{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:43:45Z","timestamp":1760939025348,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.fsi.2012.09.020","type":"journal-article","created":{"date-parts":[[2012,9,29]],"date-time":"2012-09-29T16:32:22Z","timestamp":1348936342000},"page":"1292-1302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Flow cytometry assay for intracellular detection of Infectious Pancreatic Necrosis virus (IPNV) in Atlantic salmon (Salmo salar L.) leucocytes"],"prefix":"10.1016","volume":"33","author":[{"given":"Anita","family":"R\u00f8nneseth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirin Fausa","family":"Pettersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun I.","family":"Wergeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2012.09.020_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/84701","article-title":"11-Color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity","volume":"7","author":"De Rosa","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.fsi.2012.09.020_bib2","first-page":"697","article-title":"Eleven-color flow cytometry \u2013 a powerful tool for elucidation of the complex immune system","volume":"21","author":"De Rosa","year":"2001","journal-title":"Clin Lab Med"},{"key":"10.1016\/j.fsi.2012.09.020_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-2105-12-145","article-title":"FIND: a new software tool and development platform for enhanced multicolor flow analysis","volume":"12","author":"Dabdoub","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.fsi.2012.09.020_bib4","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nri1416","article-title":"Innovation \u2013 seventeen-colour flow cytometry: unravelling the immune system","volume":"4","author":"Perfetto","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.fsi.2012.09.020_bib5","first-page":"552","article-title":"Infectious pancreatic necrosis: detection of virus and antibodies in rainbow trout IPNV-carrier (Salmo gairdneri)","volume":"33","author":"Ahne","year":"1986","journal-title":"J\u00a0Vet Med"},{"key":"10.1016\/j.fsi.2012.09.020_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0044-8486(94)00392-2","article-title":"In\u00a0vitro studies of infectious pancreatic necrosis virus-infections in leukocytes isolated from Atlantic Salmon (Salmo-Salar L)","volume":"132","author":"Johansen","year":"1995","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2012.09.020_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2761.1995.tb00272.x","article-title":"Multiplication of infectious pancreatic necrosis virus (IPNV) in head kidney and blood leukocytes isolated from Atlantic Salmon, Salmo-Salar L","volume":"18","author":"Johansen","year":"1995","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2761.1988.tb00532.x","article-title":"Studies on the carrier state of infectious pancreatic necrosis virus-infections in rainbow-trout, Salmo gairdneri Richardson","volume":"11","author":"Mangunwiryo","year":"1988","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3147\/jsfp.36.139","article-title":"Detection of infections pancreatic necrosis virus (IPNV) from leukocytes of carrier rainbow trout Oncorhynchus mykiss","volume":"36","author":"Rodriguez","year":"2001","journal-title":"Fish Pathol"},{"key":"10.1016\/j.fsi.2012.09.020_bib10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2761.1991.tb00609.x","article-title":"Detection of infectious pancreatic necrosis virus in a carrier population of rainbow trout, Oncorhynchus mykiss (Richardson), by flow cytometry","volume":"14","author":"Saint-Jean","year":"1991","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1139\/f82-030","article-title":"Isolation of infectious pancreatic necrosis virus from the blood and blood components of experimentally infected trout","volume":"39","author":"Swanson","year":"1982","journal-title":"Can J Fish Aquat Sci"},{"key":"10.1016\/j.fsi.2012.09.020_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2761.1982.tb00496.x","article-title":"Replication of infectious pancreatic necrosis virus in trout leukocytes and detection of the carrier state","volume":"5","author":"Yu","year":"1982","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3354\/dao020183","article-title":"Susceptibility of Atlantic halibut Hippoglossus hippoglossus to infectious pancreatic necrosis virus","volume":"20","author":"Biering","year":"1994","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2012.09.020_bib14","first-page":"42","article-title":"Infectious pancreatic necrosis virus, serotype N1, isolated from Norwegian halibut (Hippoglossus hippoglossus), turbot (Scophthalmus maximus) and scallops (Pecten maximus)","volume":"10","author":"Mortensen","year":"1990","journal-title":"Bull Eur Assoc Fish Pathol"},{"key":"10.1016\/j.fsi.2012.09.020_bib15","first-page":"174","article-title":"Mortality of halibut (Hippoglossus hippoglossus) challenged with infectious pancreatic necrosis virus (IPNV)","volume":"14","author":"Ness","year":"1994","journal-title":"Bull Eur Assoc Fish Pathol"},{"key":"10.1016\/j.fsi.2012.09.020_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3354\/dao028169","article-title":"Sero- and genotyping of some marine aquatic birnavirus isolates from Norway","volume":"28","author":"Biering","year":"1997","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2012.09.020_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2761.2006.00731.x","article-title":"Infectious pancreatic necrosis virus establishes an asymptomatic carrier state in kidney leucocytes of juvenile Atlantic cod, Gadus morhua L","volume":"29","author":"Garcia","year":"2006","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2761.1996.tb00380.x","article-title":"Experimental infection of Atlantic halibut, Hippoglossus hippoglossus L, yolk-sac larvae with infectious pancreatic necrosis virus: detection of virus by immunohistochemistry and in situ hybridization","volume":"19","author":"Biering","year":"1996","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3354\/dao017061","article-title":"Isolation of IPN virus serotype Vr-299 from turbot in Europe","volume":"17","author":"Novoa","year":"1993","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2012.09.020_bib20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0044-8486(93)90140-T","article-title":"The relevance of infectious pancreatic necrosis virus (IPNV) in farmed Norwegian turbot (Scophthalmus maximus)","volume":"115","author":"Mortensen","year":"1993","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2012.09.020_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3354\/dao02066","article-title":"Susceptibility of Atlantic cod Gadus morhua juveniles to different routes of experimental challenge with infectious pancreatic necrosis virus (IPNV)","volume":"85","author":"Jensen","year":"2009","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2012.09.020_bib22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2761.2009.01036.x","article-title":"Experimental study of the susceptibility of Atlantic cod, Gadus morhua (L.), to infection with an IPNV strain pathogenic for Atlantic salmon, Salmo salar L","volume":"32","author":"Urquhart","year":"2009","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.fsi.2007.03.012","article-title":"Expression kinetics of ISG15 and viral major capsid protein (VP2) in Atlantic cod (Gadus morhua L.) fry following infection with infectious pancreatic necrosis virus (IPNV)","volume":"23","author":"Das","year":"2007","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.09.020_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3354\/dao071239","article-title":"Viral and bacterial diseases of Atlantic cod Gadus morhua, their prophylaxis and treatment: a review","volume":"71","author":"Samuelsen","year":"2006","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2012.09.020_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.fsi.2009.10.021","article-title":"Phagocytosis by B-cells and neutrophils in Atlantic salmon (Salmo salar L.) and Atlantic cod (Gadus morhua L.)","volume":"28","author":"\u00d8verland","year":"2010","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.09.020_bib26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1006\/fsim.2000.0284","article-title":"Studies of Atlantic salmon (Salmo salar L.) blood, spleen and head kidney leucocytes using specific monoclonal antibodies, immunohistochemistry and flow cytometry","volume":"10","author":"Pettersen","year":"2000","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.09.020_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virol.2003.12.016","article-title":"Identification of putative motifs involved in the virulence of infectious pancreatic necrosis virus","volume":"322","author":"Santi","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2012.09.020_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.aquaculture.2007.03.021","article-title":"Mortality after IPNV challenge of Atlantic salmon (Salmo salar L.) differs based on developmental stage of fish or challenge route","volume":"271","author":"R\u00f8nneseth","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2012.09.020_bib29","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF01863914","article-title":"Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche","volume":"162","author":"K\u00e4rber","year":"1931","journal-title":"Naunyn-Schmiedebergs Arc Pharmakol Exp Pathol"},{"key":"10.1016\/j.fsi.2012.09.020_bib30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.clim.2003.11.009","article-title":"Analysis of protein phosphorylation and cellular signalling events by flow cytometry: techniques and clinical applications","volume":"110","author":"Krutzik","year":"2004","journal-title":"Clin Immunol"},{"key":"10.1016\/j.fsi.2012.09.020_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cyto.a.10072","article-title":"Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events","volume":"55A","author":"Krutzik","year":"2003","journal-title":"Cytometry A"},{"key":"10.1016\/j.fsi.2012.09.020_bib32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jim.2010.07.008","article-title":"Immunostaining of Atlantic salmon (Salmo salar L.) leucocytes","volume":"362","author":"Haugland","year":"2010","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.fsi.2012.09.020_bib33","doi-asserted-by":"crossref","first-page":"10289","DOI":"10.1128\/JVI.79.16.10289-10299.2005","article-title":"Molecular determinants of infectious pancreatic necrosis virus virulence and cell culture adaptation","volume":"79","author":"Song","year":"2005","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.fsi.2012.09.020_bib34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2761.1978.tb00034.x","article-title":"Persistent infections in salmonid fish cells with infectious pancreatic necrosis virus (IPNV)","volume":"1","author":"Hedrick","year":"1978","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.09.020_bib35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.fsi.2010.02.001","article-title":"Differentially expressed genes following persistent infection with infectious pancreatic necrosis virus in\u00a0vitro and in\u00a0vivo","volume":"28","author":"Marjara","year":"2010","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.09.020_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.vetimm.2010.02.015","article-title":"The persistence of infectious pancreatic necrosis virus and its influence on the early immune response","volume":"136","author":"Saint-Jean","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.fsi.2012.09.020_bib37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0042-6822(79)90428-8","article-title":"Infectious pancreatic necrosis virus persistently infects Chinook salmon embryo cells independent of interferon","volume":"95","author":"MacDonald","year":"1979","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2012.09.020_bib38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetmic.2010.10.017","article-title":"Characterization of an infectious pancreatic necrosis (IPN) virus carrier cell culture with resistance to superinfection with heterologous viruses","volume":"149","author":"Garcia","year":"2011","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.fsi.2012.09.020_bib39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jviromet.2004.12.005","article-title":"Development of a flow cytometry based method for rapid and sensitive detection of a novel marine fish iridovirus in cell culture","volume":"125","author":"Qin","year":"2005","journal-title":"J\u00a0Virol Methods"},{"key":"10.1016\/j.fsi.2012.09.020_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3147\/jsfp.30.1","article-title":"In\u00a0vitro quantitative kinetic-study of infections pancreatic necrosis viral-antigen by flow-cytometry","volume":"30","author":"Rodriguez","year":"1995","journal-title":"Fish Pathol"},{"key":"10.1016\/j.fsi.2012.09.020_bib41","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0007-1935(17)34791-7","article-title":"The pathology of infectious pancreatic necrosis. I. The sequential histopathology of the naturally occurring condition","volume":"132","author":"McKnight","year":"1976","journal-title":"Br Vet J"},{"key":"10.1016\/j.fsi.2012.09.020_bib42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1099\/0022-1317-58-2-361","article-title":"Persistent infection with infectious pancreatic necrosis virus mediated by defective-interfering (DI) virus particles in a cell line showing strong interference but little DI replication","volume":"58","author":"Kennedy","year":"1982","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.fsi.2012.09.020_bib43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0065-3527(08)60279-1","article-title":"Effects of defective interfering viruses on virus replication and pathogrnesis in\u00a0vitro and in\u00a0vivo","volume":"40","author":"Roux","year":"1991","journal-title":"Adv Virus Res"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481200352X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481200352X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:06:21Z","timestamp":1760936781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046481200352X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S105046481200352X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2012.09.020","relation":{},"ISSN":["1050-4648"],"issn-type":[{"type":"print","value":"1050-4648"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flow cytometry assay for intracellular detection of Infectious Pancreatic Necrosis virus (IPNV) in Atlantic salmon (Salmo salar L.) leucocytes","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2012.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}