{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:57:36Z","timestamp":1771664256898,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.fsi.2005.05.004","type":"journal-article","created":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T12:04:42Z","timestamp":1122033882000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Complement component C3 transcription in Atlantic halibut (Hippoglossus hippoglossus L.) larvae"],"prefix":"10.1016","volume":"20","author":[{"given":"Sigrun","family":"Lange","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slavko H.","family":"Bambir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alister W.","family":"Dodds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Bricknell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrun","family":"Espelid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berglj\u00f3t","family":"Magnad\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2005.05.004_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-065X.1998.tb01250.x","article-title":"Structural and functional identification of complement components of the bony fish, carp (Cyprinus carpio)","volume":"166","author":"Nakao","year":"1998","journal-title":"Immunol Rev"},{"key":"10.1016\/j.fsi.2005.05.004_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-065X.1998.tb01251.x","article-title":"Evolution and diversity of the complement system of poikilothermic vertebrates","volume":"166","author":"Sunyer","year":"1998","journal-title":"Immunol Rev"},{"key":"10.1016\/j.fsi.2005.05.004_bib3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/excr.1996.0269","article-title":"Complement proteins are present in developing endochondral bone and may mediate cartilage cell death and vascularization","volume":"227","author":"Andrades","year":"1996","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.fsi.2005.05.004_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF02918258","article-title":"Complement in human reproduction - activation and control","volume":"12","author":"Rooney","year":"1993","journal-title":"Immunol Res"},{"key":"10.1016\/j.fsi.2005.05.004_bib5","doi-asserted-by":"crossref","first-page":"12763","DOI":"10.1074\/jbc.M311160200","article-title":"The embryothrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction","volume":"13","author":"Lee","year":"2004","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.fsi.2005.05.004_bib6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1471-4906(02)02287-1","article-title":"Complement: more than a \u2018guard\u2019 against invading pathogens?","volume":"23","author":"Mastellos","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0161-5890(01)00055-4","article-title":"Complement and apoptosis","volume":"38","author":"Fishelson","year":"2001","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2249.2003.02330.x","article-title":"Phagocytosis of opsonized apoptotic cells: roles for \u2018old-fashioned\u2019 receptors for antibody and complement","volume":"135","author":"Hart","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib9","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.4049\/jimmunol.161.12.6819","article-title":"Expression of the third component of complement, C3, in regenerating limb blastema cells of urodeles","volume":"161","author":"Del Rio-Tsonis","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1050-4648(03)00081-0","article-title":"Isolation and characterisation of complement component C3 from Atlantic cod (Gadus morhua L.) and Atlantic halibut (Hippoglossus hippoglossus L.)","volume":"16","author":"Lange","year":"2004","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/pro.5560060201","article-title":"The internal thioester and the covalent binding properties of the complement proteins C3 and C4","volume":"6","author":"Law","year":"1997","journal-title":"Protein Sci"},{"key":"10.1016\/j.fsi.2005.05.004_bib12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0167-5699(96)20028-F","article-title":"Expression of complement in the brain: role in health and disease","volume":"17","author":"Morgan","year":"1996","journal-title":"Immunol Today"},{"key":"10.1016\/j.fsi.2005.05.004_bib13","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/371474a0","article-title":"Immunology. Drawing a double-edged sword","volume":"371","author":"Colten","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2005.05.004_bib14","series-title":"The immune system in cod (Gadus morhua L.)\u2013 with emphasis on ontogeny and immunoglobulin production. PhD thesis, Norwegian College of Fishery Science","author":"Schr\u00f8der","year":"1998"},{"key":"10.1016\/j.fsi.2005.05.004_bib15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/fsim.2000.0333","article-title":"Humoral immune parameters of cultured Atlantic halibut (Hippoglossus hippoglossus L.)","volume":"11","author":"Lange","year":"2001","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/fsim.2001.0354","article-title":"The effect of temperature on non-specific defence parameters of three strains of juvenile Atlantic halibut (Hippoglossus hippoglossus L.)","volume":"12","author":"Langston","year":"2002","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1096-4959(03)00173-8","article-title":"The spontaneous haemolytic activity of Atlantic halibut (Hippoglossus hippoglossus L.) and sea bass (Dicentrarchus labrax) serum","volume":"136","author":"Lange","year":"2003","journal-title":"Comp Biochem Physiol B"},{"key":"10.1016\/j.fsi.2005.05.004_bib18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1365-2109.1998.29120857.x","article-title":"Atlantic halibut, Hippoglossus hippoglossus L., larvae cultivation literature, including a bibliography","volume":"29","author":"Mangor-Jensen","year":"1998","journal-title":"Aquacult Res"},{"key":"10.1016\/j.fsi.2005.05.004_bib19","first-page":"148","article-title":"Preliminary study into the short term effects of adjuvants on Atlantic halibut (Hippoglossus hippoglossus L.)","volume":"20","author":"Bowden","year":"2000","journal-title":"Bull Eur Assoc Fish Pathol"},{"key":"10.1016\/j.fsi.2005.05.004_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0044-8486(99)00025-3","article-title":"Susceptibility of Atlantic halibut, Hippoglossus hippoglossus (L.) to infection with typical and atypical Aeromonas salmonicida","volume":"175","author":"Bricknell","year":"1999","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2005.05.004_bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/fsim.1999.0240","article-title":"Susceptibility of juvenile and sub-adult Atlantic halibut (Hippoglossus hippoglossus L.) to infection by Vibrio anguillarum and efficacy of protection induced by vaccination","volume":"10","author":"Bricknell","year":"2000","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/fsim.1999.0231","article-title":"Bath exposure of Atlantic halibut (Hippoglossus hippoglossus L.) yolk sac larvae to bacterial lipopolysaccharide (LPS): absorption and distribution of the LPS and effect on fish survival","volume":"10","author":"Dalmo","year":"2000","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0305-0491(00)00221-2","article-title":"Detection and basic properties of carbamoyl phosphate synthetase III during teleost ontogeny: a case study in the Atlantic halibut (Hippoglossus hippoglossus L.)","volume":"126","author":"Terjesen","year":"2000","journal-title":"Comp Biochem Physiol B"},{"key":"10.1016\/j.fsi.2005.05.004_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/gcen.2001.7653","article-title":"Ontogeny of cholecystokinin-immunoreactive cells in the digestive tract of Atlantic halibut, Hippoglossus hippoglossus, larvae","volume":"123","author":"Kamisaka","year":"2001","journal-title":"Gen Comp Endocrinol"},{"key":"10.1016\/j.fsi.2005.05.004_bib25","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.dci.2003.10.006","article-title":"An immunohistochemical study on complement component C3 in juvenile Atlantic halibut (Hippoglossus hippoglossus L.)","volume":"28","author":"Lange","year":"2004","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib26","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.fsi.2005.05.004_bib27","series-title":"Nonradioactive in situ hybridization application manual","article-title":"Detection of mRNA in tissue sections using DIG-labelled RNA and oligonucleotide probes","author":"Komminoth","year":"1996"},{"key":"10.1016\/j.fsi.2005.05.004_bib28","series-title":"Nonradioactive in situ hybridization application manual","article-title":"Detection of mRNA on paraffin embedded material of the central nervous system with DIG-labelled RNA probes","author":"Breitschopf","year":"1996"},{"key":"10.1016\/j.fsi.2005.05.004_bib29","doi-asserted-by":"crossref","first-page":"6123","DOI":"10.4049\/jimmunol.151.11.6123","article-title":"Third component of trout complement","volume":"151","author":"Lambris","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib30","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4049\/jimmunol.140.5.1577","article-title":"A 34-amino acid peptide of the third component of complement mediates properdin binding","volume":"140","author":"Daoudaki","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00251-002-0518-9","article-title":"Molecular cloning of the complement regulatory factor I isotypes from the common carp (Cyprinus carpio)","author":"Nakao","year":"2003","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2005.05.004_bib32","doi-asserted-by":"crossref","first-page":"19398","DOI":"10.1074\/jbc.273.31.19398","article-title":"The complement cofactor protein (SBP1) from the barred sand bass (Paralabrax nebulifer) mediates overlapping regulatory activities of both human C4b binding protein and factor H","volume":"31","author":"Kemper","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.fsi.2005.05.004_bib33","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.4049\/jimmunol.129.5.2051","article-title":"Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity","volume":"129","author":"Ross","year":"1982","journal-title":"J Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/eji.1830130607","article-title":"Role of human factor I and C3b receptor in the cleavage of surface bound C3b","volume":"13","author":"Medicus","year":"1983","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib35","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.1021\/bi00266a003","article-title":"Structural characterization of factor I mediated cleavage of the third component of complement","volume":"21","author":"Davis","year":"1982","journal-title":"Biochemistry"},{"key":"10.1016\/j.fsi.2005.05.004_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0145-305X(00)00039-2","article-title":"Cloning and structure of three rainbow trout C3 molecules: a plausible explanation for their functional diversity","volume":"25","author":"Zarkadis","year":"2001","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1050-4648(02)00135-3","article-title":"The spotted wolfish (Anarhichas minor Olafsen) complement component C3: isolation, characterization and tissue distribution","volume":"15","author":"Stensvag","year":"2003","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib38","first-page":"41","article-title":"Ontogeny of immune parameters in Atlantic halibut (Hippoglossus hippoglossus L.)","author":"Bowden","year":"2004","journal-title":"larvae. In: Handbook of the 6th International Symposium on Fish Immunology, Finland: Turku; May 24\u201329"},{"key":"10.1016\/j.fsi.2005.05.004_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2005.03.009","article-title":"The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.) \u2013 a role in development and homeostasis?","author":"Lange","year":"2005","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib40","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.170.5.2331","article-title":"Expression of complement 3 and complement 5 in newt limb and lens regeneration","volume":"170","author":"Kimura","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib41","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.4049\/jimmunol.160.6.2619","article-title":"Local synthesis of C3 within the splenic lymphoid compartment can reconstitute the impaired immune response in C3-deficient mice","volume":"160","author":"Fischer","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.fsi.2005.05.004_bib42","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/10454411950060020301","article-title":"Complement biosynthesis in the central nervous system","volume":"6","author":"Barnum","year":"1995","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.fsi.2005.05.004_bib43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0162-3109(00)80302-1","article-title":"Complement components of the innate immune system in health and disease in the CNS","volume":"49","author":"Gasque","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.fsi.2005.05.004_bib44","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.4049\/jimmunol.166.4.2479","article-title":"A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration","volume":"166","author":"Mastellos","year":"2001","journal-title":"J Immunol"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464805000914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464805000914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:04:15Z","timestamp":1760936655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464805000914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1050464805000914"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2005.05.004","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement component C3 transcription in Atlantic halibut (Hippoglossus hippoglossus L.) larvae","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2005.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}