{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:26:16Z","timestamp":1781562376091,"version":"3.54.5"},"reference-count":95,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Commission of the European Communities","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}]},{"name":"ARRAINA","award":["KBBE-2011-288925"],"award-info":[{"award-number":["KBBE-2011-288925"]}]},{"name":"AQUAEXCEL","award":["262336"],"award-info":[{"award-number":["262336"]}]},{"name":"ANDROMEDA","award":["0019\/02\/04\/14"],"award-info":[{"award-number":["0019\/02\/04\/14"]}]},{"name":"Spanish MINECO","award":["AGL2013-48560"],"award-info":[{"award-number":["AGL2013-48560"]}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"crossref","award":["PROMETEOII\/2014\/085"],"award-info":[{"award-number":["PROMETEOII\/2014\/085"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"crossref","award":["ISIC\/2012\/003"],"award-info":[{"award-number":["ISIC\/2012\/003"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.fsi.2015.01.039","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T17:53:06Z","timestamp":1423677186000},"page":"117-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Effects of dietary NEXT ENHANCE\u00ae150 on growth performance and expression of immune and intestinal integrity related genes in gilthead sea bream (Sparus aurata L.)"],"prefix":"10.1016","volume":"44","author":[{"given":"Jaume","family":"P\u00e9rez-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Benedito-Palos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Estensoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Petropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Alvar","family":"Calduch-Giner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig L.","family":"Browdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Sitj\u00e0-Bobadilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2015.01.039_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2010.08.009","article-title":"Microbial manipulations to improve fish health and production \u2013 a Mediterranean perspective","volume":"30","author":"Dimitroglou","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.anifeedsci.2011.12.015","article-title":"Fish immune system and its nutritional modulation for preventive health care","volume":"173","author":"Kiron","year":"2012","journal-title":"Anim Feed Sci Tech"},{"key":"10.1016\/j.fsi.2015.01.039_bib3","doi-asserted-by":"crossref","first-page":"M141","DOI":"10.1111\/j.1365-2621.2004.tb10724.x","article-title":"From probiotics to prebiotics and a healthy digestive system","volume":"69","author":"Gibson","year":"2004","journal-title":"J\u00a0Food Sci"},{"key":"10.1016\/j.fsi.2015.01.039_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/nyas.12377","article-title":"Probiotics and prebiotics: prospects for public health and nutritional recommendations","volume":"1309","author":"Sanders","year":"2014","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.fsi.2015.01.039_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2095.2009.00731.x","article-title":"Prebiotics in aquaculture: a review","volume":"16","author":"Ringo","year":"2010","journal-title":"Aquacult Nutr"},{"key":"10.1016\/j.fsi.2015.01.039_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.aquaculture.2010.09.003","article-title":"Effects of dietary prebiotics on growth performance, immune response and intestinal morphology of red drum (Sciaenops ocellatus)","volume":"309","author":"Zhou","year":"2010","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.fsi.2014.06.016","article-title":"Prebiotics as immunostimulants in aquaculture: a review","volume":"40","author":"Song","year":"2014","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib8","first-page":"7313","article-title":"A\u00a0review of the use of prebiotic in aquaculture for fish and shrimp","volume":"8","author":"Yousefian","year":"2009","journal-title":"Afr J Biotechnol"},{"key":"10.1016\/j.fsi.2015.01.039_bib9","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.fsi.2012.02.025","article-title":"Increases in immune parameters by inulin and Bacillus subtilis dietary administration to gilthead seabream (Sparus aurata L.) did not correlate with disease resistance to Photobacterium damselae","volume":"32","author":"Cerezuela","year":"2012","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.fsi.2014.02.006","article-title":"The effects of dietary Immunogen\u00ae on innate immune response, immune related genes expression and disease resistance of rainbow trout (Oncorhynchus mykiss)","volume":"37","author":"Ahmadi","year":"2014","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2011.03.039","article-title":"Impact of plant products on innate and adaptive immune system of cultured finfish and shellfish","volume":"317","author":"Harikrishnan","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aquaculture.2014.05.048","article-title":"Use of plant extracts in fish aquaculture as an alternative to chemotherapy: current status and future perspectives","volume":"433","author":"Reverter","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3354\/dao02486","article-title":"Effect of nutrition and Enteromyxum leei infection on gilthead sea bream Sparus aurata intestinal carbohydrate distribution","volume":"100","author":"Estensoro","year":"2012","journal-title":"Dis Aquat Org"},{"key":"10.1016\/j.fsi.2015.01.039_bib14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.fsi.2011.02.023","article-title":"Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar)","volume":"31","author":"Tacchi","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1577\/H09-040.1","article-title":"Effect of a mixed herb-enriched diet on the innate immune response and disease resistance of Paralichthys olivaceus against Philasterides dicentrarchi infection","volume":"22","author":"Harikrishnan","year":"2010","journal-title":"J\u00a0Aquat Anim Health"},{"key":"10.1016\/j.fsi.2015.01.039_bib16","first-page":"1839","article-title":"Immune response of common carp (cyprinus carpio) fed with herbal immunostimulants diets","volume":"9","author":"Abasali","year":"2010","journal-title":"J\u00a0Anim Vet Adv"},{"key":"10.1016\/j.fsi.2015.01.039_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11259-010-9458-2","article-title":"Herbal plants and their derivatives as growth and health promoters in animal nutrition","volume":"35","author":"Hashemi","year":"2011","journal-title":"Vet Res Commun"},{"key":"10.1016\/j.fsi.2015.01.039_bib18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1017\/S0029665111000152","article-title":"Plant secondary metabolites and gut health: the case for phenolic acids","volume":"70","author":"Russell","year":"2011","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.fsi.2015.01.039_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.livsci.2012.01.005","article-title":"The effect of essential oils on performance, immunity and gut microbial population in weaner pigs","volume":"145","author":"Li","year":"2012","journal-title":"Livest Sci"},{"key":"10.1016\/j.fsi.2015.01.039_bib20","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.3382\/ps.2012-02685","article-title":"Effect of thymol and carvacrol feed supplementation on performance, antioxidant enzyme activities, fatty acid composition, digestive enzyme activities, and immune response in broiler chickens","volume":"92","author":"Hashemipour","year":"2013","journal-title":"Poult Sci"},{"key":"10.1016\/j.fsi.2015.01.039_bib21","first-page":"103","article-title":"Antimicrobial activity of thymol against pathogenic gram-negative bacteria of fishes","volume":"49","author":"Heo","year":"2012","journal-title":"Philipp J Vet Med"},{"key":"10.1016\/j.fsi.2015.01.039_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1541-4337.2011.00156.x","article-title":"Natural antioxidants: sources, compounds, mechanisms of action, and potential applications","volume":"10","author":"Brewer","year":"2011","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"10.1016\/j.fsi.2015.01.039_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/1040841X.2013.763219","article-title":"Synergy between essential oil components and antibiotics: a review","volume":"40","author":"Langeveld","year":"2014","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijfoodmicro.2004.03.022","article-title":"Essential oils: their antibacterial properties and potential applications in foods \u2013 a review","volume":"94","author":"Burt","year":"2004","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib25","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.fm.2004.03.001","article-title":"Bacterial microflora of carp (Cyprinus carpio) and its shelf-life extension by essential oil compounds","volume":"21","author":"Mahmoud","year":"2004","journal-title":"Food Microbiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib26","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.foodchem.2011.11.127","article-title":"The effect of diets supplemented with thyme essential oils and rosemary extract on the deterioration of farmed gilthead seabream (Sparus aurata) during storage on ice","volume":"132","author":"\u00c1lvarez","year":"2012","journal-title":"Food Chem"},{"key":"10.1016\/j.fsi.2015.01.039_bib27","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.2174\/138161208786404227","article-title":"Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils","volume":"14","author":"Baser","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.fsi.2015.01.039_bib28","first-page":"178","article-title":"Immunostimulatory effect of dietary oregano etheric oils on lymphocytes from growth-retarded, low-weight growing-finishing pigs and productivity","volume":"129","author":"Walter","year":"2004","journal-title":"Tijdschr Diergeneeskd"},{"key":"10.1016\/j.fsi.2015.01.039_bib29","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.2527\/jas.2005-414","article-title":"Effects of spray-dried porcine plasma and plant extracts on intestinal morphology and on leukocyte cell subsets of weaned pigs","volume":"84","author":"Nofrarias","year":"2006","journal-title":"J\u00a0Anim Sci"},{"key":"10.1016\/j.fsi.2015.01.039_bib30","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.tiv.2007.11.023","article-title":"Influence of carvacrol on proliferation and survival of porcine lymphocytes and intestinal epithelial cells in\u00a0vitro","volume":"22","author":"Bimczok","year":"2008","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.fsi.2015.01.039_bib31","first-page":"420","article-title":"Assessment of synergistic efficacy of carvacrol and cymene against Edwardsiella tarda in\u00a0vitro and in Tilapia (Oreochromis niloticus)","volume":"4","author":"Rattanachaikunsopon","year":"2010","journal-title":"Afr J Microbiol Res"},{"key":"10.1016\/j.fsi.2015.01.039_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2109.2012.03202.x","article-title":"Growth parameters, innate immune response and resistance to Listonella (Vibrio) anguillarum of Dicentrarchus labrax fed carvacrol supplemented diets","volume":"45","author":"Volpatti","year":"2014","journal-title":"Aquacult Res"},{"key":"10.1016\/j.fsi.2015.01.039_bib33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.aquaculture.2009.04.025","article-title":"Evaluation of oregano essential oil (Origanum heracleoticum L.) on growth, antioxidant effect and resistance against Aeromonas hydrophila in channel catfish (Ictalurus punctatus)","volume":"292","author":"Zheng","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib34","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1439-0426.2011.01763.x","article-title":"Effects of dietary thymol-carvacrol on growth performance, hematological parameters and tissue composition of juvenile rainbow trout, Oncorhynchus mykiss","volume":"27","author":"Ahmadifar","year":"2011","journal-title":"J\u00a0Appl Ichthyol"},{"key":"10.1016\/j.fsi.2015.01.039_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.aquaculture.2012.04.027","article-title":"Assessment of dietary supplementation with carvacrol or thymol containing feed additives on performance, intestinal microbiota and antioxidant status of rainbow trout (Oncorhynchus mykiss)","volume":"350\u2013353","author":"Giannenas","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/1471-2164-14-178","article-title":"Deep sequencing for de novo construction of a marine fish (Sparus aurata) transcriptome database with a large coverage of protein-coding transcripts","volume":"14","author":"Calduch-Giner","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2015.01.039_bib37","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.molimm.2011.07.003","article-title":"Molecular profiling of the gilthead sea bream (Sparus aurata L.) response to chronic exposure to the myxosporean parasite Enteromyxum leei","volume":"48","author":"Davey","year":"2011","journal-title":"Mol Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10126-014-9562-3","article-title":"Transcriptional assessment by microarray analysis and large-scale meta-analysis of the metabolic capacity of cardiac and skeletal muscle tissues to cope with reduced nutrient availability in gilthead sea bream (Sparus aurata L.)","volume":"16","author":"Calduch-Giner","year":"2014","journal-title":"Mar Biotechnol"},{"key":"10.1016\/j.fsi.2015.01.039_bib39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.fsi.2014.01.022","article-title":"Interleukin gene expression is strongly modulated at the local level in a fish-parasite model","volume":"37","author":"P\u00e9rez-Cord\u00f3n","year":"2014","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib40","doi-asserted-by":"crossref","first-page":"e65457","DOI":"10.1371\/journal.pone.0065457","article-title":"Mucins as diagnostic and prognostic biomarkers in a fish-parasite model: transcriptional and functional analysis","volume":"8","author":"P\u00e9rez-S\u00e1nchez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2015.01.039_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2527\/jas.2010-3028","article-title":"Galactoglucomannan oligosaccharide supplementation affects nutrient digestibility, fermentation end-product production, and large bowel microbiota of the dog","volume":"89","author":"Faber","year":"2011","journal-title":"J\u00a0Anim Sci"},{"key":"10.1016\/j.fsi.2015.01.039_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.aquaculture.2009.07.028","article-title":"Assessment of the health and antioxidant trade-off in gilthead sea bream (Sparus aurata L.) fed alternative diets with low levels of contaminants","volume":"296","author":"Saera-Vila","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2015.01.039_bib44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.aquaculture.2005.03.005","article-title":"Evaluation of the prebiotic GroBiotic\u00ae-A and brewers yeast as dietary supplements for sub-adult hybrid striped bass (Morone chrysops x M.\u00a0saxatilis) challenged in situ with Mycobacterium marinum","volume":"248","author":"Li","year":"2005","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/are.12501","article-title":"Effect of a dairy-yeast prebiotic (GroBiotic\u00ae-A) on growth performance, body composition, antioxidant capacity and immune functions of juvenile starry flounder (Platichthys stellatus)","author":"Wang","year":"2014","journal-title":"Aquacul Res"},{"key":"10.1016\/j.fsi.2015.01.039_bib46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1577\/A07-093.1","article-title":"Effects of dietary lipid concentration, a dairy-yeast prebiotic, and fish and nonfish protein sources on growth, survival, and nonspecific immune response of golden shiners in indoor tanks and outdoor pools","volume":"71","author":"Lochmann","year":"2009","journal-title":"N\u00a0Am J Aquacult"},{"key":"10.1016\/j.fsi.2015.01.039_bib47","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2109.2009.02178.x","article-title":"Effects of dietary prebiotics on the growth, feed efficiency and non-specific immunity of juvenile red drum Sciaenops ocellatus fed soybean-based diets","volume":"41","author":"Buentello","year":"2010","journal-title":"Aquacult Res"},{"key":"10.1016\/j.fsi.2015.01.039_bib48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aquaculture.2012.06.020","article-title":"Oxidative status and gut morphology of white sea bream, Diplodus sargus fed soluble non-starch polysaccharide supplemented diets","volume":"358","author":"Enes","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib49","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","article-title":"The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens","volume":"35","author":"G\u00f3mez","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib50","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/mnfr.201300559","article-title":"Nutritional aspects of metabolic inflammation in relation to health-insight from transcriptomic biomarkers in PBMC of fatty acids and polyphenols","volume":"58","author":"Afman","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.fsi.2015.01.039_bib51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1546-5098(10)03003-7","article-title":"Barrier function and immunology","volume":"30","author":"Cain","year":"2011","journal-title":"Fish Physiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.imlet.2013.11.013","article-title":"Toll-like receptors (TLRs) in aquatic animals: signaling pathways, expressions and immune responses","volume":"158","author":"Rauta","year":"2014","journal-title":"Immunol Lett"},{"key":"10.1016\/j.fsi.2015.01.039_bib53","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.dci.2013.08.010","article-title":"Ligand specificities of toll-like receptors in fish: indications from infection studies","volume":"43","author":"Pietretti","year":"2014","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib54","doi-asserted-by":"crossref","first-page":"e24978","DOI":"10.4161\/tisb.24978","article-title":"Claudins in intestines: distribution and functional significance in health and diseases","volume":"1","author":"Lu","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.fsi.2015.01.039_bib55","doi-asserted-by":"crossref","first-page":"e25391","DOI":"10.4161\/tisb.25391","article-title":"Claudins in teleost fishes","volume":"1","author":"Kolosov","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.fsi.2015.01.039_bib56","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.resp.2012.05.020","article-title":"Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: a review","volume":"184","author":"Chasiotis","year":"2012","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib57","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cbpa.2009.11.025","article-title":"Claudin-15 and -25b expression in the intestinal tract of Atlantic salmon in response to seawater acclimation, smoltification and hormone treatment","volume":"155","author":"Tipsmark","year":"2010","journal-title":"Comp Biochem Physiol Phys A"},{"key":"10.1016\/j.fsi.2015.01.039_bib58","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1186\/1471-2164-15-594","article-title":"Genome-wide microarray analysis of Atlantic cod (Gadus morhua) oocyte and embryo","volume":"15","author":"Skugor","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2015.01.039_bib59","first-page":"1","article-title":"Gap junctions","volume":"137C","author":"Beyer","year":"1993","journal-title":"Int Rev Cytol"},{"key":"10.1016\/j.fsi.2015.01.039_bib60","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/cdd.2008.196","article-title":"Connexin-related signaling in cell death: to live or let die?","volume":"16","author":"Decrock","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.fsi.2015.01.039_bib61","first-page":"53","article-title":"Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?","volume":"1795","author":"Vinken","year":"2009","journal-title":"BBA Rev Cancer"},{"key":"10.1016\/j.fsi.2015.01.039_bib62","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00018-005-5571-8","article-title":"The vertebrate connexin family","volume":"63","author":"Cruciani","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.fsi.2015.01.039_bib63","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s101269900019","article-title":"Structural organization of the Atlantic croaker connexin 32.2 gene and its 5' flanking region","volume":"2","author":"Yoshizaki","year":"2000","journal-title":"Mar Biotechnol"},{"key":"10.1016\/j.fsi.2015.01.039_bib64","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/gcen.2000.7549","article-title":"Hormonal regulation and cellular distribution of connexin 32.2 and connexin 32.7 RNAs in the ovary of Atlantic croaker","volume":"120","author":"Chang","year":"2000","journal-title":"Gen Comp Endocrinol"},{"key":"10.1016\/j.fsi.2015.01.039_bib65","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/ijd.12062","article-title":"Overview of skin diseases linked to connexin gene mutations","volume":"53","author":"Avshalumova","year":"2014","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.fsi.2015.01.039_bib66","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4291\/wjgp.v1.i4.115","article-title":"Emerging roles of connexin hemichannels in gastrointestinal and liver pathophysiology","volume":"1","author":"Vinken","year":"2010","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib67","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.aquaculture.2012.08.035","article-title":"Severity of soybean meal induced distal intestinal inflammation, enterocyte proliferation rate, and fatty acid binding protein (Fabp2) level differ between strains of rainbow trout (Oncorhynchus mykiss)","volume":"364","author":"Venold","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib68","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cbpa.2012.09.009","article-title":"Intestinal fatty acid binding protein (fabp2) in Atlantic salmon (Salmo salar): localization and alteration of expression during development of diet induced enteritis","volume":"164","author":"Venold","year":"2013","journal-title":"Comp Biochem Physiol A"},{"key":"10.1016\/j.fsi.2015.01.039_bib69","first-page":"249","article-title":"Intestinal fatty acid binding protein gene expression reveals the cephalocaudal patterning during zebrafish gut morphogenesis","volume":"44","author":"Andre","year":"2000","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.fsi.2015.01.039_bib70","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1111\/j.1742-4658.2008.06480.x","article-title":"Spatio-temporal distribution of fatty acid-binding protein-6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio)","volume":"275","author":"Alves-Costa","year":"2008","journal-title":"FEBS J"},{"key":"10.1016\/j.fsi.2015.01.039_bib71","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1073\/pnas.91.11.4741","article-title":"Molecular-cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol","volume":"91","author":"Gong","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fsi.2015.01.039_bib72","first-page":"769","article-title":"Regulation of tight junction permeability by intestinal bacteria and dietary components","volume":"141","author":"Ulluwishewa","year":"2011","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.fsi.2015.01.039_bib73","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0169-409X(01)00231-9","article-title":"Oral drug absorption enhancement by chitosan and its derivatives","volume":"52","author":"Thanou","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.fsi.2015.01.039_bib74","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1023\/A:1023470709071","article-title":"Mechanics of vimentin intermediate filaments","volume":"23","author":"Wang","year":"2002","journal-title":"J\u00a0Muscle Res Cell Motil"},{"key":"10.1016\/j.fsi.2015.01.039_bib75","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1096\/fj.09-151639","article-title":"Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition","volume":"24","author":"Mendez","year":"2010","journal-title":"Faseb J"},{"key":"10.1016\/j.fsi.2015.01.039_bib76","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00441-011-1262-y","article-title":"Identification of vimentin- and elastin-like transcripts specifically expressed in developing notochord of Atlantic salmon (Salmo salar L.)","volume":"346","author":"Sagstad","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.fsi.2015.01.039_bib77","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11160-010-9181-7","article-title":"Expression of a highly differentiated phenotype and hepatic functionality markers in gilthead seabream (Sparus aurata L.) long-cultured hepatocytes: first morphological and functional in\u00a0vitro characterization","volume":"21","author":"Santacroce","year":"2011","journal-title":"Rev Fish Biol Fish"},{"key":"10.1016\/j.fsi.2015.01.039_bib78","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2478\/v10042-008-0105-5","article-title":"An immunohistochemical study of gill epithelium cells in the Nile tilapia, Oreochromis niloticus","volume":"48","author":"Monteiro","year":"2010","journal-title":"Folia Histochem Cytobiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib79","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/cvr\/cvt117","article-title":"Vimentin is an endogenous ligand for the pattern recognition receptor dectin-1","volume":"99","author":"Thiagarajan","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.fsi.2015.01.039_bib80","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ejcb.2011.09.010","article-title":"Interleukin-6 signalling: more than Jaks and STATs","volume":"91","author":"Eulenfeld","year":"2012","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.fsi.2015.01.039_bib81","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aquaculture.2014.03.042","article-title":"TLR2 signaling may play a key role in the probiotic modulation of intestinal microbiota in grouper Epinephelus coioides","volume":"430","author":"Sun","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib82","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10499-012-9619-0","article-title":"Immunomodulatory effects of dietary Bacillus coagulans in grouper (Epinephelus coioides) and zebrafish (Danio rerio) infected with Vibrio vulnificus","volume":"21","author":"Pan","year":"2013","journal-title":"Aquacult Int"},{"key":"10.1016\/j.fsi.2015.01.039_bib83","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.dci.2008.08.008","article-title":"The function of rhamnose-binding lectin in innate immunity by restricted binding to Gb3","volume":"33","author":"Watanabe","year":"2009","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib84","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbagen.2006.09.015","article-title":"Isolation and characterization of a fish F-type lectin from gilt head bream (Sparus aurata) serum","volume":"1770","author":"Cammarata","year":"2007","journal-title":"BBA Gen Subj"},{"key":"10.1016\/j.fsi.2015.01.039_bib85","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nrmicro2146","article-title":"Roles of galectins in infection","volume":"7","author":"Vasta","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.fsi.2015.01.039_bib86","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.sbi.2004.09.008","article-title":"Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates","volume":"14","author":"Vasta","year":"2004","journal-title":"Curr Opin Struc Biol"},{"key":"10.1016\/j.fsi.2015.01.039_bib87","doi-asserted-by":"crossref","first-page":"33151","DOI":"10.1074\/jbc.M002337200","article-title":"Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins","volume":"275","author":"Honda","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.fsi.2015.01.039_bib88","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/1471-2164-13-470","article-title":"Dietary vegetable oils do not alter the intestine transcriptome of gilthead sea bream (Sparus aurata), but modulate the transcriptomic response to infection with Enteromyxum leei","volume":"13","author":"Calduch-Giner","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fsi.2015.01.039_bib89","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2013.02.034","article-title":"Tissue-specific transcriptional modulation of fatty acid-binding protein genes, fabp2, fabp3 and fabp6, by fatty acids and the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio)","volume":"520","author":"Venkatachalam","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.fsi.2015.01.039_bib90","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/0264-6021:3550481","article-title":"Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine","volume":"355","author":"Poirier","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.fsi.2015.01.039_bib91","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.dci.2013.12.014","article-title":"Nutritional impacts on gene expression in the surface mucosa of blue catfish (Ictalurus furcatus)","volume":"44","author":"Li","year":"2014","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2015.01.039_bib92","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/anu.12033","article-title":"Effects of dietary supplementation of fructooligosaccharide on growth performance, body composition, intestinal enzymes activities and histology of blunt snout bream (Megalobrama amblycephala) fingerlings","volume":"19","author":"Wu","year":"2013","journal-title":"Aquacult Nutr"},{"key":"10.1016\/j.fsi.2015.01.039_bib93","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.aquaculture.2007.11.008","article-title":"Dietary mannan oligosaccharide enhances salinity tolerance and gut development of larval cobia","volume":"274","author":"Salze","year":"2008","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.01.039_bib94","first-page":"182","article-title":"Effects of dietary mannan oligosaccharides on growth, body composition, and intestine and liver histology of rainbow trout, Oncorhynchus mykiss","volume":"59","author":"Yilmaz","year":"2007","journal-title":"Isr J Aquacult Bamid"},{"key":"10.1016\/j.fsi.2015.01.039_bib95","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1111\/j.1365-2109.2010.02513.x","article-title":"Dietary supplementation of mannan oligosaccharide on white sea bream (Diplodus sargus L.) larvae: effects on development, gut morphology and salinity tolerance","volume":"41","author":"Dimitroglou","year":"2010","journal-title":"Aquacult Res"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815000571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815000571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T22:39:31Z","timestamp":1598740771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464815000571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":95,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1050464815000571"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2015.01.039","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of dietary NEXT ENHANCE\u00ae150 on growth performance and expression of immune and intestinal integrity related genes in gilthead sea bream (Sparus aurata L.)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2015.01.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}