{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:53:36Z","timestamp":1775087616470,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB114402"],"award-info":[{"award-number":["2012CB114402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB114404"],"award-info":[{"award-number":["2012CB114404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31372566"],"award-info":[{"award-number":["31372566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31172437"],"award-info":[{"award-number":["31172437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31172445"],"award-info":[{"award-number":["31172445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31330082"],"award-info":[{"award-number":["31330082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National High Technology Development Program of China","award":["SS2014AA091607"],"award-info":[{"award-number":["SS2014AA091607"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.fsi.2014.09.011","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T02:48:44Z","timestamp":1410835724000},"page":"308-316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Involvement of fish signal transducer and activator of transcription 3 (STAT3) in SGIV replication and virus induced paraptosis"],"prefix":"10.1016","volume":"41","author":[{"given":"Xiaohong","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shina","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2014.09.011_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","article-title":"The JAK-STAT pathway at twenty","volume":"36","author":"Stark","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2014.09.011_bib2","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nri1226","article-title":"Regulation of JAK-STAT signalling in the immune system","volume":"3","author":"Shuai","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2011.09.016","article-title":"A\u00a0critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory","volume":"35","author":"Siegel","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2014.09.011_bib4","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.1400683111","article-title":"STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation","volume":"111","author":"Koganti","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fsi.2014.09.011_bib5","doi-asserted-by":"crossref","first-page":"e71932","DOI":"10.1371\/journal.pone.0071932","article-title":"STAT3 activation promotes oncolytic HSV1 replication in glioma cells","volume":"8","author":"Okemoto","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2014.09.011_bib6","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/hep.26496","article-title":"Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus","volume":"58","author":"McCartney","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.fsi.2014.09.011_bib7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1073\/pnas.1114232109","article-title":"Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis","volume":"109","author":"Sen","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fsi.2014.09.011_bib8","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.4049\/jimmunol.1004128","article-title":"STAT3 negatively regulates type I IFN-mediated antiviral response","volume":"187","author":"Wang","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib9","doi-asserted-by":"crossref","first-page":"14111","DOI":"10.1074\/jbc.M511797200","article-title":"Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation","volume":"281","author":"Ho","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2014.09.011_bib10","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1242\/jcs.103093","article-title":"GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis","volume":"125","author":"Shulga","year":"2012","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.fsi.2014.09.011_bib11","first-page":"2741","article-title":"Evidence that STAT3 controls NLRP3 inflammasome\u2013dependent release of IL-1\u03b2 and pyronecrosis through regulation of mitochondrial activity","volume":"65","author":"Edwan","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.fsi.2014.09.011_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ncb2171","article-title":"Stat3 controls lysosomal-mediated cell death in\u00a0vivo","volume":"13","author":"Kreuzaler","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.fsi.2014.09.011_bib13","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1016\/j.yexcr.2007.08.007","article-title":"Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity","volume":"313","author":"Thyrell","year":"2007","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.fsi.2014.09.011_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-0934(01)00350-0","article-title":"Electron microscopic observations of a marine fish iridovirus isolated from brown-spotted grouper, Epinephelus tauvina","volume":"98","author":"Qin","year":"2001","journal-title":"J\u00a0Virol Methods"},{"key":"10.1016\/j.fsi.2014.09.011_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0044-8486(02)00092-3","article-title":"Characterization, pathogenicity and neutralization studies of a nervous necrosis virus isolated from grouper, Epinephelus tauvina, in Singapore","volume":"213","author":"Hegde","year":"2002","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2014.09.011_bib16","article-title":"Identification and characterization of a novel lymphocystis disease virus isolate from cultured grouper in China","author":"Huang","year":"2014","journal-title":"J\u00a0Fish Dis"},{"key":"10.1016\/j.fsi.2014.09.011_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3354\/dao053001","article-title":"Characterization of a novel ranavirus isolated from grouper Epinephelus tauvina","volume":"53","author":"Qin","year":"2003","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2014.09.011_bib18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10495-011-0616-y","article-title":"Singapore grouper iridovirus, a large DNA virus, induces nonapoptotic cell death by a cell type dependent fashion and evokes ERK signaling","volume":"16","author":"Huang","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.fsi.2014.09.011_bib19","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1099\/vir.0.029173-0","article-title":"Roles of stress-activated protein kinases in the replication of Singapore grouper iridovirus and regulation of the inflammatory responses in grouper cells","volume":"92","author":"Huang","year":"2011","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.fsi.2014.09.011_bib20","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.dci.2011.01.021","article-title":"Identification and functional characterization of an interferon regulatory factor 7-like (IRF7-like) gene from orange-spotted grouper, Epinephelus coioides","volume":"35","author":"Cui","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/1471-2164-12-556","article-title":"Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Singapore grouper iridovirus","volume":"12","author":"Huang","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2014.09.011_bib22","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.fsi.2013.01.010","article-title":"Molecular cloning, expression and functional analysis of ISG15 in orange-spotted grouper, Epinephelus coioides","volume":"34","author":"Huang","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib23","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.fsi.2013.09.023","article-title":"Characterization of LPS-induced TNF\u03b1 factor (LITAF) from orange-spotted grouper, Epinephelus coioides","volume":"35","author":"Cai","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.dci.2014.05.006","article-title":"Molecular cloning and characterization of a new G-type lysozyme gene (Ec-lysG) in orange-spotted grouper, Epinephelus coioides","volume":"46","author":"Wei","year":"2014","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fsi.2013.10.002","article-title":"Identification and characterization of Rab7 from orange-spotted grouper, Epinephelus coioides","volume":"36","author":"Fu","year":"2014","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.fsi.2014.02.019","article-title":"Molecular cloning and characterization of two types of I\u03baB\u03b1 orthologues in orange-spotted grouper, Epinephelus coioides","volume":"38","author":"Gao","year":"2014","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquaculture.2009.04.019","article-title":"Characterization of two grouper Epinephelus akaara cell lines: application to studies of Singapore grouper iridovirus (SGIV) propagation and virus\u2013host interaction","volume":"292","author":"Huang","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2014.09.011_bib28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/1743-422X-10-354","article-title":"Characterization of\u00a0an envelope gene VP19 from Singapore grouper iridovirus","volume":"10","author":"Huang","year":"2013","journal-title":"Virol J"},{"key":"10.1016\/j.fsi.2014.09.011_bib29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.fsi.2009.06.001","article-title":"The JAK and STAT family members of the mandarin fish Siniperca chuatsi: molecular cloning, tissues distribution and immunobiological activity","volume":"27","author":"Guo","year":"2009","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib30","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.fsi.2013.09.012","article-title":"Cloning, molecular characterization, and expression analysis of the signal transducer and activator of transcription 3 (STAT3) gene from grass carp (Ctenopharyngodon idellus)","volume":"35","author":"Guo","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib31","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1242\/jcs.072520","article-title":"The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3","volume":"124","author":"M1","year":"2011","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.fsi.2014.09.011_bib32","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/01.ASN.0000114556.19556.F9","article-title":"The STAT3 DNA-binding domain mediates interaction with NF-kappaB p65 and inducible nitric oxide synthase transrepression in mesangial cells","volume":"15","author":"Yu","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.fsi.2014.09.011_bib33","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1128\/MCB.20.19.7132-7139.2000","article-title":"The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6","volume":"20","author":"Zhang","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.fsi.2014.09.011_bib34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4049\/jimmunol.1203516","article-title":"\u201cActivated\u201d STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells","volume":"192","author":"Trilling","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.fsi.2014.09.011_bib35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.antiviral.2013.09.011","article-title":"Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection","volume":"100","author":"Reitsma","year":"2013","journal-title":"Antiviral Res"},{"key":"10.1016\/j.fsi.2014.09.011_bib36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20012127","article-title":"Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation","volume":"196","author":"Yoshida","year":"2002","journal-title":"J\u00a0Exp Med"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464814003465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464814003465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T13:39:52Z","timestamp":1572356392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464814003465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1050464814003465"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2014.09.011","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of fish signal transducer and activator of transcription 3 (STAT3) in SGIV replication and virus induced paraptosis","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2014.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}