{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:58:36Z","timestamp":1786989516937,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.fsi.2011.10.031","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T04:18:48Z","timestamp":1320812328000},"page":"121-131","source":"Crossref","is-referenced-by-count":115,"title":["Inductive expression of toll-like receptor 5 (TLR5) and associated downstream signaling molecules following ligand exposure and bacterial infection in the Indian major carp, mrigal (Cirrhinus mrigala)"],"prefix":"10.1016","volume":"32","author":[{"given":"M.","family":"Basu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.K.","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Routray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Samanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2011.10.031_bib1","unstructured":"Aoki T, Takano T, Santos MD, Kondo H, Hirono I. Molecular innate immunity in Teleost fish: review and future perspectives. 5th World Fisheries Congress 2008;263\u2013276."},{"key":"10.1016\/j.fsi.2011.10.031_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2011.10.031_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","article-title":"Innate immunity of fish (overview)","volume":"20","author":"Magnadottir","year":"2006","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)80412-2","article-title":"Innate immunity: the virtues of a nonclonal system of recognition","volume":"91","author":"Medzhitov","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2011.10.031_bib5","doi-asserted-by":"crossref","first-page":"792","DOI":"10.4049\/jimmunol.0900173","article-title":"Cutting edge: TNF-\u03b1 mediated sensitization to ATP and Silica via the NLRP3 inflammasome in the absence of microbial stimulation","volume":"183","author":"Franchi","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.pathol.4.110807.092239","article-title":"NOD-like receptors: role in innate immunity and inflammatory disease","volume":"4","author":"Chen","year":"2009","journal-title":"Annu Rev Pathol Mech"},{"key":"10.1016\/j.fsi.2011.10.031_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2183\/pjab.85.143","article-title":"Pathogen recognition by innate immunity and its signaling","volume":"85","author":"Akira","year":"2009","journal-title":"Proc Jpn Acad Ser B"},{"key":"10.1016\/j.fsi.2011.10.031_bib10","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2011.10.031_bib11","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.167.4.1882","article-title":"Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression","volume":"167","author":"Gewirtz","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib12","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.4049\/jimmunol.172.11.6922","article-title":"Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response","volume":"172","author":"Didierlaurent","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00281-007-0100-5","article-title":"Toll-like receptor-5: protecting the gut from enteric microbes","volume":"30","author":"Vijay-Kumar","year":"2008","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.fsi.2011.10.031_bib14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.194.6.863","article-title":"Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens","volume":"194","author":"Kadowaki","year":"2001","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.fsi.2011.10.031_bib15","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.4049\/jimmunol.170.10.5165","article-title":"The toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells","volume":"170","author":"Means","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00251-002-0519-8","article-title":"Prediction of the prototype of the human toll-like receptor gene family from the pufferfish, Fugu rubripes, genome","volume":"54","author":"Oshiumi","year":"2003","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2011.10.031_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.vetimm.2005.05.013","article-title":"Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in Atlantic salmon during Aeromonas salmonicida infection","volume":"109","author":"Tsoi","year":"2006","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.fsi.2011.10.031_bib18","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.fsi.2007.06.002","article-title":"Divergent toll-like receptors in catfish (Ictalurus punctatus): TLR5S, TLR20, TLR21","volume":"23","author":"Baoprasertkul","year":"2007","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib19","doi-asserted-by":"crossref","first-page":"48588","DOI":"10.1074\/jbc.M407634200","article-title":"Sensing bacterial flagellin by membrane and soluble orthologs of toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss)","volume":"279","author":"Tsujita","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2011.10.031_bib20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.fsi.2010.06.011","article-title":"Molecular cloning and expression study on toll like receptor 5 paralogs in Japanese flounder, Paralichthys olivaceus","volume":"29","author":"Hwang","year":"2010","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib21","series-title":"Quarterly aquatic animal disease report (Asia and Pacific region)","year":"2003"},{"key":"10.1016\/j.fsi.2011.10.031_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C (T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2011.10.031_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2010.01.006","article-title":"Host-microbe interactions in the developing zebrafish","volume":"22","author":"Kanther","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib24","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.fsi.2005.07.008","article-title":"Carp (Cyprinus carpio L.) innate immune factors are present before hatching","volume":"20","author":"Huttenhuis","year":"2006","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib25","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.fsi.2011.02.014","article-title":"Ontogeny and tissue-specific expression of innate immune related genes in rohu, Labeo rohita (Hamilton)","volume":"30","author":"Nayak","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.fsi.2008.10.014","article-title":"Molecular cloning and expression of MyD88 in large yellow croaker, Pseudosciaena crocea","volume":"26","author":"Yao","year":"2009","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib27","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.dci.2009.04.007","article-title":"Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar)","volume":"33","author":"Skj\u00e6veland","year":"2009","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib28","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.dci.2005.11.003","article-title":"Identification and characterization of a myeloid differentiation factor 88 (MyD88) cDNA and gene in Japanese flounder, Paralichthys olivaceus","volume":"30","author":"Takano","year":"2006","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fsi.2010.09.003","article-title":"Molecular characterization and functional analysis of MyD88 in Chinese soft-shelled turtle Trionyx sinensis","volume":"30","author":"Li","year":"2010","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib30","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.fsi.2011.04.012","article-title":"Orange spotted grouper (Epinephelus coioides) TLR2, MyD88 and IL-1\u03b2 involved in anti-cryptocaryon irritans response","volume":"30","author":"Li","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.fsi.2010.11.012","article-title":"Molecular cloning, characterization and expression analysis of TLR9, MyD88 and TRAF6 genes in common carp (Cyprinus carpio)","volume":"30","author":"Kongchum","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbd.2005.07.003","article-title":"Conservation of toll-like receptor signaling pathways in teleost fish","volume":"1","author":"Purcell","year":"2006","journal-title":"Comp Biochem Physiol Part D Genomics Proteomics"},{"key":"10.1016\/j.fsi.2011.10.031_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.vetimm.2009.03.006","article-title":"Characterization of two key molecules of teleost innate immunity from rainbow trout (Oncorhynchus mykiss): MyD88 and SAA","volume":"131","author":"Rebl","year":"2009","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.fsi.2011.10.031_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.vetimm.2009.09.021","article-title":"Toll-like receptor signaling in bony fish","volume":"134","author":"Rebl","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.fsi.2011.10.031_bib35","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1016\/j.molimm.2007.04.001","article-title":"Ligand-induced differential cross-regulation of toll-like receptors 2, 4 and 5 in intestinalepithelial cells","volume":"44","author":"van Aubel","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib36","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1086\/500467","article-title":"Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes","volume":"193","author":"Cabral","year":"2006","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.fsi.2011.10.031_bib37","doi-asserted-by":"crossref","first-page":"G767","DOI":"10.1152\/ajpgi.00447.2006","article-title":"Flagellin-induced tolerance of the toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells","volume":"292","author":"Sun","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.fsi.2011.10.031_bib38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib39","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.fsi.2011.03.023","article-title":"Interleukin-8 of Cynoglossus semilaevis is a chemoattractant with immunoregulatory property","volume":"30","author":"Sun","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib40","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.molimm.2009.09.004","article-title":"Induction of IL-8 expression by bacterial flagellin is mediated through lipid raft formation and intracellular TLR5 activation in A549 cells","volume":"47","author":"Im","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2011.10.031_bib41","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1128\/IAI.74.4.2436-2441.2006","article-title":"MyD88 innate immune function in a zebrafish embryo infection model","volume":"74","author":"Van der Sar","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.fsi.2011.10.031_bib42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.vetimm.2011.02.016","article-title":"Cloning and expression of toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides","volume":"141","author":"Wei","year":"2011","journal-title":"Vet Immunol Immunopathol"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464811003895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464811003895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T04:26:28Z","timestamp":1593231988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464811003895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1050464811003895"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2011.10.031","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}