{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:40:14Z","timestamp":1793036414780,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504003"],"award-info":[{"award-number":["2023YFC3504003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504002"],"award-info":[{"award-number":["2023YFC3504002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504000"],"award-info":[{"award-number":["2023YFC3504000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["242301420098"],"award-info":[{"award-number":["242301420098"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food Chemistry: X"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.fochx.2026.104564","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:16:26Z","timestamp":1791558986000},"page":"104564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Candidate compounds associated with sourness and astringency in Corni Fructus: an integrated analysis of chemical profiles, sensory evaluation, and molecular docking"],"prefix":"10.1016","volume":"39","author":[{"given":"Yadi","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.fochx.2026.104564_bb0005","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00216-016-0067-y","article-title":"Liquid chromatographic\/electrospray ionization quadrupole\/time of flight tandem mass spectrometric study of polyphenolic composition of different Vaccinium berry species and their comparative evaluation","volume":"409","author":"Ancillotti","year":"2017","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"3","key":"10.1016\/j.fochx.2026.104564_bb0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.15430\/JCP.2023.28.3.115","article-title":"Organic acids derived from saliva-amalgamated betel quid filtrate are predicted as a ten-eleven translocation-2 inhibitor","volume":"28","author":"Bhatkar","year":"2023","journal-title":"J Cancer Prev"},{"key":"10.1016\/j.fochx.2026.104564_bb0015","article-title":"Flavor evolution of unsweetened green tea beverage during actual storage: Insights from multi-omics analysis","volume":"481","author":"Cao","year":"2025","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.142289","article-title":"Combining non-targeted and targeted metabolomics to study key bitter and astringent substances of Liupao tea","volume":"467","author":"Chen","year":"2025","journal-title":"Food Chemistry"},{"issue":"03","key":"10.1016\/j.fochx.2026.104564_bb0025","first-page":"268","article-title":"Study on the variation patterns of total organic acid content in Cornus officinalis at different harvesting periods","volume":"6","author":"Chen","year":"2011","journal-title":"World Chinese Medicine"},{"key":"10.1016\/j.fochx.2026.104564_bb0030","article-title":"PungentDB: Bridging traditional Chinese medicine of medicine food homology and modern food flavor chemistry","volume":"23","author":"Chen","year":"2024","journal-title":"Food Chemistry: X"},{"issue":"10","key":"10.1016\/j.fochx.2026.104564_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13101044","article-title":"Ultra-Performance liquid chromatography coupled with mass metabolic profiling of Ammi majus roots as waste product with isolation and assessment of oral mucosal toxicity of its psoralen component xanthotoxin","volume":"13","author":"Fathallah","year":"2023","journal-title":"Metabolites"},{"issue":"8","key":"10.1016\/j.fochx.2026.104564_bb0040","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1248\/cpb.37.2083","article-title":"Tannins of Cornaceous plants. I. Cornusiins A, B and C, dimeric monomeric and trimeric hydrolyzable tannins from Cornus officinalis, and orientation of valoneoyl group in related tannins","volume":"37","author":"Hatano","year":"1989","journal-title":"Chemical & Pharmaceutical Bulletin"},{"key":"10.1016\/j.fochx.2026.104564_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.141283","article-title":"Determination of antioxidant capacity and phenolic content of haskap berries (Lonicera caerulea L.) by attenuated total reflectance-Fourier transformed-infrared spectroscopy","volume":"463","author":"He","year":"2025","journal-title":"Food Chemistry"},{"issue":"12","key":"10.1016\/j.fochx.2026.104564_bb0050","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1016\/0031-9422(89)80366-8","article-title":"Sedoheptulose digallate from Cornus officinalis","volume":"28","author":"Ho Lee","year":"1989","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118065","article-title":"Investigating the mechanism of cornel iridoid glycosides on type 2 diabetes mellitus using serum and urine metabolites in rats","volume":"328","author":"Hou","year":"2024","journal-title":"Journal of Ethnopharmacology"},{"issue":"42","key":"10.1016\/j.fochx.2026.104564_bb0060","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1016\/j.chroma.2011.08.059","article-title":"Ultra high performance liquid chromatography-time of flight mass spectrometry for analysis of avocado fruit metabolites: Method evaluation and applicability to the analysis of ripening degrees","volume":"1218","author":"Hurtado-Fern\u00e1ndez","year":"2011","journal-title":"Journal of Chromatography. A"},{"key":"10.1016\/j.fochx.2026.104564_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144004","article-title":"Anthocyanin-rich extracts: Susceptibility to color loss by hydration and thermal degradation, influence of metal ions and endogenous copigments","volume":"481","author":"Idir","year":"2025","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156509","article-title":"An effective strategy for exploring the taste markers in alum-processed Pinellia ternata tuber based on the analysis of substance and taste by LC-MS and electronic tongue","volume":"139","author":"Kang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fochx.2026.104564_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113454","article-title":"Metabolomic analysis reveals linkage between chemical composition and sensory quality of different floral honey samples","volume":"173","author":"Kang","year":"2023","journal-title":"Food Research International"},{"issue":"6","key":"10.1016\/j.fochx.2026.104564_bb0080","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1560-24.2024","article-title":"Epitope tagging with genome editing in mice reveals that the proton channel OTOP1 is apically localized and not restricted to type III \u201csour\u201d taste receptor cells","volume":"45","author":"Kaplan","year":"2025","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.fochx.2026.104564_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.142050","article-title":"Correlation analysis of taste phenotype and Gynostemma pentaphyllum saponins using computer virtual screening and UPLC-(HR)MS\/MS metabolomics","volume":"465","author":"Li","year":"2025","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0090","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cophys.2020.12.006","article-title":"Sour taste: Receptors, cells and circuits","volume":"20","author":"Liman","year":"2021","journal-title":"Current Opinion in Physiology"},{"key":"10.1016\/j.fochx.2026.104564_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144995","article-title":"Flavor characterization of aged Citri Reticulatae Pericarpium from core regions: An integrative approach utilizing GC-IMS, GC\u2013MS, E-nose, E-tongue, and chemometrics","volume":"490","author":"Liu","year":"2025","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130610","article-title":"Ingredients with anti-inflammatory effect from medicine food homology plants","volume":"368","author":"Lu","year":"2022","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126549","article-title":"The exploitation of cornelian cherry (Cornus mas L.) cultivars and genotypes from Montenegro as a source of natural bioactive compounds","volume":"318","author":"Martinovi\u0107","year":"2020","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0110","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.lwt.2017.01.060","article-title":"Quantification of table olives\u2019 acid, bitter and salty tastes using potentiometric electronic tongue fingerprints","volume":"79","author":"Marx","year":"2017","journal-title":"LWT - Food Science and Technology"},{"key":"10.1016\/j.fochx.2026.104564_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130358","article-title":"The effect of different drying techniques on color parameters, ascorbic acid content, anthocyanin and antioxidant capacities of cornelian cherry","volume":"364","author":"Parveez Zia","year":"2021","journal-title":"Food Chemistry"},{"issue":"1","key":"10.1016\/j.fochx.2026.104564_bb0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jtcms.2022.01.006","article-title":"Property theory of Chinese materia medica: Clinical pharmacodynamics of traditional Chinese medicine","volume":"9","author":"Qiao","year":"2022","journal-title":"Journal of Traditional Chinese Medical Sciences"},{"issue":"10","key":"10.1016\/j.fochx.2026.104564_bb0125","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/jf050056i","article-title":"Activity-guided identification of (S)-malic acid 1-O-D-glucopyranoside (morelid) and gamma-aminobutyric acid as contributors to umami taste and mouth-drying oral sensation of morel mushrooms (Morchella deliciosa Fr.)","volume":"53","author":"Rotzoll","year":"2005","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.143937","article-title":"Characterisation of avocado fruits from different Iberian regions: Integrating ion mobility in non-targeted LC-MS metabolomics","volume":"481","author":"Serrano-Garc\u00eda","year":"2025","journal-title":"Food Chemistry"},{"issue":"11","key":"10.1016\/j.fochx.2026.104564_bb0135","first-page":"2708","article-title":"Study on drying methods of wine-steamed Corni Fructus by multi-index combined with entropy weight-TOPSIS","volume":"46","author":"Sun","year":"2023","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"10.1016\/j.fochx.2026.104564_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.109847","article-title":"Metabolomics and electronic tongue reveal the effects of different storage years on metabolites and taste quality of Oolong Tea","volume":"152","author":"Sun","year":"2023","journal-title":"Food Control"},{"key":"10.1016\/j.fochx.2026.104564_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.112330","article-title":"Characterization and identification of chemical constituents in Corni Fructus and effect of storage using UHPLC-LTQ-Orbitrap-MS","volume":"164","author":"Sun","year":"2023","journal-title":"Food Research International"},{"issue":"7","key":"10.1016\/j.fochx.2026.104564_bb0150","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1021\/acs.jnatprod.5b00211","article-title":"Tyrosyl-DNA phosphodiesterase I inhibitors from the Australian plant Macropteranthes leichhardtii","volume":"78","author":"Tian","year":"2015","journal-title":"Journal of Natural Products"},{"issue":"1","key":"10.1016\/j.fochx.2026.104564_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10010023","article-title":"Fractionation and hydrolyzation of avocado peel extract: Improvement of antibacterial activity","volume":"10","author":"Trujillo-Mayol","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.fochx.2026.104564_bb0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-physiol-060121-041637","article-title":"The cellular and molecular basis of sour taste","volume":"84","author":"Turner","year":"2022","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.fochx.2026.104564_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115931","article-title":"UPLC-Q-Exactive-based rats serum metabolomics for characterization of traditional Chinese medicine natures and flavors","volume":"302","author":"Wang","year":"2023","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"10.1016\/j.fochx.2026.104564_bb0170","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jtcme.2023.12.004","article-title":"The characterization of traditional Chinese medicine natures and flavors using network pharmacology integrated strategy","volume":"14","author":"Wang","year":"2024","journal-title":"Journal of Traditional and Complementary Medicine"},{"key":"10.1016\/j.fochx.2026.104564_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137294","article-title":"Study on the accumulation pattern of anthocyanins, sugars and organic acids in medicinal Vitis vinifera \u2018SuoSuo\u2019 during ripening","volume":"433","author":"Wang","year":"2024","journal-title":"Food Chemistry"},{"issue":"9","key":"10.1016\/j.fochx.2026.104564_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30092008","article-title":"Simultaneous determination of 32 polyphenolic compounds in berries via HPLC-MS\/MS","volume":"30","author":"Wang","year":"2025","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.fochx.2026.104564_bb0185","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0107-19.2019","article-title":"Physiological and behavioral responses to optogenetic stimulation of PKD2L1+ type III taste cells","volume":"6","author":"Wilson","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.fochx.2026.104564_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144319","article-title":"Effects of aging years on taste attributes of Huangjiu and their correlation with non-volatile compounds: A study based on E-tongue, UPLC-MS untargeted metabolomics, and WGCNA","volume":"484","author":"Wu","year":"2025","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fochx.2026.104564_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2024.116555","article-title":"Elucidation of the sweetening mechanism of sweet orange fruit aroma compounds on sucrose solution using sensory evaluation, electronic tongue, molecular docking, and molecular dynamics simulation","volume":"205","author":"Xiao","year":"2024","journal-title":"LWT"},{"key":"10.1016\/j.fochx.2026.104564_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105661","article-title":"Corni Fructus extracts ameliorate streptozotocin-induced diabetes in mice via regulating AMPK\/ACC\/CPT-1 signaling pathway","volume":"107","author":"Yang","year":"2023","journal-title":"Journal of Functional Foods"},{"key":"10.1016\/j.fochx.2026.104564_bb0205","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tifs.2022.02.031","article-title":"Bitterness and astringency of tea leaves and products: Formation mechanism and reducing strategies","volume":"123","author":"Ye","year":"2022","journal-title":"Trends in Food Science & Technology"},{"issue":"1","key":"10.1016\/j.fochx.2026.104564_bb0210","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0031-9422(94)00836-I","article-title":"Amariinic acid and related ellagitannins from Phyllanthus amarus","volume":"39","author":"Yeap Foo","year":"1995","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.fochx.2026.104564_bb0215","first-page":"153","article-title":"A sedoheptulose gallate from the fruits of Cornus officinalis","volume":"34","author":"Zhang","year":"1999","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"10.1016\/j.fochx.2026.104564_bb0220","article-title":"Study on the astringent mechanism of Chebulae fructus","volume":"29","author":"Zheng","year":"2025","journal-title":"Food Chemistry: X"},{"issue":"32","key":"10.1016\/j.fochx.2026.104564_bb0225","doi-asserted-by":"crossref","first-page":"15930","DOI":"10.1073\/pnas.1905068116","article-title":"Assembling multidomain protein structures through analogous global structural alignments","volume":"116","author":"Zhou","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"10.1016\/j.fochx.2026.104564_bb0230","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/s41596-022-00728-0","article-title":"I-TASSER-MTD: A deep-learning-based platform for multi-domain protein structure and function prediction","volume":"17","author":"Zhou","year":"2022","journal-title":"Nature Protocols"},{"issue":"11","key":"10.1016\/j.fochx.2026.104564_bb0235","doi-asserted-by":"crossref","first-page":"7944","DOI":"10.1111\/1750-3841.17296","article-title":"Relationship between consumer acceptance, sensory characteristics, and physicochemical characteristics of \u201cFuji\u201d apples from different origins","volume":"89","author":"Zhu","year":"2024","journal-title":"Journal of Food Science"}],"container-title":["Food Chemistry: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590157526010850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590157526010850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:08:10Z","timestamp":1793034490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590157526010850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S2590157526010850"],"URL":"https:\/\/doi.org\/10.1016\/j.fochx.2026.104564","relation":{},"ISSN":["2590-1575"],"issn-type":[{"value":"2590-1575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Candidate compounds associated with sourness and astringency in Corni Fructus: an integrated analysis of chemical profiles, sensory evaluation, and molecular docking","name":"articletitle","label":"Article Title"},{"value":"Food Chemistry: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fochx.2026.104564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104564"}}