{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:39:06Z","timestamp":1773358746762,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/100006788","name":"The Great Lakes Fisheries Commission","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.fsi.2014.03.024","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T18:01:43Z","timestamp":1395943303000},"page":"211-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["In\u00a0vitro immune functions in thiamine-replete and -depleted lake trout (Salvelinus namaycush)"],"prefix":"10.1016","volume":"38","author":[{"given":"Christopher A.","family":"Ottinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale C.","family":"Honeyfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L.","family":"Densmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke R.","family":"Iwanowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2014.03.024_bib1","series-title":"Early life stage mortality syndrome in fishes of the Great Lakes and Baltic Sea, Symposium 21","year":"1998"},{"key":"10.1016\/j.fsi.2014.03.024_bib2","series-title":"Chemically induced alterations in functional development and reproduction of fishes","article-title":"Early mortality syndrome in the Great Lakes","author":"Marquenski","year":"1997"},{"key":"10.1016\/j.fsi.2014.03.024_bib3","first-page":"2456","article-title":"Maternal blood, egg and larval thiamin levels correlate with larval survival in landlocked Atlantic salmon (Salmo salar)","volume":"128","author":"Fisher","year":"1996","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.fsi.2014.03.024_bib4","series-title":"Chemically induced alterations in functional development and reproduction of fishes","article-title":"M74 syndrome: a review of potential etiological factors","author":"B\u00f6rjeson","year":"1997"},{"key":"10.1016\/j.fsi.2014.03.024_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1577\/H08-025.1","article-title":"Thiamine deficiency effects on the vision and foraging ability of lake trout fry","volume":"21","author":"Carvalho","year":"2009","journal-title":"J Aquat Anim Health"},{"key":"10.1016\/j.fsi.2014.03.024_bib6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1577\/H08-019.1","article-title":"Influence of thiamine deficiency on lake trout larval growth, foraging, and predator avoidance","volume":"21","author":"Fitzsimons","year":"2009","journal-title":"J Aquat Anim Health"},{"key":"10.1016\/j.fsi.2014.03.024_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1577\/H04-059.1","article-title":"Thiamine status in adult salmonines in the Great Lakes","volume":"17","author":"Brown","year":"2005","journal-title":"J Aquat Anim Health"},{"key":"10.1016\/j.fsi.2014.03.024_bib8","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1111\/j.1095-8649.2012.03304.x","article-title":"Does spatial variation in egg thiamine and fatty-acid concentration of Lake Michigan lake trout Salvelinus namaycush lead to differential early mortality syndrome and yolk oedema mortality in offspring?","volume":"80","author":"Czesny","year":"2012","journal-title":"J\u00a0Fish Biol"},{"key":"10.1016\/j.fsi.2014.03.024_bib9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/08997659.2012.713890","article-title":"Impact of thiamine deficiency on T-cell dependent and T-cell independent antibody production in Lake Trout (Salvelinus namaycush)","volume":"24","author":"Ottinger","year":"2012","journal-title":"J\u00a0Aquat Anim Health"},{"key":"10.1016\/j.fsi.2014.03.024_bib10","series-title":"Nutrition and fish health","article-title":"Influence of dietary lipid composition on the immune system and disease resistance of fin fish","author":"Balfry","year":"2001"},{"key":"10.1016\/j.fsi.2014.03.024_bib11","series-title":"Avances en Nutricion Acuicola V","article-title":"Nutrition and health of fish","author":"Lall","year":"2000"},{"key":"10.1016\/j.fsi.2014.03.024_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10695-007-9184-z","article-title":"Use of vitamin C as an immunostimulant. Effect on growth, nutritional quality, and immune response of Labeo rohita (Ham.)","volume":"34","author":"Tewary","year":"2008","journal-title":"Fish Physiol Biochem"},{"key":"10.1016\/j.fsi.2014.03.024_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0147-9571(01)00038-8","article-title":"Immunomodulation by dietary vitamin C in healthy and aflatoxin B1-induced immunocompromised rohu (Labeo rohita)","volume":"26","author":"Sahoo","year":"2003","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"10.1016\/j.fsi.2014.03.024_bib14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/eesa.1995.1029","article-title":"Effect of lindane exposure on rainbow trout (Oncorhynchus mykiss) immunity. IV. Prevention of nonspecific and specific immunosuppression by dietary vitamin C (ascorbate-2-polyphosphate)","volume":"30","author":"Dunier","year":"1995","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.fsi.2014.03.024_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1749-6632.1992.tb17129.x","article-title":"Dietary vitamin B6 and vitamin C. Influence on immune response and disease resistance in Atlantic salmon (Salmo salar)","volume":"669","author":"Waagb\u00f8","year":"1992","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fsi.2014.03.024_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1050-4648(03)00028-7","article-title":"Nonspecific immune response of rainbow trout (Oncorhynchus mykiss Wallbaum) in relation to different status of vitamin E and highly unsaturated fatty acids","volume":"16","author":"Puangkaew","year":"2004","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0300-9629(94)90238-0","article-title":"Pancreas disease in Atlantic salmon (Salmo salar) and vitamin E supplementation","volume":"109","author":"McCoy","year":"1994","journal-title":"Comp Biochem Physiol A"},{"key":"10.1016\/j.fsi.2014.03.024_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1577\/H03-078.1","article-title":"Development of thiamine deficiencies and early mortality syndrome in lake trout by feeding experimental and feral fish diets containing thiaminase","volume":"17","author":"Honeyfield","year":"2005","journal-title":"J\u00a0Aquat Anim Health"},{"key":"10.1016\/j.fsi.2014.03.024_bib19","series-title":"Early life stage mortality syndrome in fishes of the Great Lakes and Baltic Sea, Symposium 21","article-title":"Thiamine analysis in fish egg and tissues by high-pressure liquid chromatography","author":"Brown","year":"1998"},{"key":"10.1016\/j.fsi.2014.03.024_bib20","series-title":"Nutrient requirements of fish and shrimp","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.fsi.2014.03.024_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/fsim.2002.0436","article-title":"Measurement of in\u00a0vitro mitogenesis in fish: ELISA based detection of the thymidine analogue 5\u2032-bromo-2\u2032-deoxyuridine","volume":"14","author":"Gauthier","year":"2003","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1577\/1548-8667(2000)012<0009:COTGFM>2.0.CO;2","article-title":"Correlation of transforming growth factor-\u03b2 (TGF-\u03b2 mRNA) expression with cellular immunoassays in triamcinolone-treated captive hybrid striped bass","volume":"12","author":"Harms","year":"2000","journal-title":"J\u00a0Aquat Anim Health"},{"key":"10.1016\/j.fsi.2014.03.024_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0955-2863(96)00011-3","article-title":"Modulation of insulin-like growth factor-I: a specific role for vitamin B-1 (thiamine)","volume":"4","author":"Molina","year":"1996","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.fsi.2014.03.024_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cbi.2006.04.014","article-title":"Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism","volume":"163","author":"Depeint","year":"2006","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.fsi.2014.03.024_sref25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0005-2728(99)00016-X","article-title":"Mammalian nitric oxide synthases","volume":"1411","author":"Stuehr","year":"1999","journal-title":"Biochim Biophys"},{"key":"10.1016\/j.fsi.2014.03.024_sref26","doi-asserted-by":"crossref","first-page":"7771","DOI":"10.1523\/JNEUROSCI.1842-04.2004","article-title":"Generation of reactive oxygen species in the reaction catalyzed by \u03b1-ketoglutarate dehydrogenase","volume":"24","author":"Tretter","year":"2004","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.fsi.2014.03.024_bib26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-1-60761-322-0_19","article-title":"Mammalian fatty acid elongases","volume":"579","author":"Jump","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.fsi.2014.03.024_bib27","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1210\/en.2005-0096","article-title":"Minireview: regulation of steroidogenesis by electron transfer","volume":"146","author":"Miller","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.fsi.2014.03.024_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-445X(00)00089-8","article-title":"Hepatic activities othiamine-dependent enzymes, glucose-6-phosphate dehydrogenase and cytochrome p4501a in Baltic salmon (Salmo salar) yolk-sac fry after thiamine treatment","volume":"48","author":"Amcoff","year":"2000","journal-title":"Aquat Toxicol"},{"key":"10.1016\/j.fsi.2014.03.024_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/alcalc\/agn120","article-title":"Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity, and inflammation","volume":"44","author":"Hazell","year":"2009","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.fsi.2014.03.024_bib30","first-page":"24","article-title":"Antioxidative systems, detoxifying enzymes and thiamine levels in Baltic salmon (Salmo salar) that develop M74","volume":"28","author":"Lundstrom","year":"1999","journal-title":"AMBIO"},{"key":"10.1016\/j.fsi.2014.03.024_bib31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1579\/0044-7447(2007)36[168:MSIBSA]2.0.CO;2","article-title":"M74 syndrome in Baltic salmon and the possible role of oxidative stresses in its development: present knowledge and perspectives for future studies","volume":"36","author":"Vuori","year":"2007","journal-title":"AMBIO"},{"key":"10.1016\/j.fsi.2014.03.024_bib32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2761.2002.00264.x","article-title":"Ultrastructural pathology of Baltic salmon, Salmo salar, L., yolk-sac fry with M74 syndrome","volume":"25","author":"Lundstrom","year":"2002","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2014.03.024_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1577\/1548-8667(2001)013<0151:UOATAT>2.0.CO;2","article-title":"Use of a thiamine antagonist to induce Cayuga-syndrome-like mortalities in larval Atlantic salmon","volume":"13","author":"Fitzsimons","year":"2001","journal-title":"J Aquat Anim Health"},{"key":"10.1016\/j.fsi.2014.03.024_bib34","first-page":"16","article-title":"Histopathological studies of yolk-sac fry of Baltic salmon (Salmo salar) with M74 syndrome","volume":"28","author":"Lundstrum","year":"1999","journal-title":"AMBIO"},{"key":"10.1016\/j.fsi.2014.03.024_bib35","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1095-8649.2002.tb02435.x","article-title":"Alterations of dopaminergic and serotondergic activity in the brain of sea-run Baltic salmon suffering a thiamine deficiency-related disorder","volume":"60","author":"Amcoff","year":"2002","journal-title":"J\u00a0Fish Biol"},{"key":"10.1016\/j.fsi.2014.03.024_bib36","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.neuint.2007.03.010","article-title":"Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability","volume":"50","author":"Shi","year":"2007","journal-title":"Neurochem Int"},{"key":"10.1016\/j.fsi.2014.03.024_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.nbd.2007.01.011","article-title":"Changes in inflammatory process associated with selective vulnerability following mild impairment of oxidative metabolism","volume":"26","author":"Karuppagounder","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.fsi.2014.03.024_bib38","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","article-title":"Linking oxidative stress to inflammation: toll-like receptors","volume":"48","author":"Gill","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.fsi.2014.03.024_bib39","doi-asserted-by":"crossref","first-page":"741","DOI":"10.18632\/oncotarget.209","article-title":"Differential activation of Toll-like receptor-mediated apoptosis induced by hypoxia","volume":"1","author":"Mkaddem","year":"2010","journal-title":"Oncotarget"},{"key":"10.1016\/j.fsi.2014.03.024_bib40","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tcb.2013.05.004","article-title":"Metabolism in physiological cell proliferation and differentiation","volume":"23","author":"Agathocleous","year":"2013","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.fsi.2014.03.024_bib41","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature11862","article-title":"Metabolism of inflammation limited by AMPK and pseudo-starvation","volume":"493","author":"O'Neill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2014.03.024_bib42","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"H1F1\u03b1-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.fsi.2014.03.024_bib43","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of TH17\/Treg balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2014.03.024_bib44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.aquatox.2004.03.019","article-title":"Baltic salmon (Salmo salar) yolk-sac fry mortality is associated with disturbances in the function of hypoxia-inducible transcription factor (HIF-1 alpha) and consecutive gene expression","volume":"68","author":"Vuori","year":"2004","journal-title":"Aquat Toxicol"},{"key":"10.1016\/j.fsi.2014.03.024_bib45","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.dci.2011.03.009","article-title":"Antimicrobial mechanisms of fish leukocytes","volume":"35","author":"Rieger","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbd.2005.07.003","article-title":"Conservation of Toll-like receptor signaling pathways in teleost fish","volume":"1","author":"Purcell","year":"2006","journal-title":"Comp Biochem Physiol D Genomics Proteomics"},{"key":"10.1016\/j.fsi.2014.03.024_bib48","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fsi.2013.04.018","article-title":"Teleost T and NK cell immunity","volume":"35","author":"Fischer","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib49","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.dci.2011.03.004","article-title":"Fish T cell: recent advance through genomics","volume":"35","author":"Laing","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib50","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.dci.2011.05.001","article-title":"The interleukins of fish","volume":"35","author":"Secombes","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib51","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.dci.2011.03.031","article-title":"Origin and evolution of TNF and TNF receptor superfamilies","volume":"35","author":"Wiens","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib52","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.dci.2011.07.001","article-title":"Teleost fish interferons and their role in immunity","volume":"35","author":"Zou","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib53","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.4049\/jimmunol.160.8.3797","article-title":"Potent apoptotic signaling and subsequent unresponsiveness induced by a single CD2 mAb (BTI-322) in activated human peripheral T cells","volume":"160","author":"Dumont","year":"1998","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib54","doi-asserted-by":"crossref","first-page":"e66364","DOI":"10.1371\/journal.pone.0066364","article-title":"Cytokine gene expression in CD4 positive cells of the Japanese pufferfish, Takifugu rubripes","volume":"8","author":"Kono","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2014.03.024_bib55","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.dci.2006.05.012","article-title":"Channel catfish, Ictalurus punctatus, CD4-like molecules","volume":"31","author":"Edholm","year":"2007","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib56","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0145-305X(02)00037-X","article-title":"Activation of channel catfish (Ictalurus punctatus) T cells involves NFAT-like transcription factors","volume":"26","author":"Park","year":"2002","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib57","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/fsim.1998.0190","article-title":"Surface markers of fish T-cell","volume":"9","author":"Partula","year":"1999","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.03.024_bib58","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S1095-6433(98)00003-8","article-title":"detection of mitogen induced stimulation of leukocytes from the rainbow trout (Oncorhynchus mykiss) by flow cytometric analysis of intracellular calcium","volume":"119","author":"Siegl","year":"1998","journal-title":"Comp Biochem Physiol A"},{"key":"10.1016\/j.fsi.2014.03.024_bib59","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1111\/j.1742-4658.2009.07019.x","article-title":"Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors","volume":"276","author":"Bettendorf","year":"2009","journal-title":"FEBS J"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464814000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464814000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T15:30:16Z","timestamp":1689089416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464814000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1050464814000941"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2014.03.024","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vitro immune functions in thiamine-replete and -depleted lake trout (Salvelinus namaycush)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2014.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}