{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:37:40Z","timestamp":1790289460083,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202311018"],"award-info":[{"award-number":["SZSM202311018"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401315"],"award-info":[{"award-number":["82401315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301226"],"award-info":[{"award-number":["82301226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271103"],"award-info":[{"award-number":["82271103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401272"],"award-info":[{"award-number":["82401272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017609","name":"Shenzhen Knowledge Innovation Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110865"],"award-info":[{"award-number":["2022A1515110865"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Free Radical Biology and Medicine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.freeradbiomed.2025.11.018","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T10:26:31Z","timestamp":1763029591000},"page":"29-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Microglial HMOX1 drives retinal angiogenesis via modulation of endothelial STAT3 signaling"],"prefix":"10.1016","volume":"243","author":[{"given":"Yaling","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mianying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios G.","family":"Vavvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2123-8125","authenticated-orcid":false,"given":"Guoming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9070","key":"10.1016\/j.freeradbiomed.2025.11.018_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0140-6736(97)01107-0","article-title":"Retinopathy of prematurity in middle-income countries","volume":"350","author":"Gilbert","year":"1997","journal-title":"Lancet"},{"issue":"9902","key":"10.1016\/j.freeradbiomed.2025.11.018_bib2","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","article-title":"Retinopathy of prematurity","volume":"382","author":"Hellstrom","year":"2013","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.freeradbiomed.2025.11.018_bib3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1056\/NEJMc1301021","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"368","author":"Jasani","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.preteyeres.2017.09.002","article-title":"Pathophysiology, screening and treatment of ROP: a multi-disciplinary perspective","volume":"62","author":"Chan-Ling","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101018","article-title":"Assessment and management of retinopathy of prematurity in the era of anti-vascular endothelial growth factor (VEGF)","volume":"88","author":"Tsai","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"issue":"11","key":"10.1016\/j.freeradbiomed.2025.11.018_bib6","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023290118","article-title":"A specific RIP3(+) subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism","volume":"118","author":"He","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00401-015-1524-y","article-title":"Microglia-blood vessel interactions: a double-edged sword in brain pathologies","volume":"131","author":"Dudvarski Stankovic","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"6506","key":"10.1016\/j.freeradbiomed.2025.11.018_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay5356","article-title":"Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy","volume":"369","author":"Binet","year":"2020","journal-title":"Science"},{"issue":"23","key":"10.1016\/j.freeradbiomed.2025.11.018_bib9","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.160940","article-title":"Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy","volume":"7","author":"Liu","year":"2022","journal-title":"JCI Insight"},{"issue":"7835","key":"10.1016\/j.freeradbiomed.2025.11.018_bib10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41586-020-2795-6","article-title":"Microglia-organized scar-free spinal cord repair in neonatal mice","volume":"587","author":"Li","year":"2020","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib11","doi-asserted-by":"crossref","first-page":"F425","DOI":"10.1152\/ajprenal.00297.2003","article-title":"The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury","volume":"286","author":"Sikorski","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.freeradbiomed.2025.11.018_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.intimp.2004.09.011","article-title":"Heme oxygenase as a therapeutic target in immunological pregnancy complications","volume":"5","author":"Zenclussen","year":"2005","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.freeradbiomed.2025.11.018_bib13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.trsl.2014.06.010","article-title":"Heme oxygenase-1 expression is associated with tumor aggressiveness and outcomes in patients with bladder cancer: a correlation with smoking intensity","volume":"164","author":"Miyata","year":"2014","journal-title":"Transl. Res."},{"issue":"5","key":"10.1016\/j.freeradbiomed.2025.11.018_bib14","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1089\/ars.2004.6.858","article-title":"Complex role of heme oxygenase-1 in angiogenesis","volume":"6","author":"Dulak","year":"2004","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.freeradbiomed.2025.11.018_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/152308603764816514","article-title":"Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX","volume":"5","author":"Jozkowicz","year":"2003","journal-title":"Antioxidants Redox Signal."},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib16","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1182\/blood-2003-06-1974","article-title":"Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration","volume":"103","author":"Bussolati","year":"2004","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.freeradbiomed.2025.11.018_bib17","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.freeradbiomed.2025.11.018_bib18","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12929-016-0219-6","article-title":"Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer","volume":"23","author":"Cheng","year":"2016","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/j.freeradbiomed.2025.11.018_bib20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ophtha.2016.12.025","article-title":"Anti-vascular endothelial growth factor therapy for primary treatment of type 1 retinopathy of prematurity: a report by the American academy of ophthalmology","volume":"124","author":"VanderVeen","year":"2017","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1001\/jamapediatrics.2017.4838","article-title":"Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity: a randomized clinical trial","volume":"172","author":"Stahl","year":"2018","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib22","first-page":"1857","article-title":"Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review","volume":"10","author":"Yang","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/EB.S94447","article-title":"Revisiting the mouse model of oxygen-induced retinopathy","volume":"8","author":"Kim","year":"2016","journal-title":"Eye Brain"},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/eye.2009.306","article-title":"Oxygen-induced retinopathy: a model for vascular pathology in the retina","volume":"24","author":"Scott","year":"2010","journal-title":"Eye (Lond)"},{"issue":"10","key":"10.1016\/j.freeradbiomed.2025.11.018_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105709","article-title":"Heme oxygenase modulation drives ferroptosis in TNBC cells","volume":"23","author":"Consoli","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.freeradbiomed.2025.11.018_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094668","article-title":"Spiro-oxindole skeleton compounds are efficient inhibitors for indoleamine 2,3-Dioxygenase 1: an attractive target for tumor immunotherapy","volume":"23","author":"Yan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.freeradbiomed.2025.11.018_bib27","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1089\/ars.2013.5184","article-title":"Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis","volume":"19","author":"Skrzypek","year":"2013","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.freeradbiomed.2025.11.018_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00011-020-01427-w","article-title":"The phase changes of M1\/M2 phenotype of microglia\/macrophage following oxygen-induced retinopathy in mice","volume":"70","author":"Li","year":"2021","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.freeradbiomed.2025.11.018_bib29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13059-023-02931-y","article-title":"YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2","volume":"24","author":"Wang","year":"2023","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.freeradbiomed.2025.11.018_bib30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jhep.2005.09.021","article-title":"Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats","volume":"44","author":"Angermayr","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154667","article-title":"Astragalus polysaccharide ameliorates vascular endothelial dysfunction by stimulating macrophage M2 polarization via potentiating Nrf2\/HO-1 signaling pathway","volume":"112","author":"Sha","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100954","article-title":"VEGFR1 signaling in retinal angiogenesis and microinflammation","volume":"84","author":"Uemura","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"issue":"555","key":"10.1016\/j.freeradbiomed.2025.11.018_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay1371","article-title":"Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche","volume":"12","author":"Liu","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"11","key":"10.1016\/j.freeradbiomed.2025.11.018_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb6260","article-title":"M-CSF, IL-6, and TGF-Beta promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery","volume":"7","author":"Li","year":"2021","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib35","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/imm.13479","article-title":"Retinal microglia: functions and diseases","volume":"166","author":"Fan","year":"2022","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.freeradbiomed.2025.11.018_bib36","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/glia.23961","article-title":"How microglia sense and regulate neuronal activity","volume":"69","author":"Umpierre","year":"2021","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.freeradbiomed.2025.11.018_bib37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.immuni.2016.09.016","article-title":"Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation","volume":"45","author":"Huang","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib38","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jconrel.2021.05.035","article-title":"Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration","volume":"335","author":"Kambhampati","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbi.2014.03.003","article-title":"Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia\/macrophages and increased angiogenesis and neurogenesis following experimental stroke","volume":"40","author":"Jin","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00401-015-1529-6","article-title":"Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors","volume":"131","author":"Brandenburg","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"7\u20138","key":"10.1016\/j.freeradbiomed.2025.11.018_bib41","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1089\/ars.2006.8.1153","article-title":"Dual role of VEGF-induced heme-oxygenase-1 in angiogenesis","volume":"8","author":"Bussolati","year":"2006","journal-title":"Antioxidants Redox Signal."},{"issue":"4","key":"10.1016\/j.freeradbiomed.2025.11.018_bib42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10456-011-9230-4","article-title":"Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer","volume":"14","author":"Ferrando","year":"2011","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.freeradbiomed.2025.11.018_bib43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13287-025-04204-w","article-title":"Fascia-derived stem cells enhance fat graft retention by promoting vascularization through the HMOX1-HIF-1alpha pathway","volume":"16","author":"Chen","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.freeradbiomed.2025.11.018_bib44","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.bbrc.2004.11.083","article-title":"Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout","volume":"326","author":"Cisowski","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bcp.2016.12.009","article-title":"Heme oxygenase (HO)-1 induction prevents endoplasmic reticulum stress-mediated endothelial cell death and impaired angiogenic capacity","volume":"127","author":"Maamoun","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105739","article-title":"Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by limiting pyroptosis","volume":"116","author":"Ji","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.freeradbiomed.2025.11.018_bib47","article-title":"STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity","author":"Zhou","year":"2025","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.freeradbiomed.2025.11.018_bib48","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/neuonc\/noac245","article-title":"ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling","volume":"25","author":"Chen","year":"2023","journal-title":"Neuro Oncol."},{"issue":"9","key":"10.1016\/j.freeradbiomed.2025.11.018_bib49","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1158\/0008-5472.CAN-18-0881","article-title":"Targeting APLN\/APLNR improves antiangiogenic efficiency and blunts proinvasive side effects of VEGFA\/VEGFR2 blockade in glioblastoma","volume":"79","author":"Mastrella","year":"2019","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.freeradbiomed.2025.11.018_bib50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrgastro.2012.221","article-title":"The digestive neuronal-glial-epithelial unit: a new actor in gut health and disease","volume":"10","author":"Neunlist","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"33","key":"10.1016\/j.freeradbiomed.2025.11.018_bib51","doi-asserted-by":"crossref","first-page":"eadl2256","DOI":"10.1126\/sciadv.adl2256","article-title":"The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria","volume":"10","author":"Kioko","year":"2024","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.freeradbiomed.2025.11.018_bib52","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jhep.2011.05.023","article-title":"HO-1-STAT3 axis in mouse liver ischemia\/reperfusion injury: regulation of TLR4 innate responses through PI3K\/PTEN signaling","volume":"56","author":"Ke","year":"2012","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.freeradbiomed.2025.11.018_bib53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13046-018-1007-9","article-title":"14-3-3zeta inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling","volume":"38","author":"Song","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.freeradbiomed.2025.11.018_bib54","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.23427","article-title":"The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat kupffer cells","volume":"51","author":"Mandal","year":"2010","journal-title":"Hepatology"}],"container-title":["Free Radical Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089158492501353X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089158492501353X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:19:59Z","timestamp":1767917999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089158492501353X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":54,"alternative-id":["S089158492501353X"],"URL":"https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.11.018","relation":{},"ISSN":["0891-5849"],"issn-type":[{"value":"0891-5849","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial HMOX1 drives retinal angiogenesis via modulation of endothelial STAT3 signaling","name":"articletitle","label":"Article Title"},{"value":"Free Radical Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}