{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:19:47Z","timestamp":1783034387897,"version":"3.54.6"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Facial Plastic Surgery Clinics of North America"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.fsc.2026.04.003","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:37:15Z","timestamp":1780918635000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biologic Improvement of Skin"],"prefix":"10.1016","volume":"34","author":[{"given":"Sunder","family":"Gidumal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Reyes","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Cahill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Pontius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.fsc.2026.04.003_bib1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/0963689717725755","article-title":"Fighting against skin aging: the way from bench to bedside","volume":"27","author":"Zhang","year":"2018","journal-title":"Cell Transplant"},{"key":"10.1016\/j.fsc.2026.04.003_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1195272","article-title":"Skin aging from mechanisms to interventions: focusing on dermal aging","volume":"14","author":"Shin","year":"2023","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.fsc.2026.04.003_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14054","article-title":"Aging in the dermis: fibroblast senescence and its significance","volume":"23","author":"Zhang","year":"2024","journal-title":"Aging Cell"},{"issue":"7","key":"10.1016\/j.fsc.2026.04.003_bib4","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/0092-8674(90)90696-C","article-title":"Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis","volume":"61","author":"Cotsarelis","year":"1990","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.fsc.2026.04.003_bib5","first-page":"5473","article-title":"Overexpression of klotho in adipose-derived stem cells protects against UVB-induced photoaging in co-cultured human fibroblasts","volume":"18","author":"Fan","year":"2018","journal-title":"Mol Med Rep"},{"issue":"2","key":"10.1016\/j.fsc.2026.04.003_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/jocd.15118","article-title":"Impact of defensins-containing body cream on skin composition","volume":"22","author":"Eggerstedt","year":"2023","journal-title":"J Cosmet Dermatol"},{"issue":"4","key":"10.1016\/j.fsc.2026.04.003_bib7","first-page":"426","article-title":"Multi-center, double-blind, vehicle-controlled clinical trial of an alpha and beta defensin-containing anti-aging skin care regimen with clinical, histopathologic, immunohistochemical, photographic, and ultrasound evaluation","volume":"17","author":"Taub","year":"2018","journal-title":"J Drugs Dermatol"},{"issue":"11","key":"10.1016\/j.fsc.2026.04.003_bib8","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.3390\/cells10113242","article-title":"The role of Fibroblast Growth Factor (FGF) signaling in tissue repair and regeneration","volume":"10","author":"Farooq","year":"2021","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.fsc.2026.04.003_bib9","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3390\/ph14111168","article-title":"Anti-aging \u03b2-Klotho gene-activated scaffold promotes rejuvenative wound healing response in human adipose-derived stem cells","volume":"14","author":"Laiva","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"4","key":"10.1016\/j.fsc.2026.04.003_bib10","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3892\/ijmm.2015.2088","article-title":"Epidermal growth factor improves the migration and contractility of aged fibroblasts cultured on 3D collagen matrices","volume":"35","author":"Kim","year":"2015","journal-title":"Int J Mol Med"},{"issue":"3","key":"10.1016\/j.fsc.2026.04.003_bib11","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor-\u03b2 in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.fsc.2026.04.003_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1524-475X.1996.40217.x","article-title":"Modulation of alpha-smooth muscle actin expression in fibroblasts by transforming growth factor-beta isoforms: an in vivo and in vitro study","volume":"4","author":"Serini","year":"1996","journal-title":"Wound Repair Regen"},{"issue":"Suppl 1","key":"10.1016\/j.fsc.2026.04.003_bib13","first-page":"s38","article-title":"Discovery and development of avotermin (recombinant human transforming growth factor beta 3): a new class of prophylactic therapeutic for the improvement of scarring","volume":"19","author":"Occleston","year":"2011","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.fsc.2026.04.003_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jare.2023.02.014","article-title":"Duo-role Platelet-rich plasma: temperature-induced fibrin gel and growth factors\u2019 reservoir for microneedles to promote hair regrowth","volume":"55","author":"Sun","year":"2024","journal-title":"J Adv Res"},{"issue":"1","key":"10.1016\/j.fsc.2026.04.003_bib15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/s13287-025-04620-y","article-title":"Unveiling exosomes in combating skin aging: insights into resources, mechanisms and challenges","volume":"16","author":"Liang","year":"2025","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"10.1016\/j.fsc.2026.04.003_bib16","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/ijms19071987","article-title":"Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data","volume":"19","author":"Pickart","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.fsc.2026.04.003_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/biom15010088","article-title":"Peptides: emerging candidates for the prevention and treatment of skin senescence: a review","volume":"15","author":"Pintea","year":"2025","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.fsc.2026.04.003_bib18","first-page":"37","article-title":"Double-blind, randomized trial on the effectiveness of Acetylhexapeptide-3 cream and palmitoyl Pentapeptide-4 cream for crow's feet","volume":"16","author":"Aruan","year":"2023","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1016\/j.fsc.2026.04.003_bib19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1467-2494.2002.00153.x","article-title":"A synthetic hexapeptide (Argireline) with antiwrinkle activity","volume":"24","author":"Blanes-Mira","year":"2002","journal-title":"Int J Cosmet Sci"},{"issue":"9","key":"10.1016\/j.fsc.2026.04.003_bib20","doi-asserted-by":"crossref","first-page":"822","DOI":"10.36849\/JDD.2020.5353","article-title":"Randomized, double-blinded, split-face study comparing the efficacy and tolerability of two topical products for melasma","volume":"19","author":"Kaufman","year":"2020","journal-title":"J Drugs Dermatol"},{"issue":"4","key":"10.1016\/j.fsc.2026.04.003_bib21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3390\/cells10040813","article-title":"Sirtuin 1 and skin: implications in intrinsic and extrinsic Aging-A systematic review","volume":"10","author":"Bielach-Bazyluk","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.fsc.2026.04.003_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s11357-019-00113-y","article-title":"Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial","volume":"41","author":"Chung","year":"2019","journal-title":"GeroScience"},{"key":"10.1016\/j.fsc.2026.04.003_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.omtn.2018.03.013","article-title":"De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient Cells","volume":"11","author":"Lescan","year":"2018","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.fsc.2026.04.003_bib24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.12688\/f1000research.23185.1","article-title":"Gene editing in dermatology: harnessing CRISPR for the treatment of cutaneous disease","volume":"9","author":"Baker","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.fsc.2026.04.003_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2025.1559510","article-title":"Genetic profiling and precision skin care: a review","volume":"16","author":"Geusens","year":"2025","journal-title":"Front Genet"},{"issue":"5","key":"10.1016\/j.fsc.2026.04.003_bib26","article-title":"Evaluation of platelet-rich plasma and microneedling for facial skin rejuvenation","volume":"12","author":"Pincelli","year":"2024","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"10.1016\/j.fsc.2026.04.003_bib27","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.12659\/MSM.907815","article-title":"The effects of a pulsed electromagnetic field on the proliferation and osteogenic differentiation of human adipose-derived stem cells","volume":"24","author":"Yin","year":"2018","journal-title":"Med Sci Monit"},{"issue":"2","key":"10.1016\/j.fsc.2026.04.003_bib28","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejogrb.2006.05.024","article-title":"Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: a pilot study","volume":"130","author":"Patriarca","year":"2007","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"10.1016\/j.fsc.2026.04.003_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijwd.2019.01.001","article-title":"Estrogen-deficient skin: the role of topical therapy","volume":"5","author":"Rzepecki","year":"2019","journal-title":"Int J Womens Dermatol"},{"key":"10.1016\/j.fsc.2026.04.003_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.reth.2023.12.005","article-title":"Exosomal microRNA-Based therapies for skin diseases","volume":"25","author":"Jibing","year":"2023","journal-title":"Regen Ther"}],"container-title":["Facial Plastic Surgery Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064740626000337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064740626000337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:46:32Z","timestamp":1783032392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064740626000337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1064740626000337"],"URL":"https:\/\/doi.org\/10.1016\/j.fsc.2026.04.003","relation":{},"ISSN":["1064-7406"],"issn-type":[{"value":"1064-7406","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biologic Improvement of Skin","name":"articletitle","label":"Article Title"},{"value":"Facial Plastic Surgery Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsc.2026.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}