{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:46:59Z","timestamp":1791917219384,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.fsi.2014.05.015","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T12:50:57Z","timestamp":1401367857000},"page":"354-364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Immune responses to live and inactivated Nocardia seriolae and protective effect of recombinant interferon gamma (rIFN \u03b3) against nocardiosis in ginbuna crucian carp, Carassius auratus langsdorfii"],"prefix":"10.1016","volume":"39","author":[{"given":"Sukanta Kumar","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shibasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyuki","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2014.05.015_bib1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.4049\/jimmunol.153.7.3116","article-title":"Studies with MHC deficient knock-out mice reveal impact of both MHC-I and MHC-II dependent T cell responses on Listeria monocytogenes infection","volume":"153","author":"Ladel","year":"1994","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2014.05.015_bib2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/IAI.66.2.830-834.1998","article-title":"Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon","volume":"66","author":"Tascon","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.fsi.2014.05.015_bib3","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1086\/315466","article-title":"CD4+ and CD8+ T cells mediate adoptive immunity to aerosol infection of Mycobacterium bovis Bacillus Calmette \u2013 Guerin","volume":"181","author":"Feng","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.fsi.2014.05.015_bib4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/35021239","article-title":"Vaccines against intracellular infections requiring cellular immunity","volume":"406","author":"Seder","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2014.05.015_bib5","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.4049\/jimmunol.173.7.4590","article-title":"Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells","volume":"173","author":"Wang","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2014.05.015_bib6","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.89.24.12013","article-title":"Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection","volume":"89","author":"Flynn","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fsi.2014.05.015_bib7","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1073\/pnas.89.23.11612","article-title":"CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion","volume":"89","author":"Harty","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.fsi.2014.05.015_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/jir.2006.0103","article-title":"IFN-gamma therapy of tuberculosis and related infections","volume":"27","author":"Reljic","year":"2007","journal-title":"J\u00a0Interferon Cytokine Res"},{"key":"10.1016\/j.fsi.2014.05.015_bib9","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1073\/pnas.261570598","article-title":"T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells","volume":"98","author":"Lighvani","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.fsi.2014.05.015_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jps.10007","article-title":"Interferon-\u03b3 therapy: evaluation of routes of administration and delivery systems","volume":"91","author":"Younes","year":"2002","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.fsi.2014.05.015_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0044-8486(87)90008-1","article-title":"Principal microbial diseases of mariculture in Japan","volume":"67","author":"Sano","year":"1987","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2014.05.015_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0044-8486(97)00234-2","article-title":"Histopathology of sea bass (Dicentrarchus labrax) experimentally infected with Mycobacterium marinum and treated with streptomycin and garlic (Allium sativum) extract","volume":"16","author":"Colorni","year":"1998","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2014.05.015_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1099\/00207713-38-2-173","article-title":"Nocardia seriolae sp. nov. causing noardiosis of cultured fish","volume":"38","author":"Kudo","year":"1988","journal-title":"Int J Syst Bacteriol"},{"key":"10.1016\/j.fsi.2014.05.015_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1365-2761.2000.00201.x","article-title":"Nocardiosis in tank reared Atlantic salmon, Salmo salar L","volume":"23","author":"Brandsen","year":"2000","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2014.05.015_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2761.2000.00217.x","article-title":"Nocardiosis in sea bass, Lateolabrax japonicas in Taiwan","volume":"23","author":"Chen","year":"2000","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2014.05.015_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3147\/jsfp.41.135","article-title":"Comparison of sensitivity between yellowtail Seriolae quinqueradiata and red sea bream Pagrus major to Nocardia seriolae","volume":"41","author":"Itano","year":"2006","journal-title":"Fish Pathol"},{"key":"10.1016\/j.fsi.2014.05.015_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.aquaculture.2007.06.019","article-title":"Nocardiosis in snakehead, Ophiocephalus argus Cantor","volume":"271","author":"Wang","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2014.05.015_bib18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2761.2005.00637.x","article-title":"Nocardiosis in large yellow croaker, Larimichthys crocea (Richardson)","volume":"28","author":"Wang","year":"2005","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2014.05.015_bib19","first-page":"297","article-title":"Nocardial infections in fish: an emerging problem in both freshwater and marine aquaculture systems in Asia","author":"Labrie","year":"2008"},{"issue":"3","key":"10.1016\/j.fsi.2014.05.015_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.vetimm.2009.09.001","article-title":"Expression of cytokine genes in head kidney and spleen cells of Japanese flounder (Paralichthys olivaceus) infected with Nocardia seriolae","volume":"134","author":"Tanekhy","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.fsi.2014.05.015_bib21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12562-010-0239-1","article-title":"Immune response of largemouth bass, Micropterus salmoides, to whole cells of different Nocardia seriolae strains","volume":"76","author":"Shimahara","year":"2010","journal-title":"Fish Sci"},{"key":"10.1016\/j.fsi.2014.05.015_bib22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3147\/jsfp.37.152","article-title":"Drug susceptibility of recent isolates of Nocardia seriolae from cultured fish","volume":"37","author":"Itano","year":"2002","journal-title":"Fish Pathol"},{"key":"10.1016\/j.fsi.2014.05.015_bib23","first-page":"85","article-title":"Therapeutic effects of erythromycin (EM) against nocardiosis in yellowtails experimentally infected with Nocardia kampachi","volume":"10","author":"Hatai","year":"1984","journal-title":"Bull Nagasaki Pref Inst Fish"},{"issue":"1","key":"10.1016\/j.fsi.2014.05.015_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12562-010-0302-y","article-title":"Application of \u03b1-glucosidase activity and drug susceptibility tests to epidemiological studies on the fish pathogen Nocardia seriolae","volume":"77","author":"Ismail","year":"2011","journal-title":"Fish Sci"},{"key":"10.1016\/j.fsi.2014.05.015_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3147\/jsfp.13.25","article-title":"Nocardia infection of cultured yellowtail","volume":"13","author":"Kusuda","year":"1978","journal-title":"Fish Pathol"},{"key":"10.1016\/j.fsi.2014.05.015_bib26","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2331\/suisan.55.1183","article-title":"Changes in peripheral and peritoneal leucocytes in yellowtail Seriola quinqueradiata immunized with Nocardia kampachi","volume":"55","author":"Kusuda","year":"1989","journal-title":"Nippon Suisan Gakkaishi"},{"key":"10.1016\/j.fsi.2014.05.015_bib27","first-page":"270","article-title":"Detection of antibody response against Nocardia seriolae by enzyme-linked immunosorbent assay (ELISA) and a preliminary vaccine trial in yellowtail Seriola quinqueradiata","volume":"25","author":"Shimahara","year":"2005","journal-title":"Bull Eur Assoc Fish Pathol"},{"key":"10.1016\/j.fsi.2014.05.015_bib28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.aquaculture.2006.09.006","article-title":"Live vaccine trials against nocardiosis in yellowtail Seriolae quinqueradiata","volume":"261","author":"Itano","year":"2006","journal-title":"Aquaculture"},{"issue":"7","key":"10.1016\/j.fsi.2014.05.015_bib29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.20031076","article-title":"Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14","volume":"198","author":"Akashi","year":"2003","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.fsi.2014.05.015_bib30","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.dci.2008.11.008","article-title":"Alloantigen-specific killing is mediated by CD8-positive T cells in fish","volume":"33","author":"Toda","year":"2009","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.05.015_bib31","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.dci.2011.01.013","article-title":"Conservation of characteristics and functions of CD4 positive lymphocytes in teleost fish","volume":"35","author":"Toda","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.05.015_bib32","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.virol.2006.01.019","article-title":"Expression profiles of TCR \u03b2 and CD8\u03b1 mRNA correlate with virus-specific cell-mediated cytotoxic activity in ginbuna crucian carp","volume":"248","author":"Somamoto","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2014.05.015_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.molimm.2007.05.005","article-title":"Molecular cloning and expression analysis of T-bet in ginbuna crucian carp (Carassius auratus langsdorfii)","volume":"45","author":"Takizawa","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2014.05.015_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/jb\/mvr108","article-title":"Antiviral protection mechanism mediated by ginbuna crucian carp interferon gamma isoforms 1 and 2 though two distinct interferon gamma-receptors","volume":"150","author":"Yabu","year":"2011","journal-title":"J\u00a0Biochem"},{"issue":"1","key":"10.1016\/j.fsi.2014.05.015_bib35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fsi.2012.10.016","article-title":"Direct antibacterial activity of CD8+ and CD4 + T cells in ginbuna crucian carp, Carassius auratus langsdorfii","volume":"34","author":"Nayak","year":"2013","journal-title":"Fish Shellfish Immunol"},{"issue":"5","key":"10.1016\/j.fsi.2014.05.015_bib36","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1128\/IAI.00024-08","article-title":"Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection","volume":"76","author":"Wu","year":"2008","journal-title":"Infect Immun"},{"issue":"31","key":"10.1016\/j.fsi.2014.05.015_bib37","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.0801496105","article-title":"ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes","volume":"105","author":"Reiley","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"45","key":"10.1016\/j.fsi.2014.05.015_bib38","doi-asserted-by":"crossref","first-page":"19408","DOI":"10.1073\/pnas.1006298107","article-title":"Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection","volume":"107","author":"Reiley","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.fsi.2014.05.015_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20071367","article-title":"Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs","volume":"205","author":"Wolf","year":"2008","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.fsi.2014.05.015_bib40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0145-305X(03)00042-9","article-title":"Channel catfish NK-like cells are armed with IgM via a putative Fc micro R","volume":"27","author":"Shen","year":"2003","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.05.015_bib41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","article-title":"Counting antigen-specific CD8 T cells: a re-evaluation of bystander activation during viral infection","volume":"8","author":"Murali-Krishna","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2014.05.015_bib42","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(00)80197-1","article-title":"Antigen-specific regulation of T cell-mediated cytokine production","volume":"12","author":"Slifka","year":"2000","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.fsi.2014.05.015_bib43","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nm0897-849","article-title":"Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants","volume":"3","author":"Roman","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.fsi.2014.05.015_bib44","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1126\/science.1065543","article-title":"Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells","volume":"295","author":"Szabo","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.fsi.2014.05.015_bib45","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fsi.2012.04.015","article-title":"Recombinant interferon \u03b3 activates immune responses against Edwardsiella tarda infection in the olive flounder, Paralichthys olivaceus","volume":"33","author":"Jung","year":"2012","journal-title":"Fish Shellfish Immunol"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464814001648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464814001648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T15:50:20Z","timestamp":1689263420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464814001648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1050464814001648"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2014.05.015","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune responses to live and inactivated Nocardia seriolae and protective effect of recombinant interferon gamma (rIFN \u03b3) against nocardiosis in ginbuna crucian carp, Carassius auratus langsdorfii","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2014.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}