{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:11:47Z","timestamp":1767924707195,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.fsi.2011.11.021","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T19:37:42Z","timestamp":1322941062000},"page":"476-481","source":"Crossref","is-referenced-by-count":79,"title":["Molecular cloning of orange-spotted grouper (Epinephelus coioides) TLR21 and expression analysis post Cryptocaryon irritans infection"],"prefix":"10.1016","volume":"32","author":[{"given":"Yan-Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Chun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Ming","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia-Zi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2011.11.021_bib1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00251-002-0519-8","article-title":"Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome","volume":"54","author":"Oshiumi","year":"2003","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2011.11.021_bib2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.molimm.2003.10.003","article-title":"Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish","volume":"40","author":"Meijer","year":"2004","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.molimm.2003.10.001","article-title":"Toll-like receptor gene family and TIR-domain adapters in Danio rerio","volume":"40","author":"Jault","year":"2004","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib4","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.fsi.2007.06.002","article-title":"Divergent Toll-like receptors in catfish (Ictalurus punctatus): TLR5S, TLR20, TLR21","volume":"23","author":"Baoprasertkul","year":"2007","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.aquaculture.2011.02.035","article-title":"Association between IL-10a single nucleotide polymorphisms and resistance to cyprinid herpesvirus-3 infection in common carp (Cyprinus carpio)","volume":"315","author":"Kongchum","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2011.11.021_bib6","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.dci.2010.03.004","article-title":"Phylogenetic and expression analysis of lamprey toll-like receptors","volume":"34","author":"Kasamatsu","year":"2010","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00251-007-0193-y","article-title":"Phylogenetic and expression analysis of amphibian Xenopus Toll-like receptors","volume":"59","author":"Ishii","year":"2007","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2011.11.021_bib8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2164-9-62","article-title":"Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss","volume":"9","author":"Temperley","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2011.11.021_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.vetmic.2009.11.001","article-title":"Involvement of TLR21 in baculovirus-induced interleukin-12 gene expression in avian macrophage-like cell line HD11","volume":"144","author":"Han","year":"2010","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.fsi.2011.11.021_bib10","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1016\/j.molimm.2009.06.002","article-title":"Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides","volume":"46","author":"Brownlie","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib11","doi-asserted-by":"crossref","first-page":"460","DOI":"10.4049\/jimmunol.0901921","article-title":"Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9","volume":"185","author":"Keestra","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib12","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.181.5.3474","article-title":"Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses","volume":"181","author":"Matsuo","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib13","doi-asserted-by":"crossref","first-page":"48588","DOI":"10.1074\/jbc.M407634200","article-title":"Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss)","volume":"279","author":"Tsujita","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2011.11.021_bib14","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.fsi.2011.04.012","article-title":"Orange-spotted grouper (Epinephelus coioides) TLR2, MyD88 and IL-1\u03b2 involved in anti-Cryptocaryon irritans response","volume":"30","author":"Li","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib15","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1109893","article-title":"TLR11 activation of dendritic cells by a protozoan profilin-like protein","volume":"308","author":"Yarovinsky","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.fsi.2011.11.021_bib16","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.4049\/jimmunol.177.6.3515","article-title":"Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection","volume":"177","author":"Bafica","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib17","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.4049\/jimmunol.175.4.2501","article-title":"The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent","volume":"175","author":"Drennan","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u25b5\u25b5CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2011.11.021_bib19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S1471-4906(03)00242-4","article-title":"Leucine-rich repeats and pathogen recognition in Toll-like receptors","volume":"24","author":"Bell","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib20","doi-asserted-by":"crossref","first-page":"27503","DOI":"10.1074\/jbc.M605003200","article-title":"Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling","volume":"281","author":"Gibbard","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2011.11.021_bib21","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.4049\/jimmunol.0900819","article-title":"Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation","volume":"182","author":"Peter","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib22","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1002\/eji.200425218","article-title":"Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner","volume":"34","author":"Rutz","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib23","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1093\/emboj\/18.23.6653","article-title":"Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1","volume":"18","author":"Ohki","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.fsi.2011.11.021_bib24","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S1471-4906(03)00115-7","article-title":"The Toll-IL-1 receptor adaptor family grows to five members","volume":"24","author":"O\u2019Neill","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib25","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1074\/jbc.275.7.4670","article-title":"Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways","volume":"275","author":"Slack","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2011.11.021_bib26","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.molimm.2006.10.018","article-title":"Molecular cloning and characterization of Toll-like receptor 9 in Japanese flounder, Paralichthys olivaceus","volume":"44","author":"Takano","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2011.11.021_bib27","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2011.11.021_bib28","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1128\/IAI.69.4.2162-2171.2001","article-title":"DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T-brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor \u03b1, and nitric oxide","volume":"69","author":"Shoda","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.fsi.2011.11.021_bib29","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S1286-4579(02)01623-4","article-title":"Stimulation of B lymphocytes, macrophages, and dendritic cells by protozoan DNA","volume":"4","author":"Brown","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.fsi.2011.11.021_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2761.2003.00457.x","article-title":"Immunostimulatory CpG oligodeoxynucleotides increase resistance against amoebic gill disease in Atlantic salmon, Salmo salar L","volume":"26","author":"Bridle","year":"2003","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2011.11.021_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.fsi.2008.10.001","article-title":"CpG-ODN increases resistance of olive flounder (Paralichthys olivaceus) against Philasterides dicentrarchi (Ciliophora: Scuticociliatia) infection","volume":"26","author":"Lee","year":"2009","journal-title":"Fish Shellfish Immunol"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464811004311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464811004311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T05:37:32Z","timestamp":1593322652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464811004311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S1050464811004311"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2011.11.021","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}