container-title":["Food Chemistry: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590157525011411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590157525011411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:05:53Z","timestamp":1773813953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590157525011411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":50,"alternative-id":["S2590157525011411"],"URL":"https:\/\/doi.org\/10.1016\/j.fochx.2025.103294","relation":{},"ISSN":["2590-1575"],"issn-type":[{"value":"2590-1575","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel multitarget ACE inhibitory peptides from grass carp swim bladder: Identification and potential antihypertensive mechanism","name":"articletitle","label":"Article Title"},{"value":"Food Chemistry: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fochx.2025.103294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103294"}}