{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:32:21Z","timestamp":1792783941602,"version":"4.5.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2014CB138600"],"award-info":[{"award-number":["2014CB138600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Department Public Benefit Research Foundation (Agriculture) of China","award":["201003020"],"award-info":[{"award-number":["201003020"]}]},{"name":"Science and Technology Support Programme of Sichuan Province of China","award":["2014NZ0003"],"award-info":[{"award-number":["2014NZ0003"]}]},{"name":"Major Scientific, Technological Achievement Transformation Project of Sichuan Province of China","award":["2012NC0007"],"award-info":[{"award-number":["2012NC0007"]}]},{"name":"Major Scientific, Technological Achievement Transformation Project of Sichuan Province of China","award":["2013NC0045"],"award-info":[{"award-number":["2013NC0045"]}]},{"name":"The Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China","award":["2015CC0011"],"award-info":[{"award-number":["2015CC0011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.fsi.2015.04.004","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T20:54:40Z","timestamp":1429131280000},"page":"307-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Dietary riboflavin deficiency decreases immunity and antioxidant capacity, and changes tight junction proteins and related signaling molecules mRNA expression in the gills of young grass carp (Ctenopharyngodon idella)"],"prefix":"10.1016","volume":"45","author":[{"given":"Liang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Yao","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Neng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-An","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2015.04.004_bib1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0044-8486(02)00513-6","article-title":"Dietary riboflavin requirement of juvenile sunshine bass (Morone chrysops\u2640\u00d7 Morone saxatilis\u2642)","volume":"218","author":"Deng","year":"2003","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.04.004_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2095.2008.00645.x","article-title":"Effect of dietary riboflavin on growth, feed utilization, body composition and intestinal enzyme activities of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"16","author":"Li","year":"2010","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2015.04.004_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10641-006-9139-8","article-title":"Effects of increased suspended sediment on growth rate and gill condition of two southern Appalachian minnows","volume":"80","author":"Sutherland","year":"2007","journal-title":"Environ. Biol. Fish."},{"key":"10.1016\/j.fsi.2015.04.004_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.anifeedsci.2011.12.015","article-title":"Fish immune system and its nutritional modulation for preventive health care","volume":"173","author":"Kiron","year":"2012","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.fsi.2015.04.004_bib5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.fsi.2011.12.008","article-title":"Molecular cloning and expression of two \u03b2-defensin and two mucin genes in common carp (Cyprinus carpio L.) and their up-regulation after \u03b2-glucan feeding","volume":"32","author":"van der Marel","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib6","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/ajcn\/77.6.1352","article-title":"Riboflavin (vitamin B-2) and health","volume":"77","author":"Powers","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fsi.2015.04.004_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jmor.10821","article-title":"Fine structure of the branchial epithelium in the teleost Oreochromis niloticus","volume":"271","author":"Monteiro","year":"2010","journal-title":"J.\u00a0Morphol."},{"key":"10.1016\/j.fsi.2015.04.004_bib8","first-page":"202","article-title":"Identification and characterization of a novel intraepithelial lymphoid tissue in the gills of Atlantic salmon","volume":"213","author":"Haugarvoll","year":"2008","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.fsi.2015.04.004_bib9","first-page":"277","article-title":"Fish immune system. A crossroads between innate and adaptive responses","volume":"22","author":"Tort","year":"2003","journal-title":"Inmunolog\u00eda"},{"key":"10.1016\/j.fsi.2015.04.004_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10126-013-9552-x","article-title":"Transcriptome profiling reveals insight into distinct immune responses to Aeromonas salmonicida in gill of two rainbow Trout strains","volume":"16","author":"Rebl","year":"2014","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.fsi.2015.04.004_bib11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1365-2109.2009.02374.x","article-title":"Nutrition and immunity: an update","volume":"41","author":"Trichet","year":"2010","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib12","first-page":"312","article-title":"Effect of antioxidative vitamins on immune function with clinical applications. Int J Vitam Nutr Res. Internationale Zeitschrift fur Vitamin-und Ernahrungsforschung","volume":"67","author":"Grimble","year":"1996","journal-title":"J.\u00a0Int. Vitaminol. Nutr."},{"key":"10.1016\/j.fsi.2015.04.004_bib13","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/jn\/135.5.978","article-title":"Riboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems","volume":"135","author":"Manthey","year":"2005","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.fsi.2015.04.004_bib14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0145-305X(01)00032-5","article-title":"Cytokines and innate immunity of fish","volume":"25","author":"Secombes","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.vetimm.2009.09.021","article-title":"Toll-like receptor signaling in bony fish","volume":"134","author":"Rebl","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2015.04.004_bib16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.immuni.2008.08.012","article-title":"The TSC-mTOR signaling pathway regulates the innate inflammatory response","volume":"29","author":"Weichhart","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2015.04.004_bib17","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.fct.2010.04.033","article-title":"Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25","volume":"48","author":"Shih","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fsi.2015.04.004_bib18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1667\/0033-7587(2002)158[0641:HSPHRM]2.0.CO;2","article-title":"Heat-shock protein 25 (Hspb1) regulates manganese superoxide dismutase through activation of Nfkb (NF-\u03baB)","volume":"158","author":"Yi","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3727\/096368908785096060","article-title":"Riboflavin inhibits IL-6 expression and p38 activation in islet cells","volume":"17","author":"Cobianchi","year":"2008","journal-title":"Cell Transpl."},{"key":"10.1016\/j.fsi.2015.04.004_bib20","series-title":"p38 regulates the mTOR-mediated innate immune response: uniwien","author":"Katholnig","year":"2011"},{"key":"10.1016\/j.fsi.2015.04.004_bib21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.vetimm.2005.08.026","article-title":"MHC class II+ cells in the gills of Atlantic salmon (Salmo salar L.) affected by amoebic gill disease","volume":"109","author":"Morrison","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2015.04.004_bib22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ygcen.2011.04.023","article-title":"Effect of cortisol on permeability and tight junction protein transcript abundance in primary cultured gill epithelia from stenohaline goldfish and euryhaline trout","volume":"172","author":"Chasiotis","year":"2011","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.fsi.2015.04.004_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.resp.2012.05.020","article-title":"Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: a review","volume":"184","author":"Chasiotis","year":"2012","journal-title":"Resp. Physiol. Neurobiol."},{"key":"10.1016\/j.fsi.2015.04.004_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.lfs.2005.04.037","article-title":"Inhibitory mechanisms of highly purified vitamin B2 on the productions of proinflammatory cytokine and NO in endotoxin-induced shock in mice","volume":"78","author":"Kodama","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.fsi.2015.04.004_bib25","doi-asserted-by":"crossref","first-page":"G126","DOI":"10.1152\/ajpgi.00231.2003","article-title":"Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice","volume":"286","author":"Han","year":"2004","journal-title":"Am. J. Physiol.-Gastroint. Liver"},{"key":"10.1016\/j.fsi.2015.04.004_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.etap.2004.11.002","article-title":"Protein carbonyls: novel biomarkers of exposure to oxidative stress-inducing pesticides in freshwater fish Channa punctata (Bloch)","volume":"20","author":"Parvez","year":"2005","journal-title":"Environ. Toxicol. Phar."},{"key":"10.1016\/j.fsi.2015.04.004_bib27","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/13547500210125040","article-title":"Effect of cadmium on antioxidant enzyme activities and lipid peroxidation in the gills of the clam Ruditapes decussatus","volume":"7","author":"Geret","year":"2002","journal-title":"Biomarkers"},{"key":"10.1016\/j.fsi.2015.04.004_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.mad.2006.12.006","article-title":"Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats","volume":"128","author":"Lambertucci","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.fsi.2015.04.004_bib29","doi-asserted-by":"crossref","first-page":"e53662","DOI":"10.1371\/journal.pone.0053662","article-title":"The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2","volume":"8","author":"Chen","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2015.04.004_bib30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.fsi.2014.07.004","article-title":"Dietary tryptophan modulates intestinal immune response, barrier function, antioxidant status and gene expression of TOR and Nrf2 in young grass carp (Ctenopharyngodon idella)","volume":"40","author":"Wen","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cardiores.2007.03.004","article-title":"Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2\/ARE complex to promote vascular smooth muscle cell survival","volume":"75","author":"Liu","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib32","doi-asserted-by":"crossref","first-page":"e30440","DOI":"10.1371\/journal.pone.0030440","article-title":"Composition, diversity, and origin of the bacterial community in grass carp intestine","volume":"7","author":"Wu","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2015.04.004_bib33","series-title":"Studies on the dietary riboflavin, biotin and pantothenic acid requirement of grass carp (Ctenopharyngodon idella) fingerling","author":"Liu","year":"2007"},{"key":"10.1016\/j.fsi.2015.04.004_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0044-8486(90)90322-E","article-title":"Riboflavin requirements in on-growing rainbow trout, Oncorhynchus mykiss","volume":"88","author":"Amezaga","year":"1990","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.04.004_bib35","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.foodchem.2009.10.062","article-title":"Lipid peroxidation, protein oxidant and antioxidant status of muscle, intestine and hepatopancreas for juvenile Jian carp (Cyprinus carpio var. Jian) fed graded levels of myo-inositol","volume":"120","author":"Jiang","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.fsi.2015.04.004_bib36","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1365-2109.2004.01150.x","article-title":"Growth, reproductive performance, muscle and egg composition in grass carp, Ctenopharyngodon idella (Valenciennes), fed hydrilla or formulated diets with varying protein levels","volume":"35","author":"Khan","year":"2004","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib37","first-page":"269","article-title":"High-performance liquid-chromatographic analysis of thiamin and riboflavin in dietetic foods","volume":"5","author":"Hasselmann","year":"1989","journal-title":"J.\u00a0Micronutr. Anal."},{"key":"10.1016\/j.fsi.2015.04.004_bib38","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.fsi.2010.07.018","article-title":"Probiotic applications of two dominant gut Bacillus strains with antagonistic activity improved the growth performance and immune responses of grouper Epinephelus coioides","volume":"29","author":"Sun","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib39","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s12011-013-9785-6","article-title":"Effects of dietary copper on growth, digestive, and brush border enzyme activities and antioxidant defense of hepatopancreas and intestine for young grass carp (Ctenopharyngodon idella)","volume":"155","author":"Tang","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10499-005-9029-7","article-title":"The influence of feeding rate on growth, feed efficiency and body composition of juvenile grass carp (Ctenopharyngodon idella)","volume":"14","author":"Du","year":"2006","journal-title":"Aquacult. Int."},{"key":"10.1016\/j.fsi.2015.04.004_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.aquaculture.2004.03.011","article-title":"Growth, feed efficiency and digestibility in salmon (Salmo salar L.) fed different dietary proportions of vegetable protein sources in combination with two fish meal qualities","volume":"237","author":"Mundheim","year":"2004","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.04.004_bib42","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.fct.2006.10.020","article-title":"Hepatic metabolism, phase I and II biotransformation enzymes in Atlantic salmon (Salmo Salar, L) during a 12 week feeding period with graded levels of the synthetic antioxidant, ethoxyquin","volume":"45","author":"Berdikova Bohne","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fsi.2015.04.004_bib43","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fsi.2013.04.013","article-title":"Can ecological history influence immunomarker responses and antioxidant enzyme activities in bivalves that have been experimentally exposed to contaminants? A new subject for discussion in \u201ceco-immunology\u201d studies","volume":"35","author":"Matozzo","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib44","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.fsi.2012.11.008","article-title":"Effects of dietary cholesterol on antioxidant capacity, non-specific immune response, and resistance to Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss) fed soybean meal-based diets","volume":"34","author":"Deng","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib45","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.fsi.2013.05.027","article-title":"Effects of dietary isoleucine on the immune response, antioxidant status and gene expression in the head kidney of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"35","author":"Zhao","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib46","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1091-255X(98)80054-1","article-title":"Mucosal production of complement C3 and serum amyloid A is differentially regulated in different parts of the gastrointestinal tract during endotoxemia in mice","volume":"2","author":"Wang","year":"1998","journal-title":"J.\u00a0Gastroint. Surg."},{"key":"10.1016\/j.fsi.2015.04.004_bib47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.aquatox.2013.02.013","article-title":"Copper induces apoptotic cell death through reactive oxygen species-triggered oxidative stress in the intertidal copepod Tigriopus japonicus","volume":"132","author":"Rhee","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2015.04.004_bib48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.aquaculture.2008.05.010","article-title":"Effects of fasting on the meat quality and antioxidant defenses of market-size farmed large yellow croaker (Pseudosciaena crocea)","volume":"280","author":"Zhang","year":"2008","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.04.004_bib49","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.archoralbio.2008.02.002","article-title":"Protein carbonyl levels in serum and gingival cervicular fluid in patients with chronic periodontitis","volume":"53","author":"Baltac\u0131o\u011flu","year":"2008","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.fsi.2015.04.004_bib50","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1016\/j.fct.2008.05.039","article-title":"Potent protective effect of apricot and \u03b2-carotene on methotrexate-induced intestinal oxidative damage in rats","volume":"46","author":"Vardi","year":"2008","journal-title":"Food Chem Toxicol."},{"key":"10.1016\/j.fsi.2015.04.004_bib51","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1111\/j.1365-2109.2009.02283.x","article-title":"Myo-inositol prevents oxidative damage, inhibits oxygen radical generation and increases antioxidant enzyme activities of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"40","author":"Jiang","year":"2009","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib52","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.fsi.2013.01.008","article-title":"Dietary lipid requirement on non-specific immune responses in juvenile grass carp (Ctenopharyngodon idella)","volume":"34","author":"Jin","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib53","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2095.2011.00934.x","article-title":"Effects of myo-inositol on proliferation, differentiation, oxidative status and antioxidant capacity of carp enterocytes in primary culture","volume":"19","author":"Jiang","year":"2013","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2015.04.004_bib54","first-page":"R100","article-title":"Oxidative stress and antioxidant defenses in goldfish Carassius auratus during anoxia and reoxygenation","volume":"280","author":"Lushchak","year":"2001","journal-title":"Am. J. Physiol.-Reg. I"},{"key":"10.1016\/j.fsi.2015.04.004_bib55","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.plaphy.2011.04.005","article-title":"Antisense-mediated depletion of tomato chloroplast glutathione reductase enhances susceptibility to chilling stress","volume":"49","author":"Shu","year":"2011","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.fsi.2015.04.004_bib56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aquaculture.2011.03.042","article-title":"Effect of dietary choline on growth, intestinal enzyme activities and relative expressions of target of rapamycin and eIF4E-binding protein2 gene in muscle, hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"317","author":"Wu","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.04.004_bib57","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2015.04.004_bib58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.aquaculture.2013.07.022","article-title":"Potential use of macro-algae Gracilaria lemaneiformis in diets for the black sea bream, Acanthopagrus schlegelii, juvenile","volume":"412","author":"Xuan","year":"2013","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.04.004_bib59","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1172\/JCI112815","article-title":"Secretory products of macrophages","volume":"79","author":"Nathan","year":"1987","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.fsi.2015.04.004_bib60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.fsi.2015.04.004_bib61","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.fsi.2006.06.012","article-title":"Differential expression of the pro-inflammatory cytokines IL-1\u03b2-1, TNF\u03b1-1 and IL-8 in vaccinated pink (Oncorhynchus gorbuscha) and chum (Oncorhynchus keta) salmon juveniles","volume":"22","author":"Fast","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib62","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.fsi.2011.07.008","article-title":"The expression analysis of inflammatory and antimicrobial genes in the goldfish (Carassius auratus L.) infected with Trypanosoma carassii","volume":"31","author":"Oladiran","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.04.004_bib63","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","article-title":"IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR","volume":"104","author":"Krishnamurthy","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib64","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1165\/ajrcmb.13.1.7541221","article-title":"Increased expression of transforming growth factor beta isoforms (beta 1, beta 2, beta 3) in bleomycin-induced pulmonary fibrosis","volume":"13","author":"Santana","year":"1995","journal-title":"Am. J. Resp. Cell Mol."},{"key":"10.1016\/j.fsi.2015.04.004_bib65","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/embor.2009.243","article-title":"IKK\/NF-\u03baB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis","volume":"10","author":"Bollrath","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.fsi.2015.04.004_bib66","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.arcmed.2008.08.001","article-title":"NF-\u03bab p65 Antisense Oligonucleotides may Serve as a novel molecular approach for the treatment of patients with ulcerative colitis","volume":"39","author":"Li","year":"2008","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib67","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0171-2985(97)80030-7","article-title":"Predominant role of NF-\u03baB p65 in the pathogenesis of chronic intestinal inflammation","volume":"198","author":"Neurath","year":"1997","journal-title":"Immunobiology"},{"key":"10.1016\/j.fsi.2015.04.004_bib68","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1101\/gad.9.22.2736","article-title":"Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice","volume":"9","author":"Beg","year":"1995","journal-title":"Gene Dev."},{"key":"10.1016\/j.fsi.2015.04.004_bib69","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0092-8674(00)80406-7","article-title":"The I\u03baB kinase complex (IKK) contains two kinase subunits, IKK\u03b1 and IKK\u03b2, necessary for I\u03baB phosphorylation and NF-\u03baB activation","volume":"91","author":"Zandi","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2015.04.004_bib70","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1158\/0008-5472.CAN-08-4882","article-title":"N-myc downstream regulated gene 1\/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of \u03baB kinase \u03b2 expression","volume":"69","author":"Hosoi","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.fsi.2015.04.004_bib71","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.jhep.2011.06.015","article-title":"m-TOR inhibitors: what role in liver transplantation?","volume":"55","author":"Kawahara","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.fsi.2015.04.004_bib72","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cbi.2008.05.014","article-title":"Effects of exposure to multiple trace metals on biochemical, histological and ultrastructural features of gills of a freshwater fish, Channa punctata Bloch","volume":"174","author":"Pandey","year":"2008","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.fsi.2015.04.004_bib73","first-page":"R504","article-title":"The tight junction protein claudin-b regulates epithelial permeability and sodium handling in larval zebrafish, Danio rerio","volume":"304","author":"Kwong","year":"2013","journal-title":"Am. J. Physiol.-Reg. I"},{"key":"10.1016\/j.fsi.2015.04.004_bib74","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1369\/jhc.6A6944.2006","article-title":"Differential expression and subcellular localization of Claudin-7, -8, -12, -13, and -15 along the mouse intestine","volume":"54","author":"Fujita","year":"2006","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.fsi.2015.04.004_bib75","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/physrev.00019.2012","article-title":"Claudins and the modulation of tight junction permeability","volume":"93","author":"G\u00fcnzel","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.fsi.2015.04.004_bib76","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1084\/jem.20071416","article-title":"JAM-A regulates permeability and inflammation in the intestine in\u00a0vivo","volume":"204","author":"Laukoetter","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.fsi.2015.04.004_bib77","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/SHK.0b013e318299e9c0","article-title":"Vagus nerve stimulation attenuates intestinal epithelial tight junctions disruption in endotoxemic mice through \u03b17 nicotinic acetylcholine receptors","volume":"40","author":"Zhou","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.fsi.2015.04.004_bib78","doi-asserted-by":"crossref","first-page":"G422","DOI":"10.1152\/ajpgi.00412.2004","article-title":"Mechanism of TNF-\u03b1 modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression","volume":"288","author":"Ma","year":"2005","journal-title":"Am. J. Physiol.-Gastroint. Liver"},{"key":"10.1016\/j.fsi.2015.04.004_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/909613","article-title":"Inflammatory bowel disease therapies and gut function in a colitis mouse model","volume":"2013","author":"Nahidi","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fsi.2015.04.004_bib80","first-page":"8887","article-title":"Copper\/zinc superoxide dismutase from the cladoceran Daphnia magna: molecular cloning and expression in response to different acute environmental stressors","volume":"47","author":"Lyu","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fsi.2015.04.004_bib81","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11160-005-7846-4","article-title":"Antioxidant defenses in fish: biotic and abiotic factors","volume":"15","author":"Martinez-Alvarez","year":"2005","journal-title":"Rev. Fish Biol. Fish."},{"key":"10.1016\/j.fsi.2015.04.004_bib82","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0147-6513(03)00009-5","article-title":"Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch","volume":"56","author":"Sayeed","year":"2003","journal-title":"Ecotoxicol. Environ. Safe"},{"key":"10.1016\/j.fsi.2015.04.004_bib83","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.3748\/wjg.v16.i21.2657","article-title":"Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats","volume":"16","author":"Wang","year":"2010","journal-title":"World J. Gastroenterol. WJG"},{"key":"10.1016\/j.fsi.2015.04.004_bib84","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.aquatox.2014.10.025","article-title":"Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-\u03baB, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine","volume":"158","author":"Wang","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2015.04.004_bib85","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1073\/pnas.0501475102","article-title":"Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype","volume":"102","author":"Devling","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2015.04.004_bib86","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1074\/jbc.M708702200","article-title":"Molecular evolution of Keap1 two Keap1 molecules with distinctive intervening region structures are conserved among fish","volume":"283","author":"Li","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2015.04.004_bib87","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.aquaculture.2012.09.019","article-title":"Effects of dietary isoleucine on growth, the digestion and absorption capacity and gene expression in hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"368","author":"Zhao","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.04.004_bib88","doi-asserted-by":"crossref","first-page":"L810","DOI":"10.1152\/ajplung.1996.270.5.L810","article-title":"Antioxidant enzyme expression in rat lungs during hyperoxia","volume":"14","author":"Ho","year":"1996","journal-title":"Am. J. Physiol.-Lung C"},{"key":"10.1016\/j.fsi.2015.04.004_bib89","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2095.2009.00686.x","article-title":"Immune response, disease resistance and intestinal microflora of juvenile Jian carp (Cyprinus carpio var. Jian) fed graded levels of pantothenic acid","volume":"16","author":"Wen","year":"2010","journal-title":"Aquacult. Nutr."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815001564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815001564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T08:15:20Z","timestamp":1717834520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464815001564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S1050464815001564"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2015.04.004","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary riboflavin deficiency decreases immunity and antioxidant capacity, and changes tight junction proteins and related signaling molecules mRNA expression in the gills of young grass carp (Ctenopharyngodon idella)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2015.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}