{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:04:28Z","timestamp":1789416268993,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.fsi.2012.11.052","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T23:48:09Z","timestamp":1357256889000},"page":"762-769","source":"Crossref","is-referenced-by-count":52,"title":["Expression profile of immune-related genes in Lates calcarifer infected by Cryptocaryon irritans"],"prefix":"10.1016","volume":"34","author":[{"given":"Norashikin","family":"Mohd-Shaharuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adura","family":"Mohd-Adnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beng-Chu","family":"Kua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2012.11.052_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1018360323287","article-title":"Cryptocaryon irritans Brown 1951, the cause of 'white spot disease' in marine fish: an update","volume":"1","author":"Colorni","year":"1997","journal-title":"Aquar Sci Conserv"},{"key":"10.1016\/j.fsi.2012.11.052_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3354\/dao054147","article-title":"Characterization of Cryptocaryon irritans, a parasite isolated from marine fishes in Taiwan","volume":"54","author":"Yambot","year":"2003","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2012.11.052_bib3","unstructured":"Kua BC. Determination and in\u00a0vitro culture of the protozoan pathogen, Cryptocaryon irritans, from seabass (Lates calcarifer) for vaccine development. PhD thesis: Universiti Sains Malaysia; 2002."},{"key":"10.1016\/j.fsi.2012.11.052_bib4","first-page":"285","article-title":"The internal transcribed spacer (ribosomal DNA) of fish protozoan, Cryptocaryon irritans, isolated from cultured seabass, Lates calcarifer, in Penang waters","volume":"21","author":"Kua","year":"2008","journal-title":"Asian Fish Sci"},{"key":"10.1016\/j.fsi.2012.11.052_bib5","series-title":"Cryptocaryon irritans infections (marin white spot disease). Program in fisheries and aquatic sciences, sfrc, florida cooperative extension service","author":"Yanong","year":"2009"},{"key":"10.1016\/j.fsi.2012.11.052_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1023\/A:1009257011431","article-title":"Treatments for ectoparasites and diseases in captive Western Australian dhufish","volume":"8","author":"Pironet","year":"2000","journal-title":"Aquac Int"},{"key":"10.1016\/j.fsi.2012.11.052_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3354\/dao036021","article-title":"Anti-immunoglobulin antisera used in an ELISA to detect antibodies in barramundi Lates calcarifer to Cryptocaryon irritans","volume":"36","author":"Bryant","year":"1999","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2012.11.052_bib8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.fsi.2006.04.011","article-title":"Protective immunity in grouper (Epinephelus coioides) following exposure to or injection with Cryptocaryon irritans","volume":"22","author":"Luo","year":"2007","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib9","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1016\/S0264-410X(02)00379-1","article-title":"Natural antibodies and their significance in active immunization and protection against a defined pathogen in fish","volume":"20","author":"Sinyakov","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2012.11.052_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","article-title":"Innate immunity of fish (overview)","volume":"20","author":"Magnadottir","year":"2006","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2761.2004.00558.x","article-title":"The parasitic ciliate Ichthyophthirius multifiliis induces expression of immune relevant genes in rainbow trout, Oncorhynchus mykiss (Walbaum)","volume":"27","author":"Sigh","year":"2004","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.11.052_bib12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.fsi.2011.07.008","article-title":"The expression analysis of inflammatory and antimicrobial genes in the goldfish (Carassius auratus L) infected with Trypanosoma carassii","volume":"31","author":"Oladiran","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib13","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.fsi.2008.01.014","article-title":"Chronic exposure to the parasite Enteromyxum leei (Myxozoa: Myxosporea) modulates the immune response and the expression of growth, redox and immune relevant genes in gilthead sea bream, Sparus aurata L","volume":"24","author":"Sitja-Bobadilla","year":"2008","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/1471-2164-11-356","article-title":"Identification and analysis of immune-related transcriptome in Asian seabass Lates calcarifer","volume":"11","author":"Xia","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2012.11.052_bib15","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.fsi.2012.07.005","article-title":"Cryptocaryon irritans infection induces the acute phase response in Lates calcarifer: a transcriptome perspective","volume":"33","author":"Khoo","year":"2012","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2164-11-76","article-title":"Transcriptome analysis of the Cryptocaryon irritans tomont stage identifies potential genes for the detection and control of cryptocaryonosis","volume":"11","author":"Lokanathan","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2012.11.052_bib17","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1095\/biolreprod63.6.1676","article-title":"Changes in the expression of genes encoding steroidogenic enzymes in the channel catfish (Ictalurus punctatus) ovary throughout a reproductive cycle","volume":"63","author":"Kumar","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.fsi.2012.11.052_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s10126-010-9277-z","article-title":"Normalizing RT-qPCR data: are we getting the right answers? an appraisal of normalization approaches and internal reference genes from a case study in the finfish Lates calcarifer","volume":"13","author":"De Santis","year":"2011","journal-title":"Mar Biotechnol"},{"key":"10.1016\/j.fsi.2012.11.052_bib19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1677\/jme.0.0250169","article-title":"Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays","volume":"25","author":"Bustin","year":"2000","journal-title":"J\u00a0Mol Endocrinol"},{"key":"10.1016\/j.fsi.2012.11.052_bib20","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST\u00a9) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.fsi.2012.11.052_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3354\/dao043211","article-title":"A\u00a0new strain of Cryptocaryon irritans from the cultured olive flounder Paralichthys olivaceus","volume":"43","author":"Jee","year":"2000","journal-title":"Dis Aquat Org"},{"issue":"6","key":"10.1016\/j.fsi.2012.11.052_bib22","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.fsi.2011.04.012","article-title":"Orange-spotted grouper (Epinephelus coioides) TLR2, MyD88 and IL-1 involved in anti-Cryptocaryon irritans response","volume":"30","author":"Li","year":"2011","journal-title":"Fish Shell\ufb01sh Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.fsi.2006.08.011","article-title":"Real-time expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses caused by the ectoparasite Ichthyophthirius multi\ufb01liis","volume":"22","author":"Gonzalez","year":"2007","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.vetimm.2006.09.007","article-title":"Ichthyophthirius multi\ufb01liis infection induces massive up-regulation of serum amyloid A in carp (Cyprinus carpio)","volume":"115","author":"Gonzalez","year":"2007","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.fsi.2012.11.052_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/fsim.1998.0181","article-title":"The morphology of the immune system in the teleost fishes","volume":"9","author":"Press","year":"1999","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib26","series-title":"The fish immune system. Organism, pathogen and environment","first-page":"1","article-title":"Cells and tissues of the immune system of fish","author":"Zapata","year":"1996"},{"key":"10.1016\/j.fsi.2012.11.052_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-2761.1997.00302.x","article-title":"Non-specific defence mechanisms in fish, with particular reference to the reticuloendothelial system (RES)","volume":"20","author":"Dalmo","year":"1997","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2012.11.052_bib28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0145-305X(00)00057-4","article-title":"Immune-relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive hybridization","volume":"25","author":"Bayne","year":"2001","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1096\/fj.06-7227rev","article-title":"Resolution of inflammation: state of the art, definitions and terms","volume":"21","author":"Serhan","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.fsi.2012.11.052_bib30","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd1383","article-title":"Inflammation resolution: new opportunities for drug discovery","volume":"3","author":"Gilroy","year":"2004","journal-title":"Nat Rev Drug Discov"},{"issue":"12","key":"10.1016\/j.fsi.2012.11.052_bib32","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.dci.2011.03.011","article-title":"Chemokines in teleost fish species","volume":"35","author":"Alejo","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.yexcr.2011.01.005","article-title":"Chemokines in health and disease","volume":"317","author":"Raman","year":"2011","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.fsi.2012.11.052_bib34","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.fsi.2009.08.003","article-title":"Chemokine transcription in rainbow trout (Oncorhynchus mykiss) is differently modulated in response to viral hemorrhagic septicaemia virus (VHSV) or infectious pancreatic necrosis virus (IPNV)","volume":"27","author":"Montero","year":"2009","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib35","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.molimm.2009.12.014","article-title":"Identification of six novel CC chemokines in gilthead seabream (Sparus aurata) implicated in the antiviral immune response","volume":"47","author":"Cuesta","year":"2010","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib36","first-page":"1295","article-title":"Extrahepatic production of acute phase serum amyloid A","volume":"20","author":"Upragarin","year":"2005","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.fsi.2012.11.052_bib37","doi-asserted-by":"crossref","first-page":"8453","DOI":"10.1016\/S0021-9258(19)83933-9","article-title":"Transcriptional regulation of serum amyloid A gene expression","volume":"261","author":"Lowell","year":"1986","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2012.11.052_bib38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1432-1327.1999.00657.x","article-title":"Serum amyloid A, the major vertebrate acute-phase reactant","volume":"265","author":"Uhlar","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.fsi.2012.11.052_bib39","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.fsi.2011.01.010","article-title":"Cellular and humoral factors involved in the response of rainbow trout gills to Ichthyophthirius multi\ufb01liis infections: molecular and immunohistochemical studies","volume":"30","author":"Olsen","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib40","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0145-305X(00)00034-3","article-title":"The major histocompatibility class II alpha chain in salmonid fishes","volume":"24","author":"Grimholt","year":"2000","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib41","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.molimm.2005.07.004","article-title":"Cloning, distribution and up-regulation of the teleost fish MHC class II suggests a role for granulocytes as antigen presenting cells","volume":"43","author":"Cuesta","year":"2006","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.fsi.2008.01.003","article-title":"Expression and characterization of recombinant single-chain salmon class I MHC fused with \u03b2-2-microglobulin with biological activity","volume":"24","author":"Zhao","year":"2008","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib43","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0145-305X(03)00036-3","article-title":"Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish","volume":"27","author":"Douglas","year":"2003","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.vetimm.2008.07.013","article-title":"Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects","volume":"126","author":"Alvarez-Pellitero","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"issue":"4","key":"10.1016\/j.fsi.2012.11.052_bib45","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.dci.2004.08.004","article-title":"Identification of genes differentially expressed in Atlantic salmon (Salmo salar) in response to infection by Aeromonas salmonicida using cDNA microarray technology","volume":"29","author":"Ewart","year":"2005","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-065X.1998.tb01185.x","article-title":"The C-type lectin superfamily in the immune system","volume":"163","author":"Weis","year":"1998","journal-title":"Immunol Rev"},{"key":"10.1016\/j.fsi.2012.11.052_bib47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fsi.2005.04.004","article-title":"Recent advances on the complement system of teleost fish","volume":"20","author":"Boshra","year":"2006","journal-title":"Fish Shellfish Immunol"},{"issue":"35","key":"10.1016\/j.fsi.2012.11.052_bib48","doi-asserted-by":"crossref","first-page":"26806","DOI":"10.1016\/S0021-9258(19)61447-X","article-title":"The conformation-dependent interaction of alpha-2-macroglobulin with vascular endothelial growth factor. A novel mechanism of alpha-2-macroglobulin\/growth factor binding","volume":"275","author":"Bhattacharjee","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2012.11.052_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0022-1759(90)90006-H","article-title":"Measurement of the \u2018fast\u2019 or complexed form of alpha-2-macroglobulin in biological fluids using a sandwich enzyme immunoassay","volume":"126","author":"Banks","year":"1990","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.fsi.2012.11.052_bib50","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.fsi.2011.02.024","article-title":"Molecular characterization of miiuy croaker CC chemokine gene and its expression following Vibrio anguillarum injection","volume":"31","author":"Cheng","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.dci.2008.07.001","article-title":"Innate immune response in rainbow trout (Oncorhynchus mykiss) against primary and secondary infections with Yersinia ruckeri 01","volume":"33","author":"Raida","year":"2009","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib52","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.molimm.2006.03.001","article-title":"Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: striking similarities and obvious differences with mammals","volume":"44","author":"Lin","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2012.11.052_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2164-9-141","article-title":"Comparative analysis of the acute response of the trout, O.\u00a0mykiss, head kidney to in\u00a0vivo challenge with virulent and attenuated infectious hematopoietic necrosis virus and LPS-induced inflammation","volume":"9","author":"MacKenzie","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2012.11.052_bib54","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.dci.2006.02.005","article-title":"Dual function of fish hepcidin: response to experimental iron overload and bacterial infection in seas bass (Dicectrarchus labrax)","volume":"30","author":"Rodrigues","year":"2006","journal-title":"Dev Comp Immunol"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464812004585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464812004585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T01:01:13Z","timestamp":1644022873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464812004585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1050464812004585"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2012.11.052","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}