{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:10:34Z","timestamp":1787890234156,"version":"build-2784847793"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["fsijournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Forensic Science International"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.forsciint.2014.10.025","type":"journal-article","created":{"date-parts":[[2014,10,25]],"date-time":"2014-10-25T01:37:41Z","timestamp":1414201061000},"page":"e29-e32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["An accidental poisoning with mitragynine"],"prefix":"10.1016","volume":"245","author":[{"given":"Ritva","family":"Karinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Toralf","family":"Fosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidsel","family":"Rogde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vigdis","family":"Vindenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.forsciint.2014.10.025_bib0005","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnbeh.2011.00060","article-title":"Beyond THC: the new generation of cannabinoid designer drugs","volume":"5","author":"Fattore","year":"2011","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0010","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2174\/156802611795371305","article-title":"Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity","volume":"11","author":"Adkins","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0015","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1248\/cpb.52.916","article-title":"Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa","volume":"52","author":"Takayama","year":"2004","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0020","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.3390\/molecules16097344","article-title":"Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay","volume":"16","author":"Kong","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.forsciint.2014.10.025_bib0025","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/jms.1607","article-title":"Studies on the metabolism of mitragynine, the main alkaloid of the herbal drug Kratom, in rat and human urine using liquid chromatography\u2013linear ion trap mass spectrometry","volume":"44","author":"Philipp","year":"2009","journal-title":"J. Mass Spectrom.: JMS"},{"key":"10.1016\/j.forsciint.2014.10.025_bib0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.forsciint.2010.10.025","article-title":"Kratom alkaloids and O-desmethyltramadol in urine of a Krypton herbal mixture consumer","volume":"208","author":"Arndt","year":"2011","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0035","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/anatox\/35.4.242","article-title":"Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton","volume":"35","author":"Kronstrand","year":"2011","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11419-009-0070-5","article-title":"Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant kratom (Mitragyna speciosa) by LC-ESI\u2013MS","volume":"27","author":"Kikura-Hanajiri","year":"2009","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0045","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-2005-837822","article-title":"Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum","volume":"71","author":"Horie","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejphar.2006.08.013","article-title":"Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa","volume":"549","author":"Matsumoto","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0055","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.lfs.2003.09.054","article-title":"Antinociceptive effect of 7-hydroxymitragynine in mice: discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa","volume":"74","author":"Matsumoto","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0060","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neubiorev.2012.11.012","article-title":"From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction","volume":"37","author":"Hassan","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0065","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2013.10.059","article-title":"The effect of Salvia divinorum and Mitragyna speciosa extracts, fraction and major constituents on place aversion and place preference in rats","volume":"151","author":"Sufka","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/anatox\/35.1.54","article-title":"A drug toxicity death involving propylhexedrine and mitragynine","volume":"35","author":"Holler","year":"2011","journal-title":"J. Anal. Toxicol."},{"issue":"Suppl. 1","key":"10.1016\/j.forsciint.2014.10.025_bib0075","doi-asserted-by":"crossref","first-page":"S278","DOI":"10.1111\/1556-4029.12009","article-title":"A drug fatality involving Kratom","volume":"58","author":"Neerman","year":"2013","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0080","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/anatox\/35.5.280","article-title":"Drug screening of whole blood by ultra-performance liquid chromatography\u2013tandem mass spectrometry","volume":"35","author":"\u00d8iestad","year":"2011","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.forsciint.2006.03.034","article-title":"Headspace gas chromatographic determination of ethanol: the use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma","volume":"161","author":"Kristoffersen","year":"2006","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0090","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jat\/29.5.387","article-title":"An automated alcohol dehydrogenase method for ethanol quantification in urine and whole blood","volume":"29","author":"Kristoffersen","year":"2005","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0095","unstructured":"The International Association of Forensic Toxicologists. Reference blood level list of therapeutic and toxic substances. Website: http:\/\/www.tiaft.org\/ (accessed 01.10.14)."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0100","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s13181-010-0079-5","article-title":"Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure","volume":"6","author":"Nelsen","year":"2010","journal-title":"J. Med. Toxicol.: Official J. Am. Coll. Med. Toxicol."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0105","first-page":"145","article-title":"Some observations on the pharmacology of mitragynine","volume":"198","author":"Macko","year":"1972","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.forsciint.2014.10.025_bib0110","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1055\/s-0034-1382760","article-title":"Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline","volume":"80","author":"Manda","year":"2014","journal-title":"Planta Med."}],"container-title":["Forensic Science International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037907381400440X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037907381400440X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T07:30:32Z","timestamp":1538119832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037907381400440X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":22,"alternative-id":["S037907381400440X"],"URL":"https:\/\/doi.org\/10.1016\/j.forsciint.2014.10.025","relation":{},"ISSN":["0379-0738"],"issn-type":[{"value":"0379-0738","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An accidental poisoning with mitragynine","name":"articletitle","label":"Article Title"},{"value":"Forensic Science International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.forsciint.2014.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}