{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:05:29Z","timestamp":1759971929945,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21790612","22590642"],"award-info":[{"award-number":["21790612","22590642"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Forensic Science International"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.forsciint.2012.01.015","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T20:38:40Z","timestamp":1327955920000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of human brain damage in fatalities due to extreme environmental temperature by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP), S100\u03b2 and single-stranded DNA (ssDNA) immunoreactivities"],"prefix":"10.1016","volume":"219","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Michiue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Wei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.forsciint.2012.01.015_bib0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.forsciint.2010.07.024","article-title":"Forensic molecular pathology of violent deaths","volume":"203","author":"Maeda","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0010","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.5858\/2006-130-1297-HAHMIO","article-title":"Hypothermia and hyperthermia medicolegal investigation of morbidity and mortality from exposure to environmental temperature extremes","volume":"130","author":"Nixdorf-Miller","year":"2006","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.forsciint.2012.01.015_bib0015","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.legalmed.2009.01.075","article-title":"Diagnostic problems with functional causes of death: analytical approaches and procedures","volume":"11","author":"Kernbach-Wighton","year":"2009","journal-title":"Leg. Med. (Tokyo)"},{"key":"10.1016\/j.forsciint.2012.01.015_bib0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00000433-200106000-00018","article-title":"An analysis of factors contributing to a series of deaths caused by exposure to high environmental temperatures","volume":"22","author":"Green","year":"2001","journal-title":"Am. J. Forensic Med. Pathol."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0025","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/j.forsciint.2010.08.018","article-title":"Armanni-Ebstein phenomenon and hypothermia","volume":"206","author":"Zhou","year":"2011","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0379-0738(01)00570-9","article-title":"Diagnosis of heat stroke in forensic medicine. Contribution of thermophysiology","volume":"124","author":"Schuliar","year":"2001","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0035","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12024-010-9142-4","article-title":"Hypothermia","volume":"6","author":"Turk","year":"2010","journal-title":"Forensic Sci. Med. Pathol."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0040","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/01.paf.0000233567.51784.31","article-title":"Heat stroke deaths caused by electric blankets: case report and review of the literature","volume":"27","author":"Zhou","year":"2006","journal-title":"Am. J. Forensic Med. Pathol."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0045","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.legalmed.2010.12.005","article-title":"Forensic biochemistry for functional investigation of death: concept and practical application","volume":"13","author":"Maeda","year":"2011","journal-title":"Leg. Med. (Tokyo)"},{"key":"10.1016\/j.forsciint.2012.01.015_bib0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.forsciint.2008.04.023","article-title":"Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia","volume":"179","author":"Ishikawa","year":"2008","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00414-009-0374-3","article-title":"Postmortem biochemistry and immunohistochemistry of chromogranin A as a stress marker with special regard to fatal hypothermia and hyperthermia","volume":"125","author":"Yoshida","year":"2011","journal-title":"Int. J. Leg. Med."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.forsciint.2009.05.017","article-title":"Post-mortem investigation of calcium content in liver, heart, and skeletal muscle in accidental hypothermia cases","volume":"190","author":"Jakubeniene","year":"2009","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0065","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00414-004-0514-8","article-title":"Pulmonary fat embolism induced by exposure to high ambient temperature in rats with a fatty liver","volume":"119","author":"Inoue","year":"2005","journal-title":"Int. J. Leg. Med."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0070","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s00414-004-0498-4","article-title":"Heat stroke in an incubator: an immunohistochemical study in a fatal case","volume":"119","author":"Fineschi","year":"2005","journal-title":"Int. J. Leg. Med."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0075","first-page":"26","article-title":"Biological roles of fibroblast growth factor-2","volume":"18","author":"Bikfalvi","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0080","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-4615-0123-7_12","article-title":"Fibroblast growth factors and neuroprotection","volume":"513","author":"Alzheimer","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0085","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0896-6273(00)80194-4","article-title":"GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination","volume":"17","author":"Liedtke","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.forsciint.2012.01.015_bib0090","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.2174\/092986706778521751","article-title":"Protein S-100\u03b2\u2014a prognostic marker for cerebral damage","volume":"13","author":"Stroick","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0095","first-page":"276","article-title":"Usefulness of S100\u03b2 protein in neurological disorders","volume":"61","author":"Yardan","year":"2011","journal-title":"J. Pak. Med. Assoc."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0100","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0079-6123(06)61022-4","article-title":"The neurotrophic protein S100\u03b2: value as a marker of brain damage and possible therapeutic implications","volume":"161","author":"Kleindienst","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0105","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.2174\/092986706779026129","article-title":"Serum S-100\u03b2 protein as a biochemical marker of brain injury: a review of current concepts","volume":"13","author":"Korfias","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.legalmed.2005.07.004","article-title":"Postmortem serum protein S100\u03b2 levels with regard to the cause of death involving brain damage in medicolegal autopsy cases","volume":"8","author":"Li","year":"2006","journal-title":"Leg. Med. (Tokyo)"},{"issue":"Suppl. 1","key":"10.1016\/j.forsciint.2012.01.015_bib0115","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.1016\/j.legalmed.2009.02.042","article-title":"Evaluation of postmortem S100\u03b2 levels in the cerebrospinal fluid with regard to the cause of death in medicolegal autopsy","volume":"11","author":"Li","year":"2009","journal-title":"Leg. Med. (Tokyo)"},{"key":"10.1016\/j.forsciint.2012.01.015_bib0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1046\/j.1471-4159.1997.69010232.x","article-title":"Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal cell death","volume":"69","author":"Chen","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.forsciint.2008.03.019","article-title":"Single-stranded DNA as an immunohistochemical marker of neuronal damage in human brain: an analysis of autopsy material with regard to the cause of death","volume":"178","author":"Michiue","year":"2008","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.forsciint.2011.03.037","article-title":"Evaluation of human brain damage in fire fatality by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP) and single-stranded DNA (ssDNA) immunoreactivities","volume":"211","author":"Wang","year":"2011","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12024-008-9029-9","article-title":"Postmortem serum nitrogen compounds and C-reactive protein levels with special regard to investigation of fatal hyperthermia","volume":"4","author":"Maeda","year":"2008","journal-title":"Forensic Sci. Med. Pathol."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0379-0738(01)00617-X","article-title":"Postmortem serum uric acid and creatinine levels in relation to the causes of death","volume":"125","author":"Zhu","year":"2002","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0145","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.legalmed.2005.04.005","article-title":"Evaluation of postmortem urea nitrogen, creatinine and uric acid levels in pericardial fluid in forensic autopsy","volume":"7","author":"Zhu","year":"2005","journal-title":"Leg. Med. (Tokyo)"},{"key":"10.1016\/j.forsciint.2012.01.015_bib0150","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.legalmed.2011.05.002","article-title":"Combined analyses of creatine kinase MB, cardiac troponin I and myoglobin in pericardial and cerebrospinal fluids to investigate myocardial and skeletal muscle injury in medicolegal autopsy cases","volume":"13","author":"Wang","year":"2011","journal-title":"Leg. Med. (Tokyo)"},{"key":"10.1016\/j.forsciint.2012.01.015_bib0155","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/clinchem\/39.4.561","article-title":"Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine","volume":"39","author":"Zweig","year":"1993","journal-title":"Clin. Chem."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0160","first-page":"13","article-title":"The use of relative operating characteristic (ROC) curves in test performance evaluation","volume":"110","author":"Beck","year":"1986","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.forsciint.2010.07.001","article-title":"Molecular pathology in forensic medicine. Preface","volume":"203","author":"Madea","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.forsciint.2010.07.017","article-title":"Molecular pathology in forensic medicine\u2014introduction","volume":"203","author":"Madea","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0175","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0006-8993(99)01557-7","article-title":"The trophic factors S-100beta and basic fibroblast growth factor are increased in the forebrain reactive astrocytes of adult callosotomized rat","volume":"835","author":"Gomide","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0180","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1471-4159.1995.65010228.x","article-title":"Overexpression of the neurotrophic cytokine S100 beta in human temporal lobe epilepsy","volume":"65","author":"Griffin","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0185","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/sj.cdd.4400439","article-title":"Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide","volume":"5","author":"Tamatani","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0169-328X(00)00285-0","article-title":"Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats","volume":"87","author":"Ay","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0195","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.legalmed.2010.01.004","article-title":"Immunohistochemistry of catecholamines in the hypothalamic-pituitary-adrenal system with special regard to fatal hypothermia and hyperthermia","volume":"12","author":"Ishikawa","year":"2010","journal-title":"Leg. Med. (Tokyo)"},{"key":"10.1016\/j.forsciint.2012.01.015_bib0200","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1056\/NEJMra011089","article-title":"Heat stroke","volume":"346","author":"Bouchama","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0205","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jcb.21401","article-title":"Hyperthermia inhibits cell proliferation and induces apoptosis: relative signaling status of P53, S100A4, and Notch in heat sensitive and resistant cell lines","volume":"103","author":"Basile","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0006-8993(97)00458-7","article-title":"Evidence of apoptosis in primary neuronal cultures after heat shock","volume":"764","author":"Vogel","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0215","first-page":"629","article-title":"Hyperthermia induced brain oedema: current status and future perspectives","volume":"123","author":"Sharma","year":"2006","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.forsciint.2012.01.015_bib0220","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/0265673021000054621","article-title":"Hyperthermia induced pathophysiology of the central nervous system","volume":"19","author":"Sharma","year":"2003","journal-title":"Int. J. Hyperthermia"}],"container-title":["Forensic Science International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0379073812000187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0379073812000187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:51:13Z","timestamp":1759945873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0379073812000187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":44,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0379073812000187"],"URL":"https:\/\/doi.org\/10.1016\/j.forsciint.2012.01.015","relation":{},"ISSN":["0379-0738"],"issn-type":[{"type":"print","value":"0379-0738"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of human brain damage in fatalities due to extreme environmental temperature by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP), S100\u03b2 and single-stranded DNA (ssDNA) immunoreactivities","name":"articletitle","label":"Article Title"},{"value":"Forensic Science International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.forsciint.2012.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}