{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:36:31Z","timestamp":1793835391431,"version":"4.6.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Forensic Science International"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.forsciint.2019.110137","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T12:10:37Z","timestamp":1577794237000},"page":"110137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Development of an UPLC\u2013MS\/MS method for the analysis of 16 synthetic opioids in segmented hair, and evaluation of the polydrug history in fentanyl analogue users"],"prefix":"10.1016","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3955-054X","authenticated-orcid":false,"given":"Mar\u00eda del Mar","family":"Ram\u00edrez Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.R.","family":"Wille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-2721","authenticated-orcid":false,"given":"Danielle","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Samyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.forsciint.2019.110137_bib0005","series-title":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)","year":"2018"},{"key":"10.1016\/j.forsciint.2019.110137_bib0010","first-page":"709","article-title":"Analysis of novel synthetic opioids U-47700, U-50488 and furanyl fentanyl by LC\u2013MS\/MS in postmortem casework","volume":"40","author":"Mohr","year":"2016","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0015","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/jat\/bkx052","article-title":"An LC\u2013MS-MS method for the analysis of carfentanil, 3-methylfentanyl, 2-furanyl fentanyl, acetyl fentanyl, fentanyl and norfentanyl in postmortem and impaired driving cases","volume":"41","author":"Sofalvi","year":"2017","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0020","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/jat\/bky054","article-title":"Quantitative analysis of fentanyl and six fentanyl analogs in postmortem specimens by UHPLC\u2013MS-MS","volume":"42","author":"Kahl","year":"2018","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0025","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1021\/acsomega.7b01536","article-title":"LC-MS\/MS-based method for the multiplex detection of 24 fentanyl analogues and metabolites in whole blood at sub ng mL\u22121 concentrations","volume":"3","author":"Strayer","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.forsciint.2019.110137_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11419-007-0039-1","article-title":"Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure\u2013analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues","volume":"26","author":"Higashikawa","year":"2008","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0035","first-page":"1548","article-title":"N-4-substituted 1-(2-arylethyl)-4-piperidinyl-N-phenylpropanamides, a novel series of extremely potent analgesics with unusually high safety margin","volume":"26","author":"Van Bever","year":"1976","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.forsciint.2019.110137_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trac.2018.01.007","article-title":"New synthetic opioids in biological and non-biological matrices: a review of current analytical methods","volume":"102","author":"Markei","year":"2018","journal-title":"Trends Analyt. Chem."},{"key":"10.1016\/j.forsciint.2019.110137_bib0045","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s40265-017-0727-z","article-title":"Fentanyl formulations in the management of pain: an update","volume":"77","author":"Schug","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.forsciint.2019.110137_bib0050","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jemermed.2011.05.017","article-title":"Whole fentanyl patch ingestion: a multi-center case series","volume":"42","author":"Mrvos","year":"2012","journal-title":"J. Emerg. Med."},{"key":"10.1016\/j.forsciint.2019.110137_bib0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/FTD.0000000000000465","article-title":"Acute intoxications and fatalities from illicit fentanyl and analogues: an update","volume":"40","author":"Pichini","year":"2018","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.forsciint.2019.110137_bib0060","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3109\/15563650.2015.1054505","article-title":"Opioid intoxications involving butyrfentanyl, 4-fluorobutyrfentanyl, and fentanyl from the Swedish STRIDA project","volume":"53","author":"B\u00e4ckberg","year":"2015","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0065","first-page":"1","article-title":"New synthetic opioid cyclopropylfentanyl together with other novel synthetic opioids in respiratory insufficient comatose patients detected by toxicological analysis","volume":"18","author":"M\u00fcller","year":"2019","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00046","article-title":"Assessing the 2004-2018 fentanyl misusing issues reported to an international range of adverse reporting systems","volume":"10","author":"Schifano","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0075","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/jat\/bkx041","article-title":"Qualitative identification of fentanyl analogs and other opioids in postmortem cases by uhplc-ion trap-MSn","volume":"41","author":"Shoff","year":"2017","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0080","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/jat\/bky093","article-title":"Detection of fentanyl analogs and synthetic opioids in real hair samples","volume":"43","author":"Salomone","year":"2018","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2019.110137_bib0085","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2019.00184","article-title":"Ultra-high-performance liquid chromatography-tandem mass spectrometry assay for quantifying fentanyl and 22 analogs and metabolites in whole blood, urine, and hair","volume":"7","author":"Busard\u1f78","year":"2019","journal-title":"Front. Chem."},{"key":"10.1016\/j.forsciint.2019.110137_bib0090","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.jchromb.2010.05.033","article-title":"Development and validation of a sensitive ultra performance liquid chromatography tandem mass spectrometry method for the analysis of fentanyl and its major metabolite norfentanyl in urine and whole blood in forensic context","volume":"878","author":"Verplaeste","year":"2010","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.forsciint.2019.110137_bib0095","first-page":"5442","article-title":"Update of standard practices for new method validation in forensic toxicology","volume":"23","author":"Wille","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.forsciint.2019.110137_bib0100","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jchromb.2005.11.009","article-title":"Standard line slopes as a measure of a relative matrix effect in quantitative HPLC\u2013MS bioanalysis","volume":"830","author":"Matuszewski","year":"2006","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.forsciint.2019.110137_bib0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jchromb.2014.05.055","article-title":"A quantitative, selective and fast ultra-high performance liquid chromatography tandem mass spectrometry method for the simultaneous analysis of 33 basic drugs in hair (amphetamines, cocaine, opiates, opioids and metabolites)","volume":"965","author":"Ram\u00edrez Fern\u00e1ndez","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.forsciint.2019.110137_bib0110","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/00952990.2018.1550652","article-title":"Testing hair for fentanyl exposure: a method to inform harm reduction behavior among individuals who use heroin","volume":"45","author":"Palamar","year":"2019","journal-title":"Am. J. Drug Alcohol Abuse"}],"container-title":["Forensic Science International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0379073819305493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0379073819305493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:59:21Z","timestamp":1759946361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0379073819305493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":22,"alternative-id":["S0379073819305493"],"URL":"https:\/\/doi.org\/10.1016\/j.forsciint.2019.110137","relation":{},"ISSN":["0379-0738"],"issn-type":[{"value":"0379-0738","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of an UPLC\u2013MS\/MS method for the analysis of 16 synthetic opioids in segmented hair, and evaluation of the polydrug history in fentanyl analogue users","name":"articletitle","label":"Article Title"},{"value":"Forensic Science International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.forsciint.2019.110137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110137"}}