{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:53:58Z","timestamp":1782564838381,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010686","name":"Folkh\u00e4lsomyndigheten","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["217677"],"award-info":[{"award-number":["217677"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Forensic Science International"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.forsciint.2025.112657","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T23:43:23Z","timestamp":1758152603000},"page":"112657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["In vitro monoamine reuptake inhibition and forensic case series in Sweden of the synthetic cathinones 2-, 3-, and 4-Me-alpha-PiHP"],"prefix":"10.1016","volume":"377","author":[{"given":"Henrik","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-398X","authenticated-orcid":false,"given":"Manuela Carla","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.forsciint.2025.112657_bib1","unstructured":"European Union Drugs Agency. EU Drug Market: New Psychoactive Substances \u2014 Distribution and Supply in Europe: Synthetic Cathinones. 2024. \u3008https:\/\/www.euda.europa.eu\/publications\/eu-drug-markets\/new-psychoactive-substances\/distribution-and-supply\/synthetic-cathinones_en#section4\u3009 (Accessed 30 October 2024)."},{"issue":"9","key":"10.1016\/j.forsciint.2025.112657_bib2","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1007\/s00204-021-03083-3","article-title":"An updated review on synthetic cathinones","volume":"95","author":"Soares","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.forsciint.2025.112657_bib3","unstructured":"European Union Drugs Agency. Synthetic stimulants \u2013 the current situation in Europe (European Drug Report 2024). 2024. \u3008https:\/\/www.euda.europa.eu\/publications\/european-drug-report\/2024\/synthetic-stimulants_en\u3009 (Accessed 16 October 2024)."},{"issue":"12","key":"10.1016\/j.forsciint.2025.112657_bib4","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1007\/s00213-019-05339-4","article-title":"Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and \u03b1-pyrrolidinopentiophenone (\u03b1-PVP) in rhesus monkeys","volume":"236","author":"Collins","year":"2019","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.forsciint.2025.112657_bib5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/jat\/bkad026","article-title":"A fatal case of poisoning with a cathinone derivative: \u03b1-PiHP and its postmortem distribution in body fluids and organ tissues","volume":"47","author":"Wachholz","year":"2023","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.forsciint.2025.112657_bib6","unstructured":"European Monitoring Centre of Drugs and Drug Addiction. EMCDDA\u2013Europol Joint Report on a New Psychoactive Substance: 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (\u03b1-PVP). 2015. \u3008https:\/\/www.euda.europa.eu\/publications\/joint-reports\/alpha-pvp_en\u3009 (Accessed 16 April 2025). (2025)."},{"issue":"7","key":"10.1016\/j.forsciint.2025.112657_bib7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/15563650.2016.1190979","article-title":"Toxicity evaluation of alpha-pyrrolidinovalerophenone (alpha-PVP): results from intoxication cases within the STRIDA project","volume":"54","author":"Beck","year":"2016","journal-title":"Clin. Toxicol."},{"issue":"4","key":"10.1016\/j.forsciint.2025.112657_bib8","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00204-020-02693-7","article-title":"Designer drugs: mechanism of action and adverse effects","volume":"94","author":"Luethi","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.forsciint.2025.112657_bib9","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/jm050797a","article-title":"1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors","volume":"49","author":"Meltzer","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.forsciint.2025.112657_bib10","doi-asserted-by":"crossref","DOI":"10.1021\/acsptsci.4c00299","article-title":"Structure\u2013Activity relationship of synthetic cathinones: an updated review","author":"Nadal-Gratac\u00f3s","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"1","key":"10.1016\/j.forsciint.2025.112657_bib11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/acschemneuro.8b00525","article-title":"DARK classics in chemical neuroscience: \u03b1-Pyrrolidinovalerophenone (\u201cFlakka\u201d)","volume":"10","author":"Kolesnikova","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"10.1016\/j.forsciint.2025.112657_bib12","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/adb.12399","article-title":"Cocaine-like discriminative stimulus effects of alpha-pyrrolidinovalerophenone, methcathinone and their 3,4-methylenedioxy or 4-methyl analogs in rhesus monkeys","volume":"22","author":"Smith","year":"2017","journal-title":"Addict. Biol."},{"issue":"10","key":"10.1016\/j.forsciint.2025.112657_bib13","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acschemneuro.5b00160","article-title":"Structural modification of the designer stimulant \u03b1-Pyrrolidinovalerophenone (\u03b1-PVP) influences potency at dopamine transporters","volume":"6","author":"Kolanos","year":"2015","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.forsciint.2025.112657_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11419-022-00639-5","article-title":"A review of synthetic cathinones emerging in recent years (2019\u20132022)","volume":"41","author":"Kuropka","year":"2023","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.forsciint.2025.112657_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/jat\/bkae011","article-title":"\u03b1-Pyrrolidinohexanophenone (\u03b1-PHP) vs. \u03b1-pyrrolidinoisohexanophenone (\u03b1-PiHP): a toxicological investigation about plasma concentrations and behavior in forensic routine cases","author":"Brueckner","year":"2024","journal-title":"J. Anal. Toxicol."},{"issue":"3","key":"10.1016\/j.forsciint.2025.112657_bib16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.euroneuro.2014.12.012","article-title":"Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones","volume":"25","author":"Rickli","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.forsciint.2025.112657_bib17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1476-5381.2012.02145.x","article-title":"Pharmacological characterization of designer cathinones in vitro","volume":"168","author":"Simmler","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.forsciint.2025.112657_bib18","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1038\/s41386-018-0209-3","article-title":"The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter","volume":"43","author":"Gannon","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.forsciint.2025.112657_bib19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/02698811221142566","article-title":"Comparison of locomotor stimulant and drug discrimination effects of four synthetic cathinones to commonly abused psychostimulants","volume":"37","author":"Shetty","year":"2023","journal-title":"J. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.forsciint.2025.112657_bib20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/jat\/bkac057","article-title":"Toxicological investigation of a case series involving the synthetic cathinone \u03b1-Pyrrolidinohexiophenone (\u03b1-PHP) and identification of phase I and II metabolites in human urine","volume":"47","author":"Grapp","year":"2022","journal-title":"J. Anal. Toxicol."},{"issue":"4","key":"10.1016\/j.forsciint.2025.112657_bib21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/15563650.2017.1370097","article-title":"Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats","volume":"56","author":"Beck","year":"2018","journal-title":"Clin. Toxicol."},{"issue":"2","key":"10.1016\/j.forsciint.2025.112657_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/15563650.2018.1502443","article-title":"Fetal death associated with the use of 3,4-MDPHP and \u03b1-PHP","volume":"57","author":"Adamowicz","year":"2019","journal-title":"Clin. Toxicol."},{"issue":"3","key":"10.1016\/j.forsciint.2025.112657_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12024-020-00236-1","article-title":"Fatal \u03b1-PVP and amphetamine poisoning during a sauna and autoerotic practices","volume":"16","author":"Lunetta","year":"2020","journal-title":"Forensic Sci. Med Pathol."},{"issue":"1","key":"10.1016\/j.forsciint.2025.112657_bib24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/cn3001763","article-title":"A combined approach using Transporter-Flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content","volume":"4","author":"Rosenauer","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.forsciint.2025.112657_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.forsciint.2023.111691","article-title":"Using in vitro receptor activity studies of synthetic cannabinoids to support the risk assessment of new psychoactive substances \u2013 a Swedish strategy to protect public health from harm","volume":"348","author":"B\u00e4ckberg","year":"2023","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.forsciint.2025.112657_bib26","article-title":"Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method","author":"Persson","year":"2023","journal-title":"Drug Test. Anal."},{"issue":"1","key":"10.1016\/j.forsciint.2025.112657_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression \u2013 a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinform."},{"issue":"2","key":"10.1016\/j.forsciint.2025.112657_bib28","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s11419-018-0409-x","article-title":"Effects of the new generation \u03b1-pyrrolidinophenones on spontaneous locomotor activities in mice, and on extracellular dopamine and serotonin levels in the mouse striatum","volume":"36","author":"Wojcieszak","year":"2018","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.forsciint.2025.112657_bib29","article-title":"Gemensamma f\u00f6rfattningssamlingen avseende h\u00e4lso- och sjukv\u00e5rd, socialtj\u00e4nst, l\u00e4kemedel, folkh\u00e4lsa m.m., HSLF-FS 2019:18","author":"Sweden","year":"2019","journal-title":"Chefsjurist P\u00e4r \u00d6dman Soc."},{"key":"10.1016\/j.forsciint.2025.112657_bib30","unstructured":"Svensk f\u00f6rfattningssamling. F\u00f6rordning (1999:58) om f\u00f6rbud mot vissa h\u00e4lsofarliga varor, SFS 2023:902. 2023. \u3008https:\/\/svenskforfattningssamling.se\/sites\/default\/files\/sfs\/2023-12\/SFS2023-902.pdf\u3009 (Accessed 11 June 2025)."},{"key":"10.1016\/j.forsciint.2025.112657_bib31","unstructured":"Socialdepartementet Sverige. Pressmeddelande fr\u00e5n Socialdepartementet - Regeringen narkotikaklassar nya substanser. 2025. \u3008https:\/\/www.regeringen.se\/pressmeddelanden\/2025\/06\/regeringen-narkotikaklassar-nya-substanser\/\u3009 (Accessed 16 June 2025)."},{"key":"10.1016\/j.forsciint.2025.112657_bib32","unstructured":"European Union Drugs Agency. New Psychoactive Substances \u2013 the Current Situation in Europe (European Drug Report 2025). 2025. \u3008https:\/\/www.euda.europa.eu\/publications\/european-drug-report\/2025\/new-psychoactive-substances_en\u3009 (Accessed 16 June 2025)."},{"key":"10.1016\/j.forsciint.2025.112657_bib33","unstructured":"European Monitoring Centre for Drugs and Drug Addiction. EU Early Warning System Formal Notification \u03b1-PHiP, EU-EWS-RCS-FN-2016-0062. 2016. (Accessed 11 June 2025)."},{"key":"10.1016\/j.forsciint.2025.112657_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jflm.2021.102287","article-title":"Severe poisoning after smoking a mixture of 4-fluoroisobutyryl fentanyl (4-FiBF) and alpha-pyrolidinoisohexaphenone (\u03b1-PiHP)","volume":"85","author":"Zawadzki","year":"2022","journal-title":"J. Forensic Leg. Med."},{"key":"10.1016\/j.forsciint.2025.112657_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.legalmed.2019.101626","article-title":"A case of intoxication with a new cathinone derivative \u03b1-PiHP \u2013 a presentation of concentrations in biological specimens","volume":"42","author":"Adamowicz","year":"2020","journal-title":"Leg. Med."},{"key":"10.1016\/j.forsciint.2025.112657_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110470","article-title":"Navigating nitazenes: a pharmacological and toxicological overview of new synthetic opioids with a 2-benzylbenzimidazole core","volume":"275","author":"Vandeputte","year":"2025","journal-title":"Neuropharmacology"}],"container-title":["Forensic Science International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0379073825003019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0379073825003019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:35:41Z","timestamp":1773128141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0379073825003019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":36,"alternative-id":["S0379073825003019"],"URL":"https:\/\/doi.org\/10.1016\/j.forsciint.2025.112657","relation":{},"ISSN":["0379-0738"],"issn-type":[{"value":"0379-0738","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro monoamine reuptake inhibition and forensic case series in Sweden of the synthetic cathinones 2-, 3-, and 4-Me-alpha-PiHP","name":"articletitle","label":"Article Title"},{"value":"Forensic Science International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.forsciint.2025.112657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112657"}}